immunogenic

GenVec Receives Grant for Malaria Vaccine Program

... Dr. Joseph Bruder, head of GenVec's malaria program. This grant, valued at approximately $600,000 over two years, will be used to identify new immunogenic antigens for malaria vaccine development. Using the funding from this grant, GenVec will be collaborating with the U.S. Naval Medical Research Center ...

DOR BioPharma Appoints Christopher P. Schnittker, CPA, as Vice President of Administration and Controller

... lethal effects of exposure to ricin toxin, botulinum toxin and anthrax. DOR's ricin toxin vaccine, RiVax(TM), has been shown to be well tolerated and immunogenic in a Phase 1 clinical trial in normal volunteers. For further information regarding DOR BioPharma, Inc., please visit the Company's website at ...

Intercell Supports the Japanese Encephalitis Vaccination Recommendations of CDC's Advisory Committee on Immunization Practices

...ARO received marketing approval from the U.S. Food and Drug Administration on March 30, 2009 on the basis of studies that showed the vaccine is highly immunogenic after only two doses. IXIARO has been shown to stimulate a long-lasting immune response and to be well tolerated. It is the only currently manufacture...

Researchers design unique method to induce immunity to certain STDs

...aid. "We found that vault nanoparticles containing immunogenic proteins can act as 'smart adjuvants' for inducing...es. Mucosal surfaces are hostile environments, and immunogenic proteins require added protection for delivery to ...ault nanoparticle is large enough to hold multiple immunogenic proteins, and because vaults are the size of small...

New TB Vaccine Passes Safety Trial

...e given the vaccine and then followed for a year. The researchers concluded that the vaccine was safe, did not produce any immunopathology and was immunogenic in the patients. Some participants had side effects that included fever, headache, fatigue and mild concerns at the site of the vaccination. The fi...

Novavax Reports Fourth Quarter and 2008 Year-End Financial Results

...dvancing our VLP based vaccine pipeline. We demonstrated in Phase II clinical studies that our VLP based flu vaccines are not only well tolerated and immunogenic in humans, but they have the potential to differentiate themselves from currently available alternatives. We also demonstrated that our VLP technolog...

Japanese Researchers Develop New Smallpox Vaccine

...n vaccines also cause a high rate of serious side effects, they said. "Developing a vaccine that is safer than first-generation vaccines yet highly immunogenic [producing immunity or an immune response] is crucial to constructing a prevention plan in the event of bioterrorist attack," they added. The resea...

DOR BioPharma Announces Potential $30 Million North American Partnership Agreement with Sigma-Tau Pharmaceuticals for orBec(R) in the Treatment of Graft-versus-Host Disease

... lethal effects of exposure to ricin toxin, botulinum toxin and anthrax. DOR's ricin toxin vaccine, RiVax(TM), has been shown to be well tolerated and immunogenic in a Phase 1 clinical trial in normal volunteers. For further information regarding DOR BioPharma, Inc., please visit the Company's website at w...

New form of intravenous iron treats anemia in chronic kidney disease patients on dialysis

...s iron, ferumoxytol, may be a safe and effective alternative to other forms of iron therapy. Ferumoxytol appears to contain less free iron and be less immunogenic than other intravenous forms of iron. Robert Provenzano, MD, FASN, of St. John Hospital and Medical Center in Detroit, MI, and his colleagues condu...

Cell transplantation and diabetes: New sites, new devices

...e cell clusters isolated from fetal or neonatal piglets retain the ability to mature and proliferate. In addition, these cells are believed to be less immunogenic than adult islet cells and more resistant to hypoxia. Van der Windt and colleagues suggest that porcine islet cells can provide an unlimited source ...

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DOR BioPharma Receives EMEA Agreement on the Design of its Confirmatory Phase 3 Clinical Trial of orBec(R) in GI GVHD

... lethal effects of exposure to ricin toxin, botulinum toxin and anthrax. DOR's ricin toxin vaccine, RiVax(TM), has been shown to be well tolerated and immunogenic in a Phase 1 clinical trial in normal volunteers. For further information regarding DOR BioPharma, Inc., please visit the Company's website at ...

DOR BioPharma, Inc. Executes $400,000 Equity Investment Agreement With Numoda Corporation

... lethal effects of exposure to ricin toxin, botulinum toxin and anthrax. DOR's ricin toxin vaccine, RiVax(TM), has been shown to be well tolerated and immunogenic in a Phase 1 clinical trial in normal volunteers. For further information regarding DOR BioPharma, Inc., please visit the Company's website at w...

GeoVax Starts Injections for Phase 2a Human HIV/AIDS Vaccine Trial in USA

... to combat its scourge," said Robert McNally, Ph.D., CEO and President of GeoVax Labs Inc. "Our Phase 1 trials found GeoVax's vaccines to be safe and immunogenic in humans. Good results from the Phase 2a human trial will build upon this foundation of safety and immunogenicity to support a Phase 2b efficacy tri...

Novavax Reports Positive Preclinical Results for a Novel, Broadly Cross-Protective H5N1 Pandemic Influenza Virus-like Particle (VLP) Vaccine Candidate

...rains ROCKVILLE, Md., Feb. 19 /PRNewswire-FirstCall/ -- NOVAVAX (Nasdaq: NVAX ) announced today favorable preclinical results for a new broadly immunogenic pandemic influenza virus-like particle (VLP) vaccine candidate that provided protection against several H5N1 virus strains. Results of a study co...

NOVAVAX Featured at Clinton Global Initiative 2008 Annual Meeting

...andidate against H5N1 avian influenza that has completed a Phase IIa clinical trial. The study demonstrated that the VLP vaccine is well tolerated and immunogenic and can be produced rapidly to supply vaccine against an emerging pandemic strain. The company has also commenced a Phase II trial in healthy adults f...

Intercell Announces Initiation of Further Phase II Clinical Trial of V710 an Investigational Vaccine to Prevent S. aureus Infection

...s eligible to receive milestone payments and royalties on future net sales. In Phase I clinical trials the S. aureus candidate vaccine was shown to be immunogenic and generally well tolerated. Hospital-acquired Infections Hospital-acquired infections caused by bacteria are one of the major causes of death an...

The New England Journal of Medicine Publishes Study Investigating the Safety and Efficacy of Baxter's Cell-Based Pandemic, Avian Flu Vaccine

...breakthrough production technology with the aim of protecting people against an H5N1 pandemic flu infection," said Hartmut J. Ehrlich, MD. "This is an immunogenic vaccine without the need for an adjuvant to boost the immune response." About CELVAPAN CELVAPAN is manufactured in a cell culture-based system in ...

Bavarian Nordic Enters Clinical Trials with HIV Multiantigen Vaccine

...Bavarian Nordic has demonstrated proof-of-concept for the MVA technology's ability to control HIV replication. Furthermore the vaccine was shown to be immunogenic and to induce a broad T-cell response to Nef. The MVA-BN(R) HIV multiantigen builds on these positive results and thus represents an excellent opportu...

Novavax Completes Enrollment in Phase I/IIa Pandemic Influenza Vaccine Clinical Trial

... dose-escalation in 70 healthy adult volunteers, were reported in December 2007. The interim findings suggested that the vaccine is well tolerated and immunogenic at the 15 microgram and 45 microgram dose levels. Based upon its review of these results, the Data and Safety Monitoring Board (DSMB) recommended that...

Aeras, Crucell and South African Tuberculosis Vaccine Initiative Announce Encouraging Preliminary Results of Tuberculosis Vaccine Clinical Trial in South Africa

...gainst the most commonly used recombinant vaccine vector, adenovirus serotype 5 (Ad5), without compromising large-scale production capabilities or the immunogenic properties of Ad5. AdVac(R) technology is based on adenoviruses that do not regularly occur in the human population, such as Ad35. In contrast to, for...

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Artificial induction of immunity

.... Adjuvants are also used in other ways in researching the immune system. A more contemporary approach for "boosting" the immune response of simpler immunogenic molecules (known as antigens ) is to conjugate the antigens. Conjugation is the attachment to the antigen of another substance which also generates...

immunogenic in Biological News

Sarcospan, a little protein for a big problem

...t 600 bp, it is easily packaged into the safest viral vectors, unlike either dystrophin or utrophin, which are about 700 times larger and require more immunogenic vectors. ...

Engineer develops detergent to promote peripheral nerve healing

...ansplanted nerve provides a type of scaffolding that serves as a bridge between the two ends of the severed nerve to promote regrowth. And because the immunogenic lipid components have been extracted, patients don't require immunosuppressant drugs. AxoGen learned about the detergent processing work in Schmidt...

Menstrual blood -- a valuable source of multipotential stem cells?

...engraft and differentiate is vast, said Patel. The ideal cell would also have the ability to be used in an allogenic manner from donors for optimal immunogenic compatibility. Due to their ease of collection and isolation, MenSCs would be a great source of multipotent cells if they exhibit this property along ...

Biomarkers allow doctors to match therapy to patient

...ven in the upcoming phase III trial, said Linda C. Benavides, M.D., a resident in general surgery at Brooke Army Medical Center. HER2, a source of immunogenic peptides, is over-expressed in approximately 25 to 30 percent of patients with early stage breast cancer. The CVDP has conducted clinical trials w...

The insect vector always bites twice

...diseases. It contains numerous proteins, including immunogenic ones that can modulate or induce a human immune re... of identifying in the arthropod vector saliva the immunogenic proteins responsible. They called on immunological...y, in total saliva extract of Glossinia flies, the immunogenic proteins responsible for synthesis of these specif...

Breast tumors in mice eradicated using cancer vaccine

... activate antigen-presenting cells. They have found that by doing this the immune system now recognizes regions of the HER-2/neu molecule that are not immunogenic when presented by other vaccine approaches. Paterson first hit on the idea of using Listeria as a cancer vaccine vector over ten years ago. "It to...

immunogenic in Biological Technology

GenVec Reports Second Quarter 2009 Financial Results

...alth (NIH) to support the Company's malaria vaccine program. This grant, valued at approximately $600,000 over two years, will be used to identify new immunogenic antigens for malaria vaccine development. Other Developments GenVec strengthened its cash position by raising $6.0 millio...

DOR BioPharma Receives FDA Orphan Drug Designation for orBec(R) for the Treatment of Chronic Gastrointestinal GVHD

... lethal effects of exposure to ricin toxin, botulinum toxin and anthrax. DOR's ricin toxin vaccine, RiVax(TM), has been shown to be well tolerated and immunogenic in a Phase 1 clinical trial in normal volunteers. For further information regarding DOR BioPharma, Inc., please visit the Company's website at ...

DOR BioPharma Announces Issuance of European Patent for its LPM(TM) Oral Drug Delivery Technology

... lethal effects of exposure to ricin toxin, botulinum toxin and anthrax. DOR's ricin toxin vaccine, RiVax(TM), has been shown to be well tolerated and immunogenic in a Phase 1 clinical trial in normal volunteers. For further information regarding DOR BioPharma, Inc., please visit the Company's website at ...

DOR BioPharma Announces Publication of orBec(R) Clinical Pulmonary Data in Bone Marrow Transplantation

... lethal effects of exposure to ricin toxin, botulinum toxin and anthrax. DOR's ricin toxin vaccine, RiVax(TM), has been shown to be well tolerated and immunogenic in a Phase 1 clinical trial in normal volunteers. For further information regarding DOR BioPharma, Inc., please visit the Company's website at w...

New Phase 3 Data Continue to Indicate that Wyeth's Investigational 13-valent Vaccine Has the Potential to Broaden Coverage Against Pneumococcal Disease

... a 20-year history of use in pediatric vaccines. Phase 3 Data Results Data from the studies presented at ESPID indicate that Prevenar 13 is immunogenic for all serotypes and showed a safety profile similar to Prevenar. Among the study findings: In a study conducted in France, 613 c...

DOR BioPharma Reports 1st Quarter 2009 Financial Results and Reviews Recent Accomplishments

... lethal effects of exposure to ricin toxin, botulinum toxin and anthrax. DOR's ricin toxin vaccine, RiVax(TM), has been shown to be well tolerated and immunogenic in a Phase 1 clinical trial in normal volunteers. For further information regarding DOR BioPharma, Inc., please visit the Company's website at h...

Medicago succesfully expresses VLP antigen for A H1N1 strain

...l be purified in preparation for an immunogenicity study in mice. The Company expects results from this study in June, with the goal of confirming the immunogenic potential of this H1 VLP. "We are thrilled with these initial results. They demonstrate that we can rapidly express an antigen from a new influenza ...

Medicago initiates work on Swine Flu strain

...Island (H1N1) and Brisbane (H1N1). Medicago is keeping health authorities informed on its work. Medicago's H5N1 pandemic VLP vaccine has shown to be immunogenic at doses as low as 5 micrograms in preclinical studies and provided 100% cross-protection to different strains of the H5N1 virus in an animal model. T...

PharmAthene Presents Data for SparVax(TM), a Novel Vaccine for the Prevention and Treatment of Anthrax Infection, at the 12th Annual Conference on Vaccine Research

... provides further confirmation that SparVax(TM) is immunogenic and promotes good immunological recall following a...) dose groups were noted. Both vaccines were immunogenic following the 3-dose series with response rates of... that SparVax(TM) appears to be well tolerated and immunogenic in humans. These studies suggest that three doses...

NOVAVAX Announces Publication of a Preclinical Study Demonstrating that a Virus-like Particle Vaccine Provided Protection Against Highly Pathogenic H1N1 and H5N1 Influenza Strains

...st different HA types. Novavax has shown in clinical trials that an H5N1 VLP candidate vaccine given by intramuscular injection is well tolerated and immunogenic in humans. Preclinical research on alternative pandemic influenza VLP vaccine approaches is expected to continue. Additional information about...

immunogenic in Biological Products

Blocker Array from BACHEM

Description:...ies specificity, QC of purified antibodies, selection of suitable blockers for Western blot, ELISA and IHC, identification of an unknown carrier in an immunogenic conjugate, clarification of high background and/or unexpected binding. Storage: 2-8 C...
Company:BACHEM

Blocker Array II from BACHEM

Description:...ies specificity, QC of purified antibodies, selection of suitable blockers for Western blot, ELISA and IHC, identification of an unknown carrier in an immunogenic conjugate, clarification of high background and/or unexpected binding....
Company:BACHEM