Idiopathic

3 studies confirm the value of etanercept therapy in treating juvenile idiopathic arthritis

Copenhagen, Denmark, Friday 12 June 2009: Three new studies have individually shown the anti-TNF (tumour necrosis factor) therapy etanercept to be effective, with a good safety profile, in children under four years of age with juvenile idiopathic arthritis (JIA), and associated with improved Healt...

Subclinical markers predict relapse in juvenile idiopathic arthritis post methotrexate withdrawal

Copenhagen, Denmark, Thursday 11 June 2009: Elevated levels of the inflammatory biomarkers Myeloid Related Protein (MRP*) 8/14 predict an increased risk of relapse following withdrawal of methotrexate (MTX) therapy in children with juvenile idiopathic arthritis (JIA) who have achieved inactive dis...

Important Data Presented on Independent Predictors of Mortality in Patients With Idiopathic Pulmonary Fibrosis

- Change in Forced Vital Capacity is among strongest predictors of one-year mortality - SAN DIEGO, May 17 /PRNewswire-FirstCall/ -- InterMune, Inc. (Nasdaq: ITMN ) today reported that results of a study assessing the relationship between various measures of clinical status and the risk of d...

As a Result of the FDA Investigation Into TNF-Alpha Inhibitors, 30 Percent of Surveyed Rheumatologists Have Altered Their Prescription Patterns for Juvenile Idiopathic Arthritis

Twenty Percent of Surveyed MCO Pharmacy Directors Say They Will Alter Reimbursement of TNF-alpha Inhibitors for Juvenile Idiopathic Arthritis and Pediatric Crohn's Disease, According to a New Report from Decision Resources WALTHAM, Mass., March 26 /PRNewswire/ -- Decision Resources, one of th...

Early life infections increase the risk of rheumatoid arthritis and juvenile idiopathic arthritis

Paris, France, Friday 13 June 2008: Infections during the first year of life are a marker of increased risk of developing specific types of arthritis later in life, according to new research from Sweden presented today at EULAR 2008, the Annual Congress of the European League Against Rheumatism i...

Specific mutations in the IL2RA gene associated with juvenile idiopathic arthritis

Paris, France, Friday 13 June 2008: Certain single nucleotide polymorphisms (SNPs) within the interleukin 2 receptor alpha (IL2RA) gene region are shown to be associated with juvenile idiopathic arthritis (JIA), according to a new study of two independent cohorts presented today at EULAR 2008, the...

High rate of complicated idiopathic gallstone disease in pediatric patients

The prevalence of gallstones in adults of industrialized countries is approximately 10% and is showing a tendency to rise. Data for pediatric patients is scarce. A research article published on March 14, 2008, in the World Journal of Gastroenterology addresses this problem. The team lead by D...

Abbott Receives FDA Approval for HUMIRA(R) (Adalimumab) for Polyarticular Juvenile Idiopathic Arthritis

HUMIRA Is the First Biologic Treatment Approved in Nine Years for Children Suffering from This Potentially Debilitating Autoimmune Disease ABBOTT PARK, Ill., Feb. 22 /PRNewswire-FirstCall/ -- Abbott (NYSE: ABT ) announced today it has received U.S. Food and Drug Administration (FDA) approva...

Eltrombopag studied in Idiopathic Thrombocytopenic Purpura

NEW YORK (Nov. 29, 2007) -- There are estimated to be between 50,000 -- 100,000 individuals in the U.S. diagnosed with chronic Immune Thrombocytopenic Purpura (ITP), an autoimmune disease that dramatically reduces the number of platelets in their blood -- causing bruises, nosebleeds and, sometim...

Viagra Helps Patients With Idiopathic Pulmonary Fibrosis

Research finds that Viagra helps patients with idiopathic pulmonary fibrosis. This disease is incurable and is characterized by progressive scarring// in the lungs, which often leads to a lung transplant. Published in the March issue of the journal Chest, the research shows that more than hal...

Idiopathic in Medical Technology

S*BIO Advances JAK2 Inhibitor SB1518 into Phase 1/2 Clinical Trial in Australia for the Treatment of Chronic Idiopathic Myelofibrosis

SINGAPORE, Dec. 1 /PRNewswire/ -- S*BIO Pte Ltd today announced the initiation of a Phase 1/2 clinical trial of SB1518, a potent and orally-active JAK2 inhibitor, in leading medical centers in Australia for patients with chronic idiopathic myelofibrosis (CIMF). The trial is designed to e...

U.S. Food and Drug Administration Approves ORENCIA(R) (abatacept) for the Treatment of Moderate-to-Severe Polyarticular Juvenile Idiopathic Arthritis (JIA) in Patients Six Years and Older

- ORENCIA is a First-in-Class Biologic Treatment Option Now Available for Use in Pediatric Patients with JIA(1,2) - PRINCETON, N.J., April 8, 2008 /PRNewswire-FirstCall/ -- Bristol-Myers Squibb Company (NYSE: BMY ) today announced that the U.S. Food and Drug Administration (FDA) ...

FDA Approves XYZAL(R) (levocetirizine dihydrochloride) Oral Solution for the Relief of Seasonal and Year Round Allergies and Chronic Idiopathic Urticaria

BRUSSELS, Belgium, and BRIDGEWATER, N.J., Feb. 19 /PRNewswire-FirstCall/ -- UCB (Euronext: UCB) and sanofi-aventis announced today that the U.S. Food and Drug Administration (FDA) approved a New Drug Application (NDA) for XYZAL(R) (levocetirizine dihydrochloride) 0.5 mg/mL oral solution, a pre...

ORENCIA(R) (abatacept) Supplemental Biologics License Application for Juvenile Idiopathic Arthritis Accepted by FDA for Filing and Review

NEW YORK, Aug. 7 /PRNewswire-FirstCall/ -- Bristol-Myers Squibb Company (NYSE: BMY ) today announced that the U.S. Food and Drug Administration (FDA) has accepted, for filing and review, the supplemental biologics license application (sBLA) for ORENCIA(R) (abatacept) for the treatment of pedi...

First-of-Its-Kind Study Shows Botox (Botulinum Toxin Type A) Significantly Improves Idiopathic Detrusor Overactivity (IDO) in Patients With Symptoms of Overactive Bladder

Treatment Benefits Were Maintained for at Least 24 Weeks, According to Report Published in The Journal of Urology LONDON, May 15, 2007 /PRNewswire/ -- Researchers from Guy's Hospital and King's College London School of Medicine have announced the results from the first randomized, double-blind, pl...

Telik Announces Publication of Positive Phase 1 Results of a Multicenter Study of Ezatiostat Hydrochloride (TELINTRA(R), TLK199) Tablets In Patients With Myelodysplastic Syndrome

...dies support the further development of TELINTRA. Phase 2 studies are ongoing in MDS (enrollment completion expected by year end), and Severe Chronic idiopathic Neutropenia. Reprints of both publications are available from Telik. Background on MDS and TELINTRA MDS is a heterogeneous group of b...

Data Demonstrated ACTEMRA(R) (tocilizumab) Significantly Inhibited Progression of Structural Joint Damage in Rheumatoid Arthritis Patients

...e; in April 2008, additional indications for rheumatoid arthritis, juvenile idiopathic arthritis and systemic-onset juvenile idiopathic arthritis were also approved in Japan. ACTEMRA (known as RoACTEMRA in Europ...

Study Results Present Efficacy and Safety Findings from the PHIRST-1 Study of Patients with Pulmonary Arterial Hypertension Taking Tadalafil Tablets Once Daily

...the patients they treat." About the Study The randomized, double-blind, 16-week, placebo-controlled Phase 3 study monitored 405 patients with idiopathic PAH or PAH associated with anorexigen use, connective tissue disease, human immunodeficiency virus (HIV) infection, or congenital systemic-to-pulmonar...

FDA Approves ADCIRCA(TM) (Tadalafil) Tablets for the Treatment of Pulmonary Arterial Hypertension

... indicated to improve exercise ability in WHO Group I PAH patients, which encompasses patients with multiple forms of PAH including etiologies such as idiopathic and familial PAH as well as PAH associated with scleroderma and congenital heart disease. "Today, thanks to the clinical development efforts l...

Two-Year Data Reinforce Effect of ACTEMRA(R) (tocilizumab) in Inhibiting Progression of Joint Damage and Improving Physical Function in Rheumatoid Arthritis Patients

...e; in April 2008, additional indications for rheumatoid arthritis, juvenile idiopathic arthritis and systemic-onset juvenile idiopathic arthritis were also approved in Japan. ACTEMRA (known as RoACTEMRA in Europ...

Idiopathic in Medical Products

Programmer System (Enterra™ Therapy)

Description:...ronic nausea and vomiting associated with gastroparesis when conventional drug therapies are not providing adequate relief of symptons for diabetic or idiopathic patients. Gastroparesis is a stomach disorder in which food moves through the stomach more slowly than normal. In some patients, this condition res...
Company:Medtronic Gastroenterology

Medtronic ITREL 3 Model 7425G Neurostimulator (Enterra™ Therapy)

Description:...ronic nausea and vomiting associated with gastroparesis when conventional drug therapies are not providing adequate relief of symptons for diabetic or idiopathic patients. Gastroparesis is a stomach disorder in which food moves through the stomach more slowly than normal. In some patients, this condition res...
Company:Medtronic Gastroenterology

Medtronic Model 4351 Lead (Enterra™ Therapy)

Description:...ronic nausea and vomiting associated with gastroparesis when conventional drug therapies are not providing adequate relief of symptons for diabetic or idiopathic patients. Gastroparesis is a stomach disorder in which food moves through the stomach more slowly than normal. In some patients, this condition res...
Company:Medtronic Gastroenterology

Androstanediol Glucuronide RIA Test

Description:...evated levels of serum 3alpha-diol G have been reported in congenital adrenal hyperplasia [3,4] and in various forms of female hirsutism [1,5,6], e.g. idiopathic hirsutism and polycystic ovary disease. Serum 3alpha-diol G may be elevated in the presence of normal levels of other circulating androgens [1,5,6]. T...
Company:Diagnostic Systems Laboratories, Inc.

Androstanediol Glucuronide EIA Test

Description:...evated levels of serum 3alpha-diol G have been reported in congenital adrenal hyperplasia [3,4] and in various forms of female hirsutism [1,5,6], e.g. idiopathic hirsutism and polycystic ovary disease. Serum 3alpha-diol G may be elevated in the presence of normal levels of other circulating androgens [1,5,6]. T...
Company:Diagnostic Systems Laboratories, Inc.

Boston Scoliosis Brace

Description:... The Boston Scoliosis Brace is the proven system for the non-operative treatment of idiopathic scoliosis. For Orthotists unfamiliar with the system, BBI offers the Boston Brace Course, every September in Avon, Massachusetts. The Boston Scolios...
Company:Boston Brace International

Idiopathic in Medical Dictionary

Idiopathic

Idiopathic is an adjective used primarily in medicine meaning arising spontaneously or from an obscure or unknown cause. From Greek ἴδιος, idios (one's own) + πάθος, pathos (suffering), it means approximately "a disease of its own kind." Idiopathic thrombocytopenic purpura ...

Urticaria

...acterised ... Autoimmune Urticaria : Chronic idiopathic urticaria (CIU), defined as the ... Differential Diagnosis of Chronic idiopathic Urticaria ... Urticaria refers to a group ... ... The scientific name for hives is chronic idiopathic urticaria (CIU) ... ...

Thromboembolism

...nically significant thromboembolism . ... A comparison of three months of anticoagulation with extended anticoagulation for a first episode of idiopathic venous thromboembolism . N Engl J Med 1999;340:901-7. ... ... in the Prolyse in Acute Cerebral Thromboembolism (PROACT) II study found ... H...

Thrombocyte

...vein, usually on inside of the elbow or the ... Blood test to evaluate, bleeding disorders, purpura/petechiae, drug induced thrombocytopenia, idiopathic thrombocytopenia purpura, disseminated intravascular ... ...

Subdural hematoma

...hematoma . ... Reports of spinal subdural hematoma are rare.1-13 In the few reported cases, ... Spinal subdural hematoma is classified as idiopathic or secondary, based on cause. ... Subdural hematoma . Increased intracranial pressure. Overview. Symptoms. Treatment ... A subdural hematom...

Short stature

... Short stature is well described as the only symptom of CD in some older children ... Prevalence of celiac disease in Iranian children with idiopathic short stature . ... If short stature is associated with a treatable medical condition, then the ... If the short stature appears to be...

Seborrhea

...rrow results in Seborrhea by using the "Search within these ... Seborrhea is sometimes secondary to some underlying problem. ... primary or idiopathic seborrhea . The treatment for seborrhea is to diagnose and treat the ... Seborrheic dermatitis is a common, inflammatory skin conditio...

Scoliosis

...lop in infancy or early childhood. ... Scoliosis is a condition that causes an abnormal curvature of the spine. ... What causes scoliosis ? ... idiopathic scoliosis is further classified by age group. ... Scoliosis treatment includes several options, these are observation, bracing, ... What sc...

Renal vein thrombosis

...ovider if ... ... for venous thrombosis , particularly deep vein and renal vein thrombosis (DVT and ... Renal vein thrombosis in idiopathic membranous glomerulopathy and nephrotic ... Renal vein thrombosis occurs in both infants and adults. ... In adults, renal vein throm...

Purpura

...emia on the calves. Meningococcemia on the leg ... idiopathic thrombocytopenic purpura (ITP) ... Petechiae...emia on the calves. Meningococcemia on the leg ... idiopathic thrombocytopenic purpura (ITP) ... Purpura ...pura . ... PURPURA AND ABNORMAL BLEEDING ... idiopathic thrombocytopenic purpura (ITP) is a bleeding c...

Idiopathic in Biological News

Pitt team first to profile genes in acutely ill idiopathic pulmonary fibrosis patients

PITTSBURGH, July 7 The first findings from a one-of-a-kind, patient-driven effort to provide lung tissue for research might help doctors predict when patients with idiopathic pulmonary fibrosis (IPF) are becoming dangerously ill and also could point the way to interventions that could sustain the...

Translational research patented first experimental treatment against idiopathic pulmonary fibrosis

This release is available in Spanish . Idiopathic pulmonary fibrosis is a disease with unknown cause with a very severe prognosis; when detected, it is already in an advanced stage. Patients suffering from it cannot develop with normality pulmonary gas exchange, and have a very reduced qual...

Extra-aggressive form of idiopathic pulmonary fibrosis identified

Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive lung disorder from which most patients die within 5 years after diagnosis. The disease is characterized by the insidious onset of dyspnea or cough and usually evolves slowly. Now, Selman and coworkers present in an article publ...

Gene expression patterns predict rapid decline in idiopathic pulmonary fibrosis patients

Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease typically characterized by the slow but progressive onset of shortness of breath or cough. Most patients live about five years after diagnosis. However, according to a new study being published today in the online journal PLoS ONE, a su...

Gene expression findings a step toward better classification and treatment of juvenile arthritis

... Scientists have discovered gene expression differences that could lead to better ways to classify, predict outcome, and treat juvenile idiopathic arthritis (JIA). Eventually such findings could enable doctors to target more aggressive treatment to children at risk of more severe arthritis, while...

UT Southwestern researchers identify gene linked to inherited form of fatal lung disease

...ame mutation may also be associated with lung cancer, the researchers said. This is the third gene that UT Southwestern scientists have linked with idiopathic pulmonary fibrosis, or IPF. The study appears online this week and in the January issue of American Journal of Human Genetics. In the U.S., about...

Stowers Institute's Baumann Lab identifies key step in maturation pathway of telomerase

... telomerase are also likely to compromise telomerase function and may thus contribute to diseases such as dyskeratosis congenita, aplastic anemia, and idiopathic pulmonary fibrosis." ...

Inflammation triggers cell fusions that could protect neurons, Stanford research shows

...und that those animals with higher-than-expected numbers of fused cells also had an inflammatory skin condition common to aging laboratory mice called idiopathic ulcerative dermatitis. This type of chronic inflammation affects the entire immune system of the animal and causes a systemwide immune response. T...

Genetic variant mimics effect of heart failure medications

...inability to pump adequate amounts of blood through the body. Heart failure can be the result of hypertension or a heart attack. In some cases, called idiopathic cardiomyopathy, the cause is not identified. As heart failure progresses, adrenalin produces a fight or flight response to stimulate the heart into ac...

Study identifies pathway required for normal reproductive development

...e Unit in the MGH Department of Medicine. The current study is the latest in a series of investigations by the MGH group into the genetic basis of idiopathic hypogonadotropic hypogonadism (IHH), a rare condition in which puberty does not take place naturally. IHH occurs when a structure in the brain called...

Idiopathic in Biological Technology

Axial Biotech Launches Genetic Test for Adolescent Idiopathic Scoliosis (AIS)

New assay is the first of its kind to determine likelihood of spinal disease progression SALT LAKE CITY, Dec. 9 /PRNewswire/ -- Axial Biotech, Inc. announced today the commercial launch of a new DNA-based test that indicates the likelihood of progression to a severe curve for children dia...

InterMune to Present at Canaccord Adams Conference

... the research, development and commercialization of innovative therapies in pulmonology and hepatology. InterMune has an R&D portfolio addressing idiopathic pulmonary fibrosis (IPF) and hepatitis C virus (HCV) infections. The pulmonology portfolio includes pirfenidone for which a Phase 3 program in patien...

InterMune Reports Second Quarter 2009 Financial Results and Business Highlights

...g lower off-label physician prescriptions of Actimmune for the treatment of idiopathic pulmonary fibrosis (IPF), which InterMune does not promote. Resear... pulmonology and hepatology. InterMune has an R&D portfolio addressing idiopathic pulmonary fibrosis (IPF) and hepatitis C virus (HCV) infections. The pulmo...

InterMune to Release Second Quarter Financial Results on August 6

... the research, development and commercialization of innovative therapies in pulmonology and hepatology. InterMune has an R&D portfolio addressing idiopathic pulmonary fibrosis (IPF) and hepatitis C virus (HCV) infections. The pulmonology portfolio includes pirfenidone for which a Phase 3 program in patien...

Data on WaferGen's SmartChip(TM) System to be Presented at 3rd Annual Rediscovering Biomarkers Conference

...bilities to identify and validate therapeutically-relevant gene expression biomarkers in areas including chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), lung cancer and wound healing. WaferGen believes this research may lead to the discovery of specific genes responsible for...

DOR BioPharma Announces Publication of orBec(R) Clinical Pulmonary Data in Bone Marrow Transplantation

... In the first 200 days after randomization, four of the patients treated with placebo developed non-infectious pulmonary complications, such as idiopathic pneumonia syndrome and cryptogenic organizing pneumonia, as compared to none of the orBec(R)-treated patients (p = 0.04). The inv...

InterMune to Present at Goldman Sachs Healthcare Conference

... the research, development and commercialization of innovative therapies in pulmonology and hepatology. InterMune has a pipeline portfolio addressing idiopathic pulmonary fibrosis (IPF) and hepatitis C virus (HCV) infections. The pulmonology portfolio includes the Phase 3 program, CAPACITY, which is evaluatin...

Oncothyreon's PX-866 is effective in preclinical model of pulmonary fibrosis

...brosis normally seen in the model. These results suggest that inhibition of the PI-3 kinase pathway might be beneficial in such human lung diseases as idiopathic pulmonary fibrosis." "Although our current development program for PX-866 is focused on cancer, we are very interested in the role the PI-3 kinase p...

Results From Phase 3 CAPACITY Program of Pirfenidone in IPF and Study of Predictors of Mortality in IPF to be Presented at ATS

...ining the predictors of mortality in patients with idiopathic pulmonary fibrosis (IPF) will be presented in a po... PREDICTORS OF MORTALITY IN PATIENTS WITH idiopathic PULMONARY FIBROSIS (IPF) POSTER 216: P.W...ALS OF PIRFENIDONE (PFD) IN PATIENTS WITH idiopathic PULMONARY FIBROSIS (IPF) TUESDAY, MA...

Axial Biotech Wins 2009 Innovation Award for Biotechnology

...ay, April 30, 2009. Axial Biotech's award winning product, ScoliScore(TM), is the first-ever genetic test for patients diagnosed with Adolescent idiopathic Scoliosis (AIS). This new molecular diagnostic tool marks a major advancement in which medical treatments can be personalized to patients diagnosed wi...

Idiopathic in Biological Definition

Infertility

...ous causes Psychological factors Drugs, alcohol Testicular factors Genetic causes, e.g. Klinefelter syndrome Neoplasm, e.g. seminoma idiopathic failure Varicocele Trauma Hydrocele Mumps Posttesticular causes Vas deferens obstruction Infection, e.g. prostatitis ...

Idiopathic in Biological Dictionary

Thrombocytes

... system with an introduction, the fluid systems, innate immunity ... leukocytes (white blood cells or WBCs), and thrombocytes (platelets) ... idiopathic thrombocytopenic purpura (ITP) is a bleeding condition in which the ... Platelets also are called thrombocytes (THROM-bo-sites) ... What does it ...

Negative interference

.... Here we describe a negative assay interference associated with an IgG paraprotein. ... first documentation of negative interference by an idiopathic ... ... idea of distinguishing between a negative and a positive sense of ... Why should the mere absence of state interference be thought to...

Brachial

...achial plexus neuritis are often misdiagnosed as having ... Acute brachial plexus neuritis has been recognized as a distinct plexus disorder ... idiopathic brachial neuritis is a well defined clinical condition that most ... MRI of the left brachial plexus showed nonspecific signal abnormality with T2...