Fox Chase Cancer Center scientists identify immune-system mutation
A team of Fox Chase Cancer Center scientists led by immunologist Dietmar J. Kappes, Ph.D., has identified the genetic mutation that keeps a mouse strain from developing white blood cells, or lymphocytes, called helper T cells. The report by Kappes and his colleagues appears in the Feb. 24 issue of Nature. Kappes' laboratory first discovered the mice with this naturally occurring defect in...Researchers identify target for cancer drugs
For nearly a decade, scientists have been trying to fully understand a particular communication pathway inside of cells that contributes to many malignant brain and prostate cancers. While scientists have identified elements of this pathway, other key components have remained a mystery. Researchers at Whitehead Institute now have discovered a missing puzzle piece, a finding that may present drug...Scientists identify genetic pathways essential to RNA interference
A research team based at Massachusetts General Hospital (MGH) has identified 80 new genes essential to the process of RNA interference (RNAi), a powerful new research tool for inactivating genes in plants or animals. They used the RNAi process itself to find new genes that participate in the gene-silencing mechanism, which someday may help to fight human disease. The report will appear in the jou...Scientists identify molecular events that drive cell senescence
UT Southwestern Medical Center at Dallasresearchers have found a way of stimulating the immune systems of miceto fight against amyloid proteins that cause the devastating plaquesthat are characteristic of Alzheimer's disease.For years scientists have examined the possibility of using aprotein-based vaccine to slow the progression of the disease in itsearly stages. UT Southwestern researcher...Scientists identify new model Of NK cell development
Scientists here have made a major discovery that sheds new light upon the growth and development of human natural killer (NK) cells, powerful but somewhat mysterious components of the body's immune system that are the first line of defense against cancer and infectious diseases. Scientists have believed for years that human NK cells are generated in bone marrow, but Michael Caligiuri, dire...TKB1 Cells Identify Receptor Tyrosine Kinase Interacting Proteins
Institute for Molecular Biology and Biotechnology, McMaster University,Ontario, Canada GST-fusion proteins expressed in TKB1 bacteria are used to affinity purifycellular proteins, which interact with a specific autophosphorylation site onthe Erb...Strategies to Identify and Confirm Phase I Metabolites of Glyburide Using the 4000 Q TRAP System
In this application note, several different metabolite identification approaches are evaluated for their merits. A comprehensive examination of four Information Dependent Acquisition (IDA) survey modes was performed to illustrate data quality and types of metabolites found. A significant number of metabolites were found with each mode of operat...Laboratory Testing Can Identify Risk of Pre-Term Labor and Delivery
A test for fetal fibronectin can predict whether a pregnant woman is at risk for early labor and delivery. Those at high risk for pre-term births are women with previous pre-term deliveries, those with multiple gestation pregnancy, and those who suffer from diabetes and/or hypertension. The current approach for finding whether a woman will go into premature labor is the use of a clinical scoring...Now you can identify Sperm and Egg donors
The British government, in a landmark decision, has ruled that henceforth donors of sperms and eggs can be identified if both the donor and recipient desire so. However if the donor feels not to reveal his/her identity, it will not be revealed. Prior to this ruling the identity of the donors of sperms and eggs have always been withheld. This would be a major ruling with far reaching consequences....Blood test may identify ovarian cancer
Some 23,300 American women are expected to be diagnosed with ovarian cancer every year, and the disease is expected to cause 13,900 deaths. It accounts for 4 percent of all cancers among women. A simple blood test may be able to identify ovarian cancer at its earliest stage. Currently, around three-quarters of women with ovarian cancer are diagnosed in advanced stages of the disease, when they ha...Identifying bacteria made amiable
A Queensland group have developed an efficient method of identifying strains of bacteria, which will help to manage outbreaks of diseases such as meningococcal disease. The Cooperative Research Centre for Diagnostics, based at Queensland University of Technology (QUT) has taken advantage of two new technologies// that have emerged in the area of DNA sequencing recently - DNA chip technology and...Identifying Virus Found To Be Essential for HIV Patients
Before the introduction of highly active antiretroviral therapy HAART, the cytomegalovirus was a major problem for AIDS patients, causing opportunistic// infections that spread out of control and led to faster progression of the disease and shorter time to death. Researchers assessed CMV status in about 375 people infected with HIV using a standard test. Investigators followed the patie...NIEHS Researchers Identify Enzyme Critical in DNA Replication
BETHESDA, Md., July 5, 2007--In this weeks issue of Science,researchers from the National Institute of Environmental HealthSciences (NIEHS) and Umeö University in Sweden report animportant discovery about a critical new role that an enzyme calledDNA polymerase epsilon plays in replicating DNA in higher organismssuch as yeast and perhaps even humans. The study places us one ste...Rosetta Genomics and Weizmann Institute Scientists Identify Role of microRNA in Cancer Suppression
Findings Published in Molecular Cell Show Potential of microRNAs asNovel Cancer Drug Targets REHOVOT, Israel and NORTH BRUNSWICK, New Jersey, July 05, 2007/PRNewswire-FirstCall/ -- Rosetta Genomics Ltd , a leading microRNAcompany, announced today research published in the journalMolecular Cell by scientists from the Weizmann Institute of Scienceand Rosetta Genomics . The findings suggest...Researchers Discover Method for Identifying How Cancer Evades the Immune System
PHILADELPHIA, July 3, 2007-- One of the fundamental traits of atumor – how it avoids the immune system – might becomeits greatest vulnerability, according to researchers from theUniversity of Southern California. Their findings,demonstrated in human breast and colorectal cancers, indicate thata technique for determining a tumor’s “immunesignature,” could be...Schepens Scientists Identify Key to Integrating Transplanted Nerve Cells Into Injured Tissue
Discovery promises to make retina, spinal cord and other centralnervous system transplants possible BOSTON, April 26, 2007 /PRNewswire/ -- Scientists at theSchepens Eye Research Institute, an affiliate of Harvard MedicalSchool, have identified a key mechanism for successfullytransplanting tissue into the adult central nervous system. Thestudy found that a molecule known as MMP-2 (which is...Researchers Identify New Genetic Risk Factors for Type 2 Diabetes
Landmark Study Shows At Least 10 Genetic Variants Are AssociatedWith Adult Onset Diabetes BETHESDA, Md., April 26, 2007 – In the mostcomprehensive look at genetic risk factors for type 2 diabetes todate, a U.S.-Finnish team, working in close collaboration with twoother groups, has identified at least four new genetic variantsassociated with increased risk of diabetes and conf...