Genetic analysis may predict risk of invasive bladder cancer
...G therapy, the current treatment standard for non-muscle invasive bladder cancer.
If a patient had a genotype containing the variant allele of the inos
gene, there was a significant reduction in the risk of recurrence compared with those patients who did not have this variance.
Genetic variants predict recurrence of bladder cancer, patient survival
...ame treatment. The results suggest that BCG may be more effective when administered to individuals with genotypes containing the variant allele of the inos
"We aimed to determine why some patients respond to BCG and others don't," said lead author Hushan Yang, Ph.D., a postdoctoral fellow in the ...
What is the mechanism of the chronic radiation enteritis?
...ed radiation induced elevated expression of IL-1beta, TNF alpha, MCP-1, and inos
in distal colonic mucosa during the early post-irradiation phase. At that t...ghout the irradiation protocol. After 6 mo, despite the 2-fold reduction of inos
and MCP-1 levels, the Th2 profile persisted, as shown by a 50% reduction in...
In blood vessel stents, innovative materials allow better control, delivery of gene therapy
...or carries genes that code for inducible nitric oxide synthase (iNOS), a protein that controls cell damage in blood vessels. In the current study, the inos
reduced restenosis by 56 percent in the carotid arteries of treated rats, as compared with control animals.
Although this particular study used ade...
Who is the arch-criminal in the development of hepatopulmonary syndrome?
...OS, HO-1 and increased number of capillaries, which demonstrated that eNOS, inos
and HO-1 were involved in increased NO and CO production in the lung. The elevated NO resulted preferably from inos
of pulmonary macrophages and, to a lesser extent, from eNOS in the lung of ...
iNOS expression may links chronic biliary inflammation to malignant transformation
.... Kitasato and colleagues investigated the role of inos
activation, NO generation, and DNA damage as the l...es was completely suppressed by the addition of an inos
inhibitor. The expression of inos
mRNA in the gallbladder epithelial cells was clear...
Research Shows Carbon Monoxide Prevents Inflammations
...to limit tissue inflammation and injury induced by inos
and nitric oxide during transplant rejection. Thei...ides critical protection against the OB induced by inos
expression. It’s a balancing mechanism. When Hmox expression goes up, it reduces inos
expression and suppresses a key-signaling pathway ...