Navigation Links
huntingtin in Medical News

Why Huntington's Shows Up in Midlife

...until middle age, and the disease is generally fatal 10 to 30 years after onset. Research at the university's medical school shows that the mutated huntingtin gene, long known to cause the disease, switches on the JNK3 enzyme produced by neurons, the cells that process and carry signals through the nervous s...

Discovery Sheds Light on Huntington's Disease

...n the corpus striatum -- interacts with the mutant huntingtin proteins, causing cell death. The findings expl...t interacted specifically and exclusively with the huntingtin protein in that part of the brain. Rhes is foun...nteracted with both healthy and mutant versions of huntingtin protein, but that it bound much more strongly to m...

Genetic disease treatments and pharmacogenetics: From scientific discovery to medical delivery

...ally, the current results indicate that PPARd (a peroxisome proliferator-activated receptor that is positively modulated by PGC1-a) interacts with the huntingtin protein, and altered function of PPARd contributes to HD neurodegeneration. If PPARd is involved in this neurological disease, then tractable therapie...

'Intrabody' can mop up mutant protein in Huntington's disease model

...the virus into the brains of mice that make mutant huntingtin improves their ability to move their limbs, althou... and the cytoplasm," he says. "The intrabody binds huntingtin proteins with expanded poly-glutamine regions and ...ured cells that make both the intrabody and mutant huntingtin are able to get rid of the mutant protein faster a...

Breaking down Huntington's disease one protein at a time

...n recent years, there is currently no cure. The disease begins when the huntingtin protein falls off HIP1. The vacancy allows another protein, HIPPI, to then ...ity to function normally. "Until we understand the relationship between huntingtin protein, HIP1, clathrin and HIPPI -- we are not going to understand what is...

Huntington's disease problem start early

...ollege of Medicine in Houston in a report that appears in the current edition of the journal Neuron. This research provides evidence of toxicity by huntingtin (the protein involved in the disease) early during the disease process, said Dr. Juan Botas, associate professor of molecular and human genetics at BC...

Penn talks at ASCB touch on cancer, neurodegenerative diseases, and MD

...ll Biology takes place on December 1-5, 2007 in Washington, D.C. Some highlights are: Huntington's Disease: A new role has been discovered for huntingtin (Htt), the defective protein in Huntington's Disease. Htt is crucial for the movement of packets inside cells that recycle and transport important mol...

A new molecular zip code, and a new drug target for Huntington's disease

...science, Mental Health and Addiction. Even if the huntingtin protein has been known for almost 20 years, the ca...nces, has been studying the biological role of the huntingtin protein and the sequences in the protein that tell...Atwal, have discovered a small protein sequence in huntingtin that allows it to locate to the part of the cell c...

Myelin Associated With Early Evolution of Huntington's Disease

... It affects around 30,000 people in the U.S., with another 150,000 at risk. While it is known that HD is caused by a mutation in a gene called huntingtin (Htt), the correct mechanism by which the Htt gene causes or contributes to neuronal cell death and HD symptoms remains uncertain. Bartzokis' research...

Animal Study Found Cure For Huntington Disease

...ered that by preventing the cleavage of the mutant huntingtin protein responsible for Huntington disease (HD) in...achieved. ‘Ten years ago, we discovered that huntingtin is cleaved by 'molecular scissors' which led to the hypothesis that cleavage of huntingtin may play a key role in causing Huntington disease’...
huntingtin in Biological News

Huntington's disease deciphered

...ollege of Medicine have discovered how the mutated huntingtin gene acts on the nervous system to create the deva...The researchers were able to show that the mutated huntingtin gene activates a particular enzyme, called JNK3, w.... They found that at extremely low concentrations, huntingtin was a potent inhibitor of axonal transport, the sy...

Small molecules might block mutant protein production in Huntington's disease

...f CAG repeats; the effectiveness varied, however, among cells taken from different patients. Some forms of these compounds left the normal forms of huntingtin and ataxin-3 proteins undisturbed, but other compounds partly or completely blocked their formation. In some cells, some of the RNA mimics drastically...

New therapeutic strategy could target toxic protein in most patients with Huntington's disease

...fering RNA could reduce production of the damaging huntingtin protein in nearly half of people with the disease.... disease, which is caused by a mutant form of the huntingtin gene. huntingtin is required for healthy nerve cells, but the muta...

Pitt researchers describe molecular '2-step' leading to protein clumps of Huntington's disease

...isease is called huntingtin. Most people have a huntingtin protein whose polyglutamine segment contains 20 or...el's, study how polyglutamine expansion alters the huntingtin protein's behavior. In its most recent studies,...out the details of how the aggregation behavior of huntingtin depends, in a surprisingly intricate way, on the n...

Huntington's disease: catching it early

...ase, called huntingtin, lured an overactive immune response. But since the immune cells that make IL-6 also make huntingtin, it's possible that mutant huntingtin might wrongly set these cells on attack mode throughout the body. Early intervention strategies to suppress the production of IL-6 might thus stave of...

A protein sequence associated with Huntington’s disease may become life-saving vaccine component

...ngton's disease results from mutations in the protein huntingtin, which contains a sequence of polyglutamine residues (polyQ). In healthy individuals, huntingtin contains less than 35 glutamines in the polyQ segment. However, in neurons of Huntington's patients, the number of glutamine residues in the sequence ...

Proteasome activator enhances survival of Huntington's disease neuronal model cells

...disease (HD) the disease provoking mutation in the huntingtin gene eventually causes the cell to build up intran...intraneuronal nuclear protein aggregates of mutant huntingtin in HD brains indicate dysfunction of the UPS. From...t shows that cellular changes due to expression of huntingtin protein with longer CAG repeats can reduce the ubi...

MIT research holds promise for Huntington's treatment

...'s disease is caused by misfolded proteins, called huntingtin proteins, that aggregate and eventually form large...mpounds that prevent or reverse the aggregation of huntingtin proteins. However, recent evidence suggests that t...ion, thus blocking one of the toxic effects of the huntingtin protein. The B2 compound also promoted large in...

Old drug shows new promise for Huntington's Disease

...he drug in vivo, on mice bred to express the toxic huntingtin protein. The mice were given approximately 1 milli...effect may interfere with production of the mutant huntingtin protein in some way. "But there are still a couple...vitro system in which toxic and non-toxic forms of huntingtin are made in the same cell. He and his team will th...
huntingtin in Biological Products
Other Tags
(Date:8/21/2014)... on her body in terms of how it can ... complete human being with thoughts and feelings. While objectification ... how does it affect individual romantic relationships? New research ... SAGE journal, finds that more objectification of a female ... pressure and coercion., Researchers Laura R. Ramsey and Tiffany ...
(Date:8/21/2014)... New York, New York (PRWEB) August 21, 2014 ... allege the blood thinner caused patients to suffer uncontrollable ... in U.S. courts, Bernstein Liebhard LLP reports. According to ... August 14th in U.S. District Court, Easter District of ... who died due to a bleeding event that was ...
(Date:8/21/2014)... (PRWEB) August 21, 2014 According to ... “Home Audio Equipment (Product Types - Home Theatre in-a-box, ... Market - Global Industry Analysis, Size, Share, Growth, Trends ... at USD 15.94 billion in 2012 and is expected ... a CAGR of 3.7% from 2013 to 2019. Europe ...
(Date:8/21/2014)... American Addiction Centers, a leading national provider ... drug and/or alcohol addiction, has been named to the ... , The company is ranked 7th on the “Top ... on the list in the “Nashville Metro Area” sub-category. ... Addiction Centers (AAC) ascended to number 474 on the ...
(Date:8/21/2014)... Sasha is a 10 year old Alaskan malamute, and ... older, and is having trouble getting up and down, and ... an owner who purchased a Butler Mobility Inclined Platform Wheelchair ... no longer get up and down the stairs from main ... had tried a stair lift, but had to transfer from ...
Breaking Medicine News(10 mins):Health News:Objectification in romantic relationships related to sexual pressure and coercion 2Health News:Xarelto Lawsuits Mount With New Filing in New York Federal Court, Bernstein Liebhard LLP Reports 2Health News:Xarelto Lawsuits Mount With New Filing in New York Federal Court, Bernstein Liebhard LLP Reports 3Health News:Xarelto Lawsuits Mount With New Filing in New York Federal Court, Bernstein Liebhard LLP Reports 4Health News:Home Audio Equipment Market Expected to Reach USD 20.68 Billion in 2019 2Health News:Home Audio Equipment Market Expected to Reach USD 20.68 Billion in 2019 3Health News:American Addiction Centers Named to Inc. 500 List Recognition for Three-Year Sales Growth of 995% 2Health News:Sasha Gets a Butler Mobility Inclined Platform Lift 2
(Date:8/21/2014)... geologist Juliane Mller the Fram Strait is a key region ... this passage between Greenland and Svalbard warm Atlantic water flows ... west side cold Arctic water masses and sea ice push ... A considerable portion of the Atlantic water cools here on ... The circulation of the water caused in this manner drives ...
(Date:8/21/2014)... standards process, will be available soon and will improve ... in the OnlineFirst version of Nutrition in Clinical ... the American Society for Parenteral and Enteral Nutrition (A.S.P.E.N.), ... misconnection that can be harmful and even fatal to ... medical devices, components, and accessories to deliver fluids or ...
(Date:8/21/2014)... involves the pancreas digesting itself resulting in severe abdominal ... UK around 20,000 patients are diagnosed with the disease ... and treatment is restricted to intravenous fluid and nutritional ... of Life Sciences, who led the research, said "The ... gall stones and excessive alcohol intake combined with a ...
Breaking Biology News(10 mins):Arctic sea ice influenced force of the Gulf Stream 2Arctic sea ice influenced force of the Gulf Stream 3New feeding tube connectors will improve patient safety 2Insulin offers new hope for the treatment of acute pancreatitis 2
Other Contents