homolog

Dormant cancer cells rely on cellular self-cannibalization to survive

...ng a blood supply, but the mechanism for this has not been well understood," Bast said. Bast and colleagues focused on ARHI, short for aplasia Ras homolog member I, a gene found in normal cells, but that is underexpressed in 60-70 percent of ovarian cancers. When normal levels of ARHI were restored ...

Also in the Nov. 11 JNCI

... Downstream RAS Signaling Protein May Be Lung Cancer Target Blocking expression of a protein involved in RAS signaling, called seven-in-absentia homolog 2 (SIAH-2), in lung cancer cells increased cell death and decreased the tumorigenicity of the cells. The RAS signaling pathway drives cell prolifer...

Targeted Anticancer Drugs - In Vitro Assessment and Non-Invasive Imaging of Patient and Tumor Status Will Determine Clinical and Commercial Success

...; FGFr; focal adhesion kinase (FAK); folate receptor (FOLr); FOLr1; galectin 3 (GAL3) receptor; gastrin 17 (G17); GD2; GD3; glioma-associated oncogene homolog (Gli- 1); glucoprotein A33 (GPA33); glutathione (GHS); glutathione S-transferase pi (GSTP1); glycinamide ribonucleotide formyltransferase (GARFT); gly...

ASPB engages Latin America colleagues at Annual Meeting in Merida, Mexico June 22-25

...case study: tomato Solanaceae. Felipe Cruz, Mexico Synthesis and transfer to the stigmatic surface of NaStEP, a vacuolar Kunitz proteinase inhibitor homolog and its role in pollen rejection in Nicotiana. Esther Van Der Knaap, Ohio State University, USA - Underlying mechanisms of diversity in tomato fruit ...

Immune system kick-started in moist nasal lining in sinusitis, asthma and colds

...s. But corticosteroid drugs, she says, do not work for everyone and their effectiveness often wanes over time. This may be related to the B7 homolog triggers in the mucous membranes, Kim says, as study results showed that corticosteroid therapy does not fully shut down or prevent their overproducti...

How does Fu-Zheng-Jie-Du-Decoction act on PTEN expression in hepatocellular carcinoma?

...of the TCM group than in the chemotherapy group. Particularly the results of immunohistochemistry showed the intensity of PTEN (Phosphatase and Tensin homolog deleted on Chromosome 10) in the TCM group was higher than in the chemotherapy group. PTEN was recently identified as a tumor suppressor gene by th...

DNA damage response confers a barrier for viral tumorigenesis

...overn cell proliferation and modulate apoptosis. The results of this study demonstrate that one of the viral latent proteins, viral cyclin, which is a homolog of cellular D-type cyclins, induces replicative stress in endothelial cells, which leads to senescence and activation of the DNA damage response. ...

Protein Essential for Kidney-to-Bladder Urine Transfer

...alloons and becomes at risk of failure." Swat and colleagues found a similar condition in mice after the gene for a protein known as discs-large homolog 1 (DLGH1) was disabled. When properly diagnosed, functional obstruction is normally treatable with surgery. But the study also produced tentati...

Susceptibility Of TB In Humans Might Be Due To Three Human Gene Variants

...teria monocytogenes inside host cells. (http://www.hsph.harvard.edu/press/ releases/press04062005.html) The Hill team then examined the closest homolog of the mouse gene Ipr1 that can be found in humans--a gene called SP110. Three variations of the SP110 gene were found to be associated with tuberculo...

New target for antidiabetic agents identified

...ers have identified a protein that could serve as a new target for drugs designed to treat type II diabetes. The protein, known as TRB3, is actually a homolog of a protein found in the fruit fly Drosophila tribbles, senior author Dr. Marc Montminy, from the Salk Institute for Biological Studies in La Jolla, ...

homolog in Medical Technology

Intellect Neurosciences, Inc. Announces Independent Studies on Copper Binding Properties of its Lead Candidate OXIGON(TM)

...ew York University more than ten years ago regarding a direct physical interaction between the beta amyloid protein and melatonin, a close structural homolog of OXIGON(TM). The interaction was shown to involve four specific amino acids, which now are known to comprise the high affinity copper binding site ...

PC-DAC:Exendin-4 Phase I/II Multiple-Dose Study Preliminary Results Demonstrate Safety and Efficacy at Once-Weekly Dosing

... in a Phase II study, which is planned for initiation by year-end. About PC-DAC(TM):Exendin-4 Exendin-4 is a Glucagon-like peptide-1 (GLP-1) homolog and an agonist for the GLP-1 receptor. Exendin-4 decreases glucagon and increases insulin secretion in a glucose-dependent manner. Exendin-4 may...

homolog in Medical Definition

Autoimmune regulator

...mary adrenocortical failure and chronic mucocutaneous candidiasis. [1] AIRE is expressed primarily in the thymus. A gene knockout of the murine homolog Aire has created a transgenic mouse model to study the mechanism of disease in human patients. [2] Research on the knockout mouse has demonstra...

homolog in Medical Dictionary

Gene

...tors The history of gene therapy Diseases targeted for treatment by gene Lrp4 (low density lipoprotein receptor-related protein 4) mouse homolog has similarity to the low density lipoprotein receptor family, however, it does not bind very ... PLoS Genetics is an open-access ... Similarly,...

Chromosomes

...investigating how chromosomes are reorganized during this unique cell ... We have recorded large-scale chromosome movements during the stages of homolog ... Researchers at the Department of Energy's Joint Genome Institute in Walnut Creek, California, have decoded in draft form the genetic ...

homolog in Biological News

Open access research celebrated

...sored by Microsoft Research, were won by the following research articles: Biology Award Basil Honegger, University of Zrich Imp-L2, a putative homolog of vertebrate IGF-binding protein 7, counteracts insulin signaling in Drosophila and is essential for starvation resistance Honegger B, Galic M, Khle...

Suppressing cancer with a master control gene

...alization step inhibit tumor formation. In collaboration with colleagues from the United States, they show that loss of one of those genes, Atonal homolog 1 (ATOH1), causes colon cancer in mice. The gene regulates the last step in the specialization to epithelial cells of the colon. Humans with colon can...

Genome sequence of small marine creature sheds light on vertebrate origins

...ified several DNA regulatory elements conserved between amphioxus and humans. Three conserved elements from two human paralogs and a single amphioxus homolog were all shown to drive gene expression in both amphioxus and the mouse. "This is the widest phylogenetic distance to date over which both the sequen...

Scientists discover that ancient genes dictate flowering, fall bud set

...Centre at Umea University; and Steven H. Strauss of the forest science department at Oregon State University. "In this study, we looked at a poplar homolog of the gene FT, which has been shown to regulate flowering in annual plants. Surprisingly, we found that this gene not only controls the multi-year de...

PTEN: the Treg's handbrake

...ation, Laurence Turka and colleagues from the University of Pennsylvania have shown that Tregs from mice with T cells that lack phosphatase and tensin homolog (PTEN) proliferate in response to IL-2. Importantly, PTEN-deficient Tregs retained their suppressive function in vitro and in vivo, indicating that lo...

Gene expands malaria's invasion options

...ered between parasites that used sialic acid and those that did not. The first of these was a gene known as P. falciparum reticulocyte-binding like homolog 4 (PfRh4) that's similar to other genes known to play a role in the invasion of red blood cells by P. falciparum and related parasites. The secon...

Study reveals candidate targets for anti-retroviral therapeutics

...that affect the replication of the retrovirus-like element Ty3. Over half of the genes identified in this study have at least one clear relative or homolog in the human genome, thus providing a rich source of candidate retrovirus host genes. Sandmeyer and colleagues hope that this study, along with relate...

homolog in Biological Technology

Anti-cancer gene discovered: Perspective for therapy

..., from flies to humans. With mice, and in collaboration with colleagues from the United States, they showed that loss of one of those genes, Atonal homolog 1 or ATOH1, causes colon cancer. The gene regulates the last step in the specialization to epithelial cell of the colon. Humans with colon cancer freq...

deCODE Discovers Gene Variants that May Help to Distribute the Work of Evolution between Men and Women

...or approximately 22% of paternal variability in recombination and 6.5% of maternal variability. Little is known about RNF212, though it is a mammalian homolog of a gene called ZHP-3 known to be crucial for the success of recombination in other organisms. The paper, entitled 'Sequence Variants in the RNF212 G...

RNA Interference and Gene Silencing: History and Overview

... href="#17">17 , 18 ). Although no homolog of an RdRP has been found in flies or humans, an RdRP activity has...s , required for transposon silencing and RNA interference, is a homolog of Werner syndrome helicase and RNase D. Cell 99 : 133-141. (...

Mouse Anti-LATS, large tumor suppressor, homolog 2 (Drosophila) Monoclonal Antibody, Unconjugated, Clone 3D10 from Novus Biologicals

Description: Mouse monoclonal antibody to Lats2....
Company:Novus Biologicals

Rabbit Anti-Jun B, phospho (Ser79) Polyclonal Antibody, Unconjugated from Lab Vision

Description:... The c-Jun proto-oncogene was first identified as the cellular homolog of the avian sarcoma virus v-jun oncogene. Jun B and Jun D have been shown to be almost identical to c-Jun in their C-terminal regions, which are invo...
Company:Lab Vision

Rabbit Anti-Human JUB Polyclonal Antibody, Unconjugated from Proteintech Group, Inc.

Description:... jub, ajuba homolog (Xenopus laevis)...
Company:Proteintech Group, Inc.

Rabbit Anti-DLK1 Polyclonal Antibody, Unconjugated from Proteintech Group, Inc.

Description:... delta-like 1 homolog (Drosophila)...
Company:Proteintech Group, Inc.

Rabbit Anti-QKI Polyclonal Antibody, Unconjugated from Bethyl Laboratories

Description:... The epitope recognized by A300-183A maps to the C-terminus of isoform 5 of human quaking homolog according to entry AAH19917.1 (GeneID 9444). The epitope is not found in isoforms 1, 2, 3, 4, 6, 7 or 7B according to TrEMBL entries Q9P0Y1, Q9P0Y0, ...
Company:Bethyl Laboratories

Mouse Anti-Human XPMC2H Polyclonal Antibody, Unconjugated from Novus Biologicals

Description:... Mouse polyclonal antibody to REXO4 - XPMC2 prevents mitotic catastrophe 2 homolog (Xenopus laevis)...
Company:Novus Biologicals

Rabbit Anti-Human ODZ1 Polyclonal Antibody, Unconjugated from Atlas Antibodies

Description:... odz, odd Oz/ten-m homolog 1 [Source:RefSeq_peptide;Acc:NP_055068] Antigen: Recombinant Protein Epitope Signature Tag (PrEST)....
Company:Atlas Antibodies

homolog in Biological Definition

Gene duplication

...nts on human gene function can often be carried out on other species if a homolog to a human gene can be found in the genome of that species. But only if the homolog is orthologous. If they are paralogs and resulted from a gene duplication e...

homolog in Biological Dictionary

Vitelline membrane

...embrane ... Human protein-coding gene VMO1. Represented by 37 ESTs from 22 cDNA libraries. ... Homo sapiens vitelline membrane outer layer 1 homolog (chicken), mRNA (cDNA ... The dictionary term vitelline membrane was found in Taber's Medical Dictionary Online, along with 60,000 other medica...

Viral oncogene

... v-rel reticuloendotheliosis viral oncogene homolog (avian), also known as REL, is a human gene. The...RAS1. KRAS2 ... ... leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) ... oncogene ; ovarian ; progression ; ...

UvrA

...DNA ... ... acid sequence homology with the E. coli UvrA protein comprising 940 residues. ... defined by the mutation in DB7 represents a homolog of the E. coli uvrA gene. ... In vivo, UvrA is present as both a monomer and a dimer, the latter complexing ... In the case of uvrA , uvrB, an...

Transport protein

...... Mouse protein -coding gene Vat1. Represented by 685 ESTs from 170 cDNA libraries. ... Mus musculus vesicle amine transport protein 1 homolog (T californica), mRNA ... ... Auxin Transport Proteins ... fluorescent protein fusion to an IAA transport protein (PIN1) ... protein , w...

RNA interference

...s topic. until the discovery of RNA interference provided a most unexpected ... RNA ... transposon silencing and RNA interference , is a homolog of ... RNA INTERFERENCE ... The discovery of RNA interference ... Potent and specific genetic interference by double-stranded RNA in Ca...

RecA protein

... RecA is a 38 kilodalton Escherichia coli protein essential for the repair and maintenance of DNA. RecA has a structural and functional homolog in every species in which it has been seriously sought and serves as an archetype for this class of homologous DNA repair... RecA promotes th...

Protein biosynthesis

...an Bioinformatics Institute ... biosynthesis protein coq7. IPR011566 Ubiquinone biosynthesis ... P48376 Ubiquinone biosynthesis protein COQ7 homolog ... The European ... Aflatoxin biosynthesis regulatory protein is involved in the ... IPR002409 Aflatoxin biosynthesis regulatory protein 3...

Pre-mRNA

..., treatments, and ... to find out more about Pre mRNA : powered by. Search the Web ... The European ... O22785 Pre - mRNA -processing factor 19 homolog 2 ... Pre - mRNA -splicing factor 19. IPR011046. WD40 repeat-like. IPR017986. WD40 ... In a discovery that upends a longstanding tenet of human ...

Optic lobes

... variant D, mRNA. PA ... Human protein-coding gene SOLH. Represented by 250 ESTs from 114 cDNA libraries. ... Homo sapiens small optic lobes homolog (Drosophila), mRNA (cDNA clone IMAGE: ... Britannica online encyclopedia article on optic lobe (anatomy), ...portion of the brain stem. Senso...

MutS

...tions, thesaurus, Word of the Day, and word games. ... Gene: MSH4 mutS homolog 4 (E. ... Human MutS homologue MSH4 physically interacts with von ... hMS...ighest ... Complete information for MSH5 gene (protein-coding), mutS homolog 5 (E. coli) ... Human MutS homologue MSH4 physically interacts with von H...

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