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First-ever Compounds To Target Only Metastatic Cells Are Highly Effective Against Breast, Prostate, And Colon Cancers

Two compounds that zero in on cancer cells spreading throughout the body, while ignoring primary tumor cells, could someday give doctors a whole new weapon in the fight against tough-to-treat metastatic disease, according to Weill Medical College of Cornell University researchers. The compounds, called synthetic migrastatin analogues, prevented 91 to 99 percent of metastatic breast cancer...

Highly adaptable genome in gut bacterium key to intestinal health

A bacterium that lives in the human gut adaptively shifts more than a quarter of its genes into high gear when its host's diet changes from sugar to complex carbohydrates. This adaptive mechanism not only allows the bacterial species to survive rapidly changing nutrient conditions but also helps maintain the functions and stability of the gut's highly complex microbial society, according...

Roundup®highly lethal to amphibians, finds University of Pittsburgh researcher

The herbicide Roundup® is widely used to eradicate weeds. But a study published today by a University of Pittsburgh researcher finds that the chemical may be eradicating much more than that. Pitt assistant professor of biology Rick Relyea found that Roundup®, the second most commonly applied herbicide in the United States, is "extremely lethal" to amphibians. This field experiment is one o...

FDA: 'Highly Unlikely' Green Tea Lowers Cancer Risk

The new surgical assistant at the University of North Carolina Hospitals arrived in February sporting three arms, a computerized brain and a glowing track record in helping to repair heart valves, remove cancerous prostates, bypass blocked coronary arteries and perform gastric bypass operations for morbid obesity. The new arrival is a robotic machine, the da Vinci Surgical System, manufact...

Highly concentrated botulinum preparation for cosmetic injections can result in severe illness

An examination of 4 cases of botulism following cosmetic injections to the face indicates that the adults received a highly concentrated, unlicensed preparation that resulted in toxin levels up to 40 times the estimated human lethal dose, according to a report in the November 22/29 issue of JAMA. Botulism is a rare paralytic illness caused by the toxins of the spore-forming bacterium Clos...

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Highly Active and Removable AffinityTagged Lambda Phosphatase

Dualspecificity Lambda Phosphatase useful for dephosphorylation serine,threonine or tyrosine residues Stratagene Cloning Systems, Inc. Stratagene's recombinant Lambda Phosphatase is a dualspecificity proteinphosphatase that has been produced as a fusion to Stratagene's novel affinitytag, the calmodulin...

Eppendorf Electroporation Application Notes Your participation is highly welcome !!!

E-mail us your application notes for inclusion in this Eppendorf web page. Each contribution published will be acknowledged with a set of electroporation cuvettes. ...

Eppendorf Electroporation Application Notes Your participation is highly welcome !!!

E-mail us your application notes for inclusion in this Eppendorf web page. Each contribution published will be acknowledged with a set of electroporation cuvettes. ...

Detection of Variation in Highly Polymorphic Mhc Genes by Denaturing Gradient Gel Electrophoresis Using the DCode System

Kristi M. Miller, Tobi J. Ming and Ruth E. Withler, Pacific Biological Station,Department of Fisheries and Oceans, Nanaimo, B.C. V9R 5K6, Canada Introduction We describe a rapid and sensitive method for the detection of nucleotide sequence variation which can be used for largescale screening of population...

A highly sensitive ATP-luminescence assay using VICTOR2 with the dispenser option

In high sensitivity flash type luminescence assays the measurement is done just after dispensing the activating reagent or after a short delay time. Over the past years luminescence substrates have been improved towards providing more stable signal. These so-called glow type substrates allow microplates to be counted without dispensors. Ho...

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Alzheimer's Disease Progresses Rapidly In Highly Educated

A recent study has now found that educated people could face increased risk from Alzheimer's disease, which is the most common cause of dementia in old people. // Although Alzheimer's tends to be associated with a later age of onset among the educated, it progresses more rapidly. In other words, in highly educated people, a rapid decline is noted following onset of Alzheimer's manifes...

MRI with nanoparticles highly sensitive in detecting prostate cancer metastases

High-resolution MRI with magnetic nanoparticles is highly sensitive in detecting clinically occult lymph-node metastases in prostate cancer, according to a new report. In fact, routine use of this modality preoperatively could obviate many unneeded surgeries.// The nanoparticles, which are given intravenously 24 hours before scanning, work by binding to lymphatic cells. The particles only...

Highly Educated More Prone To Parkinsons Disease

In a shocking revelation, researchers from the Mayo Clinic, in Olmsted County, Minnesota, suggest that Parkinson's disease is more likely to strike the highly-educated than manual workers,// meaning that an individual's educational and career paths impact Parkinson's disease risk later in life. The researchers said that probably early Parkinson's triggered a desire to spend a lot of time...

Mapping Of Brain Highly Beneficial For Safer Brain Tumor Surgery

Mapping of brain during brain tumor surgery was found to be of much safer for patients by protecting them from the damage to speech and language centers, which happens// at times while performing such delicate surgeries. According to researchers, "intraoperative language mapping" involves operating on an awake patient and mapping the anatomy of the patient's language function during t...

Highly Pure Form Of heroin Proving To be lethal Killer

Strathclyde police have issued a warning to drug users about the quality of the class-A drug. A lethally pure form of heroin is being sold on the west coast// of Scotland has caused a sharp rise in drug-related deaths. Since the beginning of this year there has been 82 inquiries into drug-related deaths in Strathclyde, compared to 48 for the same period last year. The police have said...

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Repros' Androxal Shows Highly Statistically Significant Positive Effects in Men with Secondary Hypogonadism

THE WOODLANDS, Texas--(BUSINESS WIRE)--Jun 5, 2007 - ReprosTherapeutics Inc. (NasdaqGM:RPRX) announced topline results of asix month U.S. Phase 3 study of Androxal(TM), an oral drug beingdeveloped to restore normal testicular function in men withsecondary hypogonadism. Further, Androxal demonstratesnon-inferiority in all the endpoints of the study, compared toAndrogel(R), a cream which is t...

NanoViricides Drugs Found To Be Highly Effective Against Most Recent Strain of the H5N1 Avian Flu Virus

WEST HAVEN, Conn.--(BUSINESS WIRE)--May 7, 2007 - NanoViricides,Inc. (Pink Sheets: NNVC) presented results of recent animal studiesagainst rabies and BSL3 in vitro studies against a Clade 2 H5N1(avian influenza) virus at the 23rd Annual Symposium of the PanAmerican Society for Clinical Virology in Tampa, FL, on Wednesday,May 2. (Pan American Society for Clinical Virology (PASCV):Clinical Vi...

Telik Reports Positive Data Demonstrating Synergy in Combination and Highly Statistically Significant Effect of Telcyta as Maintenance Therapy in First-Line Non-Small Cell Lung Cancer

PALO ALTO, Calif., April 17, 2007 /PRNewswire-FirstCall/ --Telik, Inc. announced the presentation today of results from aPhase 2 clinical trial of the triplet combination of TELCYTA(R)(canfosfamide HCl, TLK286), carboplatin and paclitaxel in thefirst-line treatment of advanced non-small cell lung cancer. Theresults include highly statistically and clinically significantimprovement in bot...