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Elusive HIV shape change revealed; Key clue to how virus infects cells

Structural biologists at Children's Hospital Boston and Harvard Medical School have shown how a key part of the human immunodeficiency virus (HIV) changes shape, triggering other changes that allow the AIDS virus to enter and infect cells. Their findings, published in the Feb. 24 issue of the journal Nature, offer clues that will help guide vaccine and treatment approaches. Researchers led...

Iron Deficiency Sparks Dramatic Changes In Gene Expression

Researchers at Duke University Medical Centerhave demonstrated for the first time what happens inside a cell when itis deprived of the essential nutrient iron. Iron is found abundantly inred meats, shellfish dried fruits, whole grains, spinach, seeds andother foods.Their study in yeast cells demonstrated that iron-starved cellspreserve the little iron they possess by shutting down the major...

New Study from Affymetrix Laboratories Points to Changing View of How Genome Works

Scientists at Affymetrix, Inc. (Nasdaq: AFFX) reported today in Science magazine online that they have completed a high-resolution scan of structure and function for nearly 30 percent of the human genome sequence. In collaboration with the National Cancer Institute, the research team used high-density GeneChip(R) microarrays to study every fifth base, on average, of 10 human chromosomes; they fou...

Researchers trace evolution to relatively simple genetic changes

In a stunning example of evolution at work, scientists have now found that changes in a single gene can produce major changes in the skeletal armor of fish living in the wild. "Our motivation is to try to understa...

Plants defy Mendel's inheritance laws, may prompt textbook changes

Contrary to inheritance laws the scientific world has accepted for more than 100 years, some plants revert to normal traits carried by their grandparents, bypassing genetic abnormalities carried by both parents. These mutant parent plants apparently have hidden templates containing genetic information from the preceding generation that can be transferred to their offspring, even though the...

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Anion Exchange ProteinChip Arrays from Ciphergen

Description:Ciphergen's ProteinChip arrays have been developed for affinity capture of proteins from biological samples. A variety of ProteinChip chemical surfaces allow differential capture of proteins according to their unique biochemical properties. Each chip has eight different spots, allowing side-by-side sample comparison, and the chips are color-coded with a unique hydrophobic coating. Ciphergen's pro...
Company:Ciphergen

Cation Exchange ProteinChip Arrays from Ciphergen

Description:Ciphergen's ProteinChip arrays have been developed for affinity capture of proteins from biological samples. A variety of ProteinChip chemical surfaces allow differential capture of proteins according to their unique biochemical properties. Each chip has eight different spots, allowing side-by-side sample comparison, and the chips are color-coded with a unique hydrophobic coating. Ciphergen's pro...
Company:Ciphergen

Anti-Na+ / H+ Exchanger-1, isoform NHE1 Monoclonal Antibody, Unconjugated from CHEMICON

Description:Na+/H+ exchanger, isoform NHE1....
Company:CHEMICON

TSTU, O-(N-Succinimidyl)-1,1,3,3-tetramethyl uranium tetrafluoroborate from GL Biochem (Shanghai) Ltd.

Description:...
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T4 Polynucleotide Kinase Exchange Reaction Buffer from Invitrogen

Description:For use with T4 Polynucleotide Kinase for labeling of 5' ends (5' phosphate ends) of nucleic acids. In the exchange reaction T4 Polynucleotide Kinase transfers the 5' phosphate group from DNA to ADP and subsequently transfers the Gamma-phosphate of ATP to the free 5' hydroxyl group to rephosphorylate the DNA....
Company:Invitrogen

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Detect Single Nucleotide Sequence Changes with Mx4000 Molecular Beacon Allelic Discrimination Kits

Allelic discrimination kits with excellent specificity, sensitivity, andassay throughput Stratagene Because of their unique hairpin conformation, molecular beacon probes canrecognize single base differences, making them ideal for mutation detection andallelic discrimination. Base...

New Temperature Cycler Features Interchangeable Blocks

Michelle Cayouette Jane Moores Jason Capodanno Michael Steege Michael Rahilly Stratagene Infinitytemperature cycler, a new temperature cycler withinterchangeable blocks for...

Mammalian Expression Vectors with Interchangeable Selectable Markers

Site-specific recombinase-based vector system Stratagene system of eukaryotic expression vectors offers unparalleled convenience. The drug-resistance genes of these vectors can be exchanged without subcloning. Through site-specific recombination, hygromycin, puromycin,...

Monitoring Receptor-Mediated Changes in [Ca2+]i Using Single-Wavelength and Dual-Wavelength Indicators on the FlexStation Workstation

Simon Lydford & Petra Averbeck, Molecular Devices Limited, U.K. The FlexStation scanning fluorometer integrates sensitive optics, fluid transfer and temperature control, making it ideal for kinetic, cell-based fluorometric assays, such as the measurement of intracellular calcium, membrane potential and intracellular pH. <...

It's not Y2K, but changes to Daylight Saving Time could cause tech problems

will have significant implications for organizations worldwide, but few business organizations are prepared to address their potential information technology impacts, according to a new <a href="http://www.gartner.com/DisplayDocument?ref=g_search&id=500284&subref=simplesea...

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GlaxoSmithKline - Changes Lamictal(R) Label Appearance and Packaging

Lamictal, an antiepileptic drug, is one of the several prescription drugs that has encountered the problem of dispensing errors. Dispensing errors are often a result of miscommunication, which can include poor hand writing of the prescription and confusion between drugs with similar names.// It is important for patients with epilepsy not to have an interruption in treatment be...

Drug abuse leads to long standing changes in the brain

Methamphetamine, a highly addictive stimulant drug, whose abuse has reached epidemic proportions in many parts of the world, causes long-term changes in the human brain that are associated with impaired memory and motor coordination, according to a study published in theAmerican Journal of Psychiatry. Researchers found that these effects are seen even in methamphetamine addicts who have b...

Link Between High Blood Sugar And Behavioral Changes

Low blood sugar levels are known to cause cognitive and behavioral changes in diabetics, but results of a recent study show that high blood sugar // has a similar effect. The study showed that type 2 diabetics have impaired cognitive functioning and experience deterioration in mood when their blood sugar is high. Diabetics' bodies have difficulty controlling blood sugar levels due to in...

Food Habits Could Change Your Genes

Eating specific food could change your genes, say researchers after success in a rodent study.Researchers Moshe Szyf, Michael Meaney and colleagues at McGill University in Montreal have found that nutrients // and supplements changed genetics by switching on or off certain genes in rodents, reports science portal EurekAlert. The new research was conducted in the lines of a two-year-o...

Flu Vaccine’s Destination Changed From Illinois To Pakistan

The Government rejected the flu vaccines that were manufactured and sent to Illinois. Blagojevich was prevented // from getting the 250,000 vials of unapproved flu vaccines from Europe to Illinois but sent to Pakistan instead. These vaccines worth $2.5 million were sent to the people affected by the recent earthquake, which plundered the joys from the South East Asians. At Illinois...

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Chang Phaco Chopper

Description:Phaco chopper, a combination of a modified microfinger and a pointed "quick chop" tip. For use in the left hand....
Company:Katena Products, Inc.

Chang Phaco Chop

Description:Phaco Chopper, double ended; a combination of a modified MicroFinger and a pointed "quick chop" tip, in titanium...
Company:Berson & Associates

Burton 1200 Chair-exchanger

Description:If you presently have an exam chair that is separate from the instrument stand, we can solve your access problem with a Burton 1200 Chair-exchanger...
Company:Burton Ophthalmic

BchiVac V-1000 vacuum pump, w/Pump Controller V-719, and automatic change over valve

Description:Model V-1000 is a new addition to the powerful PTFE membrane vacuum pump line from Bchi. This high performance pump can achieve an ultimate vacuum of 1 mbar or a flow rate of 64 L/min. Distillation applications from lab size up to industrial size rotary evaporators BchiVac V-1000 product fe...
Company:Brinkmann

TC-312 Techne Thermal Cycler (interchangeable block)

Description:The Techne TC-312 Thermal Cycler is one of the smallest footprints on the market. Features & Benefits include: Fast ramping, low cost, PC Control and networking, Alpha-numeric screen, keypad and program naming, Ready-to-go templates, interchangeable blocks. The TC-312 has numerous applications in Molecular Biology and Diagnostic laboratories and is suitable for use with diagnostic kits. Include...
Company:MIDSCI

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Clinical Trial Results Change Standard of Care for Pancreatic Cancer Patients, Future Therapies Discussed

CHICAGO, June 05, 2007 /PRNewswire-USNewswire/ -- The BarbaraAnn Karmanos Cancer Institute's Philip A. Philip, M.D., Ph.D.F.R.C.P., professor of medicine and oncology, presented the outcomeof one of the largest randomized phase III pancreas cancer clinicaltrials in North America and chaired an education session about thefuture of pancreatic cancer therapies at the American Society ofClin...

FDA Announces Change of Location Notice for Upcoming Advisory Committee Meeting

ROCKVILLE, Md., April 18, 2007--Due to water damage caused byflooding over the weekend, FDA has been forced to change thelocation for the upcoming Antiviral Drugs Advisory Committeemeeting on April 24, 2007 to discuss new drug application formaraviroc 300 milligram tablets. Originally scheduled to be held atthe FDA, Center for Drug Evaluation and Research Advisory CommitteeConference Roo...

KineMed Presents Data Measuring Changes in Reverse Cholesterol Transport for the First Time

Research Breakthrough Will Aid in Developing Therapies to Preventand Reverse Atherosclerotic Heart Disease EMERYVILLE, Calif., May 10, 2007 /PRNewswire/ -- KineMed, Inc.,a pathway-based drug discovery and development company, announcedtoday the first method for measuring the efflux of cholesterol fromtissues in animals through the pathway known as reverse cholesteroltransport (RCT). RCT i...

Study Shows Children With ADHD Who Start on Strattera are More Likely to Change Therapies

Prime Therapeutics recommends clinical utilization managementprograms ST. PAUL, Minn., April 10, 2007 /PRNewswire/ -- Pharmacy benefitmanager Prime Therapeutics (Prime) today announced the results of astudy on the utilization of Strattera(R) (atomoxetine) for treatingattention deficit hyperactivity disorder (ADHD) in children. Thestudy found that children who start on Strattera were 4.2 t...

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