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Mutant Caveolin-3 Induces Persistent Late Sodium Current and Is ...

... as the SCN5A-encoded voltage-gated Na+ channel (hNav1.5),11 the ... CAV3 and hNav1.5 Localization in ... 3. Caveolin-3 and hNav1.5 localization in human ...

SCN5A Polymorphism Restores Trafficking of a Brugada Syndrome Mutation ...

Changing the hNav1.5 amino acid 373 from cysteine to tyrosine is expected to ... C373 is located in domain 1 of hNav1.5 in the pore-forming loop (SS2) before ...

Modulatory Proteins Can Rescue a Trafficking Defective Epileptogenic ...

hNav1.1 has high rearrangement rate when propagated in bacteria, so the plasmids ... In cells transfected with hNav1.1-M1841T, Na+ currents had very small amplitude ...

Electrophysiological Properties of Mutant Nav1.7 Sodium Channels in a ...

The hNav1.7 channels were cotransfected with the human 1 and 2 subunits (Lossin ... Wild-type (WT) hNav1.7R and the two mutant derivative channels I848T and L858H ...

Charge Immobilization of Skeletal Muscle Na+ Channels: Role of Residues ...

h relations and Boltzmann fits for hNaV1.4 and mutations in the DIII-DIV linker. ... represents the voltage dependence of hNaV1.4 and charge cluster mutations for ...

Millipore - hNav1.2-CHO K1 Recombinant Cell Line

CHO-K1 cells expressing hNav1.2 were characterized in terms of their ... protocol, tetracaine dose-dependently blocked hNav1.2 currents with IC50 values ...
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