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Nitric oxide blocks hKv1.5 channels by S-nitrosylation and by a cyclic ...

Molecular modeling of hKv1.5 channel structure suggests that S-nitrosylation of ... Conclusions: NO inhibits the hKv1.5 current by a cGMP-dependent mechanism and by ...

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The experiments were performed in mouse L-cell line expressing hKv1.5 channels. ... hKv1.5 currents were measured using the whole-cell configuration of the patch ...

Mechanisms of Action of Antiarrhythmic Agent Bertosamil on hKv1.5 ...

Indeed, cloned hKv1.5 channels are remarkably sensitive to a number of compounds, ... hKv1.5 cDNA was generated by polymerase chain reaction from human heart RNA, ...

Papaverine Blocks hKv1.5 Channel Current and Human Atrial Ultrarapid ...

hKv1.5 currents expressed in heterologous expression systems are similar in ... Thus, hKv1.5 may form an important molecular target for the treatment of atrial ...

Molecular Determinants of Intracellular pH Modulation of Human Kv1.4 ...

... A-type Kv1.4 channel (hKv1.4) shows fast N-type inactivation ... These effects of pHi were completely abolished by a large deletion in the hKv1.4 N terminus. ...

Episodic ataxia type-1 mutations in the hKv1.1 cytoplasmic pore region ...

... the voltage-gated potassium channel gene hKv1.1 of different affected families. ... cytoplasmic putative pore region of hKv1.1 channels and profoundly alter their ...
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