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hERG in Medical News

New Stem Cell Technology to Improve Drug Safety

...drug development, tend to focus on one aspect of heart cell function -- the herg ion channel. But there are a whole range of other ion channels, as well as other possible issues, which herg tests miss. ReproCELL has developed the QTempo assay to comprehensively scr...

ChanTest to Highlight Expanded Ion Channel and GPCR Services and Cell Lines, Including FDA Critical Path Safety Profiling Tools at ToxExpo, Booth 3056

...lines (EZCells (TM)) are also available. "ChanTest is well known as the leader in preclinical cardiac safety testing. We were the first to prove herg as the target for adverse cardiac events linked to Seldane (terfenadine), Propulsid (cisapride), and Nizoral (ketoconazole), and the pioneer in functi...

JCI online early table of contents: June 12, 2008

...QT interval) in the heart's electrical cycle, is caused by mutations in the herg gene. What triggers the changes in the electrical activity in the heart (an... (something that is recorded in an ECG) of two LQT-2 patients with the same herg mutation (A558P), and found that fever was associated with prolonged QT int...

TetraQ recognized for toxicology services

...yte micronucleus testing; dose range finding; safety pharmacology (cardiovascular, central nervous and respiratory systems); off-target screening; and herg binding assays. TetraQ has state-of-the-art facilities and equipment which meet stringent quality and testing standards to conduct toxicology stud...

Study Offers Clues to Link Between Arrhythmia, Sudden Death

..., the mutation is in the KvLQT1 gene, while in LQT2, the mutation is in the herg gene. The animals with LQT2 exhibited spontaneous arrhythmias, and some ... did not have increased dispersion. Koren and his team also believe that herg and KvLQT1 may interact, and that a mutation of either one of these genes c...
hERG in Biological Technology

Rapid hit confirmation and early hERG liability testing using the IonWorks HT system

IONWORKS HT APPLICATION NOTE #4 By James Costantin, Ph.D., Yen-Wen Chen, Ph.D., Jinfang Liao, Ph.D., Jeff Quast, Andrew Wittel, Shawn Handran, Ph.D. and Naibo Yang, Ph.D. Molecular Devices Corporation, 3280 Whipple R...

ChanTest Acquires Applied Cell Sciences

...stamine receptors, may produce sudden cardiac death by blocking the cardiac herg ion channel. ChanTest's scientists pioneered the herg assay essential to assess this risk. On the discovery side, the central ner...

ChanTest to Highlight the World's Largest Catalog of Ion Channel-Expressing Cell Lines and Discovery Services at Assays & Cellular Targets Conference, Booth 11

... customers design an appropriate testing program to meet their specific scientific and budgetary goals." ChanTest scientists were the first to prove herg as the target for adverse cardiac events linked to non-cardiac drugs: Seldane (terfenadine), Propulsid (cisapride), and Nizoral (ketoconazole), and Ch...

ChanTest to Highlight the World's Largest Catalog of Ion Channel-Expressing Cell Lines and Discovery Services at Ion Channel Targets, Booth 5

...zation, or safety testing in preparation for an IND submission -- your ChanTest results will correlate." ChanTest scientists were the first to prove herg as the target for adverse cardiac events linked to non-cardiac drugs: Seldane (terfenadine), Propulsid (cisapride), and Nizoral (ketoconazole), and Ch...

ChanTest Launches New Business to Provide Validated Ion Channel Expressing Cell Lines to the Research Community

...ble currently include the following: Channel: herg herg KvLQT1-MinK Kir2.1 Kv1.5 Cell Type: ...K293 ChanTest scientists were the first to prove herg as the target for adverse cardiac events linked to...

ChanTest to Highlight the World's Largest Catalog of Ion Channel-Expressing Cell Lines and Discovery Services at Drug Discovery Technology, Booth 839

...termination rate of ~ 70 percent, well above the 30-percent rate for the antiarrhytmics used presently." ChanTest scientists were the first to prove herg as the target for adverse cardiac events linked to non-cardiac drugs: Seldane (terfenadine), Propulsid (cisapride), and Nizoral (ketoconazole), and Ch...

Aureus Pharma Announces Date of 2008 Annual User Symposium

... drug target classes including GPCR, Ion Channel, Kinase as well as other critical pharmaceutical topics including ADME/Drug-Drug Interactions and the herg Channel. The information contained in the Aureus Pharma system is of primary importance to aid in lead discovery and optimization as well as to build ...

ChanTest to Highlight Most-Comprehensive Range of Ion Channel Profiling Screens and Consultation Services at 14th Annual SBS Conference, Booth 1104

...ldwide. We don't just deliver raw data -- our ion channel experts tell customers what the results mean." ChanTest scientists were the first to prove herg as the target for adverse cardiac events linked to non-cardiac drugs: Seldane (terfenadine), Propulsid (cisapride), and Nizoral (ketoconazole), and Ch...

ChanTest to Highlight Expanded Ion Channel Testing Services for Preclinical Safety at ToxExpo, Including the World's Largest Catalog of Validated Ion Channels, Booth 2504

... because we don't just deliver raw data - our ion channel experts tell customers what the results mean." ChanTest scientists were the first to prove herg as the target for adverse cardiac events linked to non-cardiac drugs: Seldane (terfenadine), Propulsid (cisapride), and Nizoral (ketoconazole), and Ch...

Aureus Pharma Announces Renewal and Expansion of Licensing Agreement With Bristol-Myers Squibb for its AurSCOPE Knowledge Databases

...mportant drug target classes including GPCR, Ion Channel, Kinase as well as other critical pharma topics including ADME/Drug-Drug Interactions and the herg Channel. The data contained in the Aureus Pharma system is of importance to aid in lead discovery and optimization as well as to build predictive mode...
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