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groove in Medical News

Cell Therapeutics Initiates Process to Obtain Marketing Approval for Pixantrone in Europe

... Life Sciences Limited, a wholly-owned subsidiary of CTI, based in London, UK. About Pixantrone Pixantrone (BBR 2778) is a novel major groove binder with an aza-anthracenedione molecular structure that differentiates it from the anthracyclines and other related chemotherapy agents. Anthracyc...

Centocor Ortho Biotech Statement on the FDA ODAC Opinion Regarding Trabectedin for Relapsed Ovarian Cancer

...was originally derived from the marine tunicate, Ecteinascidia turbinata. The compound is now produced synthetically. Trabectedin binds to the minor groove of DNA and bends it toward the major groove, causing DNA adducts that interfere with cell division and genetic transcription processes and DNA repair ...

Cell Therapeutics Completes Pixantrone NDA Submission and Requests Priority Review

...art failure, myocardial infarction, cyanosis, pericardial effusion, and tachycardia. About Pixantrone Pixantrone (BBR 2778), is a novel major groove binder with an aza-anthracenedione molecular structure that differentiates it from the anthracyclines and other related chemotherapy agents. Anthracyc...

New antibiotics could come from a DNA binding compound that kills bacteria in 2 minutes

...e a helix which looks cylindrical in shape and neatly fits within the major groove of a DNA helix. It is about the same size as the parts of a protein that re...A which is negatively charged. When the iron-helicate binds to the major groove of DNA it coils the DNA so that it is no longer available to bind to anythi...

Empire Blue Cross Blue Shield to Serve as Host Sponsor for 100 Black Men of America 23rd Conference

...e Bronx NY. Among the invited guest speakers and awardees are: Terry McMillan, author of Waiting to Exhale and How Stella Got Her groove Back ; New York Knicks' Allan Houston; award-winning gospel artist Bishop Hezekiah Walker and renowned clergywoman Reverend Dr. Suzan Johnson Cook. ...

Pixantrone Now Available in Europe on a Named-Patient Basis

...rmation can be found at http://www.celltherapeutics.com/pixantrone_europe About Pixantrone Pixantrone (BBR 2778), is a novel major groove binder with an aza-anthracenedione molecular structure that differentiates it from the anthracyclines and other related chemotherapy agents. Anthracyc...
groove in Medical Technology

National Cancer Institute Research Identifies Unique Mechanism of Brostallicin's Anti-Tumor Effectiveness

...one levels are associated with chemotherapy resistance." About Brostallicin Brostallicin, a novel synthetic second-generation DNA minor groove binder, has shown potent cancer killing activity, and has demonstrated synergism in combination with standard cytotoxic agents as well as with newer t...

Responses After Completion of Therapy Increase Pixantrone Complete Remission (CR)/Unconfirmed Complete Remission (CRu) Rate to 24% and Overall Response Rate (ORR) to 40% Compared to 7% and 14% for Comparator Agents in Phase III EXTEND Trial in 3rd Line Th

... of 2009. Pixantrone is also now available in Europe on a named-patient basis. About Pixantrone Pixantrone (BBR 2778), is a novel major groove binder with an aza-anthracenedione molecular structure that differentiates it from the anthracyclines and other related chemotherapy agents. Anthracyc...

Pixantrone in Combination with Chemotherapy Regimens Produces Overall Response Rates of 58-74% with Complete Remission Rates of 37-57% in Relapsed/Refractory Aggressive or Indolent NHL

...rry W. Hancock, M.D., Professor of Medical Oncology, Weston Park Hospital, Shefield. About Pixantrone Pixantrone (BBR 2778), is a novel major groove binder with an aza-anthracenedione molecular structure that differentiates it from the anthracyclines and other related chemotherapy agents. Anthracyc...

Pixantrone Produces High Rates of Complete and Partial Remissions Even Among Aggressive NHL Patients With Extensive Prior Doxorubicin Treatment or Prior Rituximab Treatment

... 2009. Pixantrone is also now available in Europe on a named patient basis. About Pixantrone Pixantrone (BBR 2778), is a novel major groove binder with an aza-anthracenedione molecular structure that differentiates it from the anthracyclines and other related chemotherapy agents. Anthracyc...

Pixantrone Phase 3 Data to be Presented at the 2009 American Society of Clinical Oncology (ASCO) Annual Meeting

...the U.S. Food and Drug Administration ("FDA") during the fourth quarter of 2009. About Pixantrone Pixantrone (BBR 2778), is a novel major groove binder with an aza-anthracenedione molecular structure that differentiates it from the anthracyclines and other related chemotherapy agents. Anthracyc...

Medarex Announces Preclinical Data from Multiple Research Programs Demonstrating Anti-Tumor Activity in Cancer

...ition, the antibody-drug conjugate was well-tolerated in cynomolgous monkeys and mouse models. The critical role of cleavable linkers for minor groove binding alkylating agent (MGBA) based antibody-drug conjugates (Abstract #1722) The effectiveness of a cleavable linker over a non-cleavable linker...
groove in Medical Products

Midi Gel Dryer

Description:...nd timer. The gels are heated from base plate and the vacuum removes the moisture from below to dry the gel homogeneously. When applying the vacuum, a groove that frames the drying surface provides an optimal tight seal during the drying....
Company:Major Science

Optetrak Cruciate Retaining

Description:...r surface and patella to reduce wear. Constant cutting guide peg locations provide easy intraoperative change of sizes. Extended and deepened patellar groove reduces shear and compressive stress on patellar component. Less prominent femoral flange edges reduce surrounding soft tissue tension and improve pat...
Company:Exactech, Inc.

Foundation® Knee CR System

Description:...s. The patello- femoral joint has a recessed, deepened and extended patella groove to minimize advancement of the patella, which has been shown to increase flexion postoperatively. The anatomic groove promotes more normal kinematics and increases resistance to patella disloca...
Company:Encore Medical Corporation

Natural-Knee Revision system

Description:...rietary CSTi porous coating option for stable fixation in active patients, a unique bone-preserving posterior stabilizing design, a deepened trochlear groove to maximize range of motion, and simple-to-use instrumentation....
Company:Zimmer, Inc.

Optetrak Posterior stabilized Knee

Description:...urved spine/cam articulation reduces contact stress on the tibial spine. Reduced cam box width for less bone resection. Extended and deepened patellar groove reduces shear and compressive stress on patellar component. Less prominent femoral flange edges reduce surrounding soft tissue tension and improve pat...
Company:Exactech, Inc.

Optetrak Cruciate Sparing Knee

Description:...r surface and patella to reduce wear. Constant cutting guide peg locations provide easy intraoperative change of sizes. Extended and deepened patellar groove reduces shear and compressive stress on patellar component. Less prominent femoral flange edges reduce surrounding soft tissue tension and improve pat...
Company:Exactech, Inc.
groove in Medical Dictionary

Patella

...he kneecap goes back to ... Dislocating Kneecap in Dogs - Luxating Patella ... The patella (commonly known as the kneecap) normally rides in a groove at the ... Information about patella in the free online English dictionary and encyclopedia. patella ... common limpet, Patella vulgata - ma...

Medial

..... This force causes the medial aspect of the knee to widen, creating a stretch, ... Lower trunk & medial cord of brachial plexus. Ulnar groove at elbow ... Compression at Arcade of Struthers: Fascial plane in medial triceps muscle ... Medial - Definition of Medial at Dictionary....

Femur

...us at 1-800-SOLD-OUT. Your thighbone ( femur ) makes up the top part of the joint, and two lower leg ... The fourth bone, the patella, slides in a groove on the end of the femur . ... The treatment of pediatric femur fractures depends on the age of the child. ... Femur fractures are not u...
groove in Biological News

How Volvox got its groove

Some algae have been hanging together rather than going it alone much longer than previously thought, according to new research. Ancestors of Volvox algae made the transition from being a single-celled organism to becoming a multicellular colony at least 200 million years ago, during the Tri...

Some vocal-mimicking animals, particularly parrots, can move to a musical beat

... CAMBRIDGE, Mass. -- Researchers at Harvard University have found that humans aren't the only ones who can groove to a beat -- some other species can dance, too. This capability was previously believed to be specific to humans. The research team found that only sp...

New polymer coatings prevent corrosion, even when scratched

...alt solution and compared over time. The control samples corroded within 24 hours and exhibited extensive rust formation, most prevalently within the groove of the scratched regions, but also extending across the substrate surface, the researchers report. In dramatic contrast, the self-healing samples show...

Leemor Joshua-Tor, PhD, CSHL biologist and WSBS dean, is named an HHMI Investigator

...roving beyond a doubt that Argonaute was the only protein required for Slicer activity, and shedding light on a structural feature of the protein -- a groove in its topography -- into which a short RNA and messenger-RNA can nestle when the two are paired, prior to cleaving. Making those discoveries are l...

'Death protein' research secures funding for UCF scientists

...ills that could help her design new biological experiments. Together, the three scientists discovered that the occupancy of a prominent hydrophobic groove within the molecular structure of BAX could be the key to controlling the proteins lethal activity. Khaled has studied the inner workings of BAX, a...

Detailed 3-D image catches a key regulator of neural stem cell differentiation in action

...their efficacy using an established process Noel likens to molecular dentistry, because his group is striving to shape inhibitory molecules to fit the groove in Scp1 much the same way that a dentist molds a filling to fit the cavity in a patient's tooth. ...
groove in Biological Technology

Pixantrone Significantly Increases Complete Remissions, Overall Response Rates, Frequency of Durable Remissions and Progression Free Survival in Patients with Relapsed and Refractory Aggressive Non-Hodgkin's Lymphoma

... of 2009. Pixantrone is also now available in Europe on a named patient basis. About Pixantrone Pixantrone (BBR 2778), is a novel major groove binder with an aza-anthracenedione molecular structure that differentiates it from the anthracyclines and other related chemotherapy agents. Anthracyc...

Centocor Ortho Biotech Data to be Presented at American Society of Clinical Oncology (ASCO) Annual Meeting

...ed from the Caribbean tunicate, Ecteinascidia turbinate ("sea squirt"). The compound is now produced synthetically. Trabectedin binds to the minor groove of DNA, interfering with cell division and genetic transcription processes and DNA repair machinery. Trabectedin is currently in Phase 3 development ...

Low Occurrence of Severe Cardiac Side Effects Despite Extensive Prior Doxorubicin Treatment Reported in Pixantrone Pivotal Trial

... 2009. Pixantrone is also now available in Europe on a named-patient basis. About Pixantrone Pixantrone (BBR 2778), is a novel major groove binder with an aza-anthracenedione molecular structure that differentiates it from the anthracyclines and other related chemotherapy agents. Anthracyc...

Allegro Diagnostics Expands Board and Executive Team

...preneurs who take a hands-on approach to building market leaders. Previous Kodiak investments have included ALIS Corporation, Fluxion Biosciences, and groove Mobile. For more information on Kodiak Venture Partners, visit: www.kodiakvp.com . About Catalyst Health Ventures Catalyst Health Ventures i...

Medarex Announces Presentations at Annual Meeting of the American Association for Cancer Research

...sentation from 8:00 to 12:00 p.m. local time on Sunday, April 19, 2009. "The critical role of cleavable linkers for minor groove binding alkylating agent (MGBA) based antibody-drug conjugates" (Abstract #1722), S. Gangwar - Poster presentation from 1:00 to 5:00 p.m. local time o...

Rosetta Genomics Reports Fourth-Quarter and Full-Year 2007 Financial Results

...ell as prognosis, for diffuse large cell lymphoma, transformed follicular lymphoma, and for chronic lymphocytic leukemia. - Licensed Nanogen's Minor groove Binder (MGB) probe technology for polymerase chain reaction (PCR) for our microRNA-based diagnostics. - Licensed Roche PCR technology for use in Ros...
groove in Biological Products

4',6-Diamidino-2-phenylindole dihydrochloride (DAPI) from Sigma-Aldrich

Description:... Cell permeable fluorescent minor groove-binding probe for DNA. Binds to the minor groove of double-stranded DNA (preferentially to AT rich DNA), forming a stable complex which fluoresces approximately 20 times greater than DAPI alone. DAPI...
Company:Sigma-Aldrich
groove in Biological Definition

Alpha helix

...s and zinc finger motifs. This is because of the structural coincidence of the α helix diameter of 12 being the same as the width of the major groove in B-form DNA . α helices are one of the basic structural elements in proteins, together with beta sheets . The peptide backbone of an &al...
groove in Biological Dictionary

Peptide-binding groove

Pockets in the peptide - binding groove of MHC molecules accommodate anchor side ... F and to hold the peptide in the binding groove , rather than a secondary anchor ... ... of the H-2Kb molecule, which shield the dEV8 peptide in the binding groove . ... is angled away from the pe...

Oral groove

paramecium n. , pl. -cia or -ciums . Any of various freshwater ciliate protozoans of the genus Paramecium, usually oval and having an oral groove Groove (machining) In manufacturing or mechanical engineering a ... What is oral groove ? What is a carpenter's groove ? What does get you...

Wobble base pair

...at a productive ... In such a wobble base pair , G makes two hydrogen bonds with U in a geometry ... amine of G, when presented on the minor groove surface by the wobble base pair ... ...

Typhlosole

...vestibule of the stomach with the ... The typhlosole (ridge) lining the groove becomes greatly enlarged and the groove ... ...

Right atrium

...eurysm refers to an abnormality in the aorta, be it ... Right Atrium ... The left hand margin of the right atrium is marked posteriorly by the groove ... Congestive heart failure is a condition in which the cardiac muscle does not pump blood efficiently through the various ... to the right ...

Primitive streak

...ial stage in the development of a ... The initial appearance of the primitive streak is the defining criteria for stage 6b. ... The primitive groove is not found in the absence of a streak . ... ... kept getting better and on Primitive Streak they deliver a solid 5 star ... " Primitive St...
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