Gene therapy converts dead bone graft to new, living tissue
Researchers have created a way to transform the dead bone of a transplanted skeletal graft into living tissue in an experiment involving mice. The advance, which uses gene therapy to stimulate the body into treating the foreign splint as living bone, is a promising development for the thousands of cancer and trauma patients each year who suffer with fragile and failing bone grafts. The findings w...New method shows it is possible to grow bone for grafts within a patient's body
An international team of biomedical engineers has demonstrated for the first time that it is possible to grow healthy new bone reliably in one part of the body and use it to repair damaged bone at a different location. The research, which is based on a dramatic departure from the current practice in tissue engineering, is described in a paper titled "In vivo engineering of organs: The bon...Bioactive cement scaffold may improve bone grafts
A new technology for implants that may improve construction or repair of bones in the face, skull and jaw, has been developed by researchers from the American Dental Association Foundation (ADAF) and the National Institute of Standards and Technology (NIST). Described in recent and upcoming journal articles,* the new technology provides a method for making scaffolds for bone tissue. The s...OHSU surgeon implants donated tissue allografts
Over the years, orthopedic surgeon Dennis Crawford, M.D., Ph.D., of Oregon Health & Science University found it difficult to obtain tissue for transplant to treat some of his patients suffering with severe joint disorders. "I found this unfortunate and ironic," explained Crawford, assistant professor of orthopedics and rehabilitation in the OHSU School of Medicine, and a specialist in...University of Pittsburgh School of Medicine researchers develop 'off-the-shelf' vascular grafts
University of Pittsburgh School of Medicine investigators have engineered artificial blood vessels from muscle-derived stem cells (MDSCs) and a biodegradable polymer that exhibit extensive remodeling and remain free of blockages when grafted into rats. The results of their study, which is being presented at the Tissue Engineering and Regenerative Medicine International Society (TERMIS) North A...Twisted bypass grafts work better
In a new revealation, researchers have shown that twisting the graft to bypass a blockage in the blood// vessels may work better and last longer. In using a graft to bypass blockages, scientists often use plastic prosthetic tubes. Similar tubes are also used when patients with renal problems have dialysis. This is called a shunt. The problem with the usage of shunt have difficlties, as...Grafting arteries to restore blood flow is best for survival
Surgeons prefer complete revascularization technique to increase blood flow to the heart// than coronary bypass surgery. The procedure is said to increase 5 years of patients’ life than the coronary bypass surgery. Surgeons from Cedars-Sinai Medical Center, US, have found that patients who had blockages in multiple of coronary arteries have more life span when they undergo arterial gra...Protective regimen for acute Graft-versus-host disease
Allogeneic hematopoietic-cell transplantation with the use of conditioning regimens of non-myeloablative radiotherapy, chemotherapy, or both to decrease early toxic effects extends the possibility of hematopoietic-cell// transplantation to patients older than 50 years and those with coexisting conditions. However, acute graft-versus-host disease (GVHD) remains a major problem after non-...Drug-Eluting Stents Ensure Patency Of The Saphenous Vein Grafts
The new generation stents that are deigned for slow release of medication are found to be far more effective than conventional stents according to a recent study conducted on stents used for cardiac bypass // . It is also found to effectively prevent the overgrowth of scar tissue, thereby reducing incidence of restenosis (re-narrowing), heart attack and death. Stents can either be inser...Face transplant woman has new graft
The world's first face transplant recipient has undergone a further graft on Friday, even as controversy surrounds her surgery//. Isabelle Dinoire, 38, in Lyons, France, received a second transplant of bone marrow and stem cells from the same donor, which had been successful, doctors said. This is meant to cut the risk of Miss Dinoire rejecting the face. The technique was de...