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Glycosylation in Medical News

Researchers identify individuals at risk for developing colon cancer

...e Medical Center and Johns Hopkins. A defect in glycosylation is a hallmark of many cancers, but the reason for ... These mutations contribute to alterations in the glycosylation process, and in turn, to the development of colon ...elopment," said Dr. Markowitz. "Knowing how these glycosylation enzymes malfunction and contribute to tumor format...

Frost & Sullivan Lauds Toscana Biomarkers' Outstanding Contributions to the R&D of Novel Biomarkers for the Diagnosis of Autoimmune Diseases

...mmune diseases, Toscana Biomarkers aims at providing novel diagnostic solutions using disease biomarkers. PTMs such as lipidation, citrullination, and glycosylation play a vital role in antigen recognition, as they are known to alter its immunogenicity and function. Such modifications change the antigens' structur...

Selexis Now Offering Rapid-Development of Human Cell Line With FDA Approval Pedigree

...ned program will be highly desirable to biotech companies needing the rapid development of a high performance cell line expressing proteins with human glycosylation patterns. This new platform will be a viable option to our CHO program for more difficult to express proteins." About Selexis HEK293 Services: Sel...

Recent developments at Burnham Institute

...n Freeze, a former slime-mold biologist, has found his sweet spot. His lab is studying rare, yet debilitating, diseases called Congenital Disorders of glycosylation (CDG). These diseases are caused by a defect in a cell's ability to produce the sugars that promote cells binding together. Mutations in the proteins ...

Monoclonal antibody Hb3: A marker for colon cancer progression or as a therapeutic target?

...lysis. The molecular weight of CKAP4-similar protein is 62.02 kDa, including one hydrophobic region, one transmembrane domain, five coiled coils, four glycosylation sites and forty-nine phosphorylation sites. CKAP4-similar protein has high homogeneity with Np63, and the characteristic expression of agrNp63 alpha t...

JCI online early table of contents: Jan. 2, 2008

...es from the peripheral blood of patients with IgA nephropathy and demonstrated that premature sialylation is likely to contribute to the aberrant IgA1 glycosylation in individuals with this disease. The authors therefore suggested that inhibiting proteins in the biochemical pathway that mediates IgA1 sialylation, ...

Cell-surface sugar defects may trigger nerve damage in multiple sclerosis patients

...t genetic deficiencies in a process called protein glycosylation led to a spontaneous disease very similar to MS, i...lls and degeneration of axons and neurons. Protein glycosylation refers to the addition of specific sugars to prote...vailable glucosamine, corrected defects in protein glycosylation in cells and inhibited inflammatory demyelination ...

Nervous Systems of Insects may Offer Clues on Neurodegenerative Diseases

...e addition of sugars to proteins a process called glycosylation in the nervous system of insects, Karen Palter, r... two collaborative research projects exploring the glycosylation process that could eventually play important roles...tached to them in order to function properly. This glycosylation process is necessary for protein stability, may mo...
Glycosylation in Medical Technology

Shire Reports Positive Results From First of Three Phase III Trials of velaglucerase alfa for Type 1 Gaucher Disease and Provides Important Updates on Interactions With FDA

...fa is made using Shire's proprietary technology, in a human cell line. The enzyme produced has the exact human amino acid sequence and carries a human glycosylation pattern. Phase III Study Overview and Results The first trial in the Phase III program to be completed was a multicenter, randomized, do...

Shire Receives Fast Track Designation for velaglucerase alfa for Gaucher Disease

...lfa is made with Shire's proprietary technology, in a human cell line. The enzyme produced has the exact human amino acid sequence and carries a human glycosylation pattern. Background on Gaucher disease Gaucher disease is an autosomal recessive disease and the most prevalent Lysosomal Storage Disord...

Shire has Filed a Treatment Protocol for Velaglucerase Alfa for Gaucher Disease

...lfa is made with Shire's proprietary technology, in a human cell line. The enzyme produced has the exact human amino acid sequence and carries a human glycosylation pattern. Shire has sufficient supply of velaglucerase alfa to meet anticipated patient demand. Shire is working with the FDA to file a N...

Drug Development Program Started Based on CAP(R) Human Cell Line

...ologne, Germany, is a biopharmaceutical company that specializes in developing and producing therapeutic proteins and monoclonal antibodies with human glycosylation patterns. CEVEC's novel proprietary and patent-protected human CAP(R) and CAP-T(TM) expression systems are ideal for manufacturing complex biopharmace...

AlphaMed Pharmaceuticals Announces Breakthrough in the Development of Recombinant Alpha 1-Antitrypsin

...or milestone for this company and AAT research," stated Joseph McGuirl, AlphaMed's CEO, "AlphaMed is the first company to develop an AAT molecule with glycosylation that resembles the human protein that is naturally secreted from the liver. The Company has begun to develop products to treat a variety of diseases i...
Glycosylation in Medical Products

Carbohydrate Deficient Transferrin for Congenital Glycosylation Disorders

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories
Glycosylation in Biological News

GlycoFi and Dartmouth report full humanization of yeast glycosylation pathway in Science

For the first time, scientists have engineered yeast cells capable of producing a broad repertoire of recombinant therapeutic proteins with fully human sugar structures (glycosylation). These sugar structures ensure a glycoprotein's biological activity and half-life and to date, have necessitated t...

GlycoFi announces the first production of antibodies with human glycosylation in yeast

Researchers at GlycoFi and Dartmouth College have reported the first production of monoclonal antibodies with human sugar structures in yeast. This research, published online January 22 and in the February issue of the journal Nature Biotechnology, demonstrates that antibodies with human sugar s...

Researchers apply systems biology and glycomics to study human inflammatory diseases

...ses, including cell/organ development, immunity and cell adhesion. Abnormal glycosylation also is implicated in diverse diseases, including certain cardiovascular di...ico tool that can be applied to perturb the system of interest, such as the glycosylation network." Those studies, in turn, he continued, can then generate new hyp...

Novel publishing approach puts textbook in more hands

... search engines index the content." While the first edition focused primarily on vertebrate glycobiology, the second edition reflects the fact that glycosylation is universal, that all cells in all speciesfrom eubacteria and archaea to arthropods and vertebratesare coated (both inside and out) with a dense arra...

Biophysical Society announces 2008 International Travel Awards

...Hydration of Curved and Ripples States of Lipid Interphases. Silvina B. Gayol, Centro de Neurociencia de Valparaiso, Chile, In Xenopus Oocytes glycosylation of Shaker K+ Channels Alters its Expression in the Plasma Membrane and Activation Kinetics. Iffath A. Ghouri, University of Glasgow, United Kin...

Report calls for improved monoclonal antibodies against solid tumors

... large number of antibody construct and therapy variables are available for optimization including size, charge, and valence; constant region type and glycosylation pattern; presence or absence of a radioisotope or a toxic moiety; dose, route, and schedule of administration; and use of a traditional or of a pre-ta...

Integration of Agilent's MS technology, Proteome Systems' software to help scientists in proteomics research

...d systems. GlycomIQ comprises kits, consumables and informatics software developed specifically for automated glycan analysis. "Analysis of protein glycosylation is a demanding task that has often been reserved for specialized laboratories," said Nicolle Packer, executive vice president and head of glycoproteom...
Glycosylation in Biological Technology

GlycoVaxyn AG Raises CHF 25 Million in Financing Led by Edmond de Rothschild Investment Partners

...GlycoVaxyn has built a broad portfolio of novel conjugate vaccines against common severe bacterial infections based on its unique, proprietary in-vivo glycosylation platform. With this platform, the company can develop and produce immunogenic glycoproteins in a simplified biological process that circumvents many o...

Sigma-Aldrich Launches Breakthrough Genome-Editing Tools

... of new drug compounds. For biopharmaceutical manufacturers, ZFNs will enable the creation of cell lines with improved growth characteristics, altered glycosylation properties, and other traits resulting in higher yields. Through its exclusive partnership with Sangamo BioSciences, Inc. (Nasdaq: SGMO ), the pion...

Bruker Announces Availability of New HUPO World Congress Proteomics Posters on Web Site

...on-CID and Ion Trap-ETD Poster T345 -- Automated LC-MALDI Analysis of Glycopeptides from Glycoprotein Digests using DHB as Matrix Poster T348 -- glycosylation Profiling of Immunoglobulin G (IgG) Subclasses Poster T384 Metabolomics -- Detailed Investigation of the Fragmentation of aminopyridinyl-imid...

ZyStor receives first funding and buys theraputics for rare diseases

...ear on its treatment for Gauchers disease. One patients treatment for a year runs $160,000. The technology ZyStor bought from Symbiontics is called glycosylation independent lysosomal targeting. It is meant to make enzyme-replacement therapies more effective. Replacement enzymes need to attach to target cells i...

Milwaukee area biotech ZyStor seeks more funding

...atients are delivered to critical tissues, and patients must have large intravenous doses on a frequent basis. GILT complex ZyStor's response, glycosylation Independent Lysosomal Targeting or GILT, has proven effective in animal testing. With this technology, a peptide tag replaces a chemical component fou...

GenTel to distribute cancer research tool

... protein after its synthesis, in a process called glycosylation . Changes in the glycosylation of proteins are associated with many types of canc...gy uses antibody microarrays to profile changes in glycosylation of proteins captured on the surface of a chip. ...

GenTel licenses next generation cancer research

...ynthesis and is an important determinant of protein function. Changes in glycosylation are thought to play roles in certain disease processes. GenTel's technol...n per year worldwide, Negm said. Although nobody has an exact number on the glycosylation segment of that market, Negm believes that GenTel's first-to-market advanta...

ZyStor seeks to raise $15M for clinical trials

... into patients are delivered to critical tissues, and patients must have large intravenous doses on a frequent basis. With ZyStor's therapy, called glycosylation Independent Lysosomal Targeting or GILT, a peptide tag replaces a chemical component found on some of the enzyme's carbohydrates. The tag is embedded ...

High Yield Protein Production from Pichia pastoris Yeast: A Protocol for Benchtop Fermentation

...ns of the proteins being produced. Many eukaryotic proteins can be produced in E. coli but are produced in a nonfunctional, unfinished form, since glycosylation or post-translational modifications do not occur. Therefore, researchers have recently turned to eukaryotic yeast and mammalian exp...
Glycosylation in Biological Products

Tunicamycin, Streptomyces lysosuperficus from Calbiochem

Description:... White to off-white solid. A nucleoside antibiotic that inhibits N-linked glycosylation and blocks the formation of N-glycosidic protein-carbohydrate linkages. Active in vitro against Gram-positive bacteria, yeasts, fungi, and viruses. ...
Company:Calbiochem

Canine Pancreatic Microsomal Membranes from Promega

Description:...eavage, membrane insertion, translocation and core glycosylation can be examined by the translation of the appropri... microsomal membranes. In addition, processing and glycosylation events may be studied by the transcription/transla...ons are assayed for both signal peptidase and core glycosylation activities using two different control mRNAs. The ...
Company:Promega
Glycosylation in Biological Definition

Antibody

...h a T helper cell is also necessary. Structure of the antibody Immunoglobulins are heavy plasma proteins, often with added sugar chains (see glycosylation ) on N-terminal (all antibodies) and occasionally O-terminal (IgA1 and IgD) aminoacid residues. The basic unit of each antibody is a monomer . An a...

Carbohydrate

...ommission on Biochemical Nomenclature (JCBN): Carbohydrate Nomenclature Carbohydrates detailed Carbohydrates Overview Carbohydrates and glycosylation - The Virtual Library of Biochemistry and Cell Biology ...

Endoplasmic reticulum

...serted into the ER membrane after they are synthesized. Insertion into the ER membrane requires the correct topogenic sequences . Glycosylation. glycosylation involves the attachment of oligosaccharides . Disulfide bond formation and rearrangement. Disulfide bonds stabilize the tertiary and quaternary ...

Glucose

... the amino groups of proteins . This reaction ( glycosylation ) reduces or destroys the function of many enzymes . The low rate of glycosylation is due to glucose's preference for the less reacti...and peripheral neuropathy) are probably due to the glycosylation of proteins. The chain form of D -Gluco...

Proteome

...tes , in the sense there are more proteins than genes . This is due to alternative splicing of genes and post-translational modifications like glycosylation or phosphorylation . Moreover the proteome has at least two levels of complexity lacking in the genome. When the genome is defined by the sequence...

Proteomics

...mino-acid sequence, so-called post-translational modification. Specialized methods have been developed to study phosporylation (phosphoproteomics) and glycosylation (glycoproteomics). Key technologies used in proteomics One and two-dimensional gel electrophoresis are used to identify the relative m...

Endoplasmic reticulum

...serted into the ER membrane after they are synthesized. Insertion into the ER membrane requires the correct topogenic sequences . Glycosylation. glycosylation involves the attachment of oligosaccharides . Disulfide bond formation and rearrangement. Disulfide bonds stabilize the tertiary and quaternary ...

Endoplasmic reticulum

...serted into the ER membrane after they are synthesized. Insertion into the ER membrane requires the correct topogenic sequences . Glycosylation. glycosylation involves the attachment of oligosaccharides . Disulfide bond formation and rearrangement. Disulfide bonds stabilize the tertiary and quaternary ...

Endoplasmic reticulum

...serted into the ER membrane after they are synthesized. Insertion into the ER membrane requires the correct topogenic sequences . Glycosylation. glycosylation involves the attachment of oligosaccharides . Disulfide bond formation and rearrangement. Disulfide bonds stabilize the tertiary and quaternary ...
Glycosylation in Biological Dictionary

Glycosylation

Glycosylation is the enzymatic process that links saccharides to produce glycans, either free or attached to proteins and lipids. This enzymatic process produces one of four fundamental components of all cells and also... glycosylation ( glī′käsə′lāshən ) ( biochemistry ) A chemical re...

Carboxyl Terminus

...nts (residues 192–299) increases ... The results suggest that the entire carboxyl terminus up to residue 272, not a ... ... oval) to analyze glycosylation at exogenous sites within the carboxyl terminus . ... The carboxyl terminus is predicted to begin near Lys111, and the Met128-FLAG ... The ...
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