generative

Genrate: a generative model that finds and scores new genes and exons in genomic microarray data

Abstract : Recently, researchers have made some progress in using microarrays to validate predicted exons in genome sequence and find new gene structures. However, current methods rely on separately making threshold-based decisions on intensity of expression, similarity of expression profiles, and arrangements of exons in the genome. We have taken a Bayesian approach and developed GenRate,...

Pinpointing the cause of a neurodegenerative disorder

New understanding of spinocerebellar ataxiaResearchers have discovered how the abnormal repetition of a genetic sequence can have disastrous consequences that lead to the death of neurons that govern balance and motor coordination. The studies bolster the emerging theory that neurodegenerative disorders can be caused by having extra copies of a normal protein, not just a mutated one. Peopl...

Study ties 'new' cell-death mechanism to developmental and degenerative brain disorders

An international research team has provided the first conclusive evidence that neurodevelopmental disorders such as mental retardation and neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease and ataxias can be caused, at least in part, by specific gene defects that interfere with the electrical impulses of rapid-firing brain nerve cells called bursting neurons. The...

'Sticky' mice lead to discovery of new cause of neurodegenerative disease

When a faulty protein wreaks havoc in cells and causes disease, researchers are usually quick to point the finger at a wayward gene. Now scientists are learning that some neurodegenerative diseases can develop even though a gene is perfectly normal. The diseases can be caused when the genetic instructions contained in the gene are not executed properly, leading to a lethal buildup of malformed pr...

Nanotechnology propels advances in regenerative medicine research

The study, which was directed by Scripps Research Professor Benjamin Cravatt, Ph.D., is being published in the September 8 issue of The Journal of Biological Chemistry. The new study describes a pathway-different than the one previously suggested-for the biosynthesis of neurotransmitter lipids, N-acyl ethanolamines (NAEs), which include the endogenous cannabinoid ("endocannabinoid") ananda...

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Stem cell and regenerative medicine center to aid education and commerce

The center initially will operate in virtual space, and w...

UW tests adult stem cell role in regenerative heart care

The The school is among the first medical centers in the countr...

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Evidence Links Protein Damage to Neurodegenerative diseases like Parkinson's and Alzheimer's

Neurodegenerative diseases - including Parkinson's, Alzheimer's, Diffuse Lewy body disease, and Multiple System Arophy - are collectively called synucleinopathies. Most commonly they become symptomatic due to a deficiency of a specific neurotransmitter - in the case of Parkinson's it is dopamine. When the neurons that produce these chemicals die or become impaired, which occurs with oxida...

New insight for neuro-degenerative diseases discovered

Researchers have found out new information about how neuro degenerative// diseases develop and how the process can be possibly slowed. Researchers at the Rocky Mountain Laboratories of National Institutes of Health have found novel insights into how abnormal prion proteins work. Researchers have observed genetically engineered mice producing prion protein without a glycopho...

Treatment May Be Possible For Degenerative Brain And Spinal Cord Disease

Researchers have found out a key protein that can block the degenerative process of the brain diseases //like Alzheimer’s disease and many other similar diseases. The study, published in the online version of the Journal of Neuroscience Research, shows how a protein called KDI tri-peptide (KDI) can block the harmful effects of a substance called glutamate that is present in all degener...

Cell molecules behind neuro degenerative diseases

Researchers from the University of North Carolina at Chapel Hill, in the current issue of PLoS Computational Biology, had reported that there may be possible molecular origin of at least nine human diseases of nervous system degeneration. // These neuro degenerative diseases, including Huntington’s disease, share an abnormal deposit of proteins inside nerve cells. This deposition of pr...

Stem cell therapy for Neurodegenerative disorder patients

Stem cell therapy research can be carried out in terminally ill patients who are dying of neurodegenerative disorders as benefits are more than the risk involved in these patients, // views Professor Ian Wilmut, the creator of first cloned dolly sheep. Professor Wilmut is appointed as the first director to the centre of Regenerative Medicine, Edinburgh University. Professor Wilmut feel...

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Resveratrol Studies Suggest Broad Implications for SIRT1 Activation in Neurodegenerative Diseases of Aging Such as Alzheimer's Disease

CAMBRIDGE, Mass.--(BUSINESS WIRE)--Jun 26, 2007 - SirtrisPharmaceuticals, Inc. (NASDAQ: SIRT), a biopharmaceutical companyfocused on discovering and developing small molecule drugs to treatdiseases of aging, announced today that activation of SIRT1, amember of the sirtuin family of enzymes, was shown to protectagainst neurodegenerative diseases such as Alzheimer's Disease andAmyotrophic Lat...

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Degenerative joint disease

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