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fusions in Medical News

Gene Fusions May Drive Certain Cancers

Prostate cell findings could reveal targets for future treatments MONDAY, Jan. 12 (HealthDay News) -- Researchers say they have discovered genes in prostate cancer cells that fuse when their chromosomes trade places with each other, an occurrence that may initiate the development of so...

Cell Fusions During Inflammation May Protect Neurons

Surprise finding could lead to new gene therapies for nervous system WEDNESDAY, April 23 (HealthDay News) -- Chronic inflammation triggers cell fusions that may protect neurons, according to a Stanford University School of Medicine study. In research with mice, the Stanford team fou...

Assessment of Bone Growth Stimulator Is Mixed

...ng the front part of the neck -- anterior cervical fusions -- when BMP was used. "In the neck, there's no...ent. The study also found that costs for spinal fusions were higher when BMP was used. Inpatient hospital ...reduced because many surgeons aren't using BMP for fusions in that area or are using smaller doses of the bio...

Confectionery Industry Forecast Is Sweet: Globally Inspired Flavors, Eco-Friendly and Health Minded Trends Lead New Product Innovations

... growth of the industry through 2014. Top line category trends include: Chocolate explosion Health benefits Flavor fusions International influences So, what's next? Experts believe that the next "big" trend in confections will be heal...

Artificial Ankle Takes Giant Step Forward

...osthesis when giving a speech on ankle replacements -- specifically, ankle fusions -- at a conference in Denmark. "Ankle fusions work pretty well, but you don't have a lot of motion," Mann said. "You have...

Gene fusion discovery may lead to improved prostate cancer test

...g evaluated in multiple early clinical trials in the United States and Europe. Novel Gene Fusion Sheds Light on How Cancer Works Unlike the gene fusions previously found in cancers, which arise when two chromosomes join together in an abnormal way, the new fusion occurs when the genes are being copied ...

Compendia Bioscience Releases Oncomine Concepts Edition 4.0

...cess and in-depth analysis of curated cancer genomics data. Oncomine has led to several major cancer research discoveries such as the presence of gene fusions in the majority of prostate cancers ( Cancer Cell, Volume 13 Issue 6: June 2008. Nature , Aug 2 2007). "In accumulating so much high-value dat...

Tests Might Diagnose, Predict Prostate Cancer

...ped a urine test that can identify particular gene fusions associated with prostate cancer. The gene fusions involve the TMPRSS2 gene and the ERG gene. This pa...st," he said. "Another exciting aspect of the gene fusions is that they potentially provide an explanation fo...

Unnecessary Spinal Surgery Will Waste Billions of Dollars in 2009 and Patients Will Continue to Suffer Unless the Primary Cause of Most Back Pain is Treated, Says Pain Specialist Norman Marcus, M.D.

...ten the muscles and make them flexible -- and pain free. Dr. Marcus believes that a large percent of all spinal surgeries are unnecessary (spinal fusions are being performed as many as 20 times more often in some parts of the United States as in others) and finds it "disturbing" that the number continue...

Pitt-led research provides insight into development of congenital circulatory defects

... including the brain, lungs, spinal cord, and liver. By diverting blood, the misconnections rob parts of the body of nutrients and oxygen. The fragile fusions are prone to rupturing and hemorrhaging; a ruptured AVM in the brain can cause a stroke. "We discover AVMs in humans when something goes wrong and ...

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fusions in Medical Technology

Research Teams at J. Craig Venter Institute and Ludwig Institute for Cancer Research Uncover New Chromosomal Alterations in Cancer Using Transcriptome Sequencing Approach

...er Research (LICR) have uncovered new genomic alterations that lead to gene fusions in a breast cancer cell line by using 454 Life Sciences sequencing technolo...al Academy of Sciences (PNAS). Previous studies have shown that gene fusions are key gene alteration events in the development and progression of many k...

Spine Institute of Louisiana Offers Cervical Spine Motion Preservation as an Alternative to Fusion Surgery

...to successfully treat the majority of our patients with conservative treatment modalities and identify those patients who truly need surgery." "While fusions continue to be the standard, motion preservation is at the forefront of advances in spine care," said Marcy Rogers, president and CEO of SpineMark Cor...
fusions in Medical Products

EBI Bone Healing System

Description:...ider of bone growth stimulators Introduced in 1979 as a noninvasive alternative or adjunct to surgery Indicated for nonunion fractures, failed fusions and congenital pseudarthrosis FLX Flexible Treatment Coil is placed directly over fracture site Produces impulses called Pulsed Electromagneti...
Company:Biomet, Inc.

Acutrak Standard / Mini

Description:...ems. Together they are used primarily for secure fixation for fractures and fusions of the upper extremity, but have been used for numerous foot and ankle proc...ere there exists significant cartilage surrounding the bones, to phalangeal fusions where their headless design eliminates soft tissue irritation....
Company:Acumed LLC

Acutrak Fusion Screw

Description:...unique combination of variable thread pitch and taper provide excellent compression and holding power. The Acutrak Fusion is designed specifically for fusions of the IP and DIP joints of the hand and first toe....
Company:Acumed LLC

RingFix™ External Fixation System

Features:...uitive and easy for staff Broad Range of Indications- Facilitates ease of construct creation for many different types of surgery ranging from Ankle fusions & general trauma to Charcot Reconstruction Anodized Aluminum and Carbon Fiber Rings/Foot Plates- Lightweight radio-opaque materials in a variety of...
Company:Small Bone Innovations, Inc.

RingFix External Fixation System

Features:...uitive and easy for staff Broad Range of Indications- Facilitates ease of construct creation for many different types of surgery ranging from Ankle fusions & general trauma to Charcot Reconstruction Anodized Aluminum and Carbon Fiber Rings/Foot Plates- Lightweight radio-opaque materials in a variety of...
Company:Small Bone Innovations, Inc.

Standard Tibial Fixator

Features:...ill adapt to a multitude of configurations that can address periarticular as well as diaphyseal applications, including: complex fractures, malunions, fusions and corrective osteotomies Modular Compression/Distraction: Compression/distraction (CD) mechanism permits precise, incremental adjustment; each...
Company:Biomet, Inc.
fusions in Medical Dictionary

Brachial plexus

...plexus neuritis is an uncommon disorder characterized by severe ... INTRODUCTION AND BACKGROUND The brachial plexus is a network of nerve fusions ... Burners (stingers): Acute brachial plexus injury in the athlete ... Indications for Neurosurgical Repair of Brachial Plexus . Preoper...

Brachial plexopathy

...eal brachial plexopathy may include: Nerve conduction test and ... INTRODUCTION AND BACKGROUND The brachial plexus is a network of nerve fusions ... Postmedian sternotomy brachial plexopathy . Scapular winging ... Brachial plexopathy is pain, decreased movement, or decreased sensatio...

Bone graft

...l procedure that replaces missing bone with material from the patient's own body, an artificial, synthetic, or BMP-2 has shown to achieve spinal fusions faster and with higher success rates when used alone as compared to using the patient's autogenous bone graft . The use of ... Theodore Puck Bi...
fusions in Biological News

Inflammation triggers cell fusions that could protect neurons, Stanford research shows

STANFORD, Calif. - Chronic inflammation triggers bone marrow-derived blood cells to travel to the brain and fuse with a certain type of neuron up to 100 times more frequently than previously believed, according to a new study from the Stanford University School of Medicine. After the fusion, th...

Newly discovered gene fusion may lead to improved prostate cancer diagnosis

...or potential treatments. Experts believe that gene fusions -- a hybrid gene formed from two previously separa...plasia , are exciting, because unlike two previous fusions co-discovered by the same Weill Cornell Medical Co...ichigan, to develop urine tests to screen for gene fusions as a means of improving upon the current standard ...

Yeast missing sex genes undergo unexpected sexual reproduction

...human eggs or fusion products may be aneuploid, with chromosomes from mother and father not paired exactly one to one, but the great majority of those fusions of sperm and egg don't make it to the implantation and pregnancy stage," Reedy said. "That's why it is important to find models like this, so that we ...

U-M researchers discover new genes that fuse in cancer

...trade places with each other. These recurrent gene fusions are thought to be the driving mechanism that causes certain cancers to develop. The gene fusions discovered could potentially serve as a marker one... Nature , the researchers identified several gene fusions in prostate cancer cells. Some of the...

Breast cancer genome shows evolution, instability of cancer

...N (Dec. 15, 2008) A newly published genome sequence of a breast cancer cell line reveals a heavily rearranged genetic blueprint involving breaks and fusions of genes and a broken DNA repair machinery, said researchers at Baylor College of Medicine in a report that appears online in the journal Genome Rese...

Estrogen helps drive distinct, aggressive form of prostate cancer

...this line of research at Weill Cornell. Dr. Rubin, along with researchers at the University of Michigan, first discovered and described the common fusions between the TMPRSS2 and ETS family member genes subset of prostate cancer in the journal Science in 2005. "The discovery showed that these malignancie...

New, noninvasive prostate cancer test beats PSA in detecting prostate cancer

...r out, Chinnaiyan said. No test can do that now. Chinnaiyan and the Michigan researchers developed the test based on their recent finding that gene fusions pieces of chromosomes that trade places with each other, causing two genes to stick together - are common in prostate cancer, and that by overriding ...

Research points towards early cancer detection

... The Cardiff study means there is now a system which can detect chromosomal fusions from single DNA molecules, opening up the possibility of an early-warning t...linical test to pick up these events. The fact we can now detect chromosome fusions at the single molecule level offers hope that we will be able to achieve it...

UGA scientists unravel 'molecular inch-worm' structure of walking-pneumonia bacterium

...y, have described the basic structure of the terminal organelle, but Krause's team went further, using fluorescence microscopy and fluorescent protein fusions that allowed them to track the actions of specific proteins in live, growing cells. Time-lapse digital imaging let them see the development and activi...
fusions in Biological Technology

Monitoring fluorescence resonance energy transfer (FRET) between GFP fusions in lysates of the yeast Saccharomyces cerevisiae using the Varian Cary Eclipse

Monitoring fluorescence resonance energy transfer (FRET) between GFP fusions in lysates of the yeast Saccharomyces cerevisiae using the Varian Cary Eclipse Paul Gavin # and Mark Prescott # , Ph.D Daren J. Fyfe, Ph.D* # Department o...

Cardium Announces New Orthobiologics Product Initiative Extending Gene Activated Matrix Technology to Deliver Bone Growth Factors

... totaling $815 million in 2008. A recent Journal of American Medical Association article reviewing the use of bone morphogenetic proteins in spinal fusions estimated that in 2006 approximately 25% of spinal fusion procedures utilized a BMP product to improve healing of the fused vertebrae. About...

Frost & Sullivan Acknowledges ISTO Technologies' Role in Developing Advanced Biologic Products for Bone Healing

...d. InQu represents the first commercial product launched by the company using its proprietary biomaterial-based platform technology. Although spinal fusions and other orthopedic intervention methods are routinely used to eliminate back pain, surgeons are still unsure about the right choice in bone grafting...

Oncomine(TM) Again Key to Prostate Cancer Discovery

...k by many of the same scientists that previously identified ETS-family gene fusions in prostate cancer using Oncomine led to this discovery. "We extended an ...file Analysis (COPA) that had previously led us to identify ETS-family gene fusions in prostate cancer," said Dr. Rhodes. "We knew from that experience that tr...

Nventa Biopharmaceuticals Reports Full Year 2007 and Fourth Quarter Financial Results

...perty Portfolio: -- Granted a U.S. patent for HPV fusions to treat patients with HPV- related diseases ... Granted a U.S. patent covering heat shock protein fusions to treat anogenital warts -- Won an important...ter and methods of use for Company's CoVal(TM) fusions -- Granted European patent covering CoVal(TM) fus...

Nventa Biopharmaceuticals Corporation announces third-quarter 2007 financial results

... and Clinical Workshop that demonstrate that new HspE7 promotes more potent immune responses; - Granted new U.S. patent for Nventa's CoVal(TM) fusions covering their use in patients with human papillomavirus (HPV)-related diseases; - Published data in Clinical and Vaccine Immunology demonstra...

IT Fusion to Enhance Milwaukees Entrepreneurial IT Climate

...ive tech business executive from facility and resources standpoints. IT fusions dynamic, open work environment serves as a hub for the growing number of in...businesses are able to interact and expand their business opportunities. IT fusions Business Center is a way for tenants to improve their productivity and busi...

Transient Gene Expression Following Single and Double Exponential Decay Electroporation Pulses

...s., 20 , 245-250 (1992). 4. Hall, C. V., Jacob, P. E., Ringold, G. M. and Lee, F. Expression and regulation of E. coli lacZ gene fusions in mammalian cells. J. Mol. Appli. Genet., 2 , 101-109 (1983). 5. DeWet, J. R., Wood, K. V., DeLuca, M., Helinski, D. R. and Sub...

New Fusion Trans-Activator Plasmids for Studying Signal Transduction Pathways

...s in a variety of mammalian cell lines. We describe two new fusion trans-activator plasmids (constructed with the pFA-CMV plasmid) expressing GAL4 fusions with c-Fos (208-313) and ATF2 (1-96). figure 1 Recently, Stratagene introduced the PathDetect in ...

TKB1 Cells Identify Receptor Tyrosine Kinase Interacting Proteins

...d out with bacteria produced unphosphorylated and phosphorylated fusions that recapitulate associations observed in vivo. ...identified. Additional Applications Use the tyrosine-phosphorylated fusions for a variety of applications: Carry out direct interactions with soluble...
fusions in Biological Products

GPS -M Mutagenesis System from New England Biolabs

Description:...ransprimer is not designed to express in Gram positive organisms or eukaryotic cells. Transposon ends have stop codons in all frames, so translational fusions are not practical....
Company:New England Biolabs

pET GST Fusion System 41 from Novagen

Description:...ns can be purified with immobilized glutathione. Gentle elution is achieved with buffers containing reduced glutathione. Quantification of soluble GST fusions is also possible by assaying the transferase activity. In order to further enhance the utility of GST as a fusion tag, Novagen has designed two new mu...
Company:Novagen

pET GST Fusion System 41 plus Competent Cells from Novagen

Description:...ns can be purified with immobilized glutathione. Gentle elution is achieved with buffers containing reduced glutathione. Quantification of soluble GST fusions is also possible by assaying the transferase activity. In order to further enhance the utility of GST as a fusion tag, Novagen has designed two new mu...
Company:Novagen

pET GST Fusion System 42 from Novagen

Description:...ns can be purified with immobilized glutathione. Gentle elution is achieved with buffers containing reduced glutathione. Quantification of soluble GST fusions is also possible by assaying the transferase activity. In order to further enhance the utility of GST as a fusion tag, Novagen has designed two new mu...
Company:Novagen

pET GST Fusion System 42 plus Competent Cells from Novagen

Description:...ns can be purified with immobilized glutathione. Gentle elution is achieved with buffers containing reduced glutathione. Quantification of soluble GST fusions is also possible by assaying the transferase activity. In order to further enhance the utility of GST as a fusion tag, Novagen has designed two new mu...
Company:Novagen
fusions in Biological Definition

Monoclonal antibody

... ( hypoxanthine-guanine phosphoribosyltransferase , HGPRT) and therefore cannot grow under certain conditions (namely in the presence of HAT medium ). fusions between healthy B-cells and myeloma cells are rare, but when one succeeds, then the healthy partner supplies the needed enzyme and the fused cell can ...
fusions in Biological Dictionary

Transcriptome

...DNA Sequencing Services, De Novo Assembly, Mapping of Genomic DNA, PCR, & MicroRNA. ... Maher et al. Transcriptome sequencing to detect gene fusions ... Fully Supported Transcriptome Analysis Applications ... Transcriptome Discovery: Find uncharacterized transcripts, update genome ... ...

Brachial

...outcomes. ... Evaluating Brachial Plexus. Resources/Links of Interest ... INTRODUCTION AND BACKGROUND The brachial plexus is a network of nerve fusions ... Burners (stingers): Acute brachial plexus injury in the athlete ... ... nerves is called the brachial plexus. ... Brachial palsy is a l...
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