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Combined HRT increases risk of lobular breast cancer fourfold after just 3 years of use

SEATTLE Postmenopausal women who take combined estrogen/progestin hormone-replacement therapy for three years or more face a fourfold increased risk of developing various forms of lobular breast cancer, according to new findings by researchers at Fred Hutchinson Cancer Research Center. Previous ...

Phase III Trial of VELCADE(R) (Bortezomib) for Injection Showed Dramatic Fourfold Increase in Complete Remission Rates When Combined With the Most Commonly Used U.S. Regimen in Front-Line Multiple Myeloma

- VELCADE, thalidomide and dexamethasone improved pre - and post-stem cell transplantation results compared to thalidomide and dexamethasone - ATLANTA, Dec. 9 /PRNewswire-FirstCall/ -- Millennium Pharmaceuticals, Inc. (Nasdaq: MLNM ) reported the presenta...

Cough and Phlegm Cause Fourfold Increase in COPD Incidence

Young adults (ages 20 to 44) with normal lung function who later develop chronic cough and phlegm// have a fourfold higher risk of developing chronic obstructive pulmonary disease (COPD). The results of this 10-year respiratory study appear in the first issue for January 2007 of the American J...

A fourfold rise in gestational diabetes

A recent research revealed that the number of women suffering from gestational diabetes has risen four times over a period of 5 years.// Hence, overweight women are being advised to reduce weight before they conceive. Diabetes Australia-NSW has given shocking statistics. According to it, more th...

Prioritize Pregnant Women to Get Swine Flu Shot, Experts Say

...omplications from the new flu strain. "Pregnant women who have been infected with H1N1 influenza have had a higher rate of hospitalization, about a fourfold increase compared with the general population and a higher proportion than expected of the deaths were among pregnant women," noted study author Dr. D...

Many Veterans Need Mental Health Care

... more than twice the risk for drug use problems, the researchers found. Since the start of the Iraq war, mental health problems increased more than fourfold among active-duty personnel and sevenfold for members of the National Guard or Reserve, Seal said. Age also played a role in the risk for PTSD, Sea...

Lack of Good Sleep Might Be Deadly

... more than a decade, after initially being examined in a sleep laboratory. Men with insomnia who slept five or fewer hours a night had a more than fourfold higher risk of dying during the study period; men with insomnia who slept five to six hours a night had a fivefold increased risk, compared with those...

Sedatives Increase Suicide Risk Among Elderly

...he presence of mental disorders," wrote Anders Carlsten, of Gothenburg University. "Having a current prescription for a hypnotic was associated with a fourfold increase in suicide risk in the adjusted model." The drugs may increase suicide risk in the elderly by triggering aggressive or impulsive behavior,...

Heart Drug Combos Raise Risk of Gastrointestinal Bleeding

...e taking ACAP. The greatest risk came from TRIP, which correlated with a fourfold increased risk of an upper GI event, according to the study to be presented...her evaluate the risk-benefit ratio of these therapies given the twofold to fourfold increased UGIE risk, Abraham said. More information The National D...

Sensitivity to Alcohol May Predict Alcoholism

...alcoholism tends to be genetically influenced, Schuckit said, alcoholics should talk with their children. "You need to tell your kids they are at a fourfold increased risk for alcoholism," he said. "If your kid does drink, find out if they can 'drink others under the table,' and warn them that that is a ma...
fourfold in Medical Technology

In Blood Vessel Stents, Innovative Materials Allow Better Control, Delivery of Gene Therapy

...o a complex that tethers viral vectors to stent surfaces. One of the three components is an amplifier that increases the dose of gene vector more than fourfold over the previous formulation. In addition, by varying another component, the stent can be tuned to release vector at a controlled rate that can t...

Clinical Update - Debio 025 Cyclophilin Inhibitor for the Treatment of HCV

...eople are or have been infected with HCV and of these, 2.7 million have an ongoing chronic infection, the majority being between 40 to 60 years old. A fourfold increase in the number of adults diagnosed with chronic HCV infection is projected from 1990 to 2015, since most persons with chronic HCV infection ha...
fourfold in Biological News

Gutsy germs succumb to baby broccoli

...ion. In the new report, the team also shows that when H. pylori -infected mice sipped broccoli-sprout smoothies for eight weeks, there was up to a fourfold increase in the activity of two of these key enzymes that protect cells against oxidative damage. In addition, the number of Helicobacter bacteria in ...

Mayo Clinic research on tamoxifen leads to recommendation for CYP2D6 gene test

...rapy. This data confirms that women with an inherited deficiency in the CYP2D6 gene, which is important for the metabolism of tamoxifen, have a nearly fourfold higher risk of early breast cancer recurrence compared to women who have not inherited the deficiency. The research findings, announced jointly by inv...

Gene variation may elevate risk of liver tumor in patients with cirrhosis

...ide had a significantly higher risk of developing HCC than did A/A patients ranging from a more than twofold increase for those with one G to an over fourfold increase for those with two G alleles. In all three genotypes, tissue analysis showed that EGF levels were highest in the G/G patients, as was activat...

New technique boosts size of proteins that can be analyzed

...ize how those proteins are modified in cells by biological processes. But now, Cornell researchers have extended a powerful technique to increase by fourfold the size of a protein that can be analyzed, to those containing more than 2,000 amino acids, up from about 500. Called a "top-down" approach, the ...

Cancer stem cells linked to radiation resistance

...l tissue and then administered set doses of ionizing radiation to the cell cultures and to the mice. In both cases, the researchers observed a roughly fourfold jump in the number of glioma stem cells present in the tumor tissue following radiation treatment. Because ionizing radiation works primarily by ...

Overfishing in inland waters reduces biodiversity and threatens health

...nsumption of animal protein. About 1 billion people rely on fish as their primary protein source. Landings from inland waters have increased more than fourfold since 1950, mainly in developing nations, though in developed countries, in contrast, catches have decreased. But catch statistics are difficult to in...

Research Gives Hope For Liver Damage

...et to be understood and in turn, to become treatable. More women in the UK now die of liver failure than do of cancer of the cervix. "There has been a fourfold increase in the number of men aged 45-54 dying of cirrhosis since 1970 and a threefold increase in women of the same age group. Liver failure is also ...
fourfold in Biological Technology

Millennium Over-Delivers on 2007 Goals and Financial Guidance

...ive group -- The combination of VELCADE, thalidomide, and dexamethasone (VcTD), as induction therapy prior to SCT, showed a dramatic fourfold increase in complete remission rate when compared to thalidomide and dexamethasone (TD), the most commonly used induction regimen ...

Oak Ridge leads DOE INCITE effort in 2008

...a year. When the current project is complete, Jaguars 31,000 processing cores will be capable of 275 trillion calculations a second, or 275 teraflopsa fourfold increase over a year ago. Jaguars increased processing power is reflected in the size of the allocations being made available to individual project...

Investor links East Coast funds to Midwest tech

...companies is "definitely on the right track." He estimated that the amount of private equity and venture capital investment in Wisconsin has increased fourfold since the passing of Act 255 , and he praised efforts of the Wisconsin Technology Council to push such initiatives. "Act 255 provides an excelle...

Gq-coupled Receptor Assays Using FLEXstation

...ssay Kit and the FLEXstation was 47 mM (Figs. 3, 4). The values varied by less than twofold for experiments performed on the same day and by less than fourfold for experiments performed on different days. The range of values from all experiments was between 24 and 87 mM. The coefficient of variation of replic...

Total RNA Purification from Cultured Cells Using the ABI PRISM 6700 Automated Nucleic Acid Workstation and Total RNA Lysis Reagents

... lysis reagents and purification technology readily removes them. For very sensitive assessment of PCR performance, measure C T values on fourfold serial dilutions of an individual sample. To measure inhibition, plot a standard curve of the three most dilute samples and extrapolate to compare mea...

Challenge the Performance of Your Hot-Start PCRs with FastStart Taq DNA Polymerase and the Novel FastStart High Fidelity PCR System

...ty of DNA and cDNA targets up to 5 kb with high specificity, high sensitivity and yield, and approximately fourfold higher fidelity compared to Taq DNA Polymerase and FastStart Taq DNA Polymerase. Therefore, the FastStart High Fidelity Enz...
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