fibrosis

Scientists discover basic defect in cystic fibrosis airway glands

Scientists at Stanford University have determined that the buildup of sticky mucus found in cystic fibrosis is caused by a loss in the epithelial cell's ability to secrete fluid. This research appears as the "Paper of the Week" in the March 17 issue of the Journal of Biological Chemistry, an American Society for Biochemistry and Molecular Biology journal. Cystic fibrosis is the most commo...

Study reveals how cells destroy faulty proteins in cystic fibrosis

The cellular system that degrades faulty proteins created by the cystic fibrosis gene has been identified by University of North Carolina at Chapel Hill scientists. Turning off the degradation system allows some proteins to regain their proper shape, offering a new avenue for treatments aimed at curing the disease. Cystic fibrosis (CF) is a fatal disease caused by a defective gene that...

Discovery could aid fight against cystic fibrosis infection

Harvard Medical School researchers have discovered one way that a hardy disease-causing bacteria could be surviving in the lungs of chronically infected cystic fibrosis (CF) patients. "This work is important because pathogenic bacteria such as Pseudomonas aeruginosa (PA) use protein secretion systems to cause disease in their hosts," said Joseph Mougous, lead author of the study publishe...

Clues to gene expression in cystic fibrosis will guide research

Genetics tests could help provide cystic fibrosis (CF) patients with targeted treatment in future, pilot study authors suggest. Results from a French clinical trial published today in BMC Medicine show how a small percentage of CF sufferers with a rare genetic stop mutation responded positively to gentamicin treatment. Aleksander Edelman and Isabelle Sermet-Gaudelus of Faculté de Médicine...

Key found to kill cystic fibrosis superbug

Researchers from the Schulich School of Medicine & Dentistry at The University of Western Ontario , working with a group from Edinburgh, have discovered a way to kill the cystic fibrosis superbug, Burkholderia cenocepacia. These investigators, under the leadership of Dr. Miguel Valvano, Department of Microbiology and Immunology, have had their research published in the May issue of the Journa...

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Third Wave seeks approval of Cystic Fibrosis test

The test product, which Third Wave calls InPlex, is a genotyping test to determine Cystic Fibrosi...

EraGen cystic fibrosis test to be distributed worldwide through Bayer

The new assay can be automated for mutation carrier screening and neonatal and newborn testing. The agreement also allows Bayer He...

Third Wave strikes deal with Kaiser Permanente on cystic fibrosis reagents

MADISON - , the largest non-profit health plan in the United States,...

fibrosis at Medicine News

Gene Therapy For Cystic Fibrosis

Cystic fibrosis is an inherited disease in which the body's mucus becomes so thick and sticky that it prevents normal functioning. Treatment with new antibiotics now allows many children to reach adulthood, but there is no cure.// New research is moving us slightly closer to a treatment for cystic fibrosis that modifies the abnormal gene that causes the disease. Working with mice, sci...

Surprising Cystic Fibrosis Finding That Could Be A Helpful Treatment Option

Cystic fibrosis is a genetic disease where the patient has frequent respiratory infections, breathing difficulties and eventually permanent lung damage. // It’s believed that patients with CF have too much mucus in their airways. But new research shows patients actually have too little mucus. Researchers say that may studies have been done in the past , but it has never proven, that CF...

The Use Of Colistin To Treat Cystic Fibrosis Questioned

Pseudomonas aeruginosa is a potentially life-threatening infection for patients with cystic fibrosis. To treat the infection, doctors often prescribe an inhaled drug called colistin (Coly-Mycin S Otic).// However, use of this drug is controversial because some patients experience chest tightness and spasms of the bronchi, which causes severe coughing and reduced lung function. However a...

Approval for DNA test to detect cystic fibrosis

Food and Drug Administration (FDA) of US had approved the first test that// uses DNA in blood to diagnose cystic fibrosis. The test is called Tag-It Cystic Fibrosis Kit and it can analyze DNA samples from the blood and detect genes that carry the strains of the disease, both in children and in adults. The test can not only predict the advent of the disease in people, but it can also id...

Cystic fibrosis patients may require a new treatment for bacterial infection

Patients suffering from cystic fibrosis often gets bacterial infections from the bacteria Pseudomonas.// Treatment for bacterial infections is often by administering antibiotics. Research suggests that antibiotic treatment may encourage the bacteria to affect the patient in a permanent infection. Cystic fibrosis is disease of genetic origin that causes the body to produce thick mucus...

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fibrosis at Medicine Products

Tag-It Cystic Fibrosis PCR Mix

Description:The Tag-It™ Cystic Fibrosis ASR reagents can be used by high complexity CLIA approved laboratories for detection of up to 70 mutations and 6 variants (polymorphisms) in the cystic fibrosis transmembrane conductance regulator (CFTR) gene....
Company:Tm Bioscience Corporation

Tag-It Cystic Fibrosis PCR Mix B

Description:The Tag-It™ Cystic Fibrosis ASR reagents can be used by high complexity CLIA approved laboratories for detection of up to 70 mutations and 6 variants (polymorphisms) in the cystic fibrosis transmembrane conductance regulator (CFTR) gene....
Company:Tm Bioscience Corporation

Tag-It Cystic Fibrosis ASPE Mix B

Description:The Tag-It™ Cystic Fibrosis ASR reagents can be used by high complexity CLIA approved laboratories for detection of up to 70 mutations and 6 variants (polymorphisms) in the cystic fibrosis transmembrane conductance regulator (CFTR) gene....
Company:Tm Bioscience Corporation

Tag-It Cystic Fibrosis ASPE Mix

Description:The Tag-It™ Cystic Fibrosis ASR reagents can be used by high complexity CLIA approved laboratories for detection of up to 70 mutations and 6 variants (polymorphisms) in the cystic fibrosis transmembrane conductance regulator (CFTR) gene....
Company:Tm Bioscience Corporation

Tag-It™ Cystic Fibrosis Kit

Description:Tm Bioscience introduces the Tag-It™ Cystic Fibrosis Kit, the first FDA cleared IVD for cystic fibrosis genotyping. With validated performance criteria, this highly accurate and reproducible (>99.9%) assay will provide superior mutation coverage for carrier screening in adults and as an aid to diagnosis in newborns. The Tag-It™ Cystic Fibrosis Kit simultaneously screens for the 23...
Company:Tm Bioscience Corporation

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fibrosis at Medicine Technology

Ceragenix Compound Shows Promise for Treating Lethal Cystic Fibrosis Infections

DENVER--(BUSINESS WIRE)--Jul 2, 2007 - Ceragenix Pharmaceuticals,Inc. (OTCBB:CGXP), a biopharmaceutical company focused oninfectious disease and dermatology, today announced thatresearchers at the University of Pennsylvania led by Dr. PaulJanmey and Dr. Robert Bucki, in collaboration with Dr. Paul B.Savage of Brigham Young University, have demonstrated in a seriesof in vitro experiments tha...

PARI Pharma Presents Study Results of Sinus Delivery and Inhaled Liposomal Ciclosporin A at European Cystic Fibrosis Conference

MUNICH, Germany, June 14, 2007 /PRNewswire/ -- PARI Pharma willpresent in-vivo study results for their PARI SINUS pulsating drugdelivery system as well as lung deposition and pharmacokinetic dataof their proprietary inhaled liposomal Ciclosporin A formulation inlung transplant patients at the European Cystic Fibrosis Conference(ECFC) in Belek, Turkey this week. Continuing their tra...

Gilead Announces Achievement of Primary Efficacy Endpoint in Second Phase III Study of Aztreonam Lysine for Inhalation in Patients With Cystic Fibrosis

FOSTER CITY, Calif.--(BUSINESS WIRE)--May 29, 2007 - GileadSciences, Inc. (Nasdaq:GILD) today announced that its Phase IIIAIR-CF1 (CP-AI-007) study of aztreonam lysine for inhalation forthe treatment of people with cystic fibrosis (CF) who havepulmonary Pseudomonas aeruginosa (P. aeruginosa) met its primaryefficacy endpoint of change at Day 28 from baseline in respiratorysymptoms, as assess...

Gilead Announces Presentation of Positive Phase III Data on Aztreonam Lysine for Inhalation in Patients With Cystic Fibrosis

SEATTLE--(BUSINESS WIRE)--Apr 19, 2007 - Gilead Sciences, Inc.(Nasdaq:GILD) today announced detailed results of its Phase IIIAIR-CF2 study evaluating aztreonam lysine for inhalation, anantibiotic, in patients with cystic fibrosis (CF) who havepulmonary Pseudomonas aeruginosa (P. aeruginosa). In the study, a28-day treatment course of aztreonam lysine significantly improvedthe time to need fo...

AOP Orphan Pharmaceuticals and Lantibio Announce Positive Phase II Study with Novel Cystic Fibrosis Therapy

VIENNA, Austria and CHAPEL HILL, N.C., US, March 06, 2007/PRNewswire/ -- AOP Orphan Pharmaceuticals AG ("AOP Orphan") andLantibio, Inc. ("Lantibio") today announced positive final resultsfrom their placebo controlled, double-blinded Phase II clinicalstudy of Moli1901, an experimental compound to treat cysticfibrosis ("CF"). Moli1901 is being developed by AOP Orphan inEurope under a licen...

fibrosis at Medicine Dictionary

Pulmonary Fibrosis

blood</ a...

Cystic fibrosis

), affecting children and young people; median survival is 25 years in females a...