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Scientists ID molecular 'switch' in liver that triggers harmful effects of saturated and trans fats

Dana-Farber Cancer Institute researchers have identified a molecular mechanism in the liver that explains, for the first time, how consuming foods rich in saturated fats and trans-fatty acids causes elevated blood levels of cholesterol and triglycerides and increases one's risk of heart disease and certain cancers. In the Jan. 28 issue of Cell, scientists led by Bruce Spiegelman, PhD, rep...

Lack of enzyme turns fat cells into fat burners

Lack of the enzyme, acetyl CoA carboxylase 2or ACC2, appears to turn the adipose or fat cells of mice into fatburners, explaining in part why the animals can eat more and weigh lessthan their normal counterparts, said Baylor College of Medicineresearchers.The report that appears online today in the Proceedings of the NationalAcademy of Sciences. "Westudied the fat cells in these mic...

Newly-discovered class of genes determines ?and restricts ?stem cell fate

Research on adult stem cells found in the skin hints at a new class of genes, according to a study from investigators at the University of Pennsylvania School of Medicine. These genes ?dubbed pangenes ?can both govern a stem cell's fate and put a hold on future differentiation until the time is right. Understanding the molecular control of these genes has implications for therapies that involve t...

Tiny scaffolding allows stem cells to become working fat cells

Researchers here have used a new microscopic, three-dimensional scaffolding to coax mouse stem cells to transform themselves into fat cells, and then to function identical to how fat cells naturally do in the body. While other studies have previously grown fat cells, or adipocytes, in the laboratory, those cells never completely functioned in the same way they do in normal tissue. They fai...

Opposing fat metabolism pathways triggered by a single gene

Regulating metabolism of fat is an important challenge for any animal, from nematodes to humans. Central players in the regulatory network are the nuclear hormone receptors (NHRs), which are transcription factors that turn on or off a set of target genes when bound by specific lipid molecules. In the premier open-access journal PLoS Biology, Keith Yamamoto and colleagues show that the nuclear hor...

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fat at Biology Products

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fat at Biology Technology

FREE FAT CELL ASSAY

The free fat cell assay has been used extensively to demonstrate the effect of insulin and insulin analogues on target tissue (1,2). The principle of the assay has been described by Rodbell(3) and Moody et al(4). The assay uses isolated adipocytes from either mice or rats...

QBT Fatty Acid Uptake Assay Kit datasheet

NO RADIOACTIVITY NO WASH STEPS EASY SINGLE-STEP ASSAY HTS READY FATTY ACID UPTAKE AND TRANSPORTERS Fatty acids are utilized for diverse cellularprocesses including mitochondria oxidation,membrane synthesis and energy...

A Robust LC/MS/MS Method for the Quantitation of Very Long Chain Fatty Acids for Research into the Characterization of Peroxisomal Disorders

The peroxisome is a cellular organelle that plays an important role in a number of functions, including the beta-oxidation of very long chain fatty acids (VLCFA). Peroxisomal disorders are characterized by impaired, reduced or total absence of peroxisomes in cells, which can result in the accumulation of VLCFAs, such as tetracosanoic and hexaco...

Unique Surface Treatment of Novel TSK-GEL ODS Columns Provide Separation of Aqueous and Fat Soluble Vitamins

With the introduction of two new reversed-phase column types, TSKgel ODS-100V and TSKgel ODS-100Z, excellent chromatographic performance and selectivity can be achieved for a wide range of sample types. TSKgel ODS-100Z and TSKgel ODS-100V are based on a spherical, five micron, silic...

Father of life patents downplays historic role

Chakrabarty, the first person to successfully patent life forms, visited Wisconsin this we...

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fat at Medicine News

Steroid Treatment after head injury may be fatal

According to a report from Lancet, Patients with head injury who were treated with methylprednisolone had a significantly increased risk of death within //the following 2 weeks compared with untreated group of patients. "Our early results show that corticosteroids should not be used routinely to treat head injury, whatever the severity," Dr. Ian Roberts. He is clinical coordinator of...

A Sedentary Childhood Could Lead To Chronic Fatigue Latter In Life

Chronic fatigue syndrome is an often disabling condition that affects primarily women. The condition is characterized by deep-seated fatigue // that cannot be overcome with rest and often worsens with physical activity. The cause of the condition is unknown, and there are no diagnostic tests or cures. A recent study explains that children who have sedentary behaviors are at increased risk...

Canadians Grow Fatter By The Day

Canadians are becoming increasingly obese, according to a new study. The number of people in the country who are morbidly obese has risen to 1.3% in 2003, from the 1990 figure of 0.3%, according to researchers belonging to Queen's University. //The body mass index (BMI) is made use of by Health Canada for measuring obesity, and if the BMI is above 25, a person is declared overweight, and...

Role of fats and oils in vision care

The balance of fats and oils in your diet can affect your vision, according to a new study. Age-related macular degeneration (AMD) is a currently untreatable disease of the eye causing fuzziness, shadows and severe visual impairment. As the name suggests, it gets worse with age and diet has been implicated in its development. // Researchers at the Massachusetts Eye and Ear Infirmary c...

Omega-3 fatty acids impair immunity

Taking large amounts of omega-3 fatty acids may be unwise for those with weakened immunity.Researchers at the University of Missouri, Columbia, have been studying omega-3s for many years now and know that one of their effects is to damp down inflammation. That's why fish oils - rich in omega-3s - often benefit those with arthritis, a painful inflammatory condition of the joints. Yet the i...

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fat at Medicine Products

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fat at Medicine Technology

Fat Kills Cancer: Turning Stem Cells from Fat Tissue into Personalized, Cancer-Targeted Therapeutics

PHILADELPHIA, July 3, 2007 ? Researchers in Slovakia havebeen able to derive mesenchymal stem cells from human adipose, orfat, tissue and engineer them into “suicide genes” that seek out and destroy tumors like tiny homing missiles. This gene therapy approach is a novel way to attack smalltumor metastases that evade current detection techniques andtreatments, the researchers...

Bio-Matrix Scientific's Dr. O'Neill Sees University of Pittsburgh's Published Study on Culture Blood-Forming Stem Cells from Human Fat Tissue as Supporting Near Term Benefits of Banking Adipose (Fat) Derived Stem Cells

SAN DIEGO--(BUSINESS WIRE)--Jun 27, 2007 - The University ofPittsburgh School of Health Sciences issued the following study andpress release, "Scientists Culture Blood-Forming Stem Cells fromHuman Fat Tissue," June 15, 2007, Science Daily: "Researchers atthe University of Pittsburgh School of Medicine have successfullyisolated and cultured human hematopoietic stem cells from fat, oradipose...

Orexigen Therapeutics to Present Data on Contrave Impact on Visceral Fat and Insulin Resistance at American Diabetes Association 67th Scientific Sessions in Chicago June 23

SAN DIEGO, June 21, 2007 /PRNewswire-FirstCall/ -- Orexigen(TM)Therapeutics, Inc. , a biopharmaceutical company focused on thetreatment of central nervous system disorders with an initial focuson obesity, today announced that the Company will present dataabout its lead obesity product candidate Contrave(TM) and itseffect on markers of cardiovascular disease (visceral fat, serumcholestero...

GlaxoSmithKline and Genmab Present Positive Phase II Results With ofatumumab in Patients With Rheumatoid Arthritis (RA)

New Data to be Presented at the European League Against Rheumatism(EULAR) Congress Demonstrates the Potential Benefit of ofatumumabin Patients With Rheumatoid Arthritis LONDON, England; PHILADELPHIA, Pennsylvania and COPENHAGEN,Denmark, June 15, 2007 /PRNewswire-FirstCall/ -- GlaxoSmithKline(GSK) and Genmab A/S (CSE: GEN) announced today positive primaryefficacy data (evaluated at 24 Week...

Once-Fatal Metabolic Disorders Treatable, Says Stanford/Packard Researcher

STANFORD, Calif.--(BUSINESS WIRE)--May 30, 2007 - People with aclass of rare genetic disorders that often lead to brain damage,coma and death can be successfully treated with drugs, says aresearcher at the Stanford University School of Medicine and LucilePackard Children's Hospital. The researchers found in their unprecedented 25-year study thatprompt diagnosis coupled with a rapid start...

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Breaking Medicine News(10 mins):Health News:Hoana Medical Acquires CE Mark to Expand Patient Safety Technology to European Market 2Health News:Hoana Medical Acquires CE Mark to Expand Patient Safety Technology to European Market 3Health News:Hoana Medical Acquires CE Mark to Expand Patient Safety Technology to European Market 4Health News:Coastal Center for Obesity Offers Hispanics Weight Loss Surgery with a Warranty 2Health News:Older Caregivers Prone to Worse Sleep Patterns 2Health News:Lenaye Lawyer, MD, FACOG, Named KePRO Medical Director 2
(Date:8/27/2008)...ALLAS Aug. 28, 2008 Researchers at UT Southweste... brain must create new nerve cells for either exer...behavior. , In addition, the researchers found t...hemical pathway to exert their effects. , These ... of antidepressants and provide a new direction fo...
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Breaking Biology News(10 mins):Antidepressants need new nerve cells to be effective, UT Southwestern researchers find 2Southern Sierra Science Symposium planned for Visalia 2Southern Sierra Science Symposium planned for Visalia 3Southern Sierra Science Symposium planned for Visalia 4Southern Sierra Science Symposium planned for Visalia 5Southern Sierra Science Symposium planned for Visalia 6Southern Sierra Science Symposium planned for Visalia 7Southern Sierra Science Symposium planned for Visalia 8Indiana U researchers launch social networking and research management tool for scientists 2EMBO recognizes German zoologist for public communication 2Great Comebacks 28R 29 Program Announces 2007 National Award Winner 12966 1Great Comebacks 28R 29 Program Announces 2007 National Award Winner 12966 2Great Comebacks 28R 29 Program Announces 2007 National Award Winner 12966 3Great Comebacks 28R 29 Program Announces 2007 National Award Winner 12966 4Great Comebacks 28R 29 Program Announces 2007 National Award Winner 12966 5Data show a decline in cystic fibrosis since introduction of prenatal carrier screening 3575 1Data show a decline in cystic fibrosis since introduction of prenatal carrier screening 3575 2Leicester scientist announces unexpected and exciting advance in study of cancer type 12961 1Leicester scientist announces unexpected and exciting advance in study of cancer type 12961 2Michael J Simms Joins Alexza Pharmaceuticals as Senior Vice President Operations and Manufacturing 3573 1Michael J Simms Joins Alexza Pharmaceuticals as Senior Vice President Operations and Manufacturing 3573 2Michael J Simms Joins Alexza Pharmaceuticals as Senior Vice President Operations and Manufacturing 3573 3
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