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Expressing in Medical News

Scientists learn why even treated genital herpes sores boost the risk of HIV infection

... these CD4+ T cells carried CCR5 or CXCR4, the cell-surface proteins that HIV uses (in addition to CD4) to enter cells. The percentage of CD4+ T cells expressing CCR5 during acute HSV-2 infection and after healing of genital sores was twice as high in biopsies from the sites of these sores as from unaffected co...

National Coalition of Front-Line Skilled Nursing Clinicians: Bipartisan Momentum to Stop CMS Medicare Regulation, Subsequent Funding Cuts, Grows in Congress

...n, not isolation. . ." These communications add to the growing collection of bipartisan letters issued by the following legislators, with each expressing concern about the negative impact of the CMS rule on the provision of quality long term care and asking the Administration to hold issuance of the fin...

Human Rights Campaign Announces Speakers at 25th Annual Bay Area Gala

...f the person's actual or perceived race, color, religion, national origin, gender, sexual orientation, gender identity or disability. While expressing opposition to four amendments added to the Act this week by the Senate , HRC continues to work with House and Senate champions to work out these amend...

Expressing Growing Concern, THCA Urges Texas Congressional Delegation to Protect Seniors' Medicare-Funded Nursing Home Care as Health Reform Debate Proceeds

...Troubled Texas Medicaid Program; Seniors' Care at Risk, Local Jobs Base Threatened AUSTIN, Texas, July 23 /PRNewswire-USNewswire/ -- expressing growing concern that the cumulative size of funding cuts to Medicare-financed nursing home care as part of ongoing health reform negotiations could ha...

Human cells secrete cancer-killing protein, UK study finds

...ngnekar, UK professor of radiation medicine, have determined that the tumor-suppressor protein Par-4, initially thought to be active only within cells expressing the Par-4 gene, is in fact secreted by most human and rodent cells and can target large numbers of cancer cells by binding to receptors on the cell su...

Leukemia cells evade immune system by mimicking normal cells, Stanford studies show

...lace, according to Weissman, when another group showed that red blood cells expressing CD47 were bypassed by macrophages, but those without CD47 were eaten. "Our ...ors lived for a median of 22.1 months. In further study of the high-CD47 expressing cancer stem cells in a culture dish, researchers added an antibody that blo...
Expressing in Medical Technology

Vectibix(R) in Combination With Chemotherapy Significantly Improved Progression-Free Survival in First-Line Metastatic Colorectal Cancer

...(FDA) for the treatment of mCRC. Vectibix was approved in the United States in September 2006 as a monotherapy for the treatment of patients with EGFR expressing mCRC after disease progression on or following fluoropyrimidine-, oxaliplatin-, and irinotecan-containing chemotherapy regimens. The effective...

Cephalon Provides Clinical Update on Lestaurtinib in Relapsed Acute Myelogenous Leukemia

...q: CEPH ) today announced results from a pivotal clinical trial of lestaurtinib (CEP-701) in patients with relapsed acute myelogenous leukemia (AML) expressing FLT3 activating mutations. The study was designed to show the benefit of lestaurtinib in this patient population when given in sequence with standard...

Dendreon Initiates Phase 1 Clinical Trial of Small Molecule Targeting TRPM8 in Cancer

...ark Frohlich, M.D., senior vice president of clinical affairs and chief medical officer of Dendreon. "The ability of D3263 to inhibit growth of TRPM8 expressing tumors in preclinical studies coupled with its oral bioavailability make it an appealing product candidate to advance into human clinical trials." ...

Karmanos Cancer Institute Researchers Present Breast Cancer Advancements at Conference

...t typically used to treat cutaneous T-cell lymphoma was administered before a novel experimental antitumor agent -- which works best in breast cancers expressing the estrogen receptor (ER) -- estrogen receptors were reinstated in receptor-negative breast cancer cells so that treatment was also effective in figh...

Osprey Pharmaceuticals U.S.A., Inc. Initiates Phase Ib Clinical Trial in IgA Nephropathy

...s Leukocyte Population Modulators (LPMs), for the treatment of inflammatory and autoimmune diseases. CCL2-LPM selectively targets activated leukocytes expressing the chemokine receptor CCR2 that are responsible for initiating and maintaining a variety of inflammatory conditions. The Phase Ib open-label, do...

YM BIOSCIENCES ANNOUNCES NIMOTUZUMAB PRESENTATIONS TO BE MADE AT THE 100TH ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH AND EUROPEAN SOCIETY FOR MEDICAL ONCOLOGY

... AACR abstract builds on a presentation by YM at the AACR Translational Medicine conference held in June 2008, which demonstrated that, in tumor cells expressing moderate-to-high levels of the EGF receptor, nimotuzumab has binding equivalent to the currently marketed EGFR-targeting antibodies. The AACR 2009 pre...
Expressing in Medical Products

QuantiGene 2.0 RNA Quantification System

Features:... Quantitate RNA directly from crude cell lysates to eliminate amplification bias Branched DNA technology enhances assay sensitivity to detect low expressing genes Validate RNAi assays by accurate amplification of target sequences ...
Company:Sigma-Aldrich
Expressing in Medical Dictionary

Sex-linked recessive

...dividual. This mode of inheritance is in contrast to the inheritance of traits on autosomal chromosomes, where both sexes have the same probability of expressing the... Sex - linked recessive . Contents of this page: Illustrations. Alternative ... The term " sex - linked recessive " usually refers to X...

Sex-linked dominant

...dividual. This mode of inheritance is in contrast to the inheritance of traits on autosomal chromosomes, where both sexes have the same probability of expressing the... ... Encyclopedia > Sex - linked dominant . Printable Version ... Sex - linked dominant is a rare way that a trait or disorder can...

Resistance

..... Methods for overcom... resistance . ... ... the Resistance is Ciel. ... He joins the Resistance's cause for he sees the persecution of ... expressing gratitude to Zero for his work for the Resistance . ... IGN is the ultimate Resistance 2 resource for trailers, screenshots, cheats, walkthroug...

Breast milk

...breast and into your baby's mouth. ... Booklet for mothers, nurses, helpers, coucillors, doctors, Llactation Consultants ... The principle behind expressing breast milk is to aim to copy as closely as ... Making the right choice for your baby! ... BREAST MILK OR FORMULA. MAKING THE RIGHT CHOI...
Expressing in Biological News

Reprogramming human cells without inserting genes

...ll genes, including OCT4 and SOX2, into human skin cells. Those genes began expressing proteins that changed the skin cells back to a more pluripotent state. This...m cells.) Furthermore, once the stem cell genes were activated and began expressing proteins, the team found those proteins migrated back into the nucleus of t...

Hormone clue to root growth

...e meristem were made to express a mutant version of the growth-repressing protein GAI not degraded by gibberellin showed disrupted cell proliferation. expressing this mutant form, gai, in only one tissue, the endodermis (the innermost layer of the root cortex of a plant), was sufficient to stop the meristem enl...

Fatty foods -- not empty stomach -- fire up hunger hormone

...ilablegiving the green light to other calorie-consuming processes such as growing. Tschp and his team used mouse models to test the effects of over expressing the GOAT enzyme, or "knocking it out." They found that, when exposed to a lipid-rich diet, mice without GOAT accumulated less fat than normal mice, wh...

UCSF discovers new glucose-regulating protein linked with diabetes

...ording to a commentary on the paper that appears in the same journal. Brodsky said the Harvard team on this research produced the mouse capable of expressing CHC22 in its muscles and fat, which was analyzed in the study. These mice have features of diabetes, because the protein disrupts their GLUT4 transpor...

MIT reels in RNA surprise with microbial ocean catch

...) and biological engineering. "We had developed this methodology to look at protein-encoding genes, because if we know which proteins the microbes are expressing under what conditions, we can learn about the environmental conditions and how these microbes influence those. The unexpected presence and abundance o...

Study reveals conflict between doctors, midwives over homebirth

...en more importantly to Cheyney, discussions with doctors and midwives uncovered a deep gulf between the two groups of birthing providers, with doctors expressing the firm belief that only hospital births are safe, while midwives felt marginalized, mocked and put on the defensive when in contact with physicians....
Expressing in Biological Technology

ChanTest Launches New Business to Provide Validated Ion Channel Expressing Cell Lines to the Research Community

Company expands beyond core business of discovery and safety services to meet the evolving needs of the drug discovery and development community BOSTON and CLEVELAND, Aug. 6 /PRNewswire/ -- ChanTest, the world-leading provider of validated ion channel-expressing cell lines and services for d...

Use of Novel FlashPlate Technology to Measure cAMP Accumulation in Chinese Hamster Ovary Cells Expressing Human -2 Adrenoreceptors

J. Watson SmithKline Beecham Pharmaceuticals, UK Introduction Due to recent technologies in the pharmaceutical industry that have resulted in an increase in the production of potential drug candidates, it has become vital that screening assays are high th...

Use of FlashPlate Technology for In Vitro Measurement of [35S]-GTPγS Binding in CHO Cells Expressing the Human 5-HT1B Receptor

J. Watson and J.V. Selkirk SmithKline Beecham Pharmaceuticals, UK Abstract FlashPlate is a 96-well white polystyrene microplate with scintillant-coated wells designed for highvolume, in-plate radiobinding assays. This study investigates the use...

Cell lines expressing recombinant aequorin and a G-protein coupled receptor for functional screening

INTRODUCTION Many G-protein coupled receptors (GPCRs) trigger, upon binding of an agonist, a transient increase in intracellular calcium concentration. This variation acts as an internal secondary messenger and is an important modulator of many physiological mechanisms (revie...

Stable HeLa Luciferase Reporter Cell Lines Expressing GAL4 Fusion Transactivators

Stable reporter cell lines for signal transduction pathway readout Lisa Hexdall Li Xu Alan Greener Mary Buchanan John Bauer Chao-Feng Zheng Stratagene Stratagene now offers the PathDetect HLR-CREB, HLR-Elk1, and HLR-cJun, cell lines F ...

Ceregene Receives Additional Grant From Michael J. Fox Foundation to Expand Long-Term Testing of CERE-120 Patients

...for the treatment of neurodegenerative and retinal disorders using gene delivery. Ceregene's clinical programs include CERE-110, an AAV2 based vector expressing nerve growth factor that is currently in a multi-center, controlled Phase 2 study for the treatment of Alzheimer's disease, and CERE-120 (AAV2-Neurtur...
Expressing in Biological Products

High Five Cells SFM Adapted from Invitrogen

Description:... High Five cells (BTI-TN-5B1-4) derived from Trichoplusia ni egg cell homogenates have been shown to be capable of expressing significantly higher levels of secreted recombinant proteins compared to other insect cells. High Five cells offer the following features:- -Rapid dou...
Company:Invitrogen

pORF-PLAP from InvivoGen

Description:... Plasmid expressing PLAP reporter gene....
Company:InvivoGen

pORF-LacZ from InvivoGen

Description:... Plasmid expressing the LacZ reporter gene....
Company:InvivoGen

pORF39-Sh ble from InvivoGen

Description:... Plasmid expressing Zeocin resistance gene....
Company:InvivoGen

MDR1 Shift Assay from CHEMICON

Description:...ighly sensitive and specific detection of MDR1 expression. In addition, the kit is valuable for the study of structure-function relationships in cells expressing mutant MDR1 molecules. • The kit includes the UIC2 antibody, a conformation-sensitive mouse monoclonal against human MDR1, and an isotype-mat...
Company:CHEMICON

Rat Anti-Mouse NKG2A / C/ E Monoclonal Antibody, Unconjugated, Clone 20d5 from Abcam

Description:...Rat monoclonal [20d5] to NKG2A + C+ E ( Abpromise for all tested applications). Antigen: Tissue / cell preparation (Mouse): CHO transfected cells expressing the B6 allele of NKG2A. Entrez Gene ID: 3821 Swiss Protein ID: P26715...
Company:Abcam
Expressing in Biological Definition

Gamete

...ne copy of the chromosome set from the sperm and one copy of the chromosome set from the egg—that is, the cells of the offspring will have genes expressing characteristics of both the "father" and the "mother". A gamete's chromosomes are not exact duplicates of either of the sets of chromosomes carried in...

Immune system

..." (under the broader of the two definitions above) designed to combat bacteriophages (viruses that infect bacteria). They do this by simultaneously expressing restriction enzymes that cut DNA at certain sequences, and enzymes that protect their own DNA from this enzyme by methylating the same sequence. ...

Olfaction

...) smell differently. Both have the same shape and chemical characteristics but have different vibrations. The axons from all the thousands of cells expressing the same odor receptor converge in the olfactory bulb . Mitral cells in the olfactory bulb send the information about the individual features to oth...

Polymerase chain reaction

...ircular DNA molecule) (Fig. 5). The DNA can then be transferred into an organism (the GMO) where the gene and its product can be studied more closely. expressing a cloned gene (when a gene is expressed the gene product (usually protein or RNA ) is produced by the GMO) can also be a way of mass-producing us...

Rudolf Steiner

...r World War I, Steiner was extremely active and well-known in Germany in part because in many places he gave lectures on social questions. A petition expressing his basic social ideas (signed by Herman Hesse, among others) was very widely circulated. His main book on social questions, Die Kernpunkte der Soz...
Expressing in Biological Dictionary

Vessel cell

...iogenesis and vessel morphogenesis ... The Hox gene abdominal-A specifies heart cell fate in the Drosophila dorsal vessel ... non-Tin expressing cell (those cells of the dorsal vessel lacking black nuclei) ... An apparatus including a single electrolytic/reaction cell , for extracti...

Sex-linked

...al. This mode of inheritance is in contrast to the inheritance of traits on autosomal chromosomes, where both sexes have the same probability of expressing the... Genes that are carried by either sex chromosome are said to be sex linked . ... Many of the non- sex determining X-linked genes are ...

Satellite RNA

... available for this category. ... Protective effect of a satellite RNA expressed in transgenic plants on disease ... Transgenic tomato plants expressing satellite RNA are tolerant to some strains ... The BaMV satellite RNA (satBaMV) contains a single open reading frame encoding a ... that ...

Reporter Gene

... gene of interest in cell culture, animals or plants. Certain genes are chosen as reporters because the characteristics they confer on organisms expressing them are easily identified and... The GUS reporter system is a reporter gene system, particularly useful in plant molecular biology. Severa...

Reciprocal cross

...tal sex on a given inheritance pattern . All parent organisms must be true breeding to properly carry out such an experiment. In one cross , a male expressing the trait of interest... Reciprocal (grammar), a relationship between grammatical agents. Reciprocal altruism, a form of ... Reciproca...

Probability

... Probability , or chance, is a way of expressing knowledge or belief that an event will occur or has occurred. In mathematics the concept has been given an exact meaning in probability theory, that...
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(Date:8/28/2014)... DURHAM, N.C. -- Scientists have identified the developmental on-off ... microbes that produce more than two-thirds of the world,s ... would be to see whether it is possible to ... efficient. , The study, appearing August 28 in ... a small molecule called cyclic-di-GMP and a larger protein ...
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Breaking Biology News(10 mins):Small molecule acts as on-off switch for nature's antibiotic factory 2Small molecule acts as on-off switch for nature's antibiotic factory 3Sensory-tested drug-delivery vehicle could limit spread of HIV, AIDS 2Sensory-tested drug-delivery vehicle could limit spread of HIV, AIDS 3Inter-dependent networks stress test 2
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