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exacerbations in Medical News

A Biologic Drug Superior to Spiriva in Reducing COPD-Related Exacerbations Would Earn a Higher Patient Share in Europe Than in the U.S.

Spiriva Will Remain the Gold Standard Treatment Through 2017, According to a New Report from Decision Resources. WALTHAM, Mass., Jan. 12 /PRNewswire/ -- Decision Resources, one of the world's leading research and advisory firms focusing on pharmaceutical and healthcare issues, finds that ...

FDA Approves Advair(R) 250/50 for Reduction of Exacerbations in Patients With COPD

Advair 250/50 Now the Only Treatment Approved to Both Reduce Exacerbations and Improve Lung Function RESEARCH TRIANGLE PARK, N.C., April 30 /PRNewswire-FirstCall/ -- The U.S. Food and Drug Administration today approved Advair Diskus(R) 250/50 (fluticasone propionate 250 mc...

Cigarette smoke may alter immune response in COPD exacerbations

Smoking cigarettes is not only the principle cause of chronic obstructive pulmonary disease (COPD), but it may change the body's immune responses to bacteria that commonly cause exacerbations of the disease, according to new research in a mouse model. "It is well established that smoking is th...

Combo Therapy Reduces Exacerbations in Severe COPD

For patients with severe chronic obstructive pulmonary disease (COPD), combining a long-acting bronchodilator with an inhaled corticosteroid reduced the number of exacerbations by 35 percent.// Peter Kardos, M.D., of the Respiratory Medicine Section of Maingau Hospital in Frankfurt am Main, Ge...

Monoclonal Antibody Reduces Exacerbations in Asthmatics

Patients with symptomatic moderate asthma who were treated with anti-tumor necrosis factor alpha, an anti-inflammatory monoclonal antibody, experienced significantly// fewer disease exacerbations than individuals taking a placebo. This research appears in the first issue for October 2006 of th...

Questcor and Child Neurology Foundation Announce Creation of Infantile Spasms Awareness Week

... USP). Acthar is an injectable drug that is approved for the treatment of certain disorders with an inflammatory component, including the treatment of exacerbations associated with multiple sclerosis (MS) and to induce a diuresis or a remission of proteinuria in the nephrotic syndrome without uremia of the idiopat...

New HIV Study Shows That Large Numbers of Women and People of Color Can Be Successfully Enrolled In U.S. HIV Clinical Studies

...EZISTA should be used with caution in patients with known sulfonamide allergy. Diabetes Mellitus / Hyperglycemia and Hemophilia: New-onset or exacerbations of preexisting diabetes mellitus, hyperglycemia, and increased bleeding in hemophiliacs have been reported in patients receiving protease inhibitors. ...

Nycomed Announces FDA Filing for Daxas(R) in COPD

...t on the underlying mechanism of COPD and related inflammatory diseases. It could significantly improve the way these conditions are managed, reducing exacerbations requiring medical intervention, including hospitalisation. If approved, Daxas, a once-a-day tablet, will be the first drug in its class. It will also ...

Summertime Sun Exposure Can 'Burn' Acne Sufferers in More Ways than One

...However, this exposure over time can actually make acne worse by increasing oil production, damaging follicular walls and clogging pores, resulting in exacerbations that may not surface for several weeks after sun exposure. On top of this misconception, acne patients may also be at risk for increased sun sens...

Recognizing signs and symptoms of acute HF

... Although heart failure is a chronic condition, acute exacerbations are frequent and occur with serious complications; patients with heart failure and their families can help improve prognosis in acute events if they a...
exacerbations in Medical Technology

invivodata Certified to Deliver EXACT in COPD Trials

...s completed a certification program to provide the exacerbations of Chronic pulmonary disease Tool (EXACT) on its D...ing the frequency, severity, and duration of acute exacerbations of chronic obstructive pulmonary disease (COPD) an...he industry's only standardized tool for measuring exacerbations of COPD. "Being a certified provider of this ...

Study Shows Potential Benefits of Xolair(R) in Treating Children Suffering from Moderate or Severe Persistent Allergic Asthma Inadequately Controlled With Inhaled Corticosteroids

...r suffered 43% fewer clinically significant asthma exacerbations than those receiving placebo. Xolair is a biolog...ts that showed Xolair significantly reduced asthma exacerbations in children whose symptoms cannot be controlled wi...has been shown to decrease the incidence of asthma exacerbations in these patients. Safety and efficacy have not be...

Mpex Pharmaceuticals Announces Initiation of a Phase 2 Clinical Trial of Aerosol MP-376 in COPD

...in this study is a comparison of the rate of acute exacerbations in patients treated with MP-376 versus placebo con...g damage, as well as predisposes patients to acute exacerbations that arise from a variety of causes. Bacterial infections are a leading cause of these exacerbations and antibiotics are widely used to treat...

Pivotal Data Showed SYMBICORT(R) Improved Lung Function in Adults with COPD

...GOLD) recommends the addition of inhaled corticosteroids (ICS) to long-acting beta2-agonists (LABA), in addition to other treatment options, to reduce exacerbations and improve lung function and health status.(9) COPD is a progressive disease, which means people with COPD can expect lung function to worsen over ti...

Long-Term Study Evaluates Boosted PREZISTA(R) Vs. Lopinavir/Ritonavir as Part of HIV Combination Therapy in Treatment-Naive Adults

...ISTA should be discontinued if severe rash develops. PREZISTA should be used with caution in patients with known sulfonamide allergy. New-onset or exacerbations of pre-existing diabetes mellitus, hyperglycemia, and increased bleeding in hemophiliacs have been reported in patients receiving protease inhibitors....

Mpex Pharmaceuticals Presents New Data on MP-376 in Cystic Fibrosis

...ed with this pathogen and chronic infection has been shown to lead to acute exacerbations and subsequent loss of lung function. Results from this clinical trial in...veloped clinically as a maintenance therapy for the prevention of bacterial exacerbations in patients with cystic fibrosis and COPD. The company has also built a dis...

Landmark COPD Trial UPLIFT(R) Shows SPIRIVA(R) HandiHaler(R) Sustained Lung Function Improvements Over Four Years

...roduced a significant delay in time to first exacerbation by a median of 4.1 months (p<0.001) versus control, a significant reduction in the number of exacerbations per patient year (14 percent; p<0.001). In addition, it significantly reduced the risk of exacerbations leading to hospitalizations (Hazard Ratio 0.86...

National Jewish Health and Roche Diagnostics Corporation Reach Agreement to Pursue Environmental Molecular Diagnostics Opportunities

...ts, dogs, cockroaches, dust mites and mold. It will target 40 million Americans with allergic rhinitis and 20 million with asthma, many of whom suffer exacerbations from indoor allergens. Roche is supplying technology and assays to evaluate the level of mold in an indoor environment, and National Jewish is develop...

Mpex Initiates a Phase 2 Clinical Trial of Aerosol MP-376 in the Treatment of Chronic Bacterial Infections in Cystic Fibrosis Patients

...n triggered by bacteria and their toxins. Periodic exacerbations in the lung result from bacterial overgrowth, and ...otics. Chronic pulmonary infections and associated exacerbations are implicated as a major cause of morbidity and m...aintenance therapy for the prevention of bacterial exacerbations in patients with cystic fibrosis and severe chroni...

Pharmaxis Concludes Special Protocol Assessment with FDA for Bronchitol Phase 3 Trial

...ily in approximately 350 adults with bronchiectasis. Participants will be treated for 52 weeks and the primary endpoints are reduction in frequency of exacerbations and improvement in quality of life. Secondary endpoints include time to first exacerbation and duration of exacerbation. Additional secondary endpoint...
exacerbations in Medical Dictionary

ACTH

.... ACTH Stimulation Test ... ACTH stimulates the adrenals on a daily basis ... Acthar is a Natural Source ACTH for the treatment of acute exacerbations of multiple sclerosis. ... is natural source adrenocorticotropic hormone ( ACTH ) ... Information about ACTH in the free online English dictio...
exacerbations in Biological News

Monoclonal antibody reduces exacerbations in asthmatics

Patients with symptomatic moderate asthma who were treated with anti-tumor necrosis factor alpha, an anti-inflammatory monoclonal antibody, experienced significantly fewer disease exacerbations than individuals taking a placebo. This research appears in the first issue for October 2006 of the Ame...

New test promises quicker, more accurate evaluation for cystic fibrosis patients

...mRNA, scientists can identify which genes are being expressed and how strongly. The researchers evaluated 18 CF patients who were suffering severe exacerbations of their disease. They withdrew blood before and after two weeks of intravenous antibiotic therapy. The severe exacerbation and antibiotic therapy ser...

COPD? Eat your veggies

...Dr. Barnes. "Future studies should target NRF2 as a novel strategy to increase antioxidant protection in the lungs and test its ability to decrease exacerbations and improve lung function in patients with COPD," concluded Dr. Biswal. John Heffner, MD, past president of the ATS, commented that "mounting evide...

Common cold virus leads to death in lung transplant patients

...e lung in the setting of spontaneous infection has been lacking. This report informs our understanding of the mechanisms underlying rhinovirus-induced exacerbations of asthma and COPD." They continued: "These exciting new data raise the possibility that patients with asthma and other patients with chronic air...
exacerbations in Biological Technology

Phase 3 Cystic Fibrosis Trial Results Presented at European Conference

...reated with the most commonly used CF therapeutic, rhDNase. Additional endpoints included changes in the Forced Vital Capacity of the lung, pulmonary exacerbations and antibiotic use. Safety evaluation included the incidence of adverse events and the microbiology of sputum samples. Clinical Results...

New Study Funded By the National Institutes of Health (NIH) Finds Masimo SpCO(R) May Provide a Noninvasive Measure of Acute Asthma Severity in Children

...efforts. "We have limited measures to assess severity of acute asthma exacerbations and the finding of an association between carboxyhemoglobin (SpCO) by multi...ter to measure SpCO in 139 children (5-10 years of age) during acute asthma exacerbations and 2-hours after initiation of corticosteroid and bronchodilator treatment...

First oral uveitis drug reduces both inflammation and recurrence in potentially blinding eye disease

...ho are discontinuing potentially toxic medications for uveitis, such as the corticosteroid prednisone, LX211 actively reduces the rate of inflammatory exacerbations by 50% at six months, compared to placebo. The study results also show a safety profile for LX211 at the 0.4 mg/kg bid dose that suggests the experime...

Mpex Pharmaceuticals Names Mark Wiggins Chief Business Officer

...e as a maintenance therapy for the prevention of exacerbations in cystic fibrosis (CF) and chronic obstructive pu... patients suffering from cystic fibrosis or COPD. exacerbations remain a significant problem in both of these dise...lly as a maintenance therapy for the prevention of exacerbations in patients with cystic fibrosis and COPD. MP-376 ...

Novartis/Schering-Plough's Drug Will Replace AstraZeneca's Symbicort as Decision Resources' Clinical Gold Standard by 2012 for the Treatment of Asthma

... A Therapy's Effect on Reduction of exacerbations is the Attribute That Most Influences Physicians' Prescribing Decisions, Ac...xisting Agents in the Class also finds that a therapy's effect on reducing exacerbations is the attribute that most influences physicians' prescribing decisions in ...

Nycomed's Daxas(R) Shows Encouraging Preliminary Results in Phase III COPD Studies

...udies in patients with symptomatic Chronic Obstructive Pulmonary Disease (COPD) meet primary endpoints - Data show reductions in moderate and severe exacerbations requiring medical intervention - Application for marketing authorisation in EU and US expected in 2009 - Partnering process for commercialisation ...

GlaxoSmithKline and Mpex Pharmaceuticals Form Alliance to Develop Novel Efflux Pump Inhibitors for Use Against Serious Gram-Negative Infections

...-376, is a proprietary aerosol formulation of levofloxacin that is being developed clinically as a maintenance therapy for the prevention of bacterial exacerbations in patients with cystic fibrosis and severe chronic bronchitis. The company has also built a discovery and development platform and intellectual prope...

Asthma Patients Not Adequately Controlled on ICS Alone More Likely to Benefit From Advair(R) Than Doubling the Dose of ICS

...ents with asthma not adequately controlled on the inhaled corticosteroid fluticasone propionate (FP) alone experienced significant reduction in severe exacerbations when switched to the equivalent dose of FP combined with salmeterol administered as Advair Diskus(R) (fluticasone propionate and salmeterol inhalation...

Regulatory Path for Bronchitol in Bronchiectasis

...proximately 300 adults with bronchiectasis. Participants will be treated for 52 weeks during which they will be assessed for reduction in frequency of exacerbations and quality of life. The trial will be undertaken in Europe and the USA. This trial is the second Phase III study to be undertaken with Bronchitol i...

Dey L.P. and Critical Therapeutics Launch Twice-Daily ZYFLO CR(TM) (Zileuton) Extended-Release Tablets for the Chronic Treatment of Asthma

... older. ZYFLO CR(TM) and ZYFLO(R) are not indicated for use in the reversal of bronchospasm in acute asthma attacks, but can be continued during acute exacerbations of asthma. Leukotrienes are inflammatory mediators in asthma that can trigger asthma symptoms, including inflammation, swelling, bronchoconstriction a...
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