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endothelial in Medical News

UCLA scientists prove endothelial cells give rise to blood stem cells

Stem cell researchers at UCLA have proven definitively that blood stem cells are made during mid-gestational embryonic development by endothelial cells, the cells that line the inside of blood vessels. While the anatomic location in the embryo where blood stem cells originate has been well do...

Scientists Learn How Cancer Drugs Cause Hypertension

...ormation of blood vessels that feed tumors. "Anti-angiogenesis drugs like Avastin, Sutent or Nexavar inhibit an important substance called vascular endothelial growth factor [VEGF] that stimulates the creation of new vessels that support malignant growth," senior study author Dr. Thomas Coffman, a professor o...

Anti-growth factor drugs raise hope and concern for treatment of children's eye diseases

...trabismus), published by Elsevier. Dr. Robert L. Avery of Santa Barbara, Calif., discusses issues related to the use of antibodies against vascular endothelial growth factor (VEGF) in pediatric ophthalmology. The two anti-VEGF antibodies available so farbevacizumab and ranibizumabhave been rapidly adopted fo...

Boehringer Ingelheim to Commence Phase III Study Investigating the Role of BIBW 2992 as First-Line Treatment for Non-Small Cell Lung Cancer (NSCLC) Patients with EGFR Mutations

...s from a pharmacokinetic analysis of another Boehringer Ingelheim compound, BIBF 1120, an angiogenesis inhibitor that simultaneously inhibits vascular endothelial growth factor receptors (VEGFR), platelet-derived growth factor receptors (PDGFR) and fibroblast growth factor receptors (FGFR). The data presented a...

Advanced targeted therapies effective as first-line treatment for lung cancer

...on that targets two receptors already known to play a role in non-small cell lung cancer (NSCLC) epidermal growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF). These receptors are targeted separately by other drugs, but vandetanib is the first drug designed to target both. In previou...

Cancer treatment controls macular edema related to diabetes and to cataract surgery

...idespread, diffuse DME (DDME) is often resistant to laser and other standard treatments. Treating DMME with bevacizumab (Avastin), an anti-vascular endothelial growth factor (anti-VEGF) medication that inhibits abnormal blood vessels, was studied in115 patients (139 eyes) by the Pan-American Collaborative Ret...
endothelial in Medical Technology

Afinitor(R) Phase II Data Show Positive Results for Patients With Multiple Types of Lymphoma, Leading to Phase III Trial

...porting EU approval of Afinitor to treat patients with advanced renal cell carcinoma, whose disease has progressed on or after treatment with vascular endothelial growth factor (VEGF)-targeted therapy. In cancer cells, Afinitor continuously targets mTOR, a protein that acts as a central regulator of tumor c...

Three Surgeons in East Texas Are Successfully Integrating a Novel Stem Cell Procedure for Spine Surgeries

...s technology may create an option for even the most critical patient. This is minimally invasive, efficient, safe and effective. The concentrations of endothelial progenitor cells, hematopoietic stem cells, and mesenchymal stem cells have adhesion properties that ensure the cells remain localized where we need t...

vProtect(TM) Luminal Shield Stabilizes Vulnerable Plaque

... Six-Month Follow-Up Shows Reduced Stenosis, Healthy endothelial Regrowth in Vessel Treated Proactively for Vulnerable Plaque DOYLESTOW...raditional balloon-expandable stents. We are very encouraged by the healthy endothelial tissue coverage and reduced stenosis demonstrated in this patient." ...

TRACON Pharmaceuticals' Small Molecule TRC102 and Antibody TRC105 to be Presented at ASCO 2009

...tial for broad application to a wide variety of cancer types. TRC105 is a monoclonal antibody that binds CD105 (endoglin), a membrane receptor on endothelial cells that is required for angiogenesis. By inhibiting new blood vessel formation, the antibody is expected to have activity against a wide variety of...

Long Term Data Presented at EuroPCR 2009 from Randomized Study Attest to Durability of Results of OrbusNeich's Genous(TM) Bio-engineered R stent(TM) Compared to Drug-Eluting Stents

...ations, one focusing on pre-clinical results of an endothelial cell capture (EPC) surface on an abluminal, low do...eointimal hyperplasia, while also showing improved endothelial coverage relative to two other commercially availa...fective at inhibition of neointima while enhancing endothelial coverage early on." Development of the compan...

Boehringer Ingelheim to Present New Phase II Clinical Data on Two Lead Oncology Compounds at ASCO 2009

...edian time to RECIST progression was 4.8, versus 2.8 for placebo.(11) BIBF 1120 is an oral compound that works by simultaneously inhibiting vascular endothelial growth factor receptors (VEGFRs), platelet-derived growth factor receptors (PDGFRs) and fibroblast growth factor receptors (FGFRs) -- all factors whic...
endothelial in Medical Products

Vascular Endothelial Growth Factor

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Endo-PAT2000

Description:... Endo-PAT2000 is a simple and easy to use device for assessing endothelial function. The PAT signal is recorded using Itamar Medical's non-invasive, p...a cost-effective, reliable, non-invasive method to improve the detection of endothelial dysfunction, in order to screen larger segments of the population safely an...
Company:Itamar Medical Ltd.

SJM Pericardial Patch

Description:...ion to which regular glutaraldehyde-treated bovine pericardium patches are vulnerable. EnCap technology has also been shown in animals to promote host endothelial covering....
Company:St. Jude Medical, Inc.

Dingo Microvascular Clamp

Description:...With use, Stainless steel changes its elasticity, causing increased clamping pressure. It is known that pressures above 30g/mm2 may be associated with endothelial damage. Dingo clamps are made from titanium which does not change its elasticity and unlike stainless steel clamps, dingo clamps maintain their calibr...
Company:Beating Heart Surgical Instruments (Vitalcor)

LSM-12000 High-Magnification Slit-Lamp Biomicroscope

Description:... cornea to the back of the lens. Corneal stromal changes, cataractous changes, and posterior capsule changes can be seen and documented as can corneal endothelial changes. With the LSM-12000 you see a live, true real-time image. Unlike some instruments, you are in control, not the machine; you decide where...
Company:Bio-Optics

GORE-TEX Suture for Chordae Tendineae

Description:...ecifically for this application. The suture also is provided with thin ePTFE pledgets that remain soft and pliable even while becoming covered with an endothelial tissue layer. GORE-TEX Suture is available in choice of sizes, lengths and pledget configurations....
Company:W. L. Gore & Associates, Inc.
endothelial in Medical Dictionary

Smooth muscle

...ry with 8 pages of encyclopedia entries, essays, summaries, research information, and more. ... The Vascular Smooth Muscle Cell: Molecular ... endothelial and smooth muscle cells exhibited an increase in proliferation in ... In contrast, smooth muscle cells responded to stretch without contact ...

Serotonin

... Serotonin (pronounced /ˌsɛrəˈtoʊnən/) is a monoamine neurotransmitter. ... 2.3 endothelial cell function and Serotonin . 3 Biosynthesis. 4 Drugs targeting the 5 ... serotonin n. An organic compound, C 10 H 12 N 2 O, formed from ...

Platelet

...ery low (below 20,000), massive ... Increased platelet CD62p expression and increased PMPs were most pronounced in ... Platelet – leucocyte and endothelial cell conjugation may plug coronary ... Platelet - Definition of Platelet at Dictionary.com a free online dictionary ... Low Platelet Disea...

Neutrophil

...o ... About 45% of the neutrophil cytosolic protein is made of migration inhibitory ... Neutrophil adhesion to either resting or activated endothelial cells was not ... The temperature dependence of neutrophil function is thus more complicated than ... Brief and Straightforward Guide: What ...

Laceration

... ... LACERATION . Signs and Symptoms. The patient with a corneal laceration has ... Corneal Laceration . Salzmann's Nodular Degeneration. Fuchs' endothelial Dystrophy ... A laceration is a wound caused by a sharp object producing edges that may be ... The four goals of laceration repair are to stop...

Hemostasis

...his includes the changing of blood from a fluid to a solid state. Intact blood vessels are central to moderating blood's tendency to clot. The endothelial cells of intact vessels prevent thrombus ("clot") formation by secreting tissue plasminogen activator... Hemostasis , the arrest of ...
endothelial in Biological News

Understanding how oxidative stress impairs endothelial progenitor cell function

INDIANAPOLIS Although its been over a decade since endothelial progenitor cells or EPCs, cells that circulate in the blood repairing and replacing the cells that line blood vessels, were identified, the field is still evolving. EPCs are now being studied as biomarkers to assess the risk of future...

Stem cell research: From molecular physiology to therapeutic applications

...chymal stem cell (MSC) population from human fetal bone marrow and found that these cells could differentiate not only into osteogenic, adipogenic and endothelial lineages, but also hepatocyte-like cells, and neural and erythroid cells. They remained in some tissues and organs during gestation and could give ris...

Playing it safe

...gnition" of the cells has actually taken place with the aid of numerous tests. Not only can the reprogrammed cells be used to generate heart, nerve or endothelial cells, as is the case with embryonic stem cells, the scientists can also use them to produce mice with mixed genotypes, known as chimeras, from the ne...

Axel Ullrich named winner of 2009 Dr. Paul Janssen Award for Biomedical Research

...lating tumor angiogenesis, the growth of blood vessels in tumors. He discovered that inhibiting a key player in the signaling system (called vascular endothelial growth factor receptor or VEGFR) suppresses the generation of blood vessels in tumors and slows down cancer cell growth. Years later, a small molecul...

Will IVF work for a particular patient? The answer may be found in her blood

... growth of new blood vessels), endothelin signalling (blood vessel constriction), inflammation, oxidative stress (damage to cell structures), vascular endothelial growth factor (signalling processes in blood vessel growth), and pyruvate metabolism (the supply of energy to cells). "All these processes are importa...

Green tea may affect prostate cancer progression

...ith green tea's active compounds on serum biomarkers in patients with prostate cancer. The biomarkers include hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF) and prostate specific antigen (PSA). HGF and VEGF are good prognostic indicators of metastatic disease. The study included 26 ...
endothelial in Biological Technology

An Image-Based Assay of Endothelial Cell Tube Formation as a Model of Angiogenesis

Introduction Formation of new blood vessels is fundamental to the development of cancerous cell masses and has therefore been the focus of many drug screening and cell signaling research studies. Blood vessel development is a significant event in the ...

The Breast Cancer Therapeutics Market in Australia

...mp; Sullivan Research Analyst. "There are several new targeted therapies and chemotherapy drugs under development, including Epotheliones and Vascular endothelial Growth Factor Receptor (VEGFR) inhibitors." However, chemotherapy continues to be used widely for now. This may be attributed to the fact that ...

Cardium Provides Update on Phase 2b Excellarate Clinical Study and Plans for Additional Tissue Repair Applications

...ieved to stimulate angiogenesis and granulation tissue formation through the recruitment and proliferation of cells such as monocytes, fibroblasts and endothelial cells. These cell types are critical for the effective stimulation of a variety of wound healing processes. The Excellarate product candidate ...

PTC Therapeutics Initiates Phase 2 Clinical Trial of PTC299 in Patients with Neurofibromatosis Type 2

...ional new drug that is designed to selectively block tumor-related vascular endothelial growth factor (VEGF). With its novel mechanism of action, PTC299 has the p...mall-molecule compound that inhibits the production of the protein vascular endothelial growth factor (VEGF) in tumors. PTC discovered PTC299 through PTC's propri...

Peregrine Pharmaceuticals Licenses Anti-VEGF Antibodies to Affitech

...I) today announced that they have entered into a licensing agreement for antibody therapeutic rights under Peregrine's preclinical anti-VEGF (Vascular endothelial Growth Factor) antibody program. Under the terms of the agreement, Affitech will license exclusive worldwide rights to develop and commercialize prod...

Video: Axel Ullrich Named Winner of 2009 Dr. Paul Janssen Award for Biomedical Research

...ulating tumor angiogenesis, the growth of blood vessels in tumors. He discovered that inhibiting a key player in the signaling system (called vascular endothelial growth factor receptor or VEGFR) suppresses the generation of blood vessels in tumors and slows down cancer cell growth. Years later, a small molecule...
endothelial in Biological Products

Anti-Mouse VEGF-C Antibody, Unconjugated from Raybiotech, Inc.

Description:... Vascular endothelial Growth Factor C Class: Antibody Product Group: Angiogensis...
Company:Raybiotech, Inc.

UCB EPC Cell Chip-IHC from 3H Biomedical AB

Description:... Cord blood endothelial progenitor cells, For immunohistochemistry (IHC) Cell Chip with Human Umbilical Cord Blood Progenitor Cells...
Company:3H Biomedical AB

EPC Cell Chip-IHC from 3H Biomedical AB

Description:... Human endothelial progenitor cells, For immunohistochemistry (IHC) Cell Chip with Human Peripheral Blood Dendritic Cells and EPCs...
Company:3H Biomedical AB

Rosmarinic acid from Biotrend Chemikalien GmbH

Description:... tube formation of HUVEC cells. Also reduces intracellular reactive oxygen species (ROS) level, H(2)O(2)-dependent VEGF expression and IL-8 release of endothelial cells. Formula: C 18 H 16 O 8 MolWeight: 360.31484 Store at: RT CAS: 20283-92-5 Solubility: Soluble to 100 mM in water IU...
Company:Biotrend Chemikalien GmbH

Rabbit Anti-Human ZO-1 Antibody, Unconjugated from Lab Vision

Description:... Tight junctions are complexes of proteins that create intercellular boundaries between the plasma membrane domains of epithelial and endothelial cells. Antigen: Synthetic peptide corresponding to N-terminal of human ZO-1....
Company:Lab Vision

Anti-P-selectin Glycoprotein Ligand-1 (PSGL-1) Monoclonal Antibody, Unconjugated, Clone KPL-1 from CHEMICON

Description:... Interactions between P-selectin and P-selectin glycoprotein ligand-1 (PSGL-1) mediate the earliest rolling of leukocytes on the lumenal surface of endothelial cells at sites of inflammation. To date, the primary role of PSGL-1 in mediating the interaction between neutrophils and P-selectin has been well doc...
Company:CHEMICON
endothelial in Biological Definition

Anatomy

...vary gland Thyroid gland Parathyroid gland Adrenal gland Pituitary gland Pineal gland Tissues : Connective tissue endothelial tissue Epithelial tissue Glandular tissue Lymphoid tissue Externally visible parts of the human body: Abdomen Arm Back ...

Blood

... and organelles , so are not cells strictly speaking. They contain the blood's hemoglobin and distribute oxygen. The red blood cells (together with endothelial vessel cells and some other cells) are also marked by proteins that define different blood types . White blood cells or leukocytes (3.0%), are ...

Collagen

...e, assoc. with type I Type VI collagen - most interstitial tissue, assoc. with type I Type VII collagen - epithelia Type VIII collagen - some endothelial cells Type IX collagen - cartilage, assoc. with type II Type X collagen - hypertrophic and mineralizing cartilage Type XI collagen - cartilag...

Intermediate filament

.... Type III IFs Desmin IFs are structural components of the sarcomeres in muscle cells. Vimentin IFs can be found in fibroblasts and endothelial cells , they support the cell membrane and keep some organelles in a fixed place within the cytoplasm . Peripherin found in peripheral neuron...

Lipase

...fferent types of lipases are found in the human body , including pancreatic lipase, hepatic lipase, lysosomal lipase, hepatic lipase, gastric lipase, endothelial lipase, as well as various different phospholipases. At least three human genetic diseases are caused by mutations in lipase genes. Lipoprotein L...

Oncogene

...t become constitutive (permanently) active like the epidermal growth factor receptor (EGFR), platelet-derived growth factor receptor (PDGFR), vascular endothelial growth factor receptor (VEGFR), etc. Cytoplasmic tyrosine kinases like the Src-family, Syk-ZAP-70 family and BTK family of tyrosine kinases. ...
endothelial in Biological Dictionary

Venules

...Vena cava Heart. Pulmonary circulation ... High endothelial venules (HEV) are specialized post-capillary ven...rtex. ... ... lymphocytes at specialized high endothelial venules within lymph nodes and other ... of Rolling T Lymphocytes in Peripheral Lymph Node High endothelial Venules . ... direction of flow in venules a...

Negative interference

...s plus many other academic journal articles, magazine articles & newspaper ar... ... its loss through dominant- negative interference causes endothelial dysfunction. ... was due to dominant- negative interference and not to mere ... Wave-Wave Interactions: Interference of Waves ... ...

Monocytes

...roducing macrophages which ... Recipient monocytes , T cells, and donor endothelial cells (ECs) are recognized ... We show that monocytes gain their stimul...tions three ways that monocytes and macrophages can be de- activated, ... endothelial infection by Yersinia-infected monocytes has been documented (17b) ... ...

Lymphatic vessels

...ructures that carry lymph. As part of the lymphatic system, lymph vessels are complementary to the vascular system. Lymph vessels are lined by endothelial cells, and deep to that have a thin layer of smooth muscles, and adventitia that bind the lymph vessel to the surroundings. Lymph vessels are devo...

Arteries

...body. ... Arteries of varying size comprise a greater arterial blood system that includes, ... In larger arteries , the outer, middle, and inner endothelial and muscle layers ... Why do some people develop hardening of the arteries ? ... Although the arteries become progressively damaged over many ...

Allantois

...ly fuses with the ... In the mutants an allantois was present and usually relatively normal in size, ... Blood-borne seeding by hematopoietic and endothelial precursors from the allantois ... Until now the allantois has not been considered as a hematopoietic organ. ... Another new extra embryonic mem...
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