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elegans in Medical News

A map of the worm: First detailed anatomical atlas of C. elegans for use in the lab

COLD SPRING HARBOR, N.Y. To meet the demands of biologists who work with the model worm C. elegans in the laboratory, a new anatomical atlas has just been published. It is the most detailed and comprehensive atlas of C. elegans in print to date and will be an essential laboratory reference...

Muscle deterioration in patients with lung disease seen connected to CO2

...eir research appeared in a recent study published in the Proceedings of the National Academy of Sciences (PNAS) in the US. They used the worm C. elegans , in which many basic processes are discovered, to study its response to induced elevated carbon dioxide levels. They found that levels exceeding 9% (...

Worms Control Lifespan at High Temperatures, UCSF Study Finds

...SF. She is renowned for her ongoing research on C. elegans (Caenorhabditis elegans) and aging. Humans and ot...nk between cold- and warm-blooded animals. C. elegans has been known to have thermosensory or heat-sensi...s propose that this thermosensory system allows C. elegans to reduce the effect that warm temperature would o...

Worm provides clues about preventing damage caused by low-oxygen during stroke, heart attack

...w experiments, Crowder's team manipulated genes in the worm Caenorhabditis elegans to alter the organism's sensitivity to a low-oxygen environment. They did ...erapies will involve several steps. First, Crowder plans to move beyond C. elegans to see whether these techniques also will protect neurons in mammals. "...

Researchers gain new insight on wonder of cell division

...e of the journal Science -- come from basic research using Caenorhabditis elegans (roundworm) embryos. The discovery provides more basic insight than immedia...s branched microfilaments assembly came as a surprise, Bowerman said. C. elegans is used in many genetics research laboratories to discover basic requiremen...

A new world of research possibilities with 'Emerging Model Organisms'

...and from cricket and finch to quail, snail, and tomato. Until recently, a small number of organismssuch as E. coli , fruit fly, Arabidopsis , C. elegans , and mousehave been the primary focus of research in molecular, cellular, and developmental biology. But in the last few years, due in part to techn...

New research on mutation in yeast can enhance understanding of human diseases

...es cerevisiae had a very high rate of mutation from generation to generation. Its patterns of mutation, however, turned out to be unique. While C. elegans mutations were largely the result of inserting or deleting base pairs of DNA, yeast's patterns of mutation were characterized by changing one base pai...

Weight Gain May Not Be Based Just on What You Eat

...ortant to realize that there is a major contributing factor to body weight that is genetic." The new findings, based on research with so-called C. elegans worms, is published in the June issue of the journal Cell Metabolism . Ashrafi and his colleagues noted that, while the worms are obviously small...

Study identifies mechanism underlying multidrug resistance in fungi

...nt fungal infections to standard antifungal therapy, says Wagner. To further investigate the relevance of their findings, the researchers used a C. elegans roundworm model system recently developed by co-author Eleftherios Mylonakis, MD, PhD, of MGH Infectious Disease to study fungal pathogens. They fo...

Open Biosystems' Open Access RNAi Program Continues to Gain Momentum Worldwide

...he entire human and mouse genomes, the RNAi Consortium human and mouse lentiviral shRNA libraries as well as RNAi collections targeting Drosophila, C. elegans and Arabidopsis Thaliana. Participation in the Open Access RNAi program provides researchers the most complete and flexible access to their choice of ...
elegans in Medical Dictionary

Gonad

...itic gonad that contains both testicular and ovarian tissue ... The gonad is the organ that makes gametes. ... " Gonad " ... Control of C. elegans hermaphrodite gonad size and shape by... The XX gonad recruits vasculature by a typical angiogenic process. ... In the UGR explant model the ...
elegans in Biological News

Pinhead-size worms + robot = new antibiotics

...utomated with a robot to test the effects of 37,000 potential drugs on C. elegans (a type of worm) infected with E. faecalis (a type of bacteria). That bacterium causes life-threatening infections in humans. C. elegans are tiny nematode worms that are widely used in scientific research. The t...

Nematode courting caught on camera

...regulating tail muscles to achieve an exploratory embrace. The video shows an intimate moment between two nematodes of the species Caenorhabditis elegans . As the hermaphrodite does not actively co-operate in mating, it is up to the male to make and maintain the necessary contact. He presses the front s...

Recruitment of reproductive features into other cell types may underlie extended lifespan in animals

... mutations known to extend the lifespan of the C. elegans roundworm induce 'mortal' somatic cells to expres... and is receiving advance online release. " C. elegans mutants with extreme longevity accomplish this fe...n the development, longevity and metabolism of C. elegans , a tiny worm broadly used as a model for studying...

ASBMB Annual Meeting to feature talks on the biochemistry of aging

...n simply cannot be expected to work in mammals. Kennedy and his group examined this issue by carefully analyzing age-related genes in yeast and the C. elegans worm, two organisms that diverged over a billion years ago. They found a statistically significant connection in the genes and pathways that affect ag...

To swim or to crawl: For the worm it's a no brainer

...ty of Leeds has shown, for the first time, that C. elegans worms crawl and swim using the same gait, overturn...lications for biologists and geneticists using C. elegans for their research. Until recently scientists hav... of individual genes may be more apparent." C. elegans , a tiny free-living worm, was the very first anim...

Forget the antioxidants? McGill researchers cast doubt on role of free radicals in aging

...causation. But now this theory really is in the way of progress." Hekimi and postdoctoral fellow Jeremy Van Raamsdonk studied mutant Caenorhabditis elegans worms. They progressively disabled five genes responsible for producing a group of proteins called superoxide dismutases (SODs), which detoxify one of...

Studies offer guide as protein interaction mapping comes of age

... The third study uses the quality control framework from the first study to compile a new, expanded map of the interactome of the worm Caenorhabditis elegans (C. elegans), a scientific favorite whose cells have roughly the same number of genes as human cells do. The previous version of the map was assembled...

Key to 'curing' obesity may lie in worms that destroy their own fat: McGill researchers

...an Institutes of Health Research. In lean times, a normal Caenorhabditis elegans worm goes into a form of suspended animation called "dauer" that slows its ...ll division and reproduction." Unlike other "hibernating" organisms, C. elegans maintains a degree of mobility during dauer by stocking up on energy in the...

Deprived of a sense of smell, worms live longer

...ant medications made the roundworm Caenorhabditis elegans live longer. But until now, they didn't quite kno...nd Daniel Schneider. Kornfeld's lab studies C. elegans because they live only about two to three weeks, ... that some human anticonvulsants slow aging in C. elegans . Now, further investigating the effect of one ...

Worm genome offers clues to evolution of parasitism

... well known in scientific circles: Caenorhabditis elegans has long been used as a model organism in researc...ternational research collaboration. Unlike C. elegans , which lives in the dirt, P. pacificus makes it... is substantially larger and more complex than C. elegans . It has nearly 170,000 chemical bases and contain...
elegans in Biological Technology

Novel drug discovery tool could identify promising new therapies for Parkinson's disease

... two cyclic peptides. Guy Caldwell, Ph.D., and Kim Caldwell, Ph.D., professors of biology at the University of Alabama in Tuscaloosa developed this C. elegans model, and performed the testing. The researchers have not yet determined why the cyclic peptides are protective. They found that the cyclic peptid...

Peregrine Pharmaceuticals Reports Studies Published in 'Science' Highlight Key Role of Phosphatidylserine (PS) in Viral Infections

...sis and Apoptotic Mimicry to Enter Host Cells, Jason Mercer and Ari Helenius* Science 25 April 2008: Vol. 320. no. 5875, pp. 531 - 535 2. Role of C. elegans TAT-1 Protein in Maintaining Plasma Membrane Phosphatidylserine Asymmetry, Monica Darland-Ransom, Xiaochen Wang,* Chun-Ling Sun,* James Mapes, Keiko G...

Open Biosystems' Open Access RNAi Program Adopted by University of Copenhagen and University of Queensland

...he entire human and mouse genomes, the RNAi Consortium human and mouse lentiviral shRNA libraries as well as RNAi collections targeting Drosophila, C. elegans and Arabidopsis thaliana. Participation in the Open Access RNAi program, provides researchers the most complete and flexible access to their choice of...

Growing old together: Yeast, worms and people may age by similar mechanisms

... the yeast Saccharomyces cerevisiae and the nematode worm Caenorhabditis elegans , to identify genes that may regulate aging in humans. Nematodes and human...ys a similar role in people. The researchers compiled a set of 276 C. elegans genes that were known to modulate aging, and scanned the yeast genome for ...

Open Biosystems' Open Access RNAi Program Adopted by Harvard Medical School and University of North Carolina

...rgeting the entire human and mouse genomes, The RNAi Consortium human and mouse lentiviral shRNA libraries and RNAi libraries targeting Drosophila, C. elegans and Arabidopsis thaliana. Participation in the Open Access RNAi program provides researchers the most complete and flexible access to their choice of ...

In vivo visualization of alternative splicing

...gineered a transgenic alternative splicing reporter system to monitor the developmentally regulated switching of let-2 alternative splicing in live C. elegans worms. The splicing of let-2 changes during the lifetime of the worm: Embryos and early larvae express exon 9, while adult worms express exon 10. By...

Mechanism for the in-vivo transport of siRNA

...nterference, in which double-stranded RNA switches genes off efficiently and specifically. The scientists used the nematode (roundworm) Caenorhabditis elegans to study this. Subsequently, however, considerable problems arose in the attempt to transfer the strategy used by Mello and Fire to vertebrates. In pa...

Transformation of Nematodes With the Helios Gene Gun

... PREPARATION OF ADULT HERMAPHRODITE C. elegans AND COTTON RAT PARASITE L. SIGMODONTIS FOR MICROPARTICLE BOMBARDMENT C. elegans is cultivated on NGM agar plates (Brenner, 1974). ...n ice (to reduce their motility). In this state C. elegans could be used for microparticle bombard...

RNA Interference and Gene Silencing: History and Overview

... came from work in the nematode Caenorhabditis elegans . Seven years ago, researchers Guo and Ke...oth sense and antisense strands into C. elegans (10 ). This injec...ed to express dsRNA homologous to the C. elegans unc-22 gene. Surprisingly, these worms...

Silencer Validated siRNAs

...oScience. Cenix was founded in 1999 and pioneered the use of genome-wide dsRNA libraries by targeting all of the genes in the C. elegans and Drosophila genomes (1). Cenix was the first company to espouse the goal of developing siRNAs for the entire human genome. To...
elegans in Biological Products

Goat Anti-C. elegans Syd-2 (cL-19) Polyclonal Antibody, Unconjugated from Santa Cruz Biotechnology, Inc.

Description: Syd-2 (cL-19)...
Company:Santa Cruz Biotechnology, Inc.

In Situ Pan-Caspase Assay Kit from CHEMICON

Description:...ls and result in the cleavage of protein substrates, causing the disassembly of the cell. Caspases have been identified in organisms ranging from C. elegans to humans. The mammalian caspases play distinct roles in apoptosis and inflammation. In apoptosis, caspases are responsible for proteolytic cleavage...
Company:CHEMICON

In Situ Pan-Caspase Assay Kit, Sulforhodamine from CHEMICON

Description:...ls and result in the cleavage of protein substrates, causing the disassembly of the cell. Caspases have been identified in organisms ranging from C. elegans to humans. The mammalian caspases play distinct roles in apoptosis and inflammation. In apoptosis, caspases are responsible for proteolytic cleavage...
Company:CHEMICON

Mouse Anti-Nop1p / Fibrillarin Monoclonal Antibody, Unconjugated, Clone A00104.01 from GenScript Corporation

Description:...me 19 (19q13.1). Fibrillarin proteins have been cloned and sequenced from several other species (Mouse, accession P35550, Xenopus accession P22232, C. elegans accession Q22053, and S. pombe accession P35551). The N terminal 80 amino acids contain multiple copies based on the peptide RGG, and the remaining 24...
Company:GenScript Corporation
elegans in Biological Definition

Apoptosis

...alian counterpart of CED-3 (that is, the product of the ced-3 gene in C. elegans ). In 1997, a protein similar to CED-4 was identified, as well, at the l...heir results in an article titled "Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3 [21]...

Biology

...he process that gives rise to tissues , organs and anatomy . Model organisms for developmental biology include the round worm Caenorhabditis elegans , the fruit fly Drosophila melanogaster , the zebrafish Brachydanio rerio , the mouse Mus musculus , and the weed Arabidopsis thaliana . ...

Centromere

... pombe (and likely in other eukaryotes) the formation of centromeric heterochromatin is connected to RNAi * . In nematodes such as Caenorhabditis elegans and in some plants, chromosomes are "holocentric" indicating that there is not a primary site of microtubule attachments or a primary constriction, an...

Developmental biology

... Chicken Gallus gallus Mouse Mus musculus ( Mammalian embryogenesis ) Invertebrates Sea urchin Round worm Caenorhabditis elegans Fruit fly Drosophila melanogaster ( Drosophila embryogenesis ) Plants ( Plant embryogenesis ) Arabidopsis thaliana Maize ...

Genetics

...Saccharomyces cerevisiae is the first eukaryote genome sequence to be released 1998 The first genome sequnce for a multicellular eukaryote, C. elegans is released 2001 First draft sequences of the human genome are released simultaneously by the Human Genome Project and Celera Genomics . 2...

Genome project

...ays Maize (or corn) Escherichia coli bacterium E.coli SARS virus Arbacia punctulata the purple-spined sea urchin Caenorhabditis elegans a nematode worm Brachydanio rerio Zebrafish Xenopus laevis The African clawed toad Oryzias latipes A medakafish Takifugu...

Genomics

... 85% comparing all protein coding sequences, NHGRI Dog 95% Jon Entine in the San Francisco Examiner C. elegans 74% Jon Entine in the San Francisco Examiner Banana 50% source: Americans for Medical Progress Daffodi...

Glycome

...me project: concept, strategy and preliminary application to Caenorhabditis elegans (A proposal to base the glycome project on Caenorhabditis elegans a microscopic worm, whose entire genome is already sequenced) "Glycobio...

Immune system

...l organisms that lack adaptive immunity such as the plant Arabidopsis thaliana , the fly Drosophila melanogaster , and the worm Caenorhabditis elegans . Recent advances have been made in the field of innate immunology with the discovery of the toll-like receptors , which are the receptors in mamma...

Insulin

...n Principles Insulin is absolutely required for all animal (including human) life. The mechanism is almost identical in nematode worms (ie, C. elegans ), fish, and in mammals. In humans, insulin deprivation due to the removal or destruction of the pancreas leads to death in days or at most weeks. In...
elegans in Biological Dictionary

Spermatids

...d spermatids (14–16), and Sertoli (13) ... ( 14) appeared to demonstrate that spermatids had more intense immunostaining and ... Caenorhabditis elegans spermatids complete a dramatic morphogenesis to crawling ... Spermatids from males activate soon after they are ejaculated into the ... ... ...

Retrotransposons

...pheles gambiae. ... identifies intact LTR retrotransposons by using an approximate string matching technique and ... LTR retrotransposons in C. elegans and D. ... Laboratory experiments led by Hopkins scientists have revealed that so-called "jumping genes" create dramatic ... or retrotransposons ,...

Programmed cell death

...chanism in both development and ... Caenorhabditis elegans gene ced-9 protects cells from programmed c...med cell death is an integral component of C. elegans development. ... Genetic studies of programmed cell death , or apoptosis, in C. elegans led to the ... " Programmed Cell Death " fo...

Phagemid

...ector pAD3 - complete.. E. coli phagemid vector pALTER-1 (formerly ... elegans phagemid vector pAST18b - complete.. C. elegans phagemid vector ... pMGU. Vector IG Sequence Link : General : phage...

Maternal effect

...aternal glucose levels during Ramadan fasting is cumulative. ... Nematode protein-coding gene mes-4. Represented by 10 ESTs ... Caenorhabditis elegans Maternal Effect Sterile family member (mes-4) (mes-4) mRNA, complete cds ... ...

Gene knockout

...ly disabling a specific target gene in ... C. elegans Consortium Home Page ... C. elegans Gene Knockout Consortium is to ... © Copyright....elegans Gene Knockout Project OMRF ... The C. elegans gene knockout facility at the Oklahoma Medical...

Gastrulation

...ologists, gastrulation was the process by which ... 1. Summary of gastrulation events. 2. Polarization of gastrulating cells ... Movies of C. elegans gastrulation can be seen at the following web sites: ... Gastrulation is a crucial time in the development of multicellular animals. During ga...

Cell growth

...d Metabolism of Mast- Cell Growth Factor (c-kit Ligand) in Cutaneous Mastocytosis The outermost circle represents the various cell types in C. elegans in which ... genes that promote cancer cell growth in the androgen independent state. ... One cannot watch cells crawling, dividing, segre...

Asexual

... Asexual reproduction summary with 12 pages of encyclopedia entries, essays, summaries, ... Morphogenesis During Asexual Reproduction in Pygospio elegans ... asexual - 19 definitions - a person who is not interested in or does not desire ... asexual gay bisexual homosexual sex straight heterosexu...
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