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Electroporation in Medical News

Hepatitis C Therapeutic DNA Vaccine Delivered by Inovio Biomedical's Electroporation Technology Reduces Viral Load by Up to 99.7% : Clinical Data Presented at Annual Scientific Meeting of the American Association for the Study of Liver Diseases

Inovio Biomedical Corporation (AMEX:INO), a leader in enabling the development of DNA vaccines using electroporation-based DNA delivery, announced today that its partner, Tripep AB, reported positive additional interim results from its ongoing phase I/II clinical study of its therapeutic DNA vacc...

First evidence for DNA-based vaccination against chronic hepatitis C

...cal trial of a therapeutic vaccination using naked DNA delivered by in vivo electroporation (EP), antiviral effects were shown in patients with hepatitis C (HCV). Res... cytomegalovirus immediate-early promoter (ChronVac-C) delivered by in vivo electroporation (EP). A first phase I/IIa clinical trial in HCV infected patients is curren...

Hebrew University scientist develop technique for eliminating reblockage of arteries

...rkeley. The technique employs the biophysical phenomenon of irreversible electroporation (IRE). IRE destroys cells within seconds, using very short electric field p... other structures in the treated area. While the phenomenon of irreversible electroporation was known for decades, a team led by Prof. Rubinsky developed a new mode of...

Device aims to decrease wait period for patients needing immunotherapy

...annual meeting of the American Society for Blood and Marrow Transplantation in Tampa, FL, today. Choi's device, called HitMeD (high throughput medical electroporation device), has been used for preclinical studies in treatment of acute lymphocytic leukemia (ALL), with early results indicating it has the potential to...

Rhode Island Hospital first in US to treat kidney tumor with new device using electrical pulses

...he procedure -- the first time it has been used on a kidney tumor in the United States. NanoKnife is an image-guided device that uses "irreversible electroporation (IRE) technology" -- pulses of electricity that selectively destroy tumor cells while sparing nearby nerves, blood vessels and other delicate structur...

Therapeutic DNA Vaccine Company Inovio Biomedical Reports Second Quarter 2008 Financial Results

...vering R&D and clinical studies using Inovio's electroporation delivery technology. More details can be found in ...ating that the combination of this DNA vaccine and electroporation DNA delivery was safe and well-tolerated. Patients treated using electroporation displayed higher levels of antibody and cellular i...

Scientists Destroy Cancer Cells Using Electric Pulses

...te cancer soon . The development of the process called irreversible electroporation (IRE) is a result of the efforts of Virginia Techbiomedical engineer Rafael...fessor Boris Rubinsky. For decades, researchers have been aware of electroporation increasing the permeability of a cell from none to a reversible opening to ...

United States Department of Defense Selects Ichor Medical Systems to Develop Biodefense Vaccine

...INESS WIRE)--Ichor Medical Systems, whose advanced electroporation system is being used worldwide to increase the eff...oping products based on the in vivo application of electroporation to enhance intracellular delivery of DNA drugs enc...ffective, and reproducible clinical application of electroporation in a manner capable of supporting development and ...

Genetically modified Lactic acid bacteria offers HIV protection

...reducing the HIV infectivity. Professor worked on this principle and inserted the Cynovirin DNA in to the LAB through genetic engineering technique of electroporation through which the Cynovirin DNA is inserted into the LAB and when this LAB is prepared in cream and foamy lotion applications which his applied as a p...

Attacking therapy with electricity

... close up again so the drug stays inside. Research so far has applied electroporation to cancer chemotherapy, the delivery of DNA for gene therapy, and to the de...dvanced development, for head and neck tumours, for example. In the future, electroporation could be very widely applied for drug delivery. ...
Electroporation in Medical Technology

Vical Interim Clinical Results Demonstrate Safety and Tolerability of Inovio Biomedical's Electroporation DNA Delivery Technology

SAN DIEGO--(BUSINESS WIRE)--Jun 7, 2007 - Inovio Biomedical Corporation (AMEX:INO), focused on the development of DNA vaccines for cancers and infectious diseases and a novel alternative to surgery to treat localized cancers, announced today that the company's partner, Vical Incorporated, presented...

Breakthrough Large Scale Transfection Technology Accelerates Cell-Based Assay Development

...rent preparative transfection technologies which depend on expensive and complicated virus constructs, lipid based transfection agents, or small scale electroporation devices. The high efficiency and viability of cells processed by the MaxCyte ITF Inline Transfection System make it possible to focus on biologica...

Inovio Biomedical's DNA Delivery Technology Significantly Enhances Potency of HIV DNA Vaccine

...ne against HIV delivered using Inovio Biomedical's electroporation technology. The paper, titled "Effect of plasmid D...er concluded: "These results indicate that in vivo electroporation appears safe and can dramatically improve the deli...uded: -- Vaccination in combination with in vivo electroporation led to a more rapid onset and enhanced vaccine-spe...

Interferon Beta DNA Treatment Delivered with Ichor Technology Reduces Atherosclerosis Progression in Mice

...to be consistent among different operators and patients. As a result, Ichor's TriGrid enables safe, effective and reproducible clinical application of electroporation in a manner capable of supporting development and commercialization of DNA-based products. The Ichor system is currently being used on three continent...

Inovio Biomedical's Partners to Present New Data from Two Cancer Immunotherapy Clinical Trials

...ls of plasmid-based immunotherapies using Inovio's electroporation delivery technology at the Third International Con...iesen of Inovio will present a general overview of electroporation delivery of immunotherapy products currently in cl...notherapy products delivered using our proprietary electroporation technology," stated Avtar Dhillon, MD, Inovio's CE...

Inovio: DNA delivery technology shows positive human results

...an DNA Vaccine Clinical Trial Using Inovio’s electroporation DNA Delivery Technology SAN DIEGO, May 22, 20...wned by a third party, delivered by Inovio’s electroporation technology. The results demonstrated safety, toler...nt groups demonstrated the following points: 1. electroporation appears safe and it is well tolerated. 2. The n...

Vical's Vaxfectin Adjuvant With Needle-free Delivery Enhances DNA Vaccine Performance; Yields Antibody Responses Comparable to Electroporation Without Tolerability Issues

...by needle and syringe. In a separate animal study, electroporation following injection of unformulated vaccine yielde...comparable improvements in antibody responses, but electroporation required anesthesia of the animals while needle-fr...ce or a constant current multi-needle device. Both electroporation devices and the Vaxfectin(TM)/needle-free device c...

VGX Pharmaceuticals' Novel HIV and Pandemic Influenza DNA Vaccine Candidates Trigger Robust Immune Responses and Protection in Pre-Clinical Models

...0% protective effects. All of the vaccines were delivered using VGX's proprietary CELLECTRA(TM) DNA Delivery Device. CELLECTRA(TM) is a novel adaptive electroporation device developed by VGX. The avian flu data was presented by Dr. Ruxandra Draghia-Akli, VGX Vice President, Immune Therapeutics Research. Separately...

Inovio Biomedical's DNA Delivery Technology Shows Safety and Enhances Gene Expression & Tumor Responses in Interim Melanoma Clinical Study Results

...at a DNA-based immunotherapy delivered by Inovio's electroporation technology was safe and tolerable, facilitated gen...ral delivery of plasmid-based IL-12 using Inovio's electroporation technology. Interim results from 24 subjects are b...se against the targeted disease. Inovio's advanced electroporation devices facilitate delivery and expression of such...

Inovio Biomedical Highlights Enhanced DNA Vaccine Potency with Electroporation DNA Delivery Technology and New Devices at Gene Therapy Meeting

... hepatitis C, respectively. In all cases, Inovio's electroporation technology was well tolerated and significantly en...olinska Institute, Sweden, supported the safety of electroporation in detailed experiments and demonstrated that the ...fective. Two other Inovio presentations reported electroporation device innovations including the Elgen 1000 system...
Electroporation in Biological News

Society of Interventional Radiology Foundation awards $191,000 in grants

...sis of Outcome of RFA and TACE in HCC Patients," and Christina Ma, "Evaluation of 18F-FDG PET/CT in Monitoring Tumor Ablation Efficacy of Irreversible electroporation (IRE) on Rabbit VX2 Liver Tumor," all at the UCLA Medical Center, Los Angeles, Calif., and Shantanu Gaur, Harvard Medical School, Boston, Mass., "H...

Commercialization aim of grant supporting technology that destroys cancer cells

...rcial development. The technology, irreversible electroporation (IRE), was invented by Davalos and Boris Rubinsky,...ssor at the University of California, Berkeley. electroporation is a phenomenon that increases the permeability of... die. For decades, biologists have used reversible electroporation in laboratories to introduce drugs and genes into ...

Researchers test new therapy for advanced melanoma

...e clinical trial because it is the first time that electroporation is being used to deliver plasmid DNA in a gene the...elped develop the technology used in the study. electroporation is a technique in which a hand-held device applied...tion has been getting the gene into the cancer. If electroporation can deliver the gene to these tumors reliably and ...
Electroporation in Biological Technology

Transient Gene Expression Following Single and Double Exponential Decay Electroporation Pulses

James R. Wong, Ph.D. and Wei-Yu Lin, Bio-Rad Laboratories Summary A double pulse format for electroporation of mammalian tissue culture cells gave lower transient expression than a single exponential decay pulse. Moreo...

Optimizing Chemical Transfection and Electroporation of siRNAs

Rich Jarvis (Associate Scientist, Ambion, Inc.) Alan D. King (Vice President and CSO, Cyto Pulse Sciences, Inc.) Low transfection efficiency is the most frequen...

Efficient Delivery of siRNAs to Human Primary Cells: Electroporation vs. Chemical Transfection

Dmitriy Ovcharenko (Research Associate II, Ambion, Inc.) Gene silencing using small interfering RNAs (siRNAs) has become a powerful method for studying gene function. Human primary cells ...

Optimizing electroporation parameters

Other important parameters for optimizing electroporation. Field strength Pulse length Number of field pulses Ad...

Optimizing electroporation parameters

Other important parameters for optimizing electroporation. Field strength Pulse length Number of field pulses Ad...

Optimizing electroporation parameters

Other important parameters for optimizing electroporation. Field strength Pulse length Number of field pulses Ad...

Optimizing electroporation parameters

Other important parameters for optimizing electroporation. Field strength Pulse length Number of field pulses Ad...

Optimizing electroporation parameters

Other important parameters for optimizing electroporation. Field strength Pulse length Number of field pulses Adj...

Optimizing electroporation parameters

Other important parameters for optimizing electroporation. Field strength Pulse length Number of field pulses A...

Optimizing electroporation parameters

Other important parameters for optimizing electroporation. Field strength Pulse length Number of field pulses Adj...

More>>

Electroporation in Biological Products

siPORTer™-96 Electroporation Chamber from Ambion

Description: Highly efficient delivery of siRNA while maintaining high cell viability Electroporate up to 96 samples simultaneously Fast: less than one hour from cell harvest to post-electroporation incubation Highly reproducible results from well-to-well Designed for use with the Bio-Rad Gene P...
Company:Ambion

ECM 630 Electroporation System from BTX

Description: ...
Company:BTX

HT 96/200 Advanced Electroporation System from BTX

Description: BTX, the leader in electroporation products and specialty electrodes, has developed a new and innovative product line for experiment optimization and large volume electroporation. The Advanced Electroporation System is a breakthrough in Molecular Delivery. The days of researchers struggling with te...
Company:BTX

Gtporator (4 ml) from GEN-TREND s.r.o.

Description:... Highly efficient electroporation solution suitable for transfection of plasmid DNA, oligonucleotides and siRNA. Compatible with all common electroporators....
Company:GEN-TREND s.r.o.

Gene Pulser/E. coli Pulser Cuvette Rack from Bio-Rad

Description:...e the original Gene Pulser apparatus and accessory modules the most popular electroporation system available has been applied in the Gene Pulser II system, which featu...ser II system minimizes variation among experiments and delivers consistent electroporation over the lifetime of the unit. With the Gene Pulser II system, the electric...
Company:Bio-Rad

Gene Pulser Xcell Microbial System from Bio-Rad

Description:... The Gene Pulser Xcell microbial system, 100 to 240 V, 50-60 Hz, is used for electroporation of bacterial and fungal cells. This system includes the main unit, PC module for exponential decay delivery, ShockPod shocking chamber, 10 sterile cuv...
Company:Bio-Rad

Gene Pulser Xcell Eukaryotic System from Bio-Rad

Description:... The Gene Pulser Xcell eukaryotic system, 100 to 240 V, 50-60 Hz, is used for electroporation of mammalian cells. This system includes the main unit, CE module for exponential (25-3,275 microfarad range) or square-wave pulses, ShockPod shocking...
Company:Bio-Rad

OPTIMIX KIT FOR EUKARYOTE from Thermo Scientific

Description:... OptiBuffer is a fully optimised medium, designed for the electroporation of eukaryotic cells. OptiBuffer improves both transfection efficiencies and survival rates over PBS or other standard culture media....
Company:Thermo Scientific

Frozen-EZ Yeast Transformation II Kit from Zymo Research

Description:... and polyethylene glycol has made routine plasmid transformations and library screening easy and reliable, especially when compared to techniques like electroporation and spheroplasting procedures. The Frozen-EZ Yeast Transformation II Kit is designed to make yeast transformations easier and more efficient than curr...
Company:Zymo Research
Electroporation in Biological Definition

Molecular biology

... either bacterial or animal cells. Introducing DNA into bacterial cells is called transformation , and can be effected by several methods, including electroporation , microinjection and chemically. Introducing DNA into eukaryotic cells, such as animal cells, is called transfection. Several different transfectio...
Electroporation in Biological Dictionary

Electroporation

Electroporation , or electropermeabilization, is a significant increase in the electrical conductivity and permeability of the cell plasma membrane caused by an externally applied electrical field. It is usually used in... electroporation ( i′lektrōpə′rāshən ) ( biology ) The applicatio...

Competent

...... our competent cells feature the widest range of cloning efficiencies available. ... competent cell performance for your chemical and electroporation transformations. ... What makes a person " competent ?" Who designates a competent person? ... Does a competent person have to be a supervisor...
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