Hepatitis C Therapeutic DNA Vaccine Delivered by Inovio Biomedical's Electroporation Technology Reduces Viral Load by Up to 99.7% : Clinical Data Presented at Annual Scientific Meeting of the American Association for the Study of Liver Diseases
Inovio Biomedical Corporation (AMEX:INO), a leader in enabling the development of DNA vaccines using electroporation-based DNA delivery, announced today that its partner, Tripep AB, reported positive additional interim results from its ongoing phase I/II clinical study of its therapeutic DNA vacc...
First evidence for DNA-based vaccination against chronic hepatitis C
...cal trial of a therapeutic vaccination using naked DNA delivered by in vivo electroporation
(EP), antiviral effects were shown in patients with hepatitis C (HCV). Res... cytomegalovirus immediate-early promoter (ChronVac-C) delivered by in vivo electroporation
(EP). A first phase I/IIa clinical trial in HCV infected patients is curren...
Hebrew University scientist develop technique for eliminating reblockage of arteries
The technique employs the biophysical phenomenon of irreversible electroporation
(IRE). IRE destroys cells within seconds, using very short electric field p... other structures in the treated area. While the phenomenon of irreversible electroporation
was known for decades, a team led by Prof. Rubinsky developed a new mode of...
Device aims to decrease wait period for patients needing immunotherapy
...annual meeting of the American Society for Blood and Marrow Transplantation in Tampa, FL, today. Choi's device, called HitMeD (high throughput medical electroporation
device), has been used for preclinical studies in treatment of acute lymphocytic leukemia (ALL), with early results indicating it has the potential to...
Rhode Island Hospital first in US to treat kidney tumor with new device using electrical pulses
...he procedure -- the first time it has been used on a kidney tumor in the United States.
NanoKnife is an image-guided device that uses "irreversible electroporation
(IRE) technology" -- pulses of electricity that selectively destroy tumor cells while sparing nearby nerves, blood vessels and other delicate structur...
Therapeutic DNA Vaccine Company Inovio Biomedical Reports Second Quarter 2008 Financial Results
...vering R&D and clinical studies using Inovio's electroporation
delivery technology. More details can be found in ...ating that the combination of this DNA vaccine and electroporation
DNA delivery was safe and well-tolerated. Patients treated using electroporation
displayed higher levels of antibody and cellular i...
Scientists Destroy Cancer Cells Using Electric Pulses
...te cancer soon .
The development of the process called irreversible electroporation
(IRE) is a result of the efforts of Virginia Techbiomedical engineer Rafael...fessor Boris Rubinsky.
For decades, researchers have been aware of electroporation
increasing the permeability of a cell from none to a reversible opening to ...
United States Department of Defense Selects Ichor Medical Systems to Develop Biodefense Vaccine
...INESS WIRE)--Ichor Medical Systems, whose advanced electroporation
system is being used worldwide to increase the eff...oping products based on the in vivo application of electroporation
to enhance intracellular delivery of DNA drugs enc...ffective, and reproducible clinical application of electroporation
in a manner capable of supporting development and ...
Genetically modified Lactic acid bacteria offers HIV protection
...reducing the HIV infectivity. Professor worked on this principle and inserted the Cynovirin DNA in to the LAB through genetic engineering technique of electroporation
through which the Cynovirin DNA is inserted into the LAB and when this LAB is prepared in cream and foamy lotion applications which his applied as a p...
Attacking therapy with electricity
... close up again so the drug stays inside.
Research so far has applied electroporation
to cancer chemotherapy, the delivery of DNA for gene therapy, and to the de...dvanced development, for head and neck tumours, for example. In the future, electroporation
could be very widely applied for drug delivery.
Electroporation in Medical Technology
Vical Interim Clinical Results Demonstrate Safety and Tolerability
of Inovio Biomedical's Electroporation DNA Delivery Technology
SAN DIEGO--(BUSINESS WIRE)--Jun 7, 2007 - Inovio Biomedical
Corporation (AMEX:INO), focused on the development of DNA vaccines
for cancers and infectious diseases and a novel alternative to
surgery to treat localized cancers, announced today that the
company's partner, Vical Incorporated, presented...
Breakthrough Large Scale Transfection Technology Accelerates Cell-Based Assay Development
...rent preparative transfection technologies which depend on
expensive and complicated virus constructs, lipid based transfection
agents, or small scale electroporation
The high efficiency and viability of cells processed by the MaxCyte ITF
Inline Transfection System make it possible to focus on biologica...
Inovio Biomedical's DNA Delivery Technology Significantly Enhances
Potency of HIV DNA Vaccine
HIV delivered using Inovio Biomedical's electroporation
The paper, titled "Effect of plasmid D...er concluded: "These results
indicate that in vivo electroporation
appears safe and can
dramatically improve the deli...uded:
-- Vaccination in combination with in vivo electroporation
to a more rapid onset and enhanced vaccine-spe...
Interferon Beta DNA Treatment Delivered with Ichor Technology
Reduces Atherosclerosis Progression in Mice
consistent among different operators and patients. As a result,
Ichor's TriGrid enables safe, effective and reproducible clinical
application of electroporation
in a manner capable of supporting
development and commercialization of DNA-based products. The Ichor
system is currently being used on three continent...
Inovio Biomedical's Partners to Present New Data from Two Cancer
Immunotherapy Clinical Trials
...ls of plasmid-based immunotherapies using
delivery technology at the Third
International Con...iesen of Inovio will present a
general overview of electroporation
delivery of immunotherapy
products currently in cl...notherapy products delivered
using our proprietary electroporation
technology," stated Avtar
Dhillon, MD, Inovio's CE...
Inovio: DNA delivery technology shows positive human results
...an DNA Vaccine Clinical Trial Using
DNA Delivery Technology
SAN DIEGO, May 22, 20...wned by a third party, delivered by
technology. The results demonstrated
safety, toler...nt groups demonstrated the following
appears safe and it is well tolerated.
2. The n...
Vical's Vaxfectin Adjuvant With Needle-free Delivery Enhances DNA
Vaccine Performance; Yields Antibody Responses Comparable to
Electroporation Without Tolerability Issues
...by needle and syringe. In a
separate animal study, electroporation
following injection of
unformulated vaccine yielde...comparable improvements in antibody
responses, but electroporation
required anesthesia of the animals
while needle-fr...ce or a constant
current multi-needle device. Both electroporation
devices and the
Vaxfectin(TM)/needle-free device c...
VGX Pharmaceuticals' Novel HIV and Pandemic Influenza DNA Vaccine
Candidates Trigger Robust Immune Responses and Protection in
...0% protective effects. All of the vaccines were delivered using
VGX's proprietary CELLECTRA(TM) DNA Delivery Device. CELLECTRA(TM)
is a novel adaptive electroporation
device developed by VGX. The
avian flu data was presented by Dr. Ruxandra Draghia-Akli, VGX Vice
President, Immune Therapeutics Research.
Inovio Biomedical's DNA Delivery Technology Shows Safety and
Enhances Gene Expression & Tumor Responses in Interim Melanoma
Clinical Study Results
...at a DNA-based
immunotherapy delivered by Inovio's electroporation
safe and tolerable, facilitated gen...ral delivery of
plasmid-based IL-12 using Inovio's electroporation
Interim results from 24 subjects are b...se against the targeted
disease. Inovio's advanced electroporation
delivery and expression of such...
Inovio Biomedical Highlights Enhanced DNA Vaccine Potency with
Electroporation DNA Delivery Technology and New Devices at Gene
... hepatitis C, respectively. In
all cases, Inovio's electroporation
technology was well tolerated
and significantly en...olinska
Institute, Sweden, supported the safety of electroporation
detailed experiments and demonstrated that the
Two other Inovio presentations reported electroporation
innovations including the Elgen 1000 system...
Electroporation in Biological News
Society of Interventional Radiology Foundation awards $191,000 in grants
...sis of Outcome of RFA and TACE in HCC Patients," and Christina Ma, "Evaluation of 18F-FDG PET/CT in Monitoring Tumor Ablation Efficacy of Irreversible electroporation
(IRE) on Rabbit VX2 Liver Tumor," all at the UCLA Medical Center, Los Angeles, Calif., and
Shantanu Gaur, Harvard Medical School, Boston, Mass., "H...
Commercialization aim of grant supporting technology that destroys cancer cells
The technology, irreversible electroporation
(IRE), was invented by Davalos and Boris Rubinsky,...ssor at the University of California, Berkeley.
is a phenomenon that increases the permeability of... die. For decades, biologists have used reversible electroporation
in laboratories to introduce drugs and genes into ...
Researchers test new therapy for advanced melanoma
...e clinical trial because it is the first time that electroporation
is being used to deliver plasmid DNA in a gene the...elped develop the technology used in the study.
is a technique in which a hand-held device applied...tion has been getting the gene into the cancer. If electroporation
can deliver the gene to these tumors reliably and ...
Electroporation in Biological Technology
Electroporation in Biological Products
siPORTer™-96 Electroporation Chamber from Ambion
Description: Highly efficient delivery of siRNA while maintaining high cell viability
Electroporate up to 96 samples simultaneously
Fast: less than one hour from cell harvest to post-electroporation incubation
Highly reproducible results from well-to-well
Designed for use with the Bio-Rad Gene P...
ECM 630 Electroporation System from BTX
HT 96/200 Advanced Electroporation System from BTX
Description: BTX, the leader in electroporation
products and specialty electrodes, has developed a new and innovative product line for experiment optimization and large volume electroporation. The Advanced Electroporation
System is a breakthrough in Molecular Delivery. The days of researchers struggling with te...
Gtporator (4 ml) from GEN-TREND s.r.o.
Description:... Highly efficient electroporation
solution suitable for transfection of plasmid DNA, oligonucleotides and siRNA. Compatible with all common electroporators....
Gene Pulser/E. coli Pulser Cuvette Rack from Bio-Rad
Description:...e the original Gene Pulser apparatus and accessory modules the most popular electroporation
system available has been applied in the Gene Pulser II system, which featu...ser II system minimizes variation among experiments and delivers consistent electroporation
over the lifetime of the unit. With the Gene Pulser II system, the electric...
Gene Pulser Xcell Microbial System from Bio-Rad
Description:... The Gene Pulser Xcell microbial system, 100 to 240 V, 50-60 Hz, is used for electroporation
of bacterial and fungal cells. This system includes the main unit, PC module for exponential decay delivery, ShockPod shocking chamber, 10 sterile cuv...
Gene Pulser Xcell Eukaryotic System from Bio-Rad
Description:... The Gene Pulser Xcell eukaryotic system, 100 to 240 V, 50-60 Hz, is used for electroporation
of mammalian cells. This system includes the main unit, CE module for exponential (25-3,275 microfarad range) or square-wave pulses, ShockPod shocking...
OPTIMIX KIT FOR EUKARYOTE from Thermo Scientific
Description:... OptiBuffer is a fully optimised medium, designed for
of eukaryotic cells. OptiBuffer
improves both transfection efficiencies and survival
rates over PBS or other standard culture media....
Frozen-EZ Yeast Transformation II Kit from Zymo Research
Description:... and polyethylene glycol has made routine plasmid transformations and library screening easy and reliable, especially when compared to techniques like electroporation
and spheroplasting procedures. The Frozen-EZ Yeast Transformation II Kit is designed to make yeast transformations easier and more efficient than curr...
Electroporation in Biological Definition
... either bacterial or animal cells. Introducing DNA into bacterial cells is called transformation , and can be effected by several methods, including electroporation
, microinjection and chemically. Introducing DNA into eukaryotic cells, such as animal cells, is called transfection. Several different transfectio...
Electroporation in Biological Dictionary
, or electropermeabilization, is a significant increase in the electrical conductivity and permeability of the cell plasma membrane caused by an externally applied electrical field. It is usually used in... electroporation
( i′lektrōpə′rāshən ) ( biology ) The applicatio...
...... our competent cells feature the widest range of cloning efficiencies available. ... competent cell performance for your chemical and electroporation
transformations. ... What makes a person " competent ?" Who designates a competent person? ... Does a competent person have to be a supervisor...