Effects

Scientists ID molecular 'switch' in liver that triggers harmful effects of saturated and trans fats

Dana-Farber Cancer Institute researchers have identified a molecular mechanism in the liver that explains, for the first time, how consuming foods rich in saturated fats and trans-fatty acids causes elevated blood levels of cholesterol and triglycerides and increases one's risk of heart disease and certain cancers. In the Jan. 28 issue of Cell, scientists led by Bruce Spiegelman, PhD, rep...

Alcohol's effects on gene expression in the central nervous system

Alcohol's primary target is the central nervous system (CNS), where it influences neurotransmission to produce intoxication. Scientists can now use microarray technology to study brain function gene by gene. Symposium proceedings published in the February issue of Alcoholism: Clinical & Experimental Research address the effects of alcohol on what is called "gene expression" in the CNS regions...

Scientists discover how plants disarm the toxic effects of excessive sunlight

A newly discovered pathway by which cells protect themselves from a toxic byproduct of photosynthesis may hold important implications for bioenergy sources, human and plant disease, and agricultural yields, a team of University of Wisconsin-Madison bacteriologists announced Monday in the Proceedings of the National Academy of Sciences. Plants turn energy from sunlight into bioenergy throug...

Physiological effects of reduced gravity on bacteria

An article in Journal of Applied Microbiology investigates how bacteria respond when they are subjected to environmental alterations, such as those of space stations, which feature lowered effects of gravity. "Intra-specific differences in bacterial responses to modeled reduced gravity" by Paul W. Baker and Laura G. Leff describes differences in bacterial responses to reduced gravity and h...

Protein prevents detrimental immune effects of bacterial sepsis

The anti-inflammatory protein annexin 1 may protect patients from the detrimental effects of severe inflammatory response syndrome, as reported by researchers at Barts and the London, Queen Mary's School of Medicine and Dentistry. The paper by Damazo et al., "Critical protective role for annexin 1 gene expression in the endotoxemic murine microcirculation," appears in the June issue of The Americ...

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Effects of Thermal Cycler Well-To-Well Temperature Uniformity on PCR Results

Michelle Cayouette Jane Moores Jason Capodanno Michael Rahilly Stratagene produces consistent PCR results in every well. The RoboCycler systems uniquedesign uses thermal blo...

Measuring Gene Silencing Effects by RT-PCR Without RNA Isolation

Quantitative or real time RT-PCR is one of the most commonly used techniques for quantitating changes in gene expression across samples. When working with cell or tissue samples for subsequent use in RT-PCR you must extract...

Confirming RNAi Effects Is Now Easier Than Ever

To validate any RNAi experiment, target mRNA reduction should be confirmed and quantitated. Validation, using a positive control siRNA that is known to be effective, is required for optimization of transfection parameters. Validation is also necessary for assessment of the...

EFFECTS OF INSTRUMENT RESOLUTION ON ASSESSMENT OF DNA PURITY

The traditional method for quantification and assessment of purity of DNA samples is spectrophotometric measurement at 260 and 280nm . It is generally accepted that a sample of pure, double-stranded DNA of 50 g/mL will have an absorbance at 260nm of 1.0 and that the ratio of absorbance at 260 and 280nm of this...

Lord of the Rings visual effects creator talks about entrepreneurial experiences

MILWAUKEE The directors of the chose to follow a trend when picking luncheon guest speakers, as on both days the speakers were award winners. However,...

Effects at Medicine News

Acupuncture May Help Chemotherapy Side Effects

Oriental medical practice of Acupuncture along with commonly used medications may help ease the distressing and disabling side effects of chemotherapy for breast cancer patients, if researchers at National Institute of Health (NIH) are to be believed. According to Dr. Joannieshen MD, MPH, research associate at NIH, electro-acupuncture was more effective in controlling vomiting than...

Just spice it up!!!!! Anti bacterial effects of spices unraveled in the West

The West is now sitting up and taking in the aroma of Indian cuisine. The inseparable part of Indian kitchens, the spices are now the subjects of research by scientists at the Kansas State University in Manhattan, Kansas. Dr. Daniel Y. C. Fung and colleagues who conducted the study opine that cinnamon, apart from filling the air with its spicy aroma can also double up as an anti bacterial agent.<...

Protective effects of tomatoes in prostate cancer

Diets rich in tomato products, such as tomato sauce and ketchup, have long been associated with a reduced risk of various cancers, especially prostate cancer, but the reason for such an action is yet to be found. Clinical trials have suggested that lycopene, which is found in tomato products and other natural plant nutrients may be effective in preventing prostate cancer and treating t...

Toxic effects common with AIDS treatments

High levels of toxic effects associated with antiretroviral treatment for HIV have been recorded and quantified by a group of Swiss researchers in a study published this week in The Lancet. If efficacy levels of drug combinations are similar, treatment choice will depend on the toxic effects of the drugs. Therefore, the data may be useful as a reference for future analyses of adverse effects of d...

Contraceptives have dual effects

Women using the oral contraceptive pill could be up to 30% less likely to develop bowel cancer, research suggests. Researchers believe that over the last 20 years, mortality rates for bowel cancer have dropped more in women than in men because of hormones found in the Pill. Researchers believe the protective benefits of the Pill are due to the way oestrogen - a female sex hormone - works in...

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Common Preterm Labor Drug Has More Side Effects Than Alternative, Finds Study from Packard Children's Hospital and Stanford

STANFORD, Calif.--(BUSINESS WIRE)--Jun 29, 2007 - The drug mostcommonly used to arrest preterm labor, magnesium sulfate, is morelikely than another common treatment to cause mild to serious sideeffects in pregnant women, according to a study from researchers atLucile Packard Children's Hospital and Stanford University Schoolof Medicine. Their findings suggest that, since the effectivenessof...

Promising Data on Cognitive Effects of Safinamide in Early Parkinson's Disease

• Data presented at Movement Disorder Society’s 11thInternational Congress • Management of cognitive impairment in earlyParkinson’s disease patients is a critical unmet medicalneed Geneva, Switzerland, June 8, 2007 – Merck Serono S.A.(virt-x: SEO) and its partner Newron Pharmaceuticals S.p.a. (SWX:NWRN) announced today data, which suggest tha...

XYOTAX More Cost Effective With Fewer Side Effects Than Gemcitabine or Vinorelbine in Treating Non-Small Cell Lung Cancer

ASCO publication highlights health care cost benefit ofbioengineering paclitaxel CHICAGO, June 05, 2007 /PRNewswire-FirstCall/ -- CellTherapeutics, Inc. (CTI) announced that data published in the 2007Annual Meeting of the American Society of Clinical Oncology (ASCO)abstracts showed reduced medical resource utilization (MRU) andassociated costs with XYOTAX (paclitaxel polyglumex) treatment...

Repros' Androxal Shows Highly Statistically Significant Positive Effects in Men with Secondary Hypogonadism

THE WOODLANDS, Texas--(BUSINESS WIRE)--Jun 5, 2007 - ReprosTherapeutics Inc. (NasdaqGM:RPRX) announced topline results of asix month U.S. Phase 3 study of Androxal(TM), an oral drug beingdeveloped to restore normal testicular function in men withsecondary hypogonadism. Further, Androxal demonstratesnon-inferiority in all the endpoints of the study, compared toAndrogel(R), a cream which is t...

New Data Suggests Less Abuse-Related Effects For OROS Methylphenidate

Two New Studies Highlight Potential Benefit of Unique OROS(R)Formulation SAN DIEGO, May 23, 2007 /PRNewswire/ -- Stimulant drug abuseremains an ongoing concern for parents and physicians who prescribemedications to treat Attention Deficit Hyperactivity Disorder(ADHD). Data presented on Tuesday at the 160th Annual Meeting ofthe American Psychiatric Association highlighted findings thatlon...

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