Uncovering the Achilles' heel of the HIV-1 envelope
... Medical School in Boston, Massachusetts.
The BNAbs that have been identified are directed against a portion of HIV-1 called the membrane proximal ectodomain
region (MPER). This region lies at the base of the viral envelope protein comprised of the gp120 protein plus the membrane anchoring gp41 subunits adj...
ectodomain in Biological News
Novel EGFR ectodomain mutations in glioblastoma
The Epidermal Growth Factor Receptor (EGFR), a so-called kinase protein, is often abnormally active in cancer. A new class of anticancer drugs inhibiting the activated EGFR kinase have shown to be effective against such cancers, especially lung cancer. In a new study in PLoS Medicine, researchers h...
Scripps research scientists solve structure of a critical innate immune system protein
... TLR signaling together with his group in the TSRI Department of Immunology. "All of us in the TLR field have been dying to see the structure of a TLR ectodomain
since the innate immune function of TLRs was discovered seven years ago. This will open the way to a great many other studies that will allow us to un...
ectodomain in Biological Products