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duplexes in Medical Technology

Calando Pharmaceuticals Publishes Study Showing Anti-Cancer Effect with Lead RNAi Candidate

...ning nanoparticle formulation (CALAA-01). Numerous putative candidate siRNA duplexes targeting the M2 subunit of ribonucleotide reductase (RRM2) were screened, ...ch also noted that Calando has filed for patent protection on several siRNA duplexes against RRM2 in a patent application that was published in November 2006 (U...

Arrowhead Subsidiary Calando Pharmaceuticals Publishes Study Showing Anti-Cancer Effect with Lead RNAi Candidate

...-tumor effect," said John Petrovich, Calando's Chief Executive Officer. He further added that Calando has filed for patent protection on several siRNA duplexes against the RRM2 target and has licensed patents from Alnylam Pharmaceuticals to enable it to develop and commercialize an RNAi therapeutic against th...
duplexes in Biological News

Stability of mRNA/DNA and DNA/DNA duplexes modulates mRNA transcription

The distribution of the four nucleotides along the DNA sequence encodes the genetic information in living systems. However, do nucleic acids possess other attributes that contribute to their biological functions? Recent work of a team led by Stoyno Stoynov, working at the Bulgarian Academy of Scien...
duplexes in Biological Technology

Sirnaomics and GRL Establish Partnership for the Development of Two Multi-Targeted RNAi Therapeutics Products

...RNAi therapeutic products to improve scarless skin wound healing and to treat prostate cancer. The first product is expected to consist of three siRNA duplexes targeting three genes involved in scar formation during the skin wound healing process. The further in vivo study will demonstrate that the siRNA/poly...

Detection of p53 Gene in Breast Cancer by Denaturing Gradient Gel Electrophoresis and the DCode System

... of SSCP, making it an attractive technique for screening unknown mutations. The principle of DGGE is based on the fact that DNA duplexes melt at high temperature in the presence of a gradient of chemical denaturant. DNA melting is sequence specific and occurs in di...

RNA Interference and Gene Silencing: History and Overview

...eavage events degrade the RNA to 19-21 bp duplexes (siRNAs), each with 2-nucleotide 3' overh...8">28 ). In the effector step, the siRNA duplexes bind to a nuclease complex to form what i...Yalcin A, Weber K, and Tuschl T. (2001) duplexes of 21-nucleotide RNAs mediate RNA inter...

YOUR DATA: Direct Real-time RT-PCR on Sympathetic Neuron Lysates Silencing of Focal Adhesion Kinases with Silencer Validated siRNAs

...e Silencer Validated siRNAs are individual siRNA duplexes that have been verified experimentally to reduce the mRNA levels of their target genes by at least 70%. The ...

YOUR DATA: Direct Real-time RT-PCR on Sympathetic Neuron Lysates Silencing of Focal Adhesion Kinases with Silencer Validated siRNAs

...e Silencer Validated siRNAs are individual siRNA duplexes that have been verified experimentally to reduce the mRNA levels of their target genes by at least 70%. The ...

Visualizing siRNA in Mammalian Cells: Fluorescence Analysis of the RNAi Effect

.... JCEM (in press) . Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, and Tuschl T (2001) duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411 : 494-498. ...

More siRNA Vectors for RNA Interference

... REFERENCES 1. Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, and Tuschl T. (2001a). duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411 , 494-498. 2. ...

Five Ways to Produce siRNAs

... href="http://www.ambion.com/catalog/CatNum.php?51320">Validated siRNAs : Silencer Validated siRNAs are single siRNA duplexes that have been verified experimentally to reduce the expression of individual human genes. Each siRNA has been shown to reduce t...

Silencer Validated siRNAs

... Silencer Validated siRNAs are single siRNA duplexes that have been verified by real-time RT-PCR to reduce the expression of a number of important human genes. The cut-off for siRNA...

RNAi Gene Silencing System

...igonucleotides that are annealed to produce a duplex with symmetric 2-nucleotide 3'-end overhangs. Deprotected siRNA duplexes are desalted and purified to >97% purity by HPLC (ultrapure) or 80-85% (crude option). siRNA is supplied with a sterile ...
duplexes in Biological Products

TransIT-siQUEST Transfection Reagent from Mirus Bio Corporation

Description:... the induction of the interferon response, which results in a general inhibition of protein synthesis. Recently, it has been shown that when short RNA duplexes are introduced into mammalian cells in culture, sequence-specific inhibition of target mRNA can be realized without introducing an interferon response...
Company:Mirus Bio Corporation

TransIT-siQUEST Transfection Reagent from Mirus Bio Corporation

Description:... the induction of the interferon response, which results in a general inhibition of protein synthesis. Recently, it has been shown that when short RNA duplexes are introduced into mammalian cells in culture, sequence-specific inhibition of target mRNA can be realized without introducing an interferon response...
Company:Mirus Bio Corporation
duplexes in Biological Dictionary

Stringency

...m-Webster's Online Dictionary, 11th ... stringency Reaction conditions - notably temperature, salt concentration(s) and ... At high stringency , duplexes form only between strands with perfect one-to-one ... Stringency of Tests for Random ... To gauge the stringency of a test, we conduct the test...

In vivo

...vo mean? ... VIVO (Voice-In/Voice-Out): The Coming Age of Talking Computers by Small Press Bookwatch ... Stealth RNAiā„¢ siRNA - in vivo -ready duplexes ... Click for a sortable compilation of in vivo RNAi references. Last updated August 2008. ... Watch Video about In , Vivo ,Tu by Metacafe.com...

Dicer

...ssible score by finding different combinations. ... Home > Web apps >Games> Dicer ... Dicer makes staggered cuts in dsRNA to form siRNA duplexes with 3' overhangs, ... Dicer exhibits little sequence specificity for cleavage, though it favors ... Dicer contains a region of homology to...

Branch migration

...ll Temporary ... The branch migration substrates consist of two homologous duplex DNAs each ... Branch migration to the opposite end of the duplexes results in complete strand ... These processes entail branch migration , whereby the length of two arms of a ... Branch migration is carri...
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