Drugs

HIV Patients May Be at Risk of Heart Problems When Taking Protease Inhibitor Drugs

A widely-used class of drugs that keep the HIV-virus infection from progressing to AIDS may cause serious and potentially lethal heart rhythm disturbances in some patients. The finding of a Mayo Clinic-led investigation appears in the current edition of The Lancet. In collaboration with colleagues from the HIV Program of Hennepin County Medical Center, Minneapolis; the University of Minn...

Molecular machine may lead to new drugs to combat human diseases

The crystallized form of a molecular machine that can cut and paste genetic material is revealing possible new paths for treating diseases such as some forms of cancer and opportunistic infections that plague HIV patients. Purdue University researchers froze one of these molecular machines, which are chemical complexes known as a Group I intron, at mid-point in its work cycle. When frozen...

Researchers identify target for cancer drugs

For nearly a decade, scientists have been trying to fully understand a particular communication pathway inside of cells that contributes to many malignant brain and prostate cancers. While scientists have identified elements of this pathway, other key components have remained a mystery. Researchers at Whitehead Institute now have discovered a missing puzzle piece, a finding that may present drug...

MetaChip provides quick, efficient toxicity screening of potential drugs

A large, multisite trial designed to examine the safety and preliminary effectiveness of two candidate topical microbicides to prevent HIV infection has opened to volunteer enrollment. The trial, sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, represents a partnership among various research institutions in Africa and the U...

New Drugs For Bad Bugs: UF Approach Could Bolster Antibiotic Arsenal

Call it a chemical crystal ball. A new approach to predict whether a drug in development is likely to work and which dose is best could get antibiotics to market faster and more cheaply, say University of Florida researchers. In recent years, scientists worldwide have sounded the alarm: There simply aren’t enough drugs to combat bad bugs. Bacteria are increasingly adept at outwitting the t...

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High-throughput gene expression analysis to screen for anti-asthma drugs

Andreas Pahl, Uwe Oelmller,* and Susanne Ullmann Department of Pharmacology, University of Erlangen, Erlangen, Germany * QIAGEN GmbH, Hilden Germany Drug library screening based on gene expression analysis requires reliable and reproducible methods of RNA pu...

Simultaneous Screening of 23 Drugs of Abuse in Oral Fluid Using an LC/MS/MS Method

They are not as commonly available for novel sample matrices such as saliva as...

A simple and rapid LC-MS/MS method for the simultaneous determination of nine antiretroviral drugs commonly used in Europe (protease Inhibitors and non-nucleoside reverse transcriptase inhibitors)

In clinical research, the monitoring of protease inhibitor (PI) and non-nucleoside reverse transcriptase inhibitor (NNRTI) antiretroviral drugs is of significant interest due to the importance of assessing inter-individual and intra-individual metabolism variability. To be of practical use, it is essential that the analytical method used to mon...

A new LC/MS/MS Research Method for Rapid Quantitation of Five Immunosuppressant Drugs, including Mycophenolic Acid (MPA)

A previously published application note in this series describes an LC/MS/MS method for the simultaneous determination of four immunosuppressant drugs: Cyclosporin A (CsA), Tacrolimus (TAC, aka FK-506), Sirolimus (SIR, aka Rapamycin) and Everolimus (EVE, aka RAD-001) (1, 2). The method is based on a simple and robust hardware configuration and...

Rapid Screening of Amphetamine Drugs in Urine by Positive Ion Electrospray LC/MS/MS

Amphetamine drugs are often abused and misused in sports, in the work place, and by recreational users. Forensic, clinical, and doping laboratories are frequently asked to analyze for the presence of amphetamines in urine. Urine samples are most common because large sample volumes can be...

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Drugs at Medicine News

Lean Protein Could Be Key to Obesity Drugs

A protein that lets mice eat more but weigh less could prove the magic ingredient for diet drugs of the future.British scientists from drug giant SmithKline Beecham and the University of Cambridge have created mice with a human protein known as Uncoupling Protein 3 (UCP3) that increases their metabolism.In what is every dieter's dream, the mice were able to eat more than normal mice but still wei...

Life Saving Cancer Drugs – From Chicken! Possible Says 'Dolly’ Creatos

In what can be a watershed in cancer research, Scottish scientists along with US Biotech Company Viragen Inc., have used nuclear transfer technology to harvest life saving drugs to treat many serious diseases including cancer. The same team had earlier cornered world wide fame and glory (and a lot of criticism!) for creating Dolly – the world’s first cloned mammal: Using the same nuclear transfe...

Nasal Spray Could Take Drugs Direct to Brain.

Based on early studies in rats, researchers from the Stroke Lab and Alzheimer's Research Center in St. Paul, Minnesota, reported that “a direct path from the nose to the brain” could breach the blood-brain barrier, which p...

Cancer drugs in development nearly doubled since 1995

The number of drugs being developed for the treatment of cancer has nearlydoubled during the past six years, according to a new survey of pharmaceuticalcompanies.Currently, 170 pharmaceutical and biotechnology firms various CancerInstitutes are investigating 402 compounds for the treatment of variouscancers, up from 215 in 1995. Many of the drugs are alternatives to standardradiatio...

Cipla holds talks with mining giant to supply AIDS drugs for South African workers

Indian pharmaceutical giant Cipla is holding talks with London based mining giant, Anglo American for supplying AIDS drugs to South African workers. About 11% of South African population is HIV positive, totaling around 4.7 million people, giving it the dubious distinction of being the country with the maximum number of HIV positive people in the world. The HIV scourge is sure to have a...

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Drugs at Medicine Products

Triage® Drugs of Abuse Panels

Description:The Triage Drugs of Abuse Panel is the leading rapid drug screen used by U.S. hospitals. The Triage Drugs of Abuse Panel is a small, handheld urine test that provides qualitative results for up to nine commonly abused drugs in about 10 minutes....
Company:Biosite

Drugs of Abuse Urine Screen Control

Description:This control monitors the performance of Abuscreen ONLINE, AxSYM, EMIT, Triage, and other drugs of abuse screening methods. This control meets current revised guidelines established by the Substance Abuse and Mental Health Services Administration (SAMSHA). Level 1 is drug free urine. Level 2 has drug analytes below screening cut-off levels (negative threshold screen). Level 3 is designed to conta...
Company:Quantimetrix Corporation

Drugs of Abuse Array Cocaine Metabolite Assay

Description:Drugs of Abuse (DoA) Array is used for in-vitro diagnostic tests for the qualitative determination of the parent molecule and metabolites of drugs in human urine....
Company:Randox Laboratories Ltd.

Drugs of Abuse Array Evidence Opiates Assay

Description:Drugs of Abuse (DoA) Array is used for in-vitro diagnostic tests for the qualitative determination of the parent molecule and metabolites of drugs in human urine....
Company:Randox Laboratories Ltd.

Drugs of Abuse Array Evidence Methodone Assay

Description:Drugs of Abuse (DoA) Array is used for in-vitro diagnostic tests for the qualitative determination of the parent molecule and metabolites of drugs in human urine....
Company:Randox Laboratories Ltd.

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Drugs at Medicine Technology

Monitoring Options Expand for Therapeutic Agents and Drugs of Abuse

In keeping with the recent proliferation of rapid, easy-to-use diagnostic tests, many assays and collection products have entered the marketplace to help clinicians assess dosage appropriateness of therapeutic drugs and to screen for the presence of drugs of abuse. Some of these products require laboratory support while many simple test kits are suitable for point of care use by medical profe...

Clinical Study Shows Regenecare Relieves Pain and Itching of Skin Rashes Caused by Widely Used Cancer Drugs

IRVING, Texas--(BUSINESS WIRE)--Jul 11, 2007 - The Journal of theAmerican Society of Clinical Oncology has published the earlyresults of a clinical study conducted by Dr. Siu-Fun Wong, and hercolleagues, which concluded that the topical gel, Regenecare(R),caused a statistically significant reduction in the pain anditching of a rash that results from the use of anti-cancer drugsknown as EGFR...

New Drugs in Multinational Study Show Promise in Fighting Drug-Resistant HIV

Phase III clinical trial provides hope that HIV patients can livelonger lives PASADENA, Calif., July 05, 2007 /PRNewswire/ -- A newinvestigational drug used in combination with a second newer agenthas proven to be effective in fighting drug-resistant HIV,according to a Lancet article to be published in its July 7thspecial HIV/AIDS issue. The multinational phase III clinical trial,...

New Report 'Looking at Chiral Technologies' Analyzes the Global Market Growth Forecasts Driven By Two Very Important Components as Single Isomer Drugs and Single Enantiomer Pharmaceuticals

DUBLIN, Ireland--(BUSINESS WIRE)--Jun 21, 2007 - Research andMarkets (http://www.researchandmarkets.com/reports/c60415) hasannounced the addition of Looking at Chiral Technologies to theiroffering. The advancements in molecular research and continued untiringefforts of the research industry to develop better more preciselyapplicable Pharmaceuticals as well as agro compounds would have not...

Array BioPharma Reports New Clinical Data on Its Anti-Inflammatory Drugs

BOULDER, Colo.--(BUSINESS WIRE)--Jun 20, 2007 - Array BioPharmaInc. (Nasdaq: ARRY) announced new Phase 1 clinical data on its MEKinhibitor, ARRY-162, and its p38 inhibitor, ARRY-797. These resultswere presented at the Annual European Congress of Rheumatology(EULAR) in Barcelona, Spain, and at the International Associationof Inflammation Societies' (IAIS) 8th World Congress onInflammation in...

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Drugs at Medicine Dictionary

Nonsteroidal anti-inflammatory drugs

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Immunosuppressant drugs

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