Discovery of New Dopamine Action May Yield Alternative Psychiatric Drugs
Duke University Medical Center researchers have discovered a new mechanism by which chronically high levels of the neurotransmitter dopamine exert their effects on the brain. Normally associated with triggering feelings of pleasure, excess concentrations of dopamine underlie schizophrenia, attention deficit hyperactivity disorder and other psychiatric conditions. The findings therefore provide ne...Flies on speed offer insight into the roles of dopamine in sleep and arousal
Methamphetamine, the drug of choice for long-distance truckers and college students pulling all-nighters, appears to do a similar trick for fruit flies, too. This finding is one of several in a new study that demonstrates a critical role for the neurotransmitter dopamine in the modulation of sleep, wake, and arousal states. The work is reported by Dr. Ralph Greenspan and colleagues at The...Jefferson biologist coaxing human embryonic stem cells to make dopamine with simpler, faster method
For clinicians, the ability to look routinely inside the body and see -- at the level of the cell -- how it confronts disease is a distant dream. But in a series of experiments with genetically engineered mice, a team of researchers from the Howard Hughes Medical Institute (HHMI) at the University of California Los Angeles has taken a key step toward realizing that vision by demonstrating the abi...Dopamine drug leads to new neurons and recovery of function in rat model of Parkinson's
In preliminary results, researchers have shown that a drug which mimics the effects of the nerve-signaling chemical dopamine causes new neurons to develop in the part of the brain where cells are lost in Parkinson's disease (PD). The drug also led to long-lasting recovery of function in an animal model of PD. The findings may lead to new ways of treating PD and other neurodegenerative diseases....High dopamine transporter levels not correlated with ADHD
Results from a brain-imaging study conducted at the U.S. Department of Energy's Brookhaven National Laboratory in collaboration with Mount Sinai School of Medicine in New York indicate that levels of a brain protein proposed as a diagnostic marker for attention-deficit hyperactivity disorder (ADHD) are not positively correlated with the disease. In fact, the study found lower levels of these "dop...Mouse Dopaminergic Neuron Differentiation Kit, 2nd Generation from R&D Systems
Description:Reagents for the differentiation of mouse embryonic stem cells to dopaminergic neurons. Dopamine cell bodies exist in the midbrain, where they are mainly located in the substantia nigra, the ventral tegmental area, and the retrorubral field. These dopaminergic (DA) neurons give rise to extensive forebrain dopamine innervation ( e.g.projections to the caudate nucleus, putamen nucleus accumbens,...Rabbit Anti-Human D4 Dopamine Receptor Antibody, Unconjugated from Sigma-Aldrich
Description:Immunogen: synthetic peptide corresponding to the third cytoplasmic loop of human D dopamine receptor, conjugated to KLH. The immunizing peptide has 79% homology with the rat and mouse gene. Physical form: Solution in phosphate buffered saline, pH 7.7, containing 0.01% sodium azide. Titertest method: IHC (p). Titertest values: immunohistochemistry (formalin-fixed, paraffin-embedded...Anti-Dopamine D2 / D3 Receptor Polyclonal Antibody, Unconjugated from CHEMICON
Description:Dopamine D2 and D3 receptor, human and possibly mouse. AB1502 detects 40 ng of dopamine receptor peptide by ELISA. AB1502 is not neutralizing....Dopamine helps stroke survivors
A drug used in Parkinson's disease also improves the paralysis experienced by stroke survivors.Levodopa is turned into the neurotransmitter dopamine in the body, and this may help brain cells involved in controlling movement to function more normally. It's used as a treatment in Parkinson's disease, but a new trial suggests that levodopa is also helpful in alleviating stroke-induced disability....Breast Cancer risk for women on dopamine antagonists
A study, by researchers of the Harvard Medical School, of more than 100,000 women, indicates that women who use dopamine antagonists, i.e. anti-psychotics, for either psychiatric// illnesses or other conditions, may have an increased risk of breast cancer. The study involved about 52,000 women who were taking dopamine antagonists and 55,000 women who were not. The two groups were compa...New insight for dopamine transporter
Researchers of Yale University had discovered a changed version of dopamine// transporter in healthy persons with genetical variations that may be associated with substance abuse or attention deficit hyperactivity disorder (ADHD). Dopamine is a protein produced in the hypothalamus and some areas of the central and peripheral nervous system. Dopamine and its agonists play an important...