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dissociation in Medical News

Brown professor continues debate over recovered memory

... University of Oregon, appears in the current issue of Journal of Trauma & dissociation . Cheit is disputing a 2006 contest by Harvard University psychiatrists ...nore evidence that contradicts him." In the current Journal of Trauma & dissociation article, Cheit calls Pope's entire contest "a sham," accusing Pope's team ...

ForteBio Launches New Biosensor for Kinetic Analysis and Screening of Human IgG Antibodies

...duct ligand inhibition assays by expanding the variables that can be measured, such as blocking and unblocking analytes, affinity, and association and dissociation rates. The new AHC biosensor further expands the capabilities of the Octet platform which already supports quantitation of human IgG using Protein A. ...

Prism Pharmaceuticals Receives FDA Approval of NEXTERONE(R) for Life-Threatening Ventricular Fibrillation and Ventricular Tachycardia

...mergent adverse effects associated with intravenous amiodarone therapy in clinical studies were hypotension, asystole/cardiac arrest/electromechanical dissociation (EMD), cardiogenic shock, congestive heart failure, bradycardia, liver function test abnormalities, ventricular tachycardia, and atrioventricular bloc...

Bruker Daltonics Showcasing Novel Proteomics Solutions Based on Mass Spectrometry at the 7th HUPO World Congress 2008

...or quantitative proteomics and to take full advantage of ultra-high performance liquid chromatography. ETD II is the next-generation electron transfer dissociation module for Bruker's HCTultra™ high capacity ion trap. It is based on a novel and compact nCI (negative chemical ionization) source with increase...

Enzyme complex could be key to new cancer treatments

...was not observed in cells that were grown in the presence of purines. In a key experiment, the researchers were able to influence the association and dissociation of the enzyme cluster by changing the cells' exposure to purines. Not all of the cells that were grown in the absence of purines contained enzyme c...

Thermo Fisher Scientific Showcases Product Innovation at PITTCON 2008

...rtfolio include: Thermo Scientific LTQ Orbitrap XL ETD and Thermo Scientific MALDI LTQ Orbitrap -- these advancements bring electron transfer dissociation (ETD)and matrix-assisted laser desorption/ionization (MALDI)capabilities to the award-winning LTQ Orbitrap(R) hybrid series of mass spectrome...

Fighting diseases of aging by wasting energy

...re associated but may not share the same mechanisms. Given the difficulty of validating strategies to increase life span in humans and the possible dissociation between aging and age-related diseases, the researchers said, identifying a simple intervention affecting several age-related diseases is an attractiv...

A Sweet Step Toward New Cancer Therapies

...n's identity or the exact type and position of sugars present. To get around that problem, researchers have used a process called electron capture dissociation (ECD) instead of the usual "shake-it-til-it breaks" method to fragment proteins. But that method requires the presence of at least two positive charge...

Elusive Step In DNA Mutation Uncovered By Researchers

...ransition state complex, and thus the required energy for this reaction step to occur, is 0.7 electron-volts (eV) – well below the energy required for dissociation of a water molecule immersed in a water environment. Obviously, without the presence of neighboring water molecules, the above reaction mechanism invo...
dissociation in Medical Technology

InNexus Lead Candidate DXL625 Outperforms Rituxan in Additional Animal Studies

...n engaging the target receptor site, resulting in greater "molecular mass" at the point of association. DXL(TM) antibodies have significantly extended dissociation rates, as measured by surface plasmon resonance. As a consequence, this may facilitate cancer cell destruction in a target dependent manner by increas...

FDA Accepts Investigational New Drug Application for ARI-2243 and a First in Man Clinical Trial Set to Begin During the First Half of 2008

...functionally selective. In vitro, kinetic studies show that ARI-2243 has an extremely high affinity (Ki of 27 picomolar) for the DPP-4 enzyme and drug dissociation from the enzyme is very slow. Such kinetics confer potency and long activity. During OGTT in normal mice, ARI- 2243 was 250 times more potent than sit...

InterMune Presents Research on ITMN-191 in Hepatitis C at Digestive Disease Week Meeting

... Reports 'Picomolar' Potency and Slow dissociation from HCV Protease WASHINGTON, May 21, 2007 /PRN...NS3/4A was stable over this same time period. Slow dissociation of ITMN-191 from the NS3/4A protease may have a re...opment. The immediate onset of inhibition and slow dissociation observed with ITMN-191 suggest that liver concentr...
dissociation in Medical Products

MGB Alert Norovirus 1 & 2 ASR*

Description:...ection Reagents provide molecular labs a more advanced alternative for real-time PCR based assays. By using our MGB technology, combined with post-PCR dissociation melt curve analysis, Nanogen is now able to provide molecular labs more powerful tools for detecting nucleic acid sequences of specific organisms or g...
Company:Nanogen, Inc.

MGB Alert HHV-6 ASR*

Description:...ection Reagents provide molecular labs a more advanced alternative for real-time PCR based assays. By using our MGB technology, combined with post-PCR dissociation melt curve analysis, Nanogen is now able to provide molecular labs more powerful tools for detecting nucleic acid sequences of specific organisms or g...
Company:Nanogen, Inc.

MGB Alert Mycoplasma pneumoniae ASR*

Description:...ection Reagents provide molecular labs a more advanced alternative for real-time PCR based assays. By using our MGB technology, combined with post-PCR dissociation melt curve analysis, Nanogen is now able to provide molecular labs more powerful tools for detecting nucleic acid sequences of specific organisms or g...
Company:Nanogen, Inc.

MGB Alert HSV 1, 2 Typer ASR*

Description:...ection Reagents provide molecular labs a more advanced alternative for real-time PCR based assays. By using our MGB technology, combined with post-PCR dissociation melt curve analysis, Nanogen is now able to provide molecular labs more powerful tools for detecting nucleic acid sequences of specific organisms or g...
Company:Nanogen, Inc.

MBG Alert HSV 1, 2 Ensemble ASR*

Description:...ection Reagents provide molecular labs a more advanced alternative for real-time PCR based assays. By using our MGB technology, combined with post-PCR dissociation melt curve analysis, Nanogen is now able to provide molecular labs more powerful tools for detecting nucleic acid sequences of specific organisms or g...
Company:Nanogen, Inc.

MGB Alert CMV ASR*

Description:...ection Reagents provide molecular labs a more advanced alternative for real-time PCR based assays. By using our MGB technology, combined with post-PCR dissociation melt curve analysis, Nanogen is now able to provide molecular labs more powerful tools for detecting nucleic acid sequences of specific organisms or g...
Company:Nanogen, Inc.

MGB Alert Chlamydia pneumoniae ASR*

Description:...ection Reagents provide molecular labs a more advanced alternative for real-time PCR based assays. By using our MGB technology, combined with post-PCR dissociation melt curve analysis, Nanogen is now able to provide molecular labs more powerful tools for detecting nucleic acid sequences of specific organisms or g...
Company:Nanogen, Inc.

MGB Alert BK Virus ASR*

Description:...ection Reagents provide molecular labs a more advanced alternative for real-time PCR based assays. By using our MGB technology, combined with post-PCR dissociation melt curve analysis, Nanogen is now able to provide molecular labs more powerful tools for detecting nucleic acid sequences of specific organisms or g...
Company:Nanogen, Inc.

ALS, Total ELISA Test

Description:...IGF-II, and this unique acid-labile subunit (ALS) [1-6]. The first description of ALS was based on the observation that acidification would result in dissociation of the 150 KDa complex into acid-stable IGF (~7.5 KDa) and IGFBP-3 (~50 KDa) components while neutralization of the acidified sample would no longer s...
Company:Diagnostic Systems Laboratories, Inc.
dissociation in Medical Dictionary

Acid

...rial Software. Community. Forums. Blogs. My Planet. Settings. Profiles ... Acids and bases: Acid -base extraction. Acid -base reaction. Acid dissociation constant ... 4.1 Polyprotic acids . 4.2 Neutralization. 4.3 Weak acid /weak base equilibria ... ... amino acids (such as cysteine and methioni...
dissociation in Biological News

Penn researchers demonstrate a new model for drug discovery with a fluorescent anesthetic

... to the study, 1-AMA increases the transmission potential of the body's main neurotransmitter inhibitor, GABA. The compound also gives an appropriate dissociation constant, Kd 0.1 mM, for binding to the general anesthetic site in horse spleen apoferritin, meaning the compound is behaving as traditional general a...

Speeding 'fingertip' discovery -- 20 years of protein info in 1 place

...onal Academy of Sciences, while a report on the database appears in the March issue of Nature Biotechnology. Pandey’s team used electron transfer dissociation (ETD) tandem mass spectrometry, a technology that breaks apart proteins into small fragments, separates them by size and identifies the fragments base...

A sweet step toward new cancer therapies

...'s identity or the exact type and position of sugars present. To get around that problem, researchers have used a process called electron capture dissociation (ECD) instead of the usual "shake-it-til-it breaks" method to fragment proteins. But that method requires the presence of at least two positive charge...

Study illuminates how the plague bacteria causes disease

...ebbins said, suggesting that the domain acted as a mimic. Further examination confirmed the domain to be a mimic of mammalian "guanidine nucleotide dissociation inhibitor" (GDI) proteins with a critical role in the bacteria's ability to disrupt cell structure. The domain paralyzes cells by acting as an "off-sw...

Face perception is modulated by sexual orientation

...ates for the assessment of potential mates for reproductive purposes. However, the researchers in fact did not find neural evidence in support of such dissociation between attractive faces of the opposite sex, reflecting reproductive benefits, and attractive faces of the same sex, reflecting aesthetic appraisal o...

New technique helps researchers determine amino-acid charge

...ften targeted by drug treatments. Previous approaches didn't provide sufficient resolution to let researchers accurately detect the association and dissociation of protons to and from individual amino-acid residues in real time. Using the patch-clamp technique, the researchers were able to probe the electro...

DNA Recombination and Repair—A New Twist to RecA Function

... hydrolysis causes the release of RecA from DNA, but the exact rate of RecA dissociation is not known. Experiments suggest, however, that RecA molecules only dissoc...r minute. But this is not what the authors found—instead they estimated the dissociation to be at a rate of 120 RecA molecules per minute. Hence, six RecA molecules...
dissociation in Biological Technology

Thermo Fisher Scientific Unveils New Laboratory Technologies at Analytica 2008

...pectrometry Thermo Scientific LTQ Orbitrap(R) XL(TM) ETD and Thermo Scientific MALDI LTQ Orbitrap -- these advancements bring electron transfer dissociation (ETD) and matrix-assisted laser desorption/ionization (MALDI) capabilities to the award-winning LTQ Orbitrap hybrid series of mass spectromet...

Stevens researchers provide new information about mass spectrometry

...thula Attygalle and his colleagues in the Center for Mass Spectrometry at Stevens Institute of Technology. According to a study, Collision-induced dissociation (CID) mass spectra of anions derived from several hydroxyphenyl carbaldehydes and ketones were recorded and mechanistically rationalized. For example,...

Barriers will not stop convergence of medical technologies

...ral venous circulation, then taking a tour through the heart and then around the systemic arterial circulation before reaching the liver, the anatomic dissociation between glucose load and glucose control is readily apparent. For a diabetic patient to achieve normal glucose levels, the distribution of insulin th...

Increased Analyte Sensitivity through the Utility of Enhanced Mass-Resolution on the FinniganTSQ Quantum Discovery

...ecule losses, [6] analogous to the transition used in this work (m/z 473456, loss of 17 u). Since small molecule losses through collisionally-induced dissociation processes are common-place and the potential for matrix interference to the analyte SRM is much greater, analysis at enhanced mass-resolution should b...

Receptor Binding Assays using Fluorescence Polarization Detection: the [FP]2TM Characterized Tracers

... G protein-coupled receptors. J. Biomol. Screen. 5:329-334. 10. Prystay, L., Gosselin, M., Banks, P. (2001). Determination of equilibrium dissociation constants in fluorescence polarization. J. Biomol. Screen. 6:141-150. 11. Owicki J.C. (2000) Fluorescence polarization and anisotropy in ...

Polymer Degradation Mechanisms Encountered in Pyrolysis-GC/MS

... or evidence from a crime scene. In general, the degradation mechanisms experienced by polymers are free-radical processes initiated by bond dissociation at the pyrolysis temperature. The specific pathway followed by a particular polymer is related to the relative strength of the polymer bonds and the s...

Efficient Primary Structure Elucidation of Disulfide-bridged Peptides

...ecutive disulfide bridges. Consequently, the basically unspecific gas-phase dissociation of the disulfide-linked peptides by tandem mass spectrometry is an attracti...ttern was based on observation of characteristic fragment ions generated by dissociation of the peptidic bonds adjacent to the cysteines, as illustrated in Figure 3...

Laser Capture Microdissection (LCM) and Expression Profiling of Long-Range Projection Neurons

...accumulate outside the nucleus of the cell body, where the pools of mRNA of interest are located. This approach eliminates the need for lengthy tissue dissociation and related steps needed for cell sorting, thus helping to preserve the original, in vivo profile of mRNA expression. The in vivo labeling approach al...

Detection of Variation in Highly Polymorphic Mhc Genes by Denaturing Gradient Gel Electrophoresis Using the DCode System

...t and a 2 codon indel on a perpendicular gradient gel (Figure 1). dissociation of A1 alleles occurred over a 3654% gradient. The presence of thr...he DNA fragments between 48% and 53% denaturant, a range in which dissociation of the A1 low melting domain was completed and the high melting d...

Hands-free Tissue Disruption No Homogenization Needed

...d by mechanical methods using either a polytron or by grinding the tissue with a mortar and pestle. Physical dissociation of tissue, however, is cumbersome; low-throughput requires cleaning of equipment between samples, and is pot...
dissociation in Biological Products

GIBCO Cell Dissociation Buffer enzyme free PBS-based from Invitrogen

Description: Cell Dissociation Buffers are membrane-filtered isotonic and enzyme-free aqueous formulations of salts chelating agents and cell-conditioning agents in either Ca2+- and Mg2+-free Hanks' balanced salt solution or Ca2+- and Mg2+-free phosphate-buffered saline for gentle dissociation of mammalian cel...
Company:Invitrogen

GIBCO Cell Dissociation Buffer enzyme free Hanks'-based from Invitrogen

Description: Cell Dissociation Buffers are membrane-filtered isotonic and enzyme-free aqueous formulations of salts chelating agents and cell-conditioning agents in either Ca2+- and Mg2+-free Hanks' balanced salt solution or Ca2+- and Mg2+-free phosphate-buffered saline for gentle dissociation of mammalian cel...
Company:Invitrogen

Chicken Anti-Rab GDP dissociation inhibitor beta Polyclonal Antibody, Unconjugated from GenWay Biotech, Inc.

Description: Rab GDP dissociation inhibitor beta...
Company:GenWay Biotech, Inc.

Mouse Anti-PRKAR2 Monoclonal Antibody, Unconjugated, Clone RS17 from GeneTex

Description:...ion of different target proteins. The inactive holoenzyme of AMPK is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory...
Company:GeneTex

Rabbit Anti-Human PHAS-II Polyclonal Antibody, Unconjugated from Lab Vision

Description:...IF-4E, the mRNA cap-binding protein, and inhibit translation of capped mRNA in vitro and in cells. Phosphorylation in the appropriate site(s) promotes dissociation of PHAS/eIF-4E complexes. This allows eIF-4E to bind to eIF-4G (p220), thereby increasing the amount of the eIF-4F complex and the rate of translation...
Company:Lab Vision

LTQ XL with ETD from Thermo Scientific

Description:...ermo Scientific's LTQ XL is the only mass spectrometer that offers multiple dissociation techniques, PQD, ETD and CID. Pulsed Q Collision Induced dissociation (PQD) is a patented technique that eliminates the low mass cut-off concern ...
Company:Thermo Scientific

LTQ XL Linear Ion Trap from Thermo Scientific

Description:...mics and metabolism applications. Multiple dissociation techniques (PQD, ETD, CID) Extensive coverage ...rmation include: Pulsed Q Collision Induced dissociation (PQD) Electron Transfer dissociation (ETD) Option High Resolution Isolation Ult...
Company:Thermo Scientific
dissociation in Biological Definition

Actin

...g to more ATP-actin units. This rapid turnover is important for the cells movement. The protein cofilin binds to ADP-actin units and promotes their dissociation from the minus end and prevents their reassembly. The protein profilin reverses this effect by stimulating the exchange of bound ADP for ATP. In addi...

DNA

...echanical properties relevant to biology 6.1 Strands association and dissociation 6.2 Circular DNA 6.3 Great length versus tiny breadth 6.4 Differen... Mechanical properties relevant to biology Strands association and dissociation The hydrogen bonds between the strands of the double helix are weak enoug...

Michaelis-Menten kinetics

...aelis-Menten constant ( K M ) a.k.a. Michaelis constant . This represents (for enzyme reactions exhibiting simple Michaelis-Menten kinetics) the dissociation constant ( affinity for substrate ) of the enzyme - substrate (ES) complex. Low values indicate that the ES complex is held together very tightly...

Actin

...g to more ATP-actin units. This rapid turnover is important for the cells movement. The protein cofilin binds to ADP-actin units and promotes their dissociation from the minus end and prevents their reassembly. The protein profilin reverses this effect by stimulating the exchange of bound ADP for ATP. In addi...
dissociation in Biological Dictionary

Streptavidin

...fied from the bacterium Streptomyces avidinii. It finds wide use in molecular biology through its extraordinarily strong affinity for biotin ; the dissociation constant (Kd) of the biotin- streptavidin complex is on... streptavidin A protein found in Streptomyces griseus which has a high affinity for ...

Hydrolysis

...It is the type of reaction that is used to break down... hydrolysis n. Decomposition of a chemical compound by reaction with water, such as the dissociation of a dissolved salt or the catalytic conversion Hydrolysis constant This article is an orphan , as few or no other ... generalized form, the hyd...

Dorsal

...imore, MD, at Citysearch - over 1 million user reviews & editorials about local businesses. ... family transcription factor Dorsal , a ... dissociation of Dorsal from its ... diminishing concentrations towards the dorsal side of the. embryo (Gay ... ...

C-terminus

...luciferase,SKL; ... UOX has SRL, CAT has ANL, and DAOX has SHL at the C-terminus . ... C-terminus , we have further characterized the binding and dissociation of the ... illustrate that the C-terminus provides a significant entropic contribution to ... entropy of binding.pdf' target='_blank'>Full article...

Branch migration

... migration is carried out in prokaryotic cells by the RuvAB motor complex. ... Branch migration to the distal end results in irreversible dissociation of the ... Figure 2 Population-averaged branch migration assay. ... The EMBO Journal is a science journal containing review articles and resear...

Band shift assay

...ift Assay Protocol - The procedure described in this chapter for the ... dissociation constants by band - shift assay refers to an ideal antibody fragment ...bed in this chapter for the determination of affinity constants and kinetic dissociation constants by band - shift assay refers to an ideal ... The gel sh...

Allosteric site

...bind to the allosteric site , but inhibition of ATCase by UTP is possible ... Equation: One site with allosteric modulator. Introduction ... dissociation constant (Molar) of modulator binding to its allosteric site . ... ...
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