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Difficile in Medical News

ViroPharma Announces Initiation Of Non-Toxigenic Clostridium Difficile Phase 1 Program

EXTON, Pa., Aug. 6 /PRNewswire-FirstCall/ -- ViroPharma Incorporated (Nasdaq: VPHM ) today announced that dosing has begun in the Phase 1 clinical trial for NTCD (non-toxigenic Clostridium difficile ), a novel treatment approach for preventing recurrent Clostridium difficile infections (...

Cepheid Receives FDA Clearance for First On-Demand Molecular Diagnostic Test for Clostridium difficile Infection

SUNNYVALE, Calif., July 13 /PRNewswire-FirstCall/ -- Cepheid (Nasdaq: CPHD ) today announced it has received clearance from the U.S. Food & Drug Administration (FDA) to market its Xpert(R) C. difficile test, an on-demand molecular diagnostic test designed for 45-minute detection of the bac...

Transmission of MRSA and Clostridium difficile through dogs

London, UK, 7 May 2009 In a letter to the Editor of the Journal of Hospital Infection ( http://www.elsevier.com/locate/jhin ), published by Elsevier, S. Lefebvre and J.S. Weese from the University of Guelph in Canada describe a study that investigated whether MRSA and C.difficile could be pas...

Clostridium difficile Infection in Primary Care: Tackling a Virulent Pathogen

Complimentary Continuing Education Virtual Lecture for Healthcare Professionals VOORHEES, N.J., March 23 /PRNewswire/ -- The epidemiology of Clostridium difficile infection (CDI) is changing rapidly and has been marked by a significant increase in incidence and severity. Management of CDI c...

Clostridium difficile Infection: Best Strategies for Care of Older Adults

Complimentary Continuing Education Monograph for Registered Nurses and Nurse Practitioners VOORHEES, N.J., Jan. 27 /PRNewswire/ -- Over the past several years, the incidence and mortality rates of Clostridium difficile infection (CDI) have increased dramatically. CDI is a serious condition,...

Clostridium difficile Infection in Long-Term Care: Tailored Approaches to Management

A Complimentary Continuing Education Virtual Lecture for Healthcare Professionals VOORHEES, N.J., Jan. 19 /PRNewswire/ -- Clostridium difficile infection (CDI) is increasingly being seen in older adults, especially among residents of long-term care facilities (LTCFs). This is further compli...

BD Announces FDA 510(k) Clearance of Novel Molecular Assay to Diagnose Clostridium difficile Infections

SAN DIEGO, Jan. 12 /PRNewswire-FirstCall/ -- BD Diagnostics, a segment of BD (Becton, Dickinson and Company) (NYSE: BDX ), announced today it has received clearance from the U.S. Food and Drug Administration to market the BD GeneOhm(TM) Cdiff molecular assay for the rapid detection of the To...

Current Concepts in Clostridium difficile Infection: A Focus on Geriatric and Pediatric Patients

A Complimentary Continuing Medical Education Newsletter Series for Physicians VOORHEES, N.J., Dec. 17 /PRNewswire/ -- Management of Clostridium difficile infection (CDI) in geriatric and pediatric populations can be challenging and complicated. Because of the observed increase in CDI...

MRSA and C. difficile Infections Reduced by 50% in Hospital Study

ROME, N.Y., Dec. 1 /PRNewswire/ -- To help prevent the spread of germs and protect its patients from infections, Rome Memorial Hospital is using two new products that kill germs on hands and surfaces between cleanings. According to Infection Prevention Director LeAnna Grace, the hospital c...

Cepheid Launches First On-Demand Molecular Diagnostic Test for Clostridium Difficile Into European Market

Test Simultaneously Identifies and Differentiates More Virulent 027 Strain from Common Strains SUNNYVALE, Calif., Nov. 10 /PRNewswire-FirstCall/ -- Cepheid (Nasdaq: CPHD) today announced the release of Xpert(TM) C. difficile as a European CE IVD Mark product under the E...
Difficile in Medical Technology

Optimer Pharmaceuticals Presents Results From Fidaxomicin Phase 3 Study for the Treatment of Clostridium difficile Infection

Positive data from subgroup analysis presented at 19th annual European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) meeting in Helsinki , Finland SAN DIEGO, May 17 /PRNewswire-FirstCall/ -- Optimer Pharmaceuticals, Inc. (Nasdaq: OPTR ) announced that the results fr...

BD Announces CE Marking of a New Molecular Test to Diagnose Patients with Clostridium difficile Infections

BD GeneOhm(TM) Cdiff Assay Submitted for FDA Clearance SAN DIEGO, July 7 /PRNewswire-FirstCall/ -- BD Diagnostics, a segment of BD (Becton, Dickinson and Company) (NYSE: BDX ), announced today the CE marking of the BD GeneOhm(TM) Cdiff molecular assay for the rapid diagnosis of patie...

Current Concepts in Clostridium difficile Infection: A Focus on Recurrent Disease

A Complimentary Continuing Education Newsletter Series for Healthcare Professionals VOORHEES, N.J., July 1 /PRNewswire/ -- Clostridium difficile infection (CDI) is a serious condition that causes disease with a wide spectrum of severity, ranging from mild diarrhea ...

APIC Launches 'Targeting Zero' Initiative to Eradicate C. Difficile and Infections Deemed Preventable By CMS

Campaign will Arm Infection Prevention Professionals With Guidelines and Tools WASHINGTON, Dec. 18 /PRNewswire-USNewswire/ -- The Association for Professionals in Infection Control and Epidemiology (APIC) today announced a series of new educational initiatives aimed at eliminati...

Oritavancin Demonstrates Superior In Vitro Activity to Vancomycin and Metronidazole Against C. Difficile Bacteria

Novel Antibiotic Candidate Rapidly Bactericidal Against Both Cultures and Spores of the Anaerobic Bacterium Using Multiple in Vitro Methods CHICAGO, Sept. 19 /PRNewswire/ -- Targanta Therapeutics Corporation today released data from two studies comparing the in vitro activity of its lead anti...

Sanofi Pasteur Starts a Phase II Study of a Vaccine Against Clostridium Difficile

LYON, France, February 17 /PRNewswire-FirstCall/ -- Sanofi Pasteur, the vaccines division of sanofi-aventis Group (EURONEXT : SAN and NYSE : SNY), announced today that it is sponsoring a phase II clinical study of a vaccine against Clostridium difficile, which is among the most common causes o...

Replidyne's Investigational Antibacterial Agent REP3123 Prevents Toxin Production in Clostridium difficile

Poster to be Presented at the 47th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy LOUISVILLE, Colo., Sept. 19 /PRNewswire-FirstCall/ -- Replidyne, Inc. (Nasdaq: RDYN ) announced today that in preclinical studies, its antibacterial candidate REP3123 i...

Replidyne's Investigational Antibacterial Agent REP3123 Prevents Sporulation in Clostridium difficile

Poster to be Presented at the 47th Annual Interscience Conference on Antimicrobial Agents and Chemotherapy LOUISVILLE, Colo., Sept. 19 /PRNewswire-FirstCall/ -- Replidyne, Inc. (Nasdaq: RDYN ) announced today that in preclinical studies, its antibacterial candidate REP3123 i...

Genzyme Announces Data from First Phase 3 Study of Tolevamer in Patients with C. difficile Associated Diarrhea

CAMBRIDGE, Mass., July 06, 2007 /PRNewswire-FirstCall/ -- Genzyme Corp. announced top-line data today from the first of two Phase 3 clinical studies to assess the safety and efficacy of tolevamer liquid, an investigational, non-antibiotic, polymer therapy for patients with Clostridium difficile as...

Awardees for the 2009 Young Investigator Grant for Probiotics Research Announced

...Virginia was selected for her research proposal, "The Influence of Novel Oligopeptides Produced by Transgenic Bacteria on Intestinal Injury Due to C. difficile Infection." After certain inflammatory conditions, drug treatments, or infections, human gut microbiota can become unbalanced. This research will foc...
Difficile in Medical Products

Clostridium difficile Toxins (A & B) by EIA

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

Clostridium difficile Culture

Description: ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' client...
Company:ARUP Laboratories

C. Difficile Tox A/B II

Description: The C. Difficile Tox A/B II is a second-generation rapid ELISA for the detection of Clostridium difficile toxins A and B in fecal specimens. The test utilizes highly specific antibodies and produces highly sensitive results detecting not only the more common toxin A+ samples, but also samples that ...
Company:Inverness Medical Innovations

Xpect Clostridium difficile Toxin A/B Test Kit

Description: Remels newest member of the Xpect family, Xpect C. difficile Toxin A/B, detects both Toxin A and B in one rapid test. The simple-to-perform test requires no sample preparation, and results are available in 20 minutes. The Remel Xpect family of rapid diagnostic test kits includes a wide range ...
Company:Remel Inc.

Triage® C. difficile Panel

Description: The Triage® C. difficile Panel is an enzyme immunoassay used for the detection of C. difficile common antigen (glutamate dehydrogenase) and toxin A in human fecal specimens. This test is used as an aid in the diagnosis of C. difficile associated disease and is part of the Triage Microbiology pr...
Company:Biosite

Bartels® C. Difficile Toxin A Antigen EIA with Controls

Description: Bartels Clostridium difficile Toxin A Enzyme Immunoassay (EIA) is intended for the qualitative detection of Clostridium difficile Toxin A in human faecal specimens as an aid in the diagnosis of Clostridium difficile-associated disease....
Company:Trinity Biotech

VIDAS Clostridium difficile (Toxin A) assay

Description: VIDAS tests are presented in individual, ready to use form. Each test is composed of a strip and a SPR. The strip contains all the reagent required for the reaction (buffer, conjugate and substrate.) The SPR (Solid Phase Receptacle) is a plastic pippette-like device. Its inside surface is coated...
Company:bioMerieux, Inc.

BD ColorPAC Toxin A C. difficile Rapid Toxin A Test

Description: BD ColorPAC Toxin A C. difficile Rapid Toxin A Test gives your laboratory clear-cut results in as little as 10 minutes. When it might be C. difficile, you can't afford to wait. For any laboratory that performs only a few tests a day or sends out its suspected C. difficile samples for testing, Color...
Company:BD Diagnostic Systems

Premier C. difficile Toxin A

Description: ELISA for the detection of C. difficile toxin A in stool specimens...
Company:Meridian Bioscience, Inc.

Clostridium Difficile Toxin A RAPYDTEST®

Description: Clostridium difficile Toxin A Rapydtest® is a fast, simple and highly sensitive test for the rapid and reliable detection of C. difficile Toxins A in faeces....
Company:DiaSys Corporation

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Difficile in Medical Dictionary

Toxins

...h is needed to link ... ... VA) (Quik Chek), and ImmunoCard Toxins A&B (Meridian Bioscience, Cincinnati, OH) (ImmunoCard) ... of Clostridium difficile toxin : comparison of enzyme ... High-flux hemodialysis (which removes large toxins ) reduces the risk of premature death in many patients w...

Infectious Diseases

.... for Infectious Disease Research And ... Emerging and Re-emerging Infectious Diseases ... Covers infectious diseases (such as Clostridium difficile and MRSA) ... From the publishers of The New England Journal of Medicine. Keeps clinicians up-to-date on the most important research impacting in...

Enterotoxin

...xins ( enterotoxin /neurotoxin/hemoto xin/cardiotoxin) Bacterial toxins. Exotoxin. Gram positive ... · perfringens (Alpha toxin, Enterotoxin ) · difficile (A, B) ... Definition of enterotoxin from the Merriam-Webster Online Dictionary with audio pronunciations, thesaurus, Word of the Day, and word ...

Cramps

...ons, but the cramps are really bothering her. ... What is Clostridium difficile colitis?Clostridium difficile (also called C. difficile) are bacteria that can cause ... diarrhea, feve...

Clostridium

...idium , such as the Explains how Clostridium difficile bacteria cause colitis and why patients may su...ne and antibiotic ... What is Clostridium difficile (C. difficile)? What are C. difficile diseases? ... SHEA Position Paper: Clostridium ...
Difficile in Biological News

C. difficile spores spread superbug

New research suggests that antibiotic treatment could be asymptomatically inducing the transmission of the healthcare-acquired infection, C. difficile , contributing to the outbreaks that have recently been widely reported in hospitals and other settings. A team of scientists have successfully mi...

Mass Biologic Labs/UMass Med School and Medarex license C. difficile monoclonal antibody to Merck

WHITEHOUSE STATION N.J., PRINCETON, N.J. and JAMAICA PLAIN, Mass., April 21, 2009 Merck & Co., Inc., (through an affiliate), Medarex, Inc. (NASDAQ: MEDX) and Massachusetts Biologic Laboratories (MBL) of the University of Massachusetts Medical School (UMMS) today announced that they have signed an...

Understanding why C. difficile causes disease -- it's hungry

Researchers studying the genetics behind why C. difficile causes disease have come to a simple conclusion -- the bacteria do it because they are starving. That just might help them find a new treatment for what can sometimes be a very difficult disease to treat. "The genes responsible for toxin...

Reminding doctors which antibiotics to prescribe cuts C. difficile infection rates

A study published today in the Journal of Antimicrobial Chemotherapy1 provides the best available evidence that cases of Clostridium difficile infection (CDI)---one of the most common and increasing types of hospital-acquired infection---can be reduced in hospital wards if doctors prescribe narrow-...

Antibiotics take toll on beneficial microbes in gut

...d 500,000 to 1 million Americans, and Clostridium difficile , a growing and serious infection problem for hosp...fractory antibiotic-associated diarrhea due to C. difficile , there have been limited trials of treatments usi... to gain insights into colitis associated with C. difficile infection. The Young laboratory recently publishe...

Newly discovered reactions from an old drug may lead to new antibiotics

... can halt the growth of the super bug Clostridium difficile and Treponema denticola , a major contributor to gum disease. Infections of Clostridium difficile (commonly known as C-diff) lead to a spectrum of ...h of the bacteria. The initial studies with C. difficile led to studies with T. denticola, known for severa...

Monash scientists debug superbug

...s to genetically modify the bacterium Clostridium difficile and solved the mystery surrounding its toxicity. ...an a decade. Dr Lyras said strains of Clostridium difficile are found in almost every hospital in Australia. ... that in the US, more people die from Clostridium difficile infections than all other intestinal infections c...

Scientists unlock the secrets of C. difficile's protective shell

... 'jacket' that surrounds cells of the Clostridium difficile superbug, and which helps the dangerous pathogen ...reveal possible targets for new drugs to treat C. difficile infections. The 'jacket' is a surface layer, o...ns, with half a million of each covering every C. difficile cell. The S-layer is believed to help C....

Positive results in Phase 2 trial of treatment of C-difficile-associated diarrhea

...oday announced that a Phase 2 trial of an anti- C. difficile antibody combination treatment in patients with C. difficile Associated Diarrhea (CDAD) successfully met its p...1), two fully human antibodies that neutralize C. difficile toxins A and B, respectively. Consistent with ...

UV lotion lights the way to cleaner facilities

...ow that spores from the nasty bacteria Clostridium difficile (C. difficile) linger in the loo even when it has ...llin resistant Staphylococcus aureus (MRSA) and C. difficile because they are not eradicated from the hospital ...spital in Winnipeg. Seven of these patients had C. difficile infection, while 13 others did not. The toilets an...
Difficile in Biological Technology

BioNeutral's Ygiene(TM) Hospital Grade Achieves a 100% Total Kill (Pass) Against the Life Threatening Clostridium Difficile (C.diff) Spores in Independent EPA Required Protocol Testing.

NEWARK, N.J., July 21 /PRNewswire-FirstCall/ -- BioNeutral Group, Inc. ("BioNeutral") (OTC Bulletin Board: BONU), a specialty chemical technology based Life Science Company announced today that at ATS Labs using the required EPA protocol testing, BioNeutral's Ygiene(TM) Hospital Grade Antimic...

BioNeutral's Ygiene(TM) Hospital Grade Antimicrobial Demonstrates a 99.9997% Kill Rate Against Clostridium Difficile Spores (C.diff) in Independent Lab Pre-testing Phase

NEWARK, N.J., July 9 /PRNewswire-FirstCall/ -- BioNeutral Group, Inc. ("BioNeutral") (OTC Bulletin Board: BONU), a chemical technology-based Life Science company announced today that at ATS Labs, using a Quantitative Disk Carrier test starting with 5.5 million Clostridium Difficile (C.diff) spores...

Clostridium difficile Infection: Strategic Approaches for Better Outcomes

Complimentary Continuing Education Live Lectures for Healthcare Professionals VOORHEES, N.J., June 15 /PRNewswire/ -- In recent years, the epidemiology of Clostridium difficile infection (CDI) has been changing. This trend may be the result of antimicrobial use, infection control practices,...

Clostridium difficile Infection: Current Challenges and Controversies

Complimentary Continuing Education Virtual Lecture and Podcast for Healthcare Professionals VOORHEES, N.J., Jan. 20 /PRNewswire/ -- Current education about Clostridium difficile infection (CDI) is critical for several reasons. The epidemiology of CDI is changing and has been marked by incre...

Medarex and Massachusetts Biologic Laboratories Announce Primary Objective Achieved in Phase 2 Trial of Monoclonal Antibody Combination for the Treatment of Clostridium difficile Associated Diarrhea (CDAD)

Top-line data from randomized, double-blind, placebo controlled Phase 2 clinical trial indicate statistically significant reduction in recurrences of CDAD PRINCETON, N.J. and JAMAICA PLAIN, Mass., Nov. 3 /PRNewswire-FirstCall/ -- Medarex, Inc. (Nasdaq: MEDX ) a...

Optimer Pharmaceuticals Reports Second Quarter 2009 Financial Results

...omicin North American Phase 3 clinical study for patients with Clostridium difficile infection at the European Congress of Clinical Microbiology and Infectious...herapy currently in Phase 3 worldwide clinical development for Clostridium difficile infection. Prulifloxacin is an antibiotic which has completed two Phase 3...

Optimer Pharmaceuticals to Present at the Canaccord Adams 29th Annual Global Growth Conference

...evelopment. Fidaxomicin, formerly known as OPT-80, is the only antibiotic therapy currently in Phase 3 worldwide clinical development for Clostridium difficile infection. Prulifloxacin is an antibiotic which has completed two Phase 3 clinical trials for the treatment of travelers' diarrhea, a form of infect...

BioNeutral's Ygiene(TM) Hospital Grade Achieves World Class Independent Test Results in Killing Life Threatening Spores/Organisms

...e and important applications of Ygiene(TM) come to mind: 1- Perhaps the biggest challenge facing hospitals worldwide is eradication of Clostridium difficile spores in the environment in a timely fashion thereby reducing or eliminating possible nosocomial spread. Ygiene(TM) safely and efficiently solves th...

Celtic Pharma Holdings Announces Investment in Novacta Biosystems Limited

...f the platform technology and more recently the C. difficile programme. New anti-infective drugs are needed to target C. difficile without depleting other beneficial bacteria in the...at Novacta's lead lantibiotics selectively kill C. difficile with less disturbance of normal gut bacteria than ...

Optimer Pharmaceuticals to Present at June 2009 Investor Conferences

...evelopment. Fidaxomicin, formerly known as OPT-80, is the only antibiotic therapy currently in Phase 3 worldwide clinical development for Clostridium difficile infection. Prulifloxacin is an antibiotic which has completed two Phase 3 clinical trials for the treatment of travelers' diarrhea, a form of infect...
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