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determinant in Medical News

Menthol Receptor-A Thermosensitivity Determinant in Cold Temperature

According to a study in Nature by Yale School of Medicine, the University of California at San Francisco (UCSF), and the University of Wisconsin, the menthol receptor detects a wide range of cold temperatures and relays the information to the brain. The finding solves the mystery of how impo...

DNA- A Dependable Determinant to Select Treatment Plan for Alcoholics

Wendy Ooteman a Dutch researcher has stumbled upon some very interesting results following her study in pursuit of understanding// the biological and genetic characteristics of alcoholics, which ultimately determine which drugs can be used to curb the irresistible urge to drink. The urge to ...

Residential Locality, A New Determinant Factor For Weight Gain

The results of an Australian study has found that the residential locality of an individual can play a major role in determining the weight of an individual. In a survey conducted among residents of Melbourne, // people living in relatively underdeveloped areas were found to weigh 3 kg or more than...

Kansas Delegation: GAO Report Short on Expertise, Long on Errors; NBAF Critical to Protect Nation's Food Supply

...h corridor and the Biosecurity Research Institute, was ranked as meeting or exceeding all of the criteria related to existing research. This was a key determinant in the selection process. For GAO to work on this report for months and still not get this important fact right calls into question its entire report....

Ethicon Endo-Surgery Holds Metabolic Surgery Scientific Forum Featuring Research By Top Scientists

...ximal bowel may contribute to the pathophysiology of type 2 diabetes. He raised the question if BMI alone in Type 2 diabetes patients should not be a determinant for who has access to metabolic surgery, as BMI may not enable consideration of other critical patient specific health factors (e.g., uncontrolled/poo...

Mathematical modeling predicts response to Herceptin

...second messengers. Researchers worked with 122 breast cancers treated with Herceptin and found that quantitative PTEN protein expression was a key determinant of who would be resistant or sensitive to Herceptin. Furthermore, using the mathematical modeling techniques, the absence of PTEN was more predict...

AstraZeneca Studies Show Relief of Nighttime Heartburn and Reduction in GERD-Related Sleep Disturbances

... INR and prothrombin time. Like other proton pump inhibitors, esomeprazole may interfere with the absorption of drugs where gastric pH is an important determinant of bioavailability (e.g., ketoconazole, iron salts, and digoxin). Concomitant use of NEXIUM and atazanavir or nelfinavir is not recommended becau...

New study finds continued abstinence is key to increased survival from alcohol-related liver disease

... do not exist in many parts of the UK. "This study clearly confirms the common sense knowledge amongst hepatologists that the single most important determinant of long-term prognosis in alcohol-induced cirrhosis is for the patient to stop drinking. "At the most simplistic level the successful management o...

Too Much Red Meat May Shorten Life Span

...dings as "provocative." "The question is how much of it is the meat and how much is the extra calories," Brooks said. "Calories per se are a strong determinant for death from cancer and heart disease. This should make us think about our calorie intake." More information The American Dietetic Associat...

Too Much Red Meat May Shorten Lifespan

...dings as "provocative." "The question is how much of it is the meat and how much is the extra calories," Brooks said. "Calories per se are a strong determinant for death from cancer and heart disease. This should make us think about our calorie intake." More information The American Dietetic Associat...
determinant in Medical Technology

AstraZeneca Submits NDA for Low Dose Aspirin/Esomeprazole Combination Product

... INR and prothrombin time. Like other proton pump inhibitors, esomeprazole may interfere with the absorption of drugs where gastric pH is an important determinant of bioavailability (e.g., ketoconazole, iron salts, and digoxin). Concomitant use of NEXIUM and atazanavir or nelfinavir is not recommended beca...

Key Protein May Lead to Faster Acting Anti-Depression Drugs

... by current drugs. This study, Role of p11 in Cellular and Behavior Effects of 5-HT4 Receptor Stimulation , solidifies the protein p11 as a key determinant of vulnerability to depression. This new research shows that p11 activates a serotonin receptor in the brain known for producing rapid antidepressant...

When to Have That Joint Replacement?

...c groups. "Studies have shown that the timing of joint replacement surgery ( http://orthoinfo.aaos.org/topic.cfm?topic=A00220 ) is an important determinant of outcome," says James Slover, M.D., M.S., an orthopaedic surgeon at New York University Hospital for Joint Diseases. "This means that patients wit...

Studies Examine Quality of Care for Hospitalized Sickle Cell Disease Patients and Effective Methods for Detecting Risk of Stroke in Children With This Disorder

...d overt stroke, six with other neurological events, and one who had an indeterminate event. Daytime Steady-State Hemoglobin Saturation Is a determinant of Cerebral Artery Blood Flow Velocity in Children With Sickle Cell Anemia [Abstract #1424] Charles T. Quinn, MD, MS, The University o...

AstraZeneca Submits sNDA for NEXIUM(R) I.V. for Peptic Ulcer Bleed Indication

... INR and prothrombin time. Like other proton pump inhibitors, esomeprazole may interfere with the absorption of drugs where gastric pH is an important determinant of bioavailability (e.g., ketoconazole, iron salts, and digoxin). Concomitant administration of esomeprazole may reduce the plasma levels of atazanavi...

Novel Small Molecule Therapy Shows Benefit for Anemic Patients Via Hydration of Red Blood Cells

...gests that dehydration of the RBCs is one of the key contributors to the deformed shape and affects the levels of circulating hemoglobin, an important determinant of oxygen delivery throughout the body. The dehydration appears to result from loss of potassium via two pathways, one of which is known as the Gardos...

Bone Mineral Content Continues to Increase in Obese Adolescents During Weight Loss

.... "Although fractures due to low bone mineral content are mainly a problem for the elderly, the amount of bone mass acquired during puberty is the key determinant of lifetime fracture risk." Using a dual energy X-ray absorptiometry scanner (DXA), researchers looked at specific body areas including legs, arms...

Gastric Banding Reverses Impact of Type 2 Diabetes

...ly linked and combine to present one of the greatest public health problems facing our community. "We found that the amount of weight loss was a key determinant of effectiveness. Most of those losing ten per cent of their total weight had remission of the diabetes. Few who lost less did so." Dr Dixon said th...

Raptor Pharmaceuticals Provides Update of Product Programs

...d to brain. In osteoporosis, Raptor is testing the ability of WntTide, which are Mesd and engineered Mesd-based peptides and act through LRP5, a known determinant of bone density, to combat osteoporosis and increase bone density. In an effort to protect its novel approach, Raptor currently has five patent applic...

Lorus Therapeutics Announces Scientific Presentations for Lead Antisense and siRNA Drug Candidates at International Cancer Conference

...ts the R2 component of ribonucleotide reductase, which is required for DNA synthesis and cell proliferation. R2 has also been described as a malignant determinant that is elevated in a wide range of tumors, and through down regulation can cooperate with a variety of cellular cancer causing genes known as oncogen...
determinant in Medical Products

Human Myoglobin Enzyme Immunoassay

Description:...ciple of a solid phase enzyme-linked immunosorbent assay. The assay system utilizes a unique monoclonal antibody directed against a distinct antigenic determinant on the myoglobin molecule. Mouse monoclonal anti-myoglobin antibody is used for solid phase immobilization (on the microtiter wells). A goat anti-myog...
Company:Diagnostic Automation, Inc.

SphygmoCor Px Central Blood Pressure Assessment and Management System

Features:...systolic from primarily diastolic dysfunction, and for managing the efficacy of heart failure therapy. Diastolic pressure-time index (DPTI), a key determinant of coronary blood supply. Systolic pressure-time index (SPTI), a measure of myocardial oxygen demand. Subendocardial Viability Ratio the rela...
Company:AtCor Medical Pty Ltd.
determinant in Medical Definition

Depolarization-induced suppression of inhibition

...ience.137(1):337-61. Ohno-Shosaku T, Tsubokawa H, Mizushima I, Yoneda N, Zimmer A, Kano M. (2002) Presynaptic cannabinoid sensitivity is a major determinant of depolarization-induced retrograde suppression at hippocampal synapses. J Neurosci. May 15;22(10):3864-72. Ohno-Shosaku T, Maejima T, Kano M. ...
determinant in Medical Dictionary

Melanin

...sunscreen" and does not ... Broadly, melanin is any of the polyacetylene, polyaniline, and polypyrrole " ... Melanin is the primary determinant of human skin color. ... Melanin - Definition of Melanin at Dictionary.com a free online dictionary with ... Get Twice the Tan, in Half the ...

Lipoprotein

...ow density lipoprotein cholesterol level ... ... Between Lipoprotein Metabolism, Autoimmune ... Plasma lipoprotein levels are an important determinant of atherosclerosis, the ... Lipoprotein Assays ... Biochemical and lipoprotein laboratory tests for efficacy outcomes were obtained ... atorva...

Lipofuscin

...... ... between autofluorescence patterns ( lipofuscin accumulations) and clinical age ... Conversely, lipofuscin does not appear to be a major determinant of choroidal ... Lipofuscin is a brownish pigment left over from the breakdown and absorption of ... Lipofuscin is found in heart muscl...

Immunoglobulin

...Assay for Serologic Confirmation of Early Lyme Disease: ... Immunoglobulin allotypes (Gm and Km) and their interactions with HLA antigens in ... determinant formed by both immunoglobulin constant and variable regions. ... Patient handout discusses the symptoms, causes, diagnosis, and treatment. ... ...

Chromosome

...rs embryonic ... They found that human Y chromosome is able to "recombine" with itself, using ... on the Y chromosome , the defining biological determinant that makes males male. ... The Y chromosome long has been the whipping post for all stereotypical male ... The human genome is said by some to...
determinant in Biological News

Iron isotopes as a tool in oceanography

...uld rapidly accelerate. The natural supply of iron to such 'High Nutrient Low Chlorophyll (HNLC) regions is therefore, albeit indirectly, an important determinant of climate. The importance of dissolved iron in seawater derived from bottom (benthic) sediments is increasingly recognised as being important. Ar...

Trading energy for safety, bees extend legs to stay stable in wind

...fect laminar flows. Our work shows clearly that the effect of environmental turbulence on flight stability is an important and previously unrecognized determinant of flight performance." Together with Robert Dudley of the University of California, Berkeley, and the Smithsonian Tropical Research Institute, Com...

International Serious Adverse Events Consortium announces initial study results in its global research collaboration to identify genetic markers related to drug induced liver injury

...aper published on May 31, the SAEC and Newcastle University's analysis of a subset of DNA patients has led to the discovery that HLA-B*5701 is a major determinant of liver injury induced by flucloxacillin. Flucloxacillin is an antibiotic widely used in Europe and Australia, mainly in the treatment of staphyloco...

NASA uses satellite to unearth innovation in crop forecasting

...g satellite data to deliver a kind of space-based humanitarian assistance. They are cultivating the most accurate estimates of soil moisture the main determinant of crop yield changes and improving global forecasts of how well food will grow at a time when the world is confronting shortages. During a prese...

CSHL team develops mouse models of leukemia that predict response to chemotherapy

... progresses. Their study traces the intracellular network controlled by the p53 gene, a linchpin of the cell's anti-tumor defense response, as the key determinant of AML's aggressiveness and response to therapy. Most patients with AML receive the same standardized treatment an initial phase of intense chemo...

Healthy food availability could depend on where you live -- so does the quality of your diet

...d Benjamin Caballero, MD, PhD, professor at the Bloomberg School's Department of International Health. Our studies show that where you live is a major determinant of your health. The joint efforts of public health researchers in collaboration with community groups and policymakers will be required to effectively...

Understanding how oxidative stress impairs endothelial progenitor cell function

...Antioxidants & Redox Signaling that a review of the scientific literature reveals that how EPCs respond to oxidantive stress appears to be a critical determinant in maintaining a healthy cardiovascular system. A comprehensive understanding of how oxidantive stress, the biochemical modification of cells, imp...

New CU-Boulder study shows diversity decreases chances of parasitic disease

... raised together, the toad tadpoles were once again buffered from the parasites by the "dilution effect" provided by tree frogs. "Thus, the important determinant of parasite transmission was not total host diversity but the specific composition of the host community," wrote the authors. The trematode has a c...

Athletes' 'sweat and tears' linked to asthma

...e airways. As a result, individuals who sweat less also have drier airways. "It now appears that how much fluid your airways secrete could be a key determinant in protecting you from exercise-induced asthma," he said. "So, if athletes sweat, drool, or cry, at least they won't gasp." "Exercise-induced asthm...

Obesity genes revealed

...sophila melanogaster, research published today in the open access journal BMC Genetics identifies natural variation in the human LAMA5 gene as a key determinant of weight. As the prevalence of obesity and related health problems continues to increase worldwide, there is considerable effort being devoted to ...
determinant in Biological Technology

Gene Network Sciences Announces Broad Cancer Collaboration With UCSF and Initial Results

...ere not disclosed. GNS and UCSF have utilized REFS(TM) to discover and validate novel mediators of the cell cycle transition, which is a critical determinant of the rate of cancer cell proliferation and tumor growth. These results were presented by UCSF researcher Dr. Rina Gendelman, a post-doctoral fellow ...

DFG establishes 14 new research training groups

... a language and what effect does this linguistic phenomenon have on the mental representation of language? The Research Training Group "Frequency as a determinant in Usage-Based Models of Language Change, Language Processing and Language Acquisition" of the University of Freiburg will examine these questions. In...

Leading Heart Specialist Joins Duska Therapeutics as Scientific Consultant

... influences heart function is by activating the main calcium channel in the heart to release calcium from intracellular stores. Calcium is the primary determinant of contractility in the heart. A deficiency in nitric oxide disrupts the calcium cycle, inhibits heart contractility, and ultimately causes the heart ...

Interleukin Genetics Licenses its PST(R) Genetic Test to OralDNA Labs

...cer of Interleukin Genetics, commented, "We are pleased to have entered into this license agreement for OralDNA to market our PST(R) Genetic Test as a determinant of risk for periodontal disease. We believe that this relationship will allow our sales of this important product to grow with a sales force that spec...

Lorus Therapeutics Announces Publication of a Clinical Study Demonstrating Encouraging Results with LOR-2040 in Combination with Cytarabine in Patients with Acute Myeloid Leukemia (AML)

... of tumor types in both in vivo and in vitro models and is under study in a multiple Phase I/II clinical program. R2 has been described as a malignant determinant that is elevated in a wide range of tumors, which can cooperate with a variety of cellular cancer causing genes known as oncogenes to enhance tumor gr...

Lorus Therapeutics presents new findings for the anticancer drugs LOR-253 and LOR-2040

...ts the R2 component of ribonucleotide reductase, which is required for DNA synthesis and cell proliferation. R2 has also been described as a malignant determinant that is elevated in a wide range of tumors, and through down regulation can cooperate with a variety of cellular cancer causing genes known as oncogen...

MIT explains spread of 1918 flu

...igh affinity to the umbrella-shaped glycan receptors. The affinity between the influenza virus HA and the glycan receptors appears to be a critical determinant for viral transmission, said Sasisekharan. The researchers used the 1918 influenza virus as a model system to investigate the biochemical basis for...

Cepheid Enters Agreement To Exclusively License HPV Portfolio Developed by Quantovir AB

...PV with cervical cancer, HPV DNA testing has become an important diagnostic determinant of cancer risk. However, current tests approved by the U.S. Food and Drug A...ealth 2001;22:91-113. (5) Viral load of human papilloma virus 16 as a determinant for development of cervical carcinoma in situ: a nested case-control ...

Gladstone scientists uncover potential mechanism of memory loss in Alzheimer's disease

...ne research scientist and lead author of the study. "But our study suggests that this activity may actually be a primary effect of A-beta and an early determinant of cognitive failure." The Gladstone team used several genetically engineered mouse models of AD in which memory deficits are triggered by a human g...

Hot Technology, Hot Jobs and Cool Communities

...eneration communities? Rebecca Ryan: High speed and wireless networks enable any person to work anywhere. Quality health care is becoming a determinant for where seniors relocate or settle. WTN: What interesting applications of technology do you see in Wisconsin and how can that model help other...
determinant in Biological Products

Mouse Anti-Human HLA II DG+DR+DP Monoclonal Antibody, Unconjugated, Clone IQU9 from Diaclone

Description:... HLA II DG+DR+DP Monoclonal Antibody, Purified, Unconjugated, Clone: IQU9 This antibody is specific for the monomorphic determinant of the HLA Class II beta chains of the human MHC (28 kDa)....
Company:Diaclone
determinant in Biological Definition

Immune system

...ck of the sixth edition is ISBN 0815341016 . NCBI makes the 5th edition availiable electronically at [2] . See also antigen /antigenic determinant / epitope / hapten / memory cell autoimmune disorders CD4 receptor /CD8 receptor / perforin / apoptosis /clonal selection immunosuppress...

Ion channel

...ch. On activation, these helices move about and open the pore. Two of these six helices are separated by a loop that lines the pore and is the primary determinant of ion selectivity and conductance in this channel class and some others. The channel subunits of one such other class, for example, consist of just t...
determinant in Biological Dictionary

Antigenic determinant

An epitope, also known as antigenic determinant , is the part of a macromolecule that is recognized by the immune system, specifically by antibodies, B cells, or T cells. The part of an antibody that recognizes the epitope is called a paratope. Although epitopes are usually thought to be deriv...

Y chromosome

...other mammals. ... In humans, the Y chromosome spans 23 million base pairs (the building ... on the Y chromosome , the defining biological determinant that makes males male. ... The Y chromosome long has been the whipping post for all stereotypical male ... A single-source launchpad to infor...

Transformed phenotype

... phenotype of at least some human astrocytomas. ... ... caused a partial reversal of the transformed phenotype . ... Thus, thymosin ß4 is a determinant of AdoMetDC-induced transformed phenotype and invasiveness. ... Amphiregulin Contributes to the Transformed Phenotype of Human Hepatocellul...

Tet resistance

... the Tet (B) antiport protein.Antimicrob. ... tetracycline resistance mediated by hybrid Tet proteins. ... ... tetracycline resistance determinant tet (M) ... tetracycline resistance determinant, tet (E) ... tetracycline resistance determinants, including tet (M). Three ... The Euro...

Stop codon

...don.COM means unlimited great email addresses ... Translation termination is determined by the three stop codons (UAA, UGA and UAG) ... The key determinant for readthrough is located at the 3' side of the stop codon ... Normally, all three stop codons are bound and decoded by eRF1, ... Domain 1...

Methylation

...ty ... Methylation is the passing of a chemical fragment called a methyl group (a ... Methylation ... " Methylation is a major and fundamental determinant of health and sickness, or life ... evolved sufficient rather than optimal methylation . ... DNA methylation is an epigenetic modification k...

Histone

.... Acetylation of H3 at ... The Methyl- Histone H3 Antibody Sampler Kit provides a fast and economical means ... Histone methylation is a major determinant for the formation of active and ... Two molecules of each of the core histone proteins - H2A, H2B, H3 and H4 - form ... Histone H1 also assoc...
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