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degrades in Medical News

Higher drug doses needed to defeat tuberculosis, UT Southwestern researchers report

...rate that matches the rate seen in patients. "In patients, unlike in test tubes, it's not a constant concentration. A patient given multiple drugs degrades each of them at different rates," he said. "Using this model, we can actually copy this concentration profile of the drugs to human-like exposures." ...

Scientists advance safety of nanotechnology

...th. However, they found that the particles triggered autophagic cell death through the Akt-TSC2-mTOR signalling pathway. Autophagy is a process that degrades damaged materials in a cell and plays a normal part in cell growth and renewal, but scientists have found that sometimes an overactivity of this dest...

Bioengineered proteins: Trial confirms new way to tackle cancer

...ociated with aggressiveness in some of the most common types of cancer, including prostate, breast, colon and lung cancer. Under normal conditions VHL degrades HIF, but VHL is deactivated when oxygen levels are low. So, in hypoxic regions of a tumour, just where VHL is needed to inhibit cancer, it is ineffect...

Mayo Clinic researchers find tamoxifen's power comes from endoxifen

...sium, finds that, in contrast to the other tamoxifen metabolites, endoxifen degrades the estrogen receptor, and inhibits the growth of breast cancer cells even ...eptor so it can't bind to estrogen, but now we find that endoxifen actually degrades the estrogen receptor," Dr. Hawse says. "This goes a long way toward explai...

Selenium may slow march of AIDS

...ins are especially important in reducing the stress caused by an infection, thereby slowing its spread. Upon infecting a person, the virus quickly degrades selenoproteins so that it can replicate efficiently. It is unclear just how the virus is able to silence these proteins but Prabhu and his colleagues ...

UCSD researchers identify potential new drug target for chronic leukemia

...rugs that blocked PDE7B in CLL cells, and found that this raised cAMP levels and caused CLL cells to undergo cell death. He explained that since PDE7B degrades cAMP, blocking PDE7B in essence takes the clamp off of programmed cell death, enabling CLL cells to die. "PDE7B is thus a new drug target for CLL,"...

High Temps Degrade Contact Lens Solution: Study

...Nu with MoistureLoc was tied to eye infection outbreak in U.S. MONDAY, Nov. 10 (HealthDay News) -- Prolonged exposure to high temperatures degrades the antifungal properties of the ReNu with MoistureLoc contact lens solution, which was implicated in a U.S. eye infection outbreak between 2004 and 2...

Persistent bacterial infection exploits killing machinery of immune cells

...in macrophages, somehow inhibiting or escaping killing by NO. One natural NO inhibitor made by macrophages is the enzyme arginase. Arginase steals and degrades the material required to make NO, therefore limiting how much NO is made. "The bacteria designed to live inside the cell are highly adapted to the...

Afid Therapeutics Inc.'s New Anticoagulant Heparin Replacement Passes in Vivo Test

...eplacement for heparin. The new Afid Therapeutics anticoagulant mimics heparin and is designed to produce only carbohydrates and amino acids when it degrades in the blood stream thus minimizing the risks of side effects. Cell toxicity studies carried out thus far show no effect on the viability of mammalian...

Rapid wound healing

...el dressing has many advantages: it is shape-stable, pH-neutral and 100 percent bioresorbable. Once applied it remains in the body, where it gradually degrades without leaving any residues. Whats more, the fibre fleece provides the healthy cells around the edges of the wound with the structure they additional...
degrades in Medical Technology

96-Well Filtration Plate From Varian, Inc. Improves Sensitivity and Precision for Trace Bio-Analysis by LC/MS

... before analysis by liquid chromatography/mass spectroscopy (LC/MS). Incomplete removal leads to ion suppression (reduced sensitivity) and, over time, degrades the performance of both the LC column, reducing column life, and the MS ion source, increasing maintenance. Using Captiva NDLipids, plasma extracts ...

FDA Accepts Investigational New Drug Application for ARI-2243 and a First in Man Clinical Trial Set to Begin During the First Half of 2008

...eatment of cancer and cardiovascular disease. About DPP-4: Dipeptidylpeptidase (DPP) - 4 is a naturally occurring, proteolytic enzyme that rapidly degrades the incretin hormones, gastric inhibitory polypeptide (GIP) and glucagon-like protein (GLP-1). GLP-1 has a favorable anti-diabetic role because it sti...

Nuvelo Begins Phase 2 Trial and Receives Fast Track Status for Alfimeprase in Patients With Acute Ischemic Stroke

...combinant direct acting fibrinolytic (rDAF) that has the potential to rapidly dissolve blood clots through a unique mechanism of action -- it directly degrades fibrin, a protein that provides the scaffolding for blood clots. In addition, alfimeprase's thrombolytic activity appears to be localized to the site ...

Nuvelo Re-Initiates SONOMA-3 Trial of Alfimeprase in Patients With Catheter Occlusion

...combinant direct acting fibrinolytic (rDAF) that has the potential to rapidly dissolve blood clots through a unique mechanism of action -- it directly degrades fibrin, a protein that provides the scaffolding for blood clots. In addition, alfimeprase's thrombolytic activity appears to be localized to the site ...

Benitec MOU With CalbaTech, Inc.

...interference. It is activated when RNA molecules occur as double-stranded pairs in the cell. Double-stranded RNA activates biochemical machinery which degrades those mRNA molecules that carry a genetic code identical to that of the double-stranded RNA. When such mRNA molecules disappear, the corresponding gen...

BioLineRx Presents Data on BL-1040 at Cardiovascular Revascularization Therapies Conference Demonstrating Potential to Reduce Deterioration of Infarcted Heart Tissue and Maintain Functionality

...ength of the heart muscle during recovery and repair thereby preventing pathological enlargement of the left ventricle after the heart attack. BL-1040 degrades naturally six weeks after injection. Patients who have undergone an acute MI (AMI) with severe heart damage are the most likely to benefit from BL-1...

Acorda Therapeutics Presents Data from its Phase 3 Study of Fampridine-SR in Multiple Sclerosis at the American Academy of Neurology Meeting

...s is a chronic, usually progressive disease of the central nervous system in which the immune system attacks and destroys the structure, and therefore degrades the function, of nerve cells. Approximately 400,000 Americans have MS, and every week about 200 people are newly diagnosed. Most are between the ages ...

Arisaph Pharmaceuticals Announces Results of its Potent Smart DPP-4 Inhibitor, ARI-2243, at the ADA

...t of cancer and cardiovascular disease. About DPP-4: DPP-4 or dipeptidylpeptidase type 4 is a naturally occurring, proteolytic enzyme that rapidly degrades the incretin hormones, gastric inhibitory polypeptide (GIP) and glucagon-like protein (GLP-1). GLP-1 has a favorable anti-diabetic role because it sti...

Blood Gas Analysis: The Pros and Cons of Point-Of-Care Testing

...ts are "stat" tests, meaning they should be done as quickly as possible after sample collection. For arterial blood gases (ABGs), the collected sample degrades quickly and, if any testing delay is expected, it should be kept on ice and rewarmed later for accurate analysis. If, after sample collection, any air...
degrades in Medical Products

Osteomesh Bioresorbable Implant for Craniofacial Surgery

Description:... can be easily cut to any shape. The mesh offers a rigid yet flexible scaffold with sufficient mechanical strength that supports bone in-growth and it degrades as bone regeneration and remodeling takes place. Long term clinical trials showed significant bone regeneration, as the material is slowly resorbed by...
Company:Osteopore International

ActCel Hemostatic Gauze

Description:...s original size and converts to a gel that dissolves into glucose and saline over a 1-2 week period. Because of its purity and the fact that it simply degrades to these end products, ActCel does not cause delayed healing as do other hemostatic material that may have similar appearance. Research shows th...
Company:ActSys Medical, Inc.

E-Z Tac™ Soft Tissue Reattachment System

Description:... of a resorbable copolymer, a polyester derivative of lactic acid and glycolic acid colored with D&C violet #2. Polylactic/polyglycolic acid copolymer degrades and resorbs IN VIVO by hydrolysis to lactic and glycolic acids which are then metabolized by the body....
Company:USS Sports Medicine

POLYSORB™ Soft Tissue Reattachment System, 3mm

Description:... The suture anchors are made of a resorbable copolymer, derived from glycolide and lactide colored with D&C violet #2. The glycolide/lactide copolymer degrades and resorbs in vivo by hydrolysis to lactic and glycolic acids which are then metabolized by the body. U.S.P. size 2 (5 metric) TICRON™ polyeste...
Company:USS Sports Medicine

AnchorSew™ 3mm Device

Description:...soft tissue anchors are made of a resorbable copolymer, derived from glycolide and lactide colored with D&C violet #2. The glycolide/lactide copolymer degrades and resorbs in vivo by hydrolysis to lactic and glycolic acids which are then metabolized by the body. TICRON™ polyester sutures are nonabsorbab...
Company:USS Sports Medicine

POLYSORB™ Soft Tissue Reattachment System, 2mm

Description:... The suture anchors are made of a resorbable copolymer, derived from glycolide and lactide colored with D&C violet #2. The glycolide/lactide copolymer degrades and resorbs IN VIVO by hydrolysis to lactic and glycolic acids which are then metabolized by the body. U.S.P. size 2-0 (3 metric) TICRON™ polyes...
Company:USS Sports Medicine

POLYSORB Meniscal Stapler XLS

Description:...niscus. The staple is made of a resorbable copolymer, a polyester derivative of lactic acid and glycolic acids. Polylactic/polyglycolic acid copolymer degrades and resorbs IN VIVO by hydrolysis into lactic and glycolic acids which are then metabolized by the body....
Company:USS Sports Medicine
degrades in Medical Dictionary

Protein C

... is a vitamin K-dependent serine protease enzyme (EC 3.4.21.69) that is activated by thrombin into activated protein C (APC). The activated form degrades Factor Va and... Protein C deficiency is a rare genetic trait that predisposes to thrombotic disease. It was first described in 1981. The d...
degrades in Biological News

Common soil mineral degrades the nearly indestructible prion

MADISON In the rogues' gallery of microscopic infectious agents, the prion is the toughest hombre in town. Warped pathogens that lack both DNA and RNA, prions are believed to cause such fatal brain ailments as chronic wasting disease (CWD) in deer and moose, mad cow disease in cattle, scrapie in...

Plastic that degrades in seawater could be boon for cruise industry and others

The costs due to complications from preterm birth are staggering. In Canada, outlays for specialized care of surviving preterm infants are estimated to be almost $2 billion per year. In a 5-year, randomized, placebo-controlled clinical study, researchers found that giving nitroglycerin to mothers w...

Muscle atrophy through thick but not thin

...lleagues show that muscle atrophy is a more ordered process than was previously thought. These researchers find evidence that enzyme MuRF1 selectively degrades the thick filaments in muscle, while bypassing the thin filaments. We depend on skeletal muscles because they can produce movement, but they serve...

Yale researchers uncover secrets of salmonella's stealth attack

... compartment called a vesicle. SopB's second trick helps prevent the vesicle from being sucked into the lyosome, the organelle within the cell that degrades proteins. In order to accomplish this, SopB must move from the plasma membrane of the cell to the membrane of the internal vesicle containing the pat...

Case Western Reserve University engineers hit pay dirt with clay mixture

...perature polymer) with insulating properties to withstand heat at temperatures of 300 degrees centigrade. Currently, oil-based polymer foam insulation degrades at high temperatures, says Schiraldi. Clay aerogel composites have the potential to insulate hundreds of miles of noninsulated piping carrying high-t...

Team identifies a molecular switch linking infectious disease and depression

...teins also activate IDO in the body and brain. IDO degrades the amino acid tryptophan, producing metabolites t... factor-alpha and interferon-gamma. Because IDO degrades tryptophan, which is the precursor of serotonin, a...ers suspect that the metabolites produced when IDO degrades tryptophan are in some way promoting depression. M...

Stanford researchers develop biodegradable substitutes for wood, plastic bottles and other materials

...ironments. "The ideal is to have nice, stable material when it's being used," Criddle explained. "But when it's out of use, it goes to a landfill, degrades quickly, and is reprocessed into new material that stays in a nice, stable form." Recycling methane Unlike wood scraps that can sit in landfil...

Rot's unique wood degrading machinery to be harnessed for better biofuels production

...est is diverted toward replacing such decayed materials. Unlike white-rot fungi, previously characterized by DOE JGI and FPL, which simultaneously degrades lignin and cellulose, brown-rot rapidly depolymerizes the cellulose in wood without removing the lignin. Up until this study, the underlying genetics...

A scientific breakthrough on the control of the bad cholesterol

...nd increase the number of LDL-receptors, thus efficiently decreasing plasma cholesterol levels; however, they also increase the amount of PCSK9, which degrades those receptors, thus reducing the effect of statins. A drug that would block PCSK9 could either be used alone or jointly with statins and would be hi...

Biosynthetics production with detours

...pseudonomads, there are exponents that can be used in biotechnology. These include Pseudomonas putida: It produces chemicals, pharmaceutical products, degrades waste and toxins. It also plays an important role in manufacturing high-quality substances for industry. Now, in cooperation with a working group ...
degrades in Biological Technology

Palatin Technologies, Inc. Receives U.S. Patent Allowance for Heart Failure Drug Candidate

...f-life, with reduced affinity for natriuretic peptide clearance receptors and increased resistance to neutral endopeptidase, an endogenous enzyme that degrades natriuretic peptides. The result is a drug candidate with improved pharmacokinetic and pharmacodynamic properties. About Heart Failure H...

Evidence for a New Genetic Link to Therapeutic Efficacy for Alzheimer's Disease

...he insulin degrading enzyme gene (IDE) on ADAS-Cog scores were evaluated over the study course. In addition to degrading insulin, the Ide protein also degrades amyloid beta peptide and has been implicated in playing a role in Alzheimer's disease. In the population of patients who were both APOE4(-) a...

GM crops protect neighbors from pests

... Bt is currently registered and marketed for use as an insecticide in more than 50 countries worldwide. It does not contaminate groundwater because it degrades so rapidly. The authors say that Bt technology gives China a new tool for pest control, and that all farmers in a Bt cotton-planting region will e...

Germicidal UVC Lights Improve Clinical Pregnancy Rates for IVF Lab, New Study Finds

... The study goes on to say: "UVC energy will destroy 90 -- 99% of airborne microbial contaminants. By targeting the DNA and RNA of microorganisms, UVC degrades and abates the proliferation of airborne and surface embryotoxic organics. Of equal significance to the developing embryo is the suggested impact of U...

Nanoengineered barrier invented to protect plastic electronics from water degradation

...itting diodes (OLEDs) and solar cells is sensitive to moisture because water and oxygen molecules seep past the protective plastic layer over time and degrades the organic materials which form the core of these products. Current commercially available films used to protect these materials have a barrier pr...

Researchers engineer new polymers to change their stiffness and strength when exposed to liquids

...the brain is compromised. A problem observed in experimental studies is that the quality of the brain signals recorded by such microelectrodes usually degrades within a few months after implantation, making chronic applications challenging. One hypothesis for this failure is that the high stiffness of these e...

Biomatrica's RNAstable(TM) Stabilizes RNA at Room Temperature

...PCR, gel analysis, cDNA synthesis and reverse transcription without inhibition or interference. "RNA is hard to work with because it is unstable and degrades even when properly stored," said Fernando Monroy, Associate Professor at Northern Arizona University. "You are always anxious until you see the result...

Biosensors Receives CE Mark Approval for Its BioMatrix(R) Drug-Eluting Coronary Stent System

...c profile than other drugs in its class, enabling the drug to be rapidly absorbed into tissue, with reduced systemic exposure. The PLA polymer fully degrades into water and carbon dioxide as the drug is released, ultimately leaving in place a biocompatible stent surface. The polymer is coated onto the outer...

Benitec MOU With CalbaTech, Inc.

...interference. It is activated when RNA molecules occur as double-stranded pairs in the cell. Double-stranded RNA activates biochemical machinery which degrades those mRNA molecules that carry a genetic code identical to that of the double-stranded RNA. When such mRNA molecules disappear, the corresponding gen...

New Insights Into DNA Decontamination

...ronmentally safe alternative and proves its superiority towards all other commercially available decontamination reagents. DNA-ExitusPlus not only degrades and removes all DNA molecules with high efficiency but in addition is neither toxic nor corrosive. Currently, the most effective method f...
degrades in Biological Products

Mung Bean Nuclease from Promega

Description:...ytically to yield 5-phosphoryl terminated products. While the nuclease prefers ssDNA over dsDNA by 30,000-fold, at very high concentrations the enzyme degrades double-stranded DNA from both ends (1,2). Mung Bean Nuclease has been used for transcript mapping studies (3,4), for flushing staggered ends and for t...
Company:Promega

Human Cathepsin D from Calbiochem

Description:...ced as a 52 kDa proenzyme. Overexpression of cathepsin D in human breast cancers is associated with higher risk of relapse and metastasis. Cathepsin D degrades extracellular matrix and releases growth factors bound to the matrix. Specific activity: ≥300 units/mg protein. One unit is defined as the amoun...
Company:Calbiochem

S1 Nuclease from Promega

Description:... S1 Nuclease degrades single-stranded DNA and RNA endonucleolytically to yield 5-phosphoryl-terminated products. Double-stranded nucleic acids (DNA:DNA, DNA:RNA or RNA:RNA)...
Company:Promega

RQ1 RNase-Free DNase from Promega

Description:... RQ1 RNase-Free DNase is a preparation of deoxyribonuclease I that degrades single-stranded or double-stranded DNA to produce 3-hydroxyl oligonucleotides. This preparation is qualified for use in applications where maintaining...
Company:Promega

DNase I (RNase-free) (2 U/l) from Ambion

Description:... DNase I (RNase-free) (E.C. 3.1.21.1) is a nonspecific endonuclease that degrades double-and single-stranded DNA and chromatin. It functions by hydrolyzing phosphodiester linkages, producing mono and oligonucleotides with a 5'-phosp...
Company:Ambion

Benzonase Nuclease HC, Purity > 90% from Novagen

Description:... Benzonase Nuclease is a genetically engineered endonuclease. This unique enzyme degrades all forms of DNA and RNA while having no proteolytic activity. It is effective over a wide range of conditions and possesses an exceptionally high spe...
Company:Novagen
degrades in Biological Definition

Apoptosis

...as part of the hijacking of the cell's genetic system carried out by human papillomaviruses (HPV), a gene called E6 is expressed in a product that degrades p53 protein, which is a vital piece of the apoptotic pathway. This severe interference in the apoptotic capability of cells plays a critical role in...

RNA

... mRNA is "processed" before being exported), where it is bound to ribosomes and translated into protein. After a certain amount of time the message degrades into its component nucleotides, usually with the assistance of RNases . Non-coding RNA or "RNA genes" Main article: Non-coding RNA RNA ...
degrades in Biological Dictionary

S1 nuclease

...P1. IPR003154 S1 /P1 nuclease 1 - 265 ... Contact your local distributor for pricing. Promega - Distributor. S1 Nuclease ... S1 Nuclease degrades single-stranded DNA and RNA endonucleolytically to yield 5' ... ... Search: Nuclease , S1 . I.U.B.: 3.1.30.1. Nuclease S1 , isolated from ... ...

Nuclease

...nonspecific ... nuclease -free ... The nuclease as a model for protein folding, Molec. Cell. Biochem., 23, ... Nuclease BAL-31 exonuclease degrades both 3' and 5' termini of duplex DNA ... Can Nuclease BAL-31 be used to remove 10 base pairs from the end of a DNA fragment? ... Micrococcal n...

Lysosome

... Wikipedia, the free encyclopedia ... Lysosomes are the cells' garbage disposal system. ... The vacuole thus becomes a secondary lysosome and degrades the bacterium. ... Information about lysosome in the free online English dictionary and encyclopedia. ... lysosome (ls-sm) ... lysosome - an ...
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