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daclizumab in Medical News

Transplanted heart made more acceptable by daclizumab

Daclizumab has been found to reduce the risk of cellular rejection after a heart transplant// when used on top of standard immunosuppression. The drug, a humanized monoclonal antibody, is directed against the interleukin-2 receptor, thereby inhibiting T-cell proliferation. Patients who we...

Renal Transplantation in Children Younger Than 6 Years Old

...us in 39%, mycophenolate in 49% and azathioprine in 51%. A steroid-free protocol was used in 17% of the patients. In the last 21 cases, basiliximab or daclizumab was added. The group found that there were 13 (32.5%) graft losses. Four of these had artery/vein thromboses, 3 chronic rejections, 3 deaths, an...
daclizumab in Medical Technology

Primary Endpoint Met in Phase 2 Trial of Daclizumab in Patients With Relapsing Multiple Sclerosis

- Anti-IL-2 receptor antibody significantly reduced the number of new or enlarged lesions compared to placebo; data to be submitted for presentation at upcoming medical meeting - CAMBRIDGE, Mass. and FREMONT, Calif., March 12, 2007 /PRNewswire-FirstCall/ -- Biogen Idec, Inc. and PDL BioPharma, Inc...
daclizumab in Biological Technology

Phase 2 Data Show Daclizumab Significantly Reduced Multiple Sclerosis Lesions in Patients Receiving Interferon Beta Therapy

- Phase 2 monotherapy trial to be initiated by end of 2007 - PRAGUE, Czech Republic, Oct. 11 /PRNewswire-FirstCall/ -- Biogen Idec Inc. (Nasdaq: BIIB ) and PDL BioPharma, Inc. (PDL) (Nasdaq: PDLI ) announced today that Phase 2 data demonstrated a significant reduction in new or enlarge...

Astellas Receives FDA Approval for Use of Prograf(R) (Tacrolimus) in Conjunction With Mycophenolate Mofetil (MMF) in Kidney Transplant Recipients

...y transplant recipients. The trial randomly assigned 1,589 kidney transplant recipients to receive standard dose CyA, MMF and corticosteroids (CS); or daclizumab induction, MMF and corticosteroids in combination with low-dose CyA, Prograf or sirolimus (Siro). The primary endpoint of the study was renal function...

PDL BioPharma Announces Significant Strategic and Portfolio Changes to Focus on Antibody Discovery and Development

...HuLuc63 in multiple myeloma, PDL 192 in preclinical development and several additional research stage candidates. PDL's immunological programs include daclizumab in multiple sclerosis and other indications, visilizumab in various potential indications and several preclinical candidates. The company is planning ...
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