Do bacterial combinations result in enhanced cytokine production? No!
Probiotic bacteria, defined as living microorganisms that have beneficial effects on human health, have been used for the prevention and treatment of a diverse range of disorders. However, the ways in which probiotic bacteria elicit their health effects are not fully understood. One of the action ...Experimental Drug Causes Cytokine Storm
A clinical trail with an experimental drug designed to treat chronic inflammatory conditions and leukemia resulted in an immune system overreaction leading// to six British men involved in the trail becoming seriously ill. All the six men have since recovered from the drug reaction. Dr. Gane...Study identifies biomarker that safely monitors tumor response to new brain cancer treatment
...brain tumors go undetected and proliferate rapidly. In the technique devised by Castro and Lowenstein, one of the proteins (the immune stimulatory cytokine Flt3L) attracts dendritic cells from bone marrow into the tumor while another protein (thymidine kinase) and the antiviral drug gancyclovir combine to...Rare disorder gives modelers first glimpse at immune system development
...As transplanted thymus tissue took hold in the children, the team studied signals related to specific T-cell receptors and more general resources like cytokine signals or space availability. They assessed T cell receptor diversity to determine overall T cell levels and to count T cells of certain kinds. ...Early treatment of systemic onset JIA with anakinra restores the IL-18 response
...as shown that, once NK cell levels and function are restored to normal, the cytokine pathway specifically involving IL-18 is restored, which elicited a good cli...During a six month follow-up period, absolute NK cell numbers and function, cytokine profiles, and NK cell response after IL-18 stimulation, were monitored. F...Novel DNA vaccine leads to kidney damage prevention in systemic lupus erythematosus models
... Copenhagen, Denmark, Thursday 11 June 2009: DNA vaccination using lupus autoantigens and interleukin-10 (IL-10, a cytokine that plays an important role in regulating the immune system) has potential as a novel therapy to induce antigen specific tolerance and may help to pr...Genetic pathway responsible for link between body clock disturbance and worsening arthritis
...ry gene CRY was found to up-regulate expression of a gene which promotes the activation of TNF-alpha (tumour necrosis factor-alpha, a pro-inflammatory cytokine used by the body to boost the immune system) by two fold, when comparing mice with the CRY gene removed to those with a normal copy of the gene. Pro...Immunologists identify biochemical signals that help immune cells remember how to fight infection
...n another type of immune cell called CD8+ T lymphocytes. For these cells, whether they become killers or long-term memory cells depends upon which cytokine they respond to. Those that receive the IL-12 become killers while those that receive interferon alpha turn into long-term memory cells. "Regardles...CEL-SCI Corporation Reports 2009 Second Fiscal Quarter Financial Results
...ne may be able to work around that problem. While normally cytokines may play a key role in preventing and treating swine flu, in some cases excessive cytokine amounts may exacerbate disease as it appears that, unlike the normal flu which affects the very young and very old most severely, swine flu may be mor...Cytokine PharmaSciences Initiates Phase I Study of Oral Anti-Inflammatory Agent, CPSI-2364
... KING OF PRUSSIA, Pa., July 20 /PRNewswire/ -- cytokine PharmaSciences, Inc. today announced the initiatio...nic," said Dennis F. Willson, president and CEO of cytokine PharmaSciences. "As a small molecule, CPSI-2364 i...ed the oral activity of CPSI-2364. About cytokine PharmaSciences ...Video: Partnership Unites UCB with Consumer Product Innovator OXO(R)
...hophysiological effects of TNF-alpha. Over the past decade, TNF-alpha has emerged as a major target of basic research and clinical investigation. This cytokine plays a key role in mediating pathological inflammation, and excess TNF-alpha production has been directly implicated in a wide variety of diseases. T...IBT Laboratories to Launch New Pneumococcal Antibody Avidity Test at AAAAI Meeting, Booth 729
...IBT will present two scientific posters at the conference: Saturday, 9:45-10:45 am - # 41: T Cell Immunity Assessed by Intracellular cytokine Analysis Following Stimulation of Whole Blood or PBMCs with Microbial Antigens of Mitogens Sunday, 9:45-10:45 am - # 405: Presence of IgG An...Marrow-derived stem cells deliver new cytokine to kill brain tumor cells, offer protection
Attaching a recently discovered cytokine to neural stem cells derived from bone marrow, researchers at Cedars-Sinai Medical Center's Maxine Dunitz Neurosurgical Institute have developed a tool to track and kill malignant brain tumor cells and provide long-term protection against their return. Res...Discovery to aid in future treatments of third-world parasites
...immune cells. Due to their fundamental importance, cytokine research is a significant focus of research at the... their role. Trudeau investigators have devised cytokine "reporter mice" for tracking cells that produce the signature cytokine of the so-called "Th2" immune response mounted aga...Peregrine's PS-targeting antibodies highlighted in AACR Annual Meeting studies
...or components of the immune system. Together, the studies provide compelling evidence suggesting that PS-targeting antibodies facilitate an important cytokine shift in the tumor environment that subsequently encourages multiple types of immune system cells to mount anti-tumor responses." In a presentatio...'First aid' for brain cells comes from blood
...wn that certain immune cells in the blood inhibit inflammation after a stroke. These cells are known as regulatory T lymphocytes (Treg). The regulator cytokine Interleukin 10 plays an important role in this protection, perhaps offering a new approach to stroke therapy. The study has now been published in Na...Time (and PPAR-beta/delta) heals all wounds
...e in OTCs by secreting extra doses of several growth factors. The fibroblasts were stimulated to produce these growth factors by keratinocyte-released cytokine IL-1 - underscoring the reciprocity between the two cell types. Blocking either the IL-1 signal or any of the growth factors released by the fibroblas...Shades of 1918? New study compares avian flu with a notorious killer from the past
...ough the 1918 ressortant strains were found to be highly virulent, they were outmatched by H5N1's rapid onset, overwhelming transcription induction of cytokine and chemokine genes and headlong, sustained viral replication with wider distribution in the lungs. As Baskin notes, referring to the group's measurem...The quest for specific anti-inflammatory treatment
...es cell inflammation, i.e. when the cells detect the presence of this molecule, they secrete molecules that generate inflammation - prostaglandin and cytokine cells, for example. But this process does not occur with all types of cells. Although apparently contradictory, in some cells this same molecule fu...Apolipoprotein(a): A natural regulator of inflammation
...ssor of the inflammatory response in vivo. In addition, a mechanism for this novel function of apo(a) was also identified: its selective regulation of cytokine production. These effects of apo(a) are independent of its molecular mimicry of Plg. Lipoprotein(a) (Lp(a)) is similar to low density lipoprotein (...Forsyth scientist receives major grant to support rapid, accurate, affordable test for tuberculosis
... Dr. Antonio Campos-Neto, head of the department of cytokine Biology at The Forsyth Institute, has received a major grant from the internationally renowned Foundation for Innovative New Diagnostics (FIND) to con...GeneGo Donates Proprietary Cytokine Pathway Maps to ISICR
ST. JOSEPH, Mich.,. July 21 /PRNewswire/ -- GeneGo, Inc., the leading systems biology tools company, announced today that they have recently donated 41 canonical pathway maps to the International Society for Interferon and Cytokine Research (www.isicr.org). These maps are constructed fro...Selection of Standards for Bio-Plex Cytokine Assays, Rev A
Diana Davis, Aiguo Zhang, Jim Torrence, and Emily Dale, Bio-Rad Laboratories, Inc., 2000 Alfred Nobel Drive, Hercules, CA 94547 USA Introduction Bio-Plex cytokine assays are bead-based quantitative multiplex immunoassays. The concentr...LiquiChip Kits for bead-based cytokine and kinase assays
The LiquiChip Human and Mouse 10-Cytokine Kits and Ser/Thr Kinase Kit provide fast and accurate quantification of a range of cytokines and serine/threonine kinases. LiquiChip 10-Cytokine Kits enable simultaneous multiplex assay o...Scripps Research Institute Highlights Groundbreaking Work of aTyr Pharma Scientific Co-Founder
...in drugs. According to Jeff Watkins, CEO of aTyr Pharma, "By separating specific residues in the human tyrosyl tRNA synthetase required for novel cytokine activities from those involved in the protein synthesis activities, Professor Yang has proven that these naturally occurring activities hidden in the ...CEL-SCI's L.E.A.P.S. Technology Shows Potential to Treat Swine Influenza in Preclinical Studies
...ay a key role in preventing and treating swine flu, in some cases excessive cytokine amounts may exacerbate disease as it appears that, unlike the normal flu wh...cine's antigen(s) to the appropriate T lymphocyte and then deliver specific cytokine proteins to the T cell to determine the immune response outcome to the spec...ChemiArray Mouse Lysate Cytokine Antibody Array III, 62 cytokines per membrane from CHEMICON
Description: Request Info...Custom Human Cytokine Antibody Array, Choose from hundreds of proteins. from Raybiotech, Inc.
Description: ...Human Cytokine Antibody Array 1.1 (4) Kit, RayBio from Raybiotech, Inc.
Description: RayBio Human Cytokine Antibody Array 1.1 (4 array membranes) with Accessory, detects 20 cytokines (for lysate) Class: Antibody Array Products Product Group: Antibody Array...Cartesian Array Human Cytokine Set 1 from BioSource International (Invitrogen)
Description: ...Mouse Hematopoietic Stem Cell Expansion Cytokine Panel from R&D Systems
Description: Hematopoietic stem cells (HSC) are well-characterized tissue-specific stem cells that exhibit remarkable self-renewal capacity and are responsible for the life-long maintenance of the hematopoietic system. HSC are rare cells that reside in adult bone marrow where hematopoiesis is continuously takin...RayBio Human Cytokine Antibody Array I &1.1 Service from Raybiotech, Inc.
Description: Request Info...Custom Human Cytokine Antibody Array, Choose from hundreds of proteins. from Raybiotech, Inc.
Description: Request Info...Q-Plex Rat Cytokine Array (Stripwells) from BioLegend
Description: Distributed exclusively by BioLegend, the Quansys Biosciences Q-Plex Array is a new technology for multiplex analysis of cytokines/chemokines for human, mouse, and rat research. The Q-Plex Rat Cytokine Array is a fully quantitative ELISA-based test where 4 distinct capture antibodies have been abso...Mouse IR Cytokine Array 12plex from Pierce Biotechnology, Inc.
Description: The SearchLight® IR Mouse Cytokine Array is a multiplex sandwich ELISA (enzyme-linked immunosorbent assay) for the quantitative measurement of 12 cytokines in serum; EDTA, heparin, sodium citrate plasma and culture supernatants. Each well of the microplate provided is spotted with antibodies t...Human Atherosclerosis Antibody Array I Kit, ChemiArray, 20 cytokines per membrane from CHEMICON
Description:... ChemiArray Human cytokine Antibody Array VII, 60 cytokines per membrane...