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crystallography in Medical News

BioCryst Reports Second Quarter 2009 Financial Results And Provides Corporate Update

...ivir, an anti-viral for influenza, and forodesine, a purine nucleoside phosphorylase (PNP) inhibitor for cutaneous T-cell lymphoma (CTCL). Utilizing crystallography and structure-based drug design, BioCryst continues to expand its portfolio of next-generation therapeutic candidates with the potential to address th...

BioCryst Pharmaceuticals Announces Presentation of Forodesine Data at the 45th Annual Meeting of the American Society of Clinical Oncology

...ioCryst BioCryst is a biopharmaceutical company that has developed a deep pipeline of novel therapeutics targeting major illnesses by employing crystallography and structure-based drug design. BioCryst is currently advancing investigational new drugs discovered in-house in late-stage clinical trials for infl...

BioCryst to Present at the 11th Annual BIO CEO & Investor Conference

...ww.biocryst.com . The presentation will be archived for 14 days. About BioCryst BioCryst is an integrated biopharmaceutical company utilizing crystallography and structure-based drug design to develop a deep pipeline of novel therapeutics targeting major illnesses. BioCryst is currently advancing investigat...

BioCryst Pharmaceuticals to Announce Fourth Quarter and Year End 2008 Financial Results on February 6, 2009

... Web cast will be archived and available for replay for 14 days. About BioCryst BioCryst is an integrated biopharmaceutical company utilizing crystallography and structure-based drug design to develop a deep pipeline of novel therapeutics targeting major illnesses. BioCryst is currently advancing investigat...

New Jersey-Based Biotech Start-Up Nexomics Biosciences Gets Off the Ground

...large scale protein production, Nuclear Magnetic Resonance (NMR), and X-ray crystallography for use in drug discovery efforts. Nexomics Biosciences has signed a compr...large scale protein production, Nuclear Magnetic Resonance (NMR), and X-ray crystallography for use in drug discovery efforts. The company provides customers with serv...

E. coli persists against antibiotics through HipA-induced dormancy

...ed the molecular details of HipA's role in multidrug tolerance and HipB's role keeping HipA under wraps in a series of experiments: Using X-ray crystallography to determine and then compare the structures of several HipA complexes, they showed that HipA has a serine/threonine protein kinase fold and that it b...

Scientists reveal structure of new botulism nerve toxin subtype

... analyzed the molecular-level structures of various fragments of botulinum neurotoxin subtypes A to F, and that of the whole neurotoxin B, using x-ray crystallography at the National Synchrotron Light Source (NSLS) at Brookhaven Lab. In this technique, scientists beam high-intensity x-rays at a crystalline sample of...

Crystallography reveals the 3-D structure of mammalian sperm receptor

... contain a common sequence that allows them to form a matrix of filaments, the so-called zona pellucida that completely surrounds the egg. The Protein crystallography Unit at Karolinska Institutet, led by Dr. Luca Jovine, has now determined the structure of the most conserved part of this building block, the ZP-N do...

Novel enzyme inhibitor paves way for new cancer drug

...ers to identify potential agents to inhibit PI3K, the scientists identified a protein kinase inhibitor known as DW2. The scientists then used X-ray crystallography to determine the three-dimensional structure of PI3K bound to DW2, using the structure as a starting point to fashion more effective PI3K inhibitors. ...

Double binding sites on tumor target may provide future combination therapy

...ar doorway, keeping hormones from binding and signaling tumor growth. X-ray crystallography provided a snapshot of the interaction between Erbitux and the extracellula...shed in Cancer Cell, Ferguson and Merck colleagues found again using X-ray crystallography -- that matuzumab binds in a different place from Erbitux. Their binding do...
crystallography in Medical Technology

BioCryst Pharmaceuticals Reports Positive Results of Shionogi & Co. Sponsored Phase 3 Studies of i.v. Peramivir for Influenza

... BioCryst is a biopharmaceutical company that has developed a diverse pipeline of novel therapeutics targeting major illnesses by employing crystallography and structure-based drug design. BioCryst is currently advancing investigational new drugs discovered in-house in late-stage clinical trials for infl...

BioCryst Provides Peramivir Update and Reports First Quarter 2009 Financial Results

...ioCryst BioCryst is a biopharmaceutical company that has developed a deep pipeline of novel therapeutics targeting major illnesses by employing crystallography and structure-based drug design. BioCryst is currently advancing investigational new drugs discovered in-house in late-stage clinical trials for infl...

BioCryst Pharmaceuticals to Announce Peramivir Update and First Quarter 2009 Financial Results on May 8, 2009

... cast will be archived and available for replay for 14 days. About BioCryst BioCryst is an integrated biopharmaceutical company utilizing crystallography and structure-based drug design to develop a deep pipeline of novel therapeutics targeting major illnesses. BioCryst is currently advancing investiga...

Jubilant Enters Research Collaboration With AstraZeneca

...multiple disciplines to include Discovery biology, medicinal chemistry, structural biology, pharmacology, toxicology, pharma chem, molecular modeling, crystallography and information technology supporting discovery efforts. For more information please visit: http://www.jubilantbiosys.com About Jubila...

Data from Phase 2 Study of Peramivir in Patients Hospitalized with Influenza Presented at the XI International Symposium on Respiratory Viral Infections

... Phase 3 program of peramivir in outpatient influenza underway. About BioCryst BioCryst is an integrated biopharmaceutical company utilizing crystallography and structure-based drug design to develop a deep pipeline of novel therapeutics targeting major illnesses. BioCryst is currently advancing investiga...

The First Direct Structural Evidence of SV2A has Been Revealed Thanks to Protein Tomography(TM), and Published in BBRC

... can be open to either side of the membrane. Prior to this Protein Tomography(TM) study, great efforts were made to prove this mechanism both by x-ray crystallography and indirectly by site directed mutagenesis. (Logo: http://www.newscom.com/cgi-bin/prnh/20080220/294289 ) "Obtaining structures of trans-membran...

ActiveSight and CHDI Leverage Fragment-Based Lead Discovery for Huntington Disease Therapies

...rget chosen by CHDI, ActiveSight will screen fragment libraries using X-ray crystallography to visualize fragments that bind to the target. The fragments will then be ...Vicki Nienaber, Ph.D. at ActiveSight, a pioneer in the utilization of X-ray crystallography for Fragment-based screening and lead development. "We are pleased to have...

Anacor Identifies a Novel Mechanism for Its Lead Anti-Fungal Drug, AN2690; Findings Published in Science

...minoacyl-tRNA synthetases with editing sites, which are also excellent targets for anti-microbial drugs," said Cusack, whose group performed the X-ray crystallography which revealed how AN2690 binds to LeuRS. Anacor is now leveraging that knowledge to create new boron-containing drugs designed to target systemic b...
crystallography in Medical Dictionary

Antigen

... antigen is a protein or a polysaccharide, but it can be any type of ... White blood cells - B cells - Antibodies - Antigen (MHC) ... X-Ray crystallography studies of antigen -antibody interactions show that the ... The bonds that hold the antigen to the antibody combining site are all non ... To...
crystallography in Biological News

Discovery of the cell's water gate may lead to new cancer drugs

... yeast aquaporin. The results will be published in the journal PLoS Biology . Highest resolution The structure has been determined using X-ray crystallography and is the highest resolution structure that has been determined for a membrane protein. The unique high resolution has enabled the scientists to answ...

Powe Award supports research on how enzymes enable the pathogenicity of 2 human disease organisms

...ion," he said. The structural work is being done in collaboration with Andrea Mattevi, professor of molecular biology, who co-ordinates the protein crystallography group at the University of Pavia. Sobrado's team includes graduate and undergraduate students. "It is an opportunity for undergraduates to learn a...

CSHL researchers explain process by which cells 'hide' potentially dangerous DNA segments

...ow these interactions contributed to the strength of binding. For these answers, Schalch and the CSHL team made use of Joshua-Tor's expertise in X-ray crystallography the science of determining the exact position of atoms and bonds within a molecule by creating a crystal, which is then probed with powerful x-rays. ...

Scripps scientists find structure of a protein that makes cancer cells resistant to chemotherapy

... Aller, Ph.D., a postdoctoral fellow in Chang's laboratory and first author of the new study. Once the scientists succeeded in performing the x-ray crystallography and solving the structure, they found that the mouse protein P-gp, which is 87 percent identical to its human counterpart, has the shape of an upside ...

Antibody key to treating variant CJD, scientists find

...ven prevent the development of the disease. To understand the 'connection' between the antibody and the protein, scientists at Liverpool used X-ray crystallography technology to build a three-dimensional picture of the binding between an antibody called ICSM18 designed to 'stick' effectively to prion proteins a...

Scientists unlock the secrets of C. difficile's protective shell

...by scientists from Imperial College London, funded by the European Union Seventh Framework Programme and the Medical Research Council. They used X-ray crystallography techniques to produce the first ever high-resolution images of the structure of LMW-SLP, one of the two proteins that make up C. difficile 's S-layer...

Dartmouth researchers find new protein function

...related to the motor proteins that power diverse cellular activities, including intracellular transport, signaling, and cell division. They used X-ray crystallography to determine its structure, and then they used enzyme kinetics to find out how it performed. While this protein is found in fruit flies, the results a...

First Science from the Compact Light Source: A miniature synchrotron for your home lab

...m the CLS featured by the Journal of Synchrotron Radiation on its January 2009 cover; first micro-tomographic images from the CLS; and first protein crystallography data set from the CLS. The Compact Light Source prototype effort was funded by the National Institute of General Medical Sciences (NIGMS) Small B...

New technique is quantum leap forward in understanding proteins

...n interactions. Assistant Professor Hendrik Szurmant, another leader of the project from Scripps Research, says the process is so difficult with x-ray crystallography that it only rarely works for transient interactions. Another available means for studying protein interactions is a statistical method known as co...

Properties of unusual virus revealed in research

...is now a postdoctoral researcher at the University of Rochester, used X-ray crystallography to obtain a high-resolution three-dimensional image of the N4 phage's RNA-polymerase and DNA molecule. "By modifying the crystallography conditions, Michael obtained an extremely high-resolution picture of the N4...
crystallography in Biological Technology

BioCryst Pharmaceuticals to Announce Second Quarter 2009 Financial Results on July 30, 2009

...ivir, an anti-viral for influenza, and forodesine, a purine nucleoside phosphorylase (PNP) inhibitor for cutaneous T-cell lymphoma (CTCL). Utilizing crystallography and structure-based drug design, BioCryst continues to expand its portfolio of next-generation therapeutic candidates with the potential to address th...

Jubilant to Work With Endo Pharmaceuticals on Drug Development

...ities of over 300 scientists specializing in multiple disciplines including biology, chemistry, structural biology, pharmacology, molecular modelling, crystallography and information technology to support collaborations with global pharma companies in USA, Europe and Japan.For more information visit: http://www.jub...

Scientists determine the structure of highly efficient light-harvesting molecules in green bacteria

...mation that can be used to create a picture of the molecule; however, X-ray crystallography could not be used to characterize the chlorosomes in green bacteria because...variability in their compositions had prevented scientists from using X-ray crystallography to characterize the internal structure." To get around this problem, the...

Zenobia Therapeutics Successfully Completes Initial Phase of Its Service Agreement With Syntonix Pharmaceuticals

...D., Director of Chemistry at Syntonix. About Zenobia Zenobia provides a commercial fragment library and access to their structural biology, crystallography and fragment-based lead discovery expertise through partnerships, consulting and collaborations. Zenobia's internal programs combine fragment-based le...

BioCryst Reports Fourth Quarter and Year End 2008 Financial Results and Provides Corporate Update

...ioCryst BioCryst is a biopharmaceutical company that has developed a deep pipeline of novel therapeutics targeting major illnesses by employing crystallography and structure-based drug design. BioCryst is currently advancing investigational new drugs discovered in-house in late-stage clinical trials for infl...

Jubilant and BioLeap Announce New Partnership in Drug Discovery

...lities of over 300 scientists specializing in multiple disciplines including biology, chemistry, structural biology, pharmacology, molecular modeling, crystallography and information technology to support collaborations with global pharma companies in USA, Europe and Japan. About Jubilant Organosys Ju...

BioCryst to Present at the J.P. Morgan 27th Annual Healthcare Conference

...cryst.com . The presentation will be archived for ninety days. About BioCryst BioCryst is an integrated biopharmaceutical company utilizing crystallography and structure-based drug design to develop a deep pipeline of novel therapeutics targeting major illnesses. BioCryst is currently advancing investiga...

BioCryst to Present Three Posters During the 50th American Society of Hematology Annual Meeting and Exposition

...r 7, 2008, 6:00 p.m. - 8:00 p.m. Pacific Time; Hall A About BioCryst BioCryst is an integrated biopharmaceutical company utilizing crystallography and structure-based drug design to develop a deep pipeline of novel therapeutics targeting major illnesses. BioCryst is currently advancing investigat...

deCODE genetics Announces Third Quarter 2008 Financial Results

...he past few months we have continued to bring forward new products for treating and preventing common diseases. Utilizing the expertise of our protein crystallography and medicinal chemistry units we have filed an IND on an exciting new PDE4 modulator for Alzheimer's disease that has the potential to avoid some of t...

Carna Biosciences Signs Distribution Agreement with Shanghai Universal Biotech Company

...lopment. The products and services provided by Carna include kinase proteins, assay development services, kinase profiling and screening services, and crystallography products and services. About SUBC Shanghai Universal Biotech Company (http://www.univ-bio.com ), founded in December 2004, is a Chinese distributo...
crystallography in Biological Products

CrysScreen protein crystallography software from Tecan

Description: CrysScreen is a software package that provides crystallographers with an intuitive user interface for custom buffer creation, set-up of experimental conditions and data management in crystallization trials. The software helps crystallographers through the most critical steps in automated protein cr...
Company:Tecan

Labware Carriers from Tecan

Description:...lly 24-, 96- or 384-well plates. Reagent troughs, MALDI targets and microscope slide adapters. High density formats such as 1536-well plates and crystallography plates. Temperature-controlled carriers can heat or cool reagents, e.g. media for cell-based applications, microplates and tubes. Disposable tip...
Company:Tecan

Fragment-based Screening Services from ActiveSight

Description:... ActiveSight, the leading provider of X-ray crystallography services for structure-based drug design, offers fragment-based screening s...p novel, high-affinity inhibitors. Relying on state-of-the-art Rigaku X-ray crystallography automation, ActiveSight can screen up to 100 protein structures a day for p...
Company:ActiveSight

Cartesian Honeybee System for protein crystallization from Genomic Solutions

Description:... High-throughput protein crystallography involves using many of the automation concepts from High Throughput Screeni...andling requirements are similar to those for HTS: Low volume: traditional crystallography plates have 24 or 48 wells with well volumes of 100s of microliters. For hi...
Company:Genomic Solutions
crystallography in Biological Definition

X-ray crystallography

X-ray crystallography is a technique in crystallography in which the pattern produced by the diffraction of x-rays through the closely spaced lattice of atoms in a crystal is recorded and then analyzed to reveal the nature of that lattice. The spacings in the crystal lattice can be det...

Biophysics

...es work Maurice Wilkins & Rosalind Franklin , pioneers of DNA crystallography Francis Crick , co-discover of DNA structure and the genetic code Max Perutz & John Kendrew , pioneers of protein crystallography Other notable biophysicists Howard Berg , characterized proper...

Ion channel

...rmination of their molecular structure by Roderick MacKinnon using X-ray crystallography won a share of the 2003 Nobel Prize in Chemistry . Because of their sma...directly examine what channels "look like." Particularly in cases where the crystallography required removing channels from their membranes with detergent, many resear...

Louis Pasteur

... molecules, it was quite an achievement, but Pasteur then went on to his more famous work in the field of biology/medicine. His doctoral thesis on crystallography got him a position of professor of chemistry at the Facult (College) of Strasbourg . In 1854, he was named Dean of the new College of Science in...

Molecular biology

...r Foundation at the time and believed that biology was about to undergo a period of significant change given recent advances in fields such as X-ray crystallography . He therefore channeled significant amounts of (Rockefeller Institute) money into biological fields. Further reading Keith Roberts, Martin ...

Protein

...helices . This protein was the first to have its structure solved by X-ray crystallography by Max Perutz and Sir John Cowdery Kendrew in 1958, which led to them ...e, unknown class of organic compounds. See also Biochemistry crystallography Denatured protein Intein Peptide Prion Proteinoid ...

Proteomics

...of protein structures in three-dimensional space. Common methods are x-ray crystallography and NMR spectroscopy . Interaction proteomics . This concerns the inve...entify the relative mass of a protein and its isoelectric point . X-ray crystallography and nuclear magnetic resonance are used to characterize the three-dimens...

Secondary structure

...re shown in colour, and random coil in white, there are no beta sheets in shown. This protein was the first to have its structure solved by X-ray crystallography by Max Perutz and Sir John Cowdery Kendrew in 1958, which led to them receiving a Nobel Prize in Chemistry . In biochemistry and structur...

Structural biology

...sts use to determine their structures generally involving measurements on vast numbers of identical molecules at the same time. These methods include crystallography , NMR , Electron Microscopy and circular dichroism . Most often researchers use them to study the static " native states " of macromolecules. But ...

Tertiary structure

...nformatics is to predict the native conformation of a protein from its primary sequence . Conventionally, tertiary structures are deduced through crystallography or multidimensional NMR . The study of protein tertiary structure is known as structural biology . See also: primary structure -- secondary ...
crystallography in Biological Dictionary

X-ray diffraction

... and physical properties of materials and thin films. These... X - ray crystallography is a method of determining the arrangement of atoms within a crystal, in wh...by matter, especially crystals, with accompanying variation in x-ray crystallography n. The study of crystal structure by means of x-ray diffraction . ... Wh...

Structural biology

...Jonathan Goldberg. Christopher D. Lima. Stephen B. ... The Structural Biology Center (SBC) operates a national user facility for macromolecular crystallography at Sector 19 of the Advanced Photon Source at Argonne ... The New York Structural Biology Center is a 501 (c) (3) corporation incorporated ... ...

Molecular biology

...Contents ... Molecular Biology Topics. Carbohydrate Conversion. Dough. Heterotroph Hypothesis ... How genetics, biochemistry, microbiology, and crystallography converged to form molecular biology , despite early parochialism of some scientists. Department of Molecular and Cell Biology . School of Nat...
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