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crystallization in Medical News

Flu virus foiled again

...had broad neutralizing capabilities. Subsequently, they found several antibodies similar to CR6261 in other donors as well. With the help of a robotic crystallization laboratory, the Scripps team quickly determined the detailed three-dimensional structures of this antibody when bound to the H1 virus that caused the ...

Microwave synthesis connects with the (quantum) dots

...us) that must be carefully controlled under an inert gas atmosphere for the crystallization and encapsulation stages. An intermediate ligand material that can tolerate the high temperature is used to promote the crystallization process, but it must be chemically swapped afterwards for a different compo...

They were right after all

...in yields of quinine in agreement with those in the old publications. Analytically pure quinine can be isolated from this reaction by the selective crystallization of the corresponding tartrate salt, just as described by Rabe in 1939, says Williams. We have thus corroborated Rabe and Kindlers 1918 publication. Wo...

Researchers solve first structure of a key to intact DNA inheritance

...e called X-ray crystallography to discern the structure of both proteins connecting to the plasmid DNA. This technique first requires purification and crystallization of the protein or, in this case, the more challenging DNA-protein complex structure. These are usually the most difficult steps of the process. Nex...

A Glass of Orange Juice To Keep Recurrence Of Kidney Stones At Bay

...UT South western’s General Clinical Research Center. Orange juice, researchers found, boosted the levels of citrate in the urine and reduced the crystallization of uric acid and calcium oxalate – the most frequently found ingredient in kidney stones. But lemonade did not increase the levels of citrate, a...

DNA-bound p53 Tumor Suppressor Protein Structure Determined

...rerequisite for obtaining the type of three-dimensional image sought in this study.) The researchers found that the dimers formed in solution prior to crystallization attempts took on a form that was incompatible with DNA binding. "There's an inactive form of the p53 dimer that's unable to bind DNA in the corr...

Insulin Crystals Holds Promise In Diabetes research

... of crystal formation, including semiconductor and optical materials, geological crystallization, ice formation and the physiological and pathological crystallization of proteins and small molecules." source:Eureka Alet...

Cholesterol Can Cause Burst Arteries

...and other debris material released by the plaque rupture into the bloodstream that activates the clotting mechanism. Researchers had compared the crystallization of the cholesterol to putting a plastic bottle of water into a freezer. Over time the water freezes and expands, pushing its way out of the bottle or ...
crystallization in Medical Technology

New Insight Into the Controls on a Go-To Enzyme

...e studied. Then, they direct X-rays through the crystal and deduce the protein structure from the diffraction pattern of those X-rays. To overcome the crystallization bottleneck, a lengthy and unpredictable variable in X-ray crystallography, the investigators used NMR spectroscopy to tailor the perfect enzyme-inhibi...

Albemarle Optimizes Smallpox Drug Candidate for SIGA

...e leadership of Dr. Shanthakumar Tyavanagimatt, SIGA's Director CMC operations & Formulations, Albemarle's R&D group have helped us flesh out a robust crystallization step that consistently delivers the most desired polymorph for this advanced API," said Dr Hruby. "Together we have developed a process that is suitab...
crystallization in Biological News

A crystal clear view of chalk formation

... It has a beautiful, but also an unpleasant side: crystallization determines the shape of precious stones, but also ...merous phenomena. The researchers investigated the crystallization of calcium carbonate, known commonly as chalk, and...stal. Easier for organisms to intervene If crystallization really did take this route, it would be easier to ...

December 2008 Geology and GSA Today media highlights

...loped electron microscope techniques. Their results have revealed that the granules form in a complex sequence of events involving several episodes of crystallization of different minerals. What is more remarkable is that these reactions are all mediated by the earthworm and completed very quickly, probably in less ...

New insight into the controls on a go-to enzyme

...e studied. Then, they direct X-rays through the crystal and deduce the protein structure from the diffraction pattern of those X-rays. To overcome the crystallization bottleneck, a lengthy and unpredictable variable in X-ray crystallography, the investigators used NMR spectroscopy to tailor the perfect enzyme-inhibi...

Damage inflicted during cardiac attacks more widespread, MSU researchers find

...ersity's College of Human Medicine and chief of the Department of Medicine's cardiology section, is leading innovative research into the role that the crystallization and expansion of cholesterol play in heart attacks, strokes and other cardiovascular events in humans. He presented his latest research this week a...

July 2008 GEOLOGY and GSA Today media highlights

...inding that, in addition to the 1750 million-year-old zircons that date the crystallization age, there are numerous "inherited" older zircons whose ages are mostly abo...d Hf model ages of 1850 to 2000 million years, significantly older than the crystallization age of the rocks, and confirming their derivation from melting of older cru...

Montana State University researchers map iron transport protein

...awrence and Sendamarai first had find and purify samples of the protein and then turn those samples into crystals. Lawrence said the result of the crystallization process, if done correctly, is analogous to the rigid structure of a brick wall. If done incorrectly, it more closely resembles a pile of bricks. I...

Argonne scientists use lasers to align molecules

...E) Argonne National Laboratory have devised a way to eliminate the need for crystallization by using lasers to align large groups of molecules. "Strong laser fields...Using x-rays, we can investigate their properties in a totally new way." crystallization allows scientists to create a periodic structure that will strongly diffrac...

New mineralogical techniques contribute to prevent national heritage damage

...roblem: Blocking inside the stone the mineral salt crystallization process that ends up destroying it. One of the w...es de cristalizacin (Damage prevention due to salt crystallization in national heritage through the use of crystallization inhibitors), read by Encarnacin Mara Ruiz Agudo ,...

Hot springs microbes hold key to dating sedimentary rocks, researchers say

...n be used to reconstruct the pH, temperature and flux of ancient hot springs environments. The researchers also show how patterns in calcium carbonate crystallization can be used to differentiate signatures of life from those caused by environmental change. This means we can go into the rock record, on Earth or oth...

Scientists find missing evolutionary link using tiny fungus crystal

...o be able to see how the fungus' protein worked. That's where Golden's team joined the effort and crystallized the molecule at Purdue's macromolecular crystallization facility. "Obviously, we can't see the process of moving from RNA to RNA and proteins and then to DNA, without a time machine," Golden said. "But b...
crystallization in Biological Technology

Avantium Launches the Crystalline, a New Parallel System for Crystallization Research

AMSTERDAM, January 22 /PRNewswire/ -- Avantium Technologies announces the launch of a new system to study crystallization processes for the pharmaceutical industry. The system will be marketed under the name Crystalline. The Crystalline has been designed to address the need in the pharm...

Particle Sciences and Microfluidics Collaborate to Share Formulation and Nanotechnology Expertise for Pharmaceutical Drug Product Development, Analysis and Commercialization

...In addition, Microfluidics Reaction Technology (MRT), an innovative technique for bottom-up nanoparticle creation and nanoencapsulation via continuous crystallization and chemical reactions, offers even more possibilities in novel drug development and will also be incorporated into PSI's offerings. As part of t...

Microfluidics Expands Distributorship in Japan with Exclusive POWREX Partnership to Meet Increased Demand in Pharmaceutical, Biotechnology and Energy Industries

...lable, as well as novel Microfluidics Reaction Technology (MRT) for bottom-up creation of nanoparticles and efficient nanoencapsulation via continuous crystallization and chemical reactions. "Microfluidics is honored to partner with such a respected corporation as POWREX," said Michael C. Ferrara, Microfluidics...

Zenobia Therapeutics Successfully Completes Initial Phase of Its Service Agreement With Syntonix Pharmaceuticals

...'s technology and expertise in structural biology, crystallization and X-ray structure determination. Zenobia complet...he program required dedicated expertise in protein crystallization including specialized techniques and multiple roun...mination," said Vandana Sridhar, head of Zenobia's crystallization group. Zenobia has rapid access to high-ener...

Process Analytical Technology (PAT): The Official Language of Pharmaceutical Outsourcing

...d the sponsoring Bio-Pharmaceutical company. Case studies will address commonly outsourced process applications including custom organic synthesis and crystallization steps in the production of an active pharmaceutical ingredient (API) as well as the high shear granulation of a formulated drug product. ### Read...

Free Webinars in Chemistry and Chemical Engineering

...le-up, process safety and thermal hazard analysis, crystallization development and manufacturing, and Process Analyti...al R&D, Part II Crystallization Improving crystallization and Precipitation: 20 Years of Best Practice, Part I Improving crystallization and Precipitation: 20 Years of Best Practice, Part...

Researchers show how to 'stamp' nanodevices with rubber molds

...dots, magnetic spheres and other nanoparticles, they said. They also assembled arrays of single salt crystals, suggesting that any material capable of crystallization could be manipulated by the process. They began with gold nanoparticles about 12 nanometers in diameter suspended in water. To suspend metal partic...

Zenobia Therapeutics, Inc. Begins Operations as a Fragment-Based Lead Discovery Company

...g and a leader in structure-based drug design methods. Zenobia's 505 Coast Blvd facility is fully equipped for cloning, expression, purification and crystallization of proteins. Contracts are in place with synchrotron facilities for high-throughput data collection and Zenobia's compound library is available for sc...

CRELUX and ProQinase establish joint crystal-grade kinase protein and structures platform

...ile CRELUX will continue to provide customers with crystallization and x-ray crystallography services. CRELUX will support ProQinase by performing crystallization quality control for each crystal grade protein bat... expression all the way to high-throughput protein crystallization and in-house x-ray crystallography. ProQinase, a...

Protein-crystal companies join forces for better imaging process

... step forward in completely automating the protein crystallization experiment. This partnership will facilitate cryst...tegrated incubation and imaging system for protein crystallization to be offered to the crystallography community. By providing high throughput protein crystallization automation, the Crystal Farm is accelerating struc...
crystallization in Biological Products

Cartesian Honeybee System for protein crystallization from Genomic Solutions

Description: High-throughput protein crystallography involves using many of the automation concepts from High Throughput Screening (HTS). The liquid handling requirements are similar to those for HTS: Low volume: traditional crystallography plates have 24 or 48 wells with well volumes of 100s of microliters. F...
Company:Genomic Solutions

CrysScreen protein crystallography software from Tecan

Description:... of experimental conditions and data management in crystallization trials. The software helps crystallographers throu...in automated protein crystallography: Design of crystallization Conditions. Execution of crystallization Experiments. Results Analysis. CrysScreen c...
Company:Tecan

Freedom EVO 150 from Tecan

Description:...applications Proteomics Protein digestion and MALDI spotting Protein crystallization and crystallization set-up Protein solubility Recombinant protein purification Drug Disc...
Company:Tecan

Fragment Library I: Large Volume with mixtures from ActiveSight

Description:... Individual compounds are dissolved in DMSO at ca. 200 mM, mixtures of 4 are at ca. 50 mM. Supplied in 5 96-well trays. Dilute library with protein crystallization solution to make soak solutions for a complete structure based fragment screening project. Includes CD-ROM containing a full description of each frag...
Company:ActiveSight
crystallization in Biological Definition

X-ray crystallography

... each other, the signal becomes detectable. To determine a structure, one must first grow crystals of the molecule of interest using some method of crystallization . This can be a painstaking procedure for macromolecules such as protein and DNA complexes. The crystals are harvested and often frozen with liquid...
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