Researcher Studying Disease That Cripples Newborns

Each year, the parents of an estimated one in 20,000 newborns are shocked to learn their child has type 1 congenital myotonic dystrophy (CDM1), a progressive and crippling genetic disorder. Although doctors know that babies inherit CDM1 from their mother and prenatal tests are available, many chil...

10 Steps to Affordable Health Care Overhaul: NCPA Proposes Reforms to Protect Choices, Control Costs and Preserve Access

... all trapped in a dysfunctional health care system," said Goodman. "Doctors and patients are powerless to change the daily waste and inefficiency that cripples this system." Goodman noted that the way doctors relate to patients has not changed significantly in 100 years. "Doctors don't talk to their p...

Two Ways to Tackle Tuberculosis

...cking," McNeeley said. "Some interrupt protein synthesis, some interfere with DNA replication, some interrupt cell wall construction." The new drug cripples the activity of ATP synthase, an enzyme that plays a key role in biological energy metabolism. It does that only in the TB bacterium, not in other cel...

US releases updated clinical guidelines for HIV-associated opportunistic infections

...nd a former president of IDSA. "The updated guidelines outline these advances for physicians and patients across the United States and beyond." HIV cripples the immune systems of its human hosts, leaving them more vulnerable than the general population to numerous other infectious diseases. These HIV-assoc...

Blood protein may hold key to stopping tumor growth in cancer patients

...how some blood proteins are involved in that process and affect blood vessel growth. Researchers found that a protein called ferritin binds to and cripples the ability of another blood protein, called HKa, to shut down blood vessel growth. Because new blood vessels supply a steady stream of nutrients and ...

HIV conquers immune system faster than previously realized

...ocess of HIV-1 infection lay in the three to four weeks between transmission and the development of an established pool of infected CD4 T cells. HIV-1 cripples the immune system by invading and killing CD4 T cells, key infection-fighters in the body. "But this new study shows that HIV-I does a lot of dama...

A Molecular Condom Against AIDS

...els, rings, sponges or creams to prevent infection by the human immunodeficiency virus and other sexually transmitted diseases. HIV causes AIDS, which cripples the immune system, leaving patients vulnerable to other infections, cancers and death. Microbicides are seen as a way for women to gain power by...

Sleeping sickness - a silent killer

...creening in rural areas, many do not even know they have the disease until it is too late. If untreated the disease - which causes severe drowsiness - cripples the central nervous system, by which point it is almost always fatal. ...

cripples in Medical Technology

St. Jude Study Finds Treatment With New Drug Might Make Tumor Cells More Sensitive to Therapy

...ave shown that it might be possible to make tumor cells more sensitive to irradiation and some types of chemotherapy by treating them with a drug that cripples their ability to repair DNA damage caused by these therapies. The St. Jude researchers demonstrated in the laboratory that a molecule called CP466...

cripples in Biological News

Pretreating rogue cancer cells with aspirin cripples their resistance to targeted therapy

Safeguarding 595 sites around the world would help stave off an imminent global extinction crisis, according to new research published today in the Proceedings of the National Academy of Sciences ( www.pnas.org ). Conducted by scientists working with the 52 member organizations of the Alliance fo...

The structure of the Mre11 protein bound to DNA

...g of DNA ends, causes fewer problems. The other histidine mutation impairs Mre11's ability to remodel both end and internal sequences and subsequently cripples repair. Because MRN initiates only one kind of DSB repair, however homologous recombination in some species a different kind of repair called nonhom...

Trials for new drug to overcome HIV

...assembled into a cone. PA-457 stops it being clipped off, causing it to form a leaky sphere that leaves the core RNA exposed (see Diagram, left). This cripples the virus, preventing it from infecting any other cells once it buds out from the host. Previous lab experiments on infected human cells have shown...

Promising new West Nile therapy cures disease in mice

...ockville, MD-based MacroGenics Inc., to create a human-like version of the most effective antibody. MacroGenics stitched the part of the antibody that cripples the West Nile virus into the scaffold of a human antibody. The monoclonal antibody was several hundred times more potent in cell culture tests than an...