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DMP1 deletion cooperates with oncogenic K-ras in lung cancer

Scientists have identified the transcription factor DMP1 as a pivotal tumor suppressor for both human and mouse lung cancers, especially in carcinomas that exhibit intact Arf-p53 pathways. The research, published by Cell Press in the October 2007 issue of Cancer Cell , may lead to development of ...

Abbott and Oasmia Pharmaceutical Announce Exclusive Distribution Agreement for Paccal(R) Vet, a New Chemotherapeutic Agent for Dogs

... and veterinary use. The broad portfolio is focused on oncology and contains several promising products in the clinical and pre-clinical phase. Oasmia cooperates with leading universities and other biotech companies to discover and optimize substances with a favorable safety profile and better efficacy. The com...

Nestle(R) Toll House(R) Refrigerated Cookie Dough Recall Update

...he Wall Street Journal bears no relation to Nestle's recent voluntary withdrawal of Nestle Toll House refrigerated cookie dough. Nestle always fully cooperates with the regulatory authorities wherever it operates, and Nestle is fully cooperating with the Food and Drug Administration (FDA) at our Danville, Vir...

Genetic breakdown in Fanconi anemia may have link to HPV-associated cancer

...ll replication cycle. Dr. Wells and her colleagues believe FA deficiency may accelerate tumor development by promoting genomic instability, which then cooperates with HPV's inactivation of the body's natural tumor suppressors. Restoring the FA gene pathway, they suggest, can block cell cycle abnormalities stimu...

New, Informative EAU Website Launched: http://www.urologyweek.org

... of the new website is to educate and inform the lay public on urological conditions and thereby promote timely consultation of a physician. The EAU cooperates with Europa UOMO, a European advocacy movement for the fight against prostate cancer. Several national urological societies in Europe have committed...

Tailoring glioblastoma therapies: 1 size does not fit all

...ons in glioblastomas - PTEN deficiency or EGFRvIII activation -- the researchers show that PTEN regulates STAT3 tumor suppressor function, while STAT3 cooperates with the EGFRvIII oncoprotein to promote tumor growth. Thus, the researchers convincingly demonstrate a need for effective therapies tailored to th...

Src Inhibitors in Breast Cancer Therapy

...sion. They found that ER-alphanegative primary breast cancers and cell lines showed increased levels and/or activity of the protein Src, which cooperates with estrogen to activate ER-alpha breakdown via proteolysis. In line with this finding, Src inhibition was shown to impair estrogen-stimulate...

Researchers Have Found the Role of Protein in Accelerating Breast Cancer Progression

..., three animal models were tested to determine if inappropriate expression of PTN alone was sufficient to induce breast cancer or whether the cytokine cooperates with different pathogenic mechanisms to stimulate breast cancer progression. The new study identified PTN as one factor that activates stromal...

Protein Targets for Carcinogenesis

... that the cooperation of three enzymes is needed to attach Ub to another protein: E1, E2 and E3. E1 activates Ub and transfers it to E2, which in turn cooperates with an so-called Ub ligase (E3) that couples Ub to a specific target protein. However, Dikic and colleagues discovered that certain proteins can be u...

New Method For Fighting Leukemia

... the marked activation of an important pro-apoptotic protein known as Bak. Grant said that when Bak is freed from its constraints by these actions, it cooperates with other pro-death proteins to induce mitochondrial damage, culminating in the dramatic onset of apoptosis. 'Our findings are significant bec...
cooperates in Medical Technology

USAID Cooperates in Pandemic Preparedness Initiative

WASHINGTON, April 28 /PRNewswire-USNewswire/ -- The U.S. Agency for International Development (USAID) is convening a group of civil society organizations today in Addis Ababa, Ethiopia, in a regional exercise that will kick off the implementation stage of its Humanitarian Pandemic Preparedness ini...

Oasmia: FDA Grants Paclical(R) Orphan Drug Designation for Ovarian Cancer in the USA

...uman and veterinary use. The broad portfolio is focused on oncology and contains several promising products in clinical and pre-clinical phase. Oasmia cooperates with leading universities and other biotech companies to discover and optimize substances with a favourable safety profile and better efficacy. The co...

Scientists Discover Why Teeth Form in a Single Row

...out Msx1, the BMP4 signal was not amplified to the point where it could kick off the next tooth in the row. With these results, Jiang argues that BMP4 cooperates with other factors to create a temporary zone around each tooth where no other tooth can grow. When the tooth gets closer to maturity, Msx1 overwhelms...

Can-Fite Proceeds with Development of Third Drug; Progress in Development of CF502 Will Be Presented at the Annual European Congress of Rheumatology

...r Can-Fite had signed a prestigious agreement with the NIH, the leading research institute in the US. Under this agreement, titled CRADA, Can-Fite now cooperates with the laboratory of Prof. Jacobson, a worldwide leading scientist in the field of A3 adenosine receptor agonists and antagonists. Can-Fite is curre...
cooperates in Biological News

TEL2 gene cooperates with MYC gene to provoke B-cell lymphomas

The genes TEL2 and MYC cooperate with each other to promote pediatric cases of the immune system cancer B-cell lymphoma. This finding, from investigators at St. Jude Children's Research Hospital, is published in the current issue of Molecular Cell Biology (MCB). B-cell lymphoma is a cancer in whi...

Fox Chase researchers uncover one force behind the MYC oncogene in many cancers

... that a chromosomal inversion a genetic misalignment, where part of the chromosome containing the DLX5 gene gets flipped around during cell division cooperates with another known oncogene, AKT2, to drive cancer in mice. In the current paper, the researchers discover that DLX5 binds to and actively promotes th...

Scientists discover why teeth form in a single row

...out Msx1, the BMP4 signal was not amplified to the point where it could kick off the next tooth in the row. With these results, Jiang argues that BMP4 cooperates with other factors to create a temporary zone around each tooth where no other tooth can grow. When the tooth gets closer to maturity, Msx1 overwhelms...

ESA satellites focusing on the Arctic

...e Polar View initiative, established by European and Canadian organisations under the Global Monitoring for Environment and Security (GMES) programme, cooperates with European Ice Services to improve ice monitoring and forecasting. Ulf Gullne, a Polar View user responsible for ice-breaking services in Swede...

Newly identified protein complex sheds light on axon growth mechanism

... vesicle trafficking, a process that is necessary for axon growth and new synapse formation. The short coiled-coil domain-containing protein UNC-69 cooperates with UNC-76 to regulate axonal outgrowth and normal presynaptic organization in Caenorhabditis elegans Cheng-Wen Su, Suzanne Tharin, Yishi Jin, Bruce...
cooperates in Biological Technology

BASF Set To Commercialize pro-t-action(TM) Eliminating Caries Causing Bacteria From the Mouth

...on chemistry-based new materials, technologies and system solutions. BASF Future Business GmbH commissions research from BASF's R&D units but also cooperates with startup companies, industrial partners, universities and potential customers. Other alternatives include the acquisition of direct stakes, joint ...

Tigermed Sets Up Subsidiary, Hunan Tigermed Xiangya Drug R&D Ltd (Tigermed Xiangya)

...Centers: the Drug Clinical Evaluation Center (DCEC), Pharmaceutical Analysis Center (PAC) and Drug Pre-clinical Evaluation Center (DPEC). DCEC mainly cooperates with the third Xiangya Hospital of CSU to conduct Phase I clinical trials for new drugs, and Pharmacokinetics (PK) and Bioequiavailability (BE) studie...

Ziehm Imaging Extends its Training Offer

...nicians from reference clinics, to which all participants will be able to register online next year. Moreover, as part of the Academy, Ziehm Imaging cooperates closely with clinical partners and scientific organizations in the USA. In special on-site courses, the so-called Mobile Learning Labs, doctors and cl...

Look at the New Economy, Just Like the Old Economy

...ing trends suggest that the global reach of the Internet is now being complimented by the use of different technological infrastructures that actually cooperates with each other. Delivering the hottest technology no longer sells, instead delivering real sales increases or cost reductions does. At a break-out...
cooperates in Biological Dictionary

Synergism

...reek words, erg meaning to work ... monergism, synergism , regeneration, monergism ... He attacks the Catholic concept of synergism , whereby man cooperates with God in ... Synergism Belongs in a Car Dealership, not in Divine Salvation. James White ... Steve Gregg in support of synergism over agains...

PolyA tail

... and poly(A ) tail . ... Poly(A ) tail removal is thought to disrupt the circular ... In the cytoplasm, the poly(A ) tail bound by Pab1 cooperates with the cap ... supports a significant role for poly(A ) tail length control in gene regulation. ... The poly(A ) tail functions in two wa...
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Breaking Biology News(10 mins):Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 2Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 3Emerging Technologies Enable Smarter Monitoring of Assets, Push Industrial Testing, Inspection and Monitoring Market 4Inception Technologies to Release New Biometric Reader 2C-Labs Names Former Microsoft and Bsquare Executive as Chief Operating Officer 2
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