Mersana's Second Development Candidate, XMT-1107, Shows Superior Pharmacokinetics and Anti-Tumor Activity in Studies Presented at American Association of Cancer Research Meeting

...hanced antiangiogenic and in vivo anti-tumor activity of XMT-1107 compared to its in vivo release product XMT-1191 clearly demonstrated the benefit of conjugating XMT-1191 to Fleximer(R) and supports the potential clinical utility of XMT-1107 as an anti-cancer agent. "Pharmacokinetics of a novel fumagill...

conjugating in Medical Technology

Raptor Pharmaceuticals Receives Notices of Allowance for Two NeuroTrans(TM) Patent Applications

... a preliminary patent term that expires in 2023. NeuroTrans(TM) has been designed to deliver drugs across the BBB in a minimally invasive way by conjugating them to RAP peptides engineered by Raptor. Hundreds of neurodegenerative disorders are ineffectively treated because most drugs are unable to penetrat...

Immunomedics Announces Preclinical Therapy Results of SN-38 Immunoconjugate for Colorectal Cancer

.... Due to its toxicity and poor solubility, SN-38 cannot be administered systemically to cancer patients. The Company has previously reported that by conjugating SN-38 to antibodies, the powerful cancer drug can be delivered selectively to tumors, thereby increasing the amount reaching the tumors and minimizing...

CuraGen Announces Initiation of Phase II Trial of CR011-vcMMAE in Patients with Advanced Breast Cancer

...NMB is expressed in aggressive breast cancers and is believed to play a role in promoting invasion and metastasis of breast cancer cells. Furthermore, conjugating an antibody against this biologically relevant target with MMAE, a cytotoxic drug that belongs to a class of therapeutics known to be active against b...

conjugating in Biological News

Using carbon nanotubes to seek and destroy anthrax toxin and other harmful proteins

...te this protein without disturbing the other proteins in the mixture. By conjugating carbon nanotubes with different peptides, this process can be easily tailor...uld also offer a new method for the targeted destruction of tumor cells. By conjugating carbon nanotubes with peptides engineered to seek out specific cancer cells...

conjugating in Biological Technology

SoluLinK Introduces NanoLink(TM) Streptavidin Magnetic Microspheres

...ing of advanced conjugation reagents (HydraLink(TM)) biotinylation kits (ChromaLink(TM)), magnetic microspheres (NanoLink(TM)), detection reagents and conjugating services for the life sciences, diagnostic, and pharmaceutical communities. The company's proprietary bioconjugation chemistry is used to link protein...

conjugating in Biological Products

Ubiquitin Fraction I Extract from GeneTex

Description:...dle syndrome. GTX80876 is the protein fraction of HeLa cell extract that does not bind to anion exchange resin. GTX80876 contains ubiquitin, ubiquitin conjugating enzymes (E2s), and ubiquitin ligases (E3s). GTX80876 is ideal for demonstrating if FI enzymes are critical for degradation of in vitro substrates as w...
Company:GeneTex

IRS Extract from GeneTex

Description:... to anion exchange resin. This fraction is essentially ubiquitin-free and ATP-free. GTX80877 contains ubiquitin activating enzyme (E1), most ubiquitin conjugating enzymes (E2s), ubiquitin C-terminal hydrolases (UCHs) and the 20S and 26S proteasomes. GTX80877 is ideal for demonstrating ubiquitin and/or ATP depend...
Company:GeneTex

26S Proteasome Fraction Extract from GeneTex

Description:...stic fibrosis, Angelmans syndrome, and Liddle syndrome.GTX80880 contains the full Hela cell compliment of ubiquitin activating enzyme (E1), ubiquitin conjugating enzymes (E2s), 20S and 26S proteasomes, isopeptidase, proteasome PA28/11S REG complex, and ubiquitin ligase enzymes (E3s). GTX80880 is ideal for demon...
Company:GeneTex

Ubiquitin Fraction I from ABR-Affinity BioReagents

Description:...Liddle syndrome. EP-500 is the protein fraction of HeLa cell extract that does not bind to anion exchange resin. EP-500 contains ubiquitin, ubiquitin conjugating enzymes (E2s), and ubiquitin ligases (E3s). EP-500 is ideal for demonstrating if FI enzymes are critical for degradation of in vitro substrates as we...
Company:ABR-Affinity BioReagents

Ubiquitin/Proteasome Fraction II Extract from GeneTex

Description:... to anion exchange resin. This fraction is essentially ubiquitin-free and ATP-free. GTX80878 contains ubiquitin activating enzyme (E1), most ubiquitin conjugating enzymes (E2s), ubiquitin C-terminal hydrolases (UCHs) and the 20S and 26S proteasomes. GTX80878 is ideal for demonstrating ubiquitin and/or ATP depend...
Company:GeneTex

Custom Antibody Production Services from Aves Labs, Inc.

Description:...inity purifying the antibodies against immunosorbent materials. Labeling the affinity purified antibodies with biotin, HRP, fluorescent dyes, or conjugating these antibodies to agarose. Performing ELISAs and other tests to assure that the quantities, affinities, and other properties of the antibodies...
Company:Aves Labs, Inc.

Glutathione-S-Transferase (GST) Colorimetric Assay Kit from Sigma-Aldrich

Description:...sferases (GSTs) are a group of enzymes important in the detoxification of many xenobiotics in mammals. The enzymes protect cells against toxicants by conjugating the thiol group of the glutathione to electrophilic xenobiotics, and thereby defend cells against the mutagenic, carcinogenic, and toxic effects of th...
Company:Sigma-Aldrich

conjugating in Biological Dictionary

Conjugation

... of conjugation homomorphism. conjugacy class, the image of an element under the conjugation homomorphisms ... conjugation n. The act of conjugating . The state of being conjugated . Grammar. ... The genetic instructions for conjugation are encoded on a double-stranded, ... Latin conjugation...