Supercomputer Dedicated To Bioengineering, Computational Biology Installed
The University of California, San Diego, with support from the National Institutes of Health and the Whitaker Foundation, has installed a supercomputer dedicated to solving a wide range of challenging biological problems. The 210-node Dell PowerEdge Linux cluster capable of 2.6 trillion mathematical operations per second, the second most powerful computer cluster on campus, will be used to analyz...Institute for Systems Biology Symposium Addresses Need for Better Computational Tools
The Institute for Systems Biology announced today at its 2005 international symposium on Computational Challenges in Systems Biology that ISB's Human Proteome Folding Project launched on IBM's World Community Grid in November 2004 has already predicted 50,000 protein structures. "This project showcases the enormous power of collaborations," stated Dr. Richard Bonneau, senior scientist at t...Computational Method Speeds Mapping of Cell Signaling Networks
For decades, scientists have been studying how external information gets transmitted from outside of cells to the control centers inside them that trigger particular responses. But cell signaling networks are so complex that mapping them has been a slow, arduous process. Now, a research team from Stanford, MIT and Harvard has developed a new method for charting cellular signaling networks...Computational verification of protein-protein interactions by orthologous co-expression
In the March 3 issue of Nature, Johns Hopkins researchers report that two proteins best known for very different activities actually come together to turn the liver into a sugar-producing factory when food is scarce. Because the liver's production of sugar is a damaging problem in people with diabetes, the proteins' interaction might be a target for future drugs to fight the disease, the research...Computational Tool Predicts How Drugs Work In Cells, Advancing Efforts To Design Better Medicines
The ability to select and develop compounds that act on specific cellular targets has just gained a computational ally ?a mathematical algorithm that predicts the precise effects a given compound will have on a cell’s molecular components or chemical processes. Using this tool, drug developers can design compounds that will act on only desired gene and protein targets, eliciting therapeutic respo...Computational Model Reveals Working of AZT in Body
A computational model has been developed by researchers at the Virginia Bioinformatics Institute (VBI) at Virginia Tech which would allow scientists to have a better //understanding of the metabolism and toxicity of the HIV/AIDS drug zidovudine (azidothymidine, AZT). AZT is used successfully as part of Highly Active Anti-Retroviral Therapy (HAART) to control the level of the human immun...