New target for maintaining healthy blood pressure discovered
... protein called angiotensiogen. Renin, an enzyme produced by the kidneys, cleaves angiotensiogen into a peptide called angiotensin I. Angiotensin I is cleaved again to form angiotensin II, which stimulates blood vessels to narrow, thereby increasing blood pressure. At the same time, angiotensin II induces th...New tests provide new insight into why patients are in heart failure
...g heart failure or is it genetic?" A recombinant protein also called corin identified in the late 1990s helped solve the mystery of how pro-ANP got cleaved into the active state. That got Dr. Gladysheva wondering about the natural protein activator. She used antibodies to the recombinant protein to find t...Wayne State University Scientists ID New Biomarker for Prostate Cancer
...cer Institute, and his team of renowned research collaborators identified a cleaved form of galectin-3 as a marker for prostate cancer progression. According t...ciated with tumorigenicity in other tumor types. The study found that cleaved galectin-3, an inheritable gene, is present in late-stage prostate cancer, ...Scientists ID New Biomarker for Prostate Cancer
... Study finds cleaved galectin-3 may serve as treatment target against d...difference was due to the fact that galectin-3 was cleaved during prostate cancer progression. Their study found that cleaved galectin-3 is present in a late-stage prostate can...Tracon Pharmaceuticals to Present Clinical Stage Programs at AACR 2009
...h temozolomide (Temodar(R)). TRC093 is a humanized IgG1 monoclonal antibody that inhibits angiogenesis, tumor growth, and metastasis by binding cleaved collagen in the extracellular matrix of cancers. This antibody is expected to address multiple solid tumor types and may also be developed for age-rel...USC researchers identify key mechanism that regulates the development of stem cells into neurons
...yos to investigate Ryk's function in vivo. They found that during neurogenesis, when neural stem cells start to grow into neurons, Ryk protein is cleaved and translocates to the cell nucleus to regulate neuronal differentiation. This finding is extremely important for understanding the regulation of ...Same process discovered to both form skeleton and protect it for life
... Interestingly, DAPT also blocks the action of secretases that snip into fragments the amyloid precursor protein (APP) in brain cells. Some of these cleaved APP fragments clump together to form "plaques" in the brains of patients with Alzheimer's disease that contribute to the death of brain cells. DAPT is...First look at an enzyme target for antibacterial and cancer drugs
...po IIs lower domain swings open, the second DNA segment is released and the cleaved DNA segment is reconnected. In many ways, the enzyme works like a set of...nting the enzymes from completing their tasks. In the case of topo IIs, the cleaved segments of DNA remain attached to the topo II so that they cannot be resea...TRACON Pharmaceuticals' Small Molecule TRC102 and Antibody TRC105 to be Presented at ASCO 2009
...met needs in these areas with first-in-class product candidates that will complement existing therapies. TRC093 is a monoclonal antibody that binds to cleaved collagen to inhibit angiogenesis and tumor growth that began dosing in a Phase 1 clinical trial in cancer patients in July, 2007. TRC105 is a monoclon...Micromet Announces the Publication of BiTE Antibody Review in Drugs of the Future
...MT293 (formerly D93), also known as TRC093, a first-in-class humanized monoclonal antibody that inhibits angiogenesis and tumor cell growth by binding cleaved collagen. MT293, which is currently being tested in a phase 1 clinical trial, is licensed to TRACON Pharmaceuticals, Inc. and is being developed for t...Micromet Announces Changes in Management Team
...MT293 (formerly D93), also known as TRC093, a first-in-class humanized monoclonal antibody that inhibits angiogenesis and tumor cell growth by binding cleaved collagen. MT293, which is currently being tested in a phase 1 clinical trial, is licensed to TRACON Pharmaceuticals, Inc. and is being developed for t...ACE - REA Hypertension / Cardiac Evaluation, Cardiovascular 001-RK-ACD Angiotensin Converting Enzyme
Description:...l proximal tubular cells, but is mostly found in endothelial cells. It is attached to the endothelial surface membrane by an anchor peptide and can be cleaved to be released into the blood circulation as soluble enzyme. Angiotensin converting enzyme (ACE) catalyzes the conversion of angiotensin I to an...Angiotensin II RIA Hypertension / Cardiac Evaluation, Cardiovascular 001-RK-A22
Description:... cells of the kidneys, cleaves angiotensinogen to produce the decapeptide angiotensin I (Ang I) which is physiologically inactive. Ang I is rapidly cleaved by the angiotensin converting enzyme (ACE) in plasma, vascular endothelial cells, kidney, lung and other tissues, into Ang II, the major active compon...C-Peptide EIA Diabetes and Obesity Markers 008-10-1136-01
Description:...in1,3. Human C-peptide is a 31 amino acid chain with a molecular mass of approximately 3020 daltons. Within the pancreatic b-cell, proinsulin is cleaved into one molecule of C-peptide and one molecule of insulin. C-peptide is subsequently released into the circulation at concentrations equimolar to th...Ultrasensitive C-Peptide EIA Diabetes and Obesity Markers 008-10-1141-01
Description:...nsulin1,3. Human C-peptide is a 31 amino acid chain with a molecular mass of approximately 3020 daltons. Within the pancreatic -cell, proinsulin is cleaved into one molecule of C-peptide and one molecule of insulin. C-peptide is subsequently released into the circulation at concentrations equimolar to tho...Tips from the American Journal of Pathology
...es at the University of Michigan have identified a cleaved form of galectin-3 as a marker for prostate cancer...rence, Wang et al hypothesized that galectin-3 was cleaved during prostate cancer progression. They identified cleaved galectin-3 in later stage prostate cancer, and det...CSHL scientists find a new class of small RNAs and define its function
... Curiously, PASRs and non-PASRs may not be initially synthesized in their "short" form. The CSHL team proposes a model in which mature long RNAs are cleaved followed by a capping of the newly generated long RNA fragment. This is followed by the clipping of the end of the capped long RNA to produce a short ...Stowers Institute's Baumann Lab identifies key step in maturation pathway of telomerase
...rally, this involves exonucleolytic degradation, the gradual removal of nucleotides one at a time until the mature end has been reached. Some RNAs are cleaved near the end before exonucleolytic degradation proceeds to generate the mature end. We now show that 3' end processing for telomerase RNA uses a funda...Using novel tool, UD researchers dig through cell 'trash' and find treasure
...the UD technique. Rather than searching for the cleaved RNAs one by one in a tedious process that previous...on at which the molecule has been cut. Because the cleaved molecules are recognizable by the high level of th...libraries produced a distinct "signature" for each cleaved messenger RNA molecule, which can be assigned to i...Cholesterol metabolism links early- and late-onset Alzheimer's disease
...ld age than those who don't have the mutation. Bu and colleagues demonstrated that APP and apolipoprotein E have a molecular connection. When APP is cleaved by a specific enzyme in the brain, it releases A-beta plus a small protein fragment. The fragment then can regulate apolipoprotein E, which moves chol...Who gives stem cells their marching orders?
...eir neighbors. However, to carry out these tasks, the Nodal protein must be cleaved by specific enzymes. The enzymes act as a sort of regulatory switch, increa...tember issue of the journal Developmental Cell, the researchers explain how cleaved and uncleaved forms of the Nodal protein act together to let the stem cells...New understanding of parasite cell structures may provide treatments for serious tropical diseases
... with cellular energy and also serve as markers for cellular recognition. The researchers discovered a new function for these glycolipids--they are cleaved in response to cell stress caused by changes in osmotic pressure and relative acidity or alkalinity. The research by the UGA team is especially imp...Major WHO study concludes calcium supplements can reduce complications during pregnancy
...ottom. The similarity to a face ends at the top of the molecule, where two flaps open to reveal a cavity. That is where enzymes and other proteins are cleaved into the parts necessary to assemble infectious virus particles. Structural studies of this cavity helped scientists find the original protease inhibi...Computer simulation hints at new HIV drug target
...ottom. The similarity to a face ends at the top of the molecule, where two flaps open to reveal a cavity. That is where enzymes and other proteins are cleaved into the parts necessary to assemble infectious virus particles. Structural studies of this cavity helped scientists find the original protease inhibi...Advanced genomics and proteomics improve the diagnosis and treatment of a deadly lung disease
...ies of how Dicer functions, Doudna said. In particular, scientists would like to know how Dicer is involved in downstream events, how it hands off the cleaved RNA and directs it to the right gene targets. Resolving the structure of Dicer, Doudna noted, was a technical challenge as the crystals are small. ...Incorrectly cleaved protein leads to schizophrenia
Leuven, Belgium Schizophrenia is a disease that strikes an average of 4000 Belgians every year. The causes of this psychiatric disorder are not yet clear. But now, VIB researchers connected to the Katholieke Universiteit Leuven have discovered that a disturbed cleavage of the Nrg-1 protein lies a...Micromet to Present at the 2007 RBC Capital Markets Healthcare Conference on December 12, 2007
...MT293 (formerly D93); also known as TRC093, a first-in-class humanized monoclonal antibody that inhibits angiogenesis and tumor cell growth by binding cleaved collagen. MT293 is licensed to TRACON Pharmaceuticals, Inc. and is being developed in a phase 1 clinical trial for the treatment of patients with canc...Micromet, Inc. Elects Joseph P. Slattery to Board of Directors
...MT293 (formerly D93), also known as TRC093, a first-in-class humanized monoclonal antibody that inhibits angiogenesis and tumor cell growth by binding cleaved collagen. MT293, which is currently being tested in a phase 1 clinical trial, is licensed to TRACON Pharmaceuticals, Inc. and is being developed for t...Isis Awarded $1.5 Million NIH Grant to Improve Chemical Properties of RNAi-Based Therapeutics
... associate with proteins to form an RNA-induced silencing complex (RISC). The antisense RNA within active RISC binds to its mRNA target, which is then cleaved and degraded by the RNase enzyme in the complex. Although most currently practiced methods of inducing the RNAi mechanism utilize double-stranded RNAs...Anti-Notch 1, cleaved (Val1744) Antibody, Unconjugated from Cell Signaling Technology
Description: ...AmpliTaq Gold DNA Polymerase from Applied Biosystems
Description:... is inactive. The result is that mis-primed primers are not extended. Once the reaction reaches optimal annealing temperatures, the chemical moiety is cleaved during a heat activation step, releasing active AmpliTaq® DNA enzyme. The yield of specific product increases because reactants are not wasted in...TACE Fluorometric (MCA)) Assay Kit, InnoZyme™ from Calbiochem
Description:...the scissile amide bond, G-L, releases the fluorophore from the quenching molecule, Dpa, resulting in an increase in fluorescence. Fluorescence of the cleaved product, MCA-KPLG, is measured at an excitation wavelength of ~324 nm and emission wavelength of ~400 nm. The level of fluorescence is directly relate...PARP Cleavage Detection Kit from Calbiochem
Description:...DP-ribose) polymerase (PARP) cleavage by Western blotting. PARP is an enzyme implicated in DNA damage and repair mechanisms. During apoptosis, PARP is cleaved by caspase-3. Cleavage of PARP from the native 116 kDa to 85 kDa is a hallmark of apoptosis. Each kit is provided with a highly specific rabbit polycl...