Navigation Links
cleaved in Medical News

Advanced Analytical Reveals New Platform for Rapid Genotypic Identification of Microorganisms at ASM 2009

... results in under 4 hours by using 4 easy steps: DNA extraction, DNA amplification, controlled cleavage of the DNA, and multiplex CE separation of the cleaved fragments. With this multi-step technique, the DNA PROfiler (TM) combines the advantages of DNA sequencing with the advantages of Ribotyping technol...

New target for maintaining healthy blood pressure discovered

... protein called angiotensiogen. Renin, an enzyme produced by the kidneys, cleaves angiotensiogen into a peptide called angiotensin I. Angiotensin I is cleaved again to form angiotensin II, which stimulates blood vessels to narrow, thereby increasing blood pressure. At the same time, angiotensin II induces th...

New tests provide new insight into why patients are in heart failure

...g heart failure or is it genetic?" A recombinant protein also called corin identified in the late 1990s helped solve the mystery of how pro-ANP got cleaved into the active state. That got Dr. Gladysheva wondering about the natural protein activator. She used antibodies to the recombinant protein to find t...

Wayne State University Scientists ID New Biomarker for Prostate Cancer

...cer Institute, and his team of renowned research collaborators identified a cleaved form of galectin-3 as a marker for prostate cancer progression. According t...ciated with tumorigenicity in other tumor types. The study found that cleaved galectin-3, an inheritable gene, is present in late-stage prostate cancer, ...

Scientists ID New Biomarker for Prostate Cancer

... Study finds cleaved galectin-3 may serve as treatment target against d...difference was due to the fact that galectin-3 was cleaved during prostate cancer progression. Their study found that cleaved galectin-3 is present in a late-stage prostate can...

Tracon Pharmaceuticals to Present Clinical Stage Programs at AACR 2009

...h temozolomide (Temodar(R)). TRC093 is a humanized IgG1 monoclonal antibody that inhibits angiogenesis, tumor growth, and metastasis by binding cleaved collagen in the extracellular matrix of cancers. This antibody is expected to address multiple solid tumor types and may also be developed for age-rel...

USC researchers identify key mechanism that regulates the development of stem cells into neurons

...yos to investigate Ryk's function in vivo. They found that during neurogenesis, when neural stem cells start to grow into neurons, Ryk protein is cleaved and translocates to the cell nucleus to regulate neuronal differentiation. This finding is extremely important for understanding the regulation of ...

Same process discovered to both form skeleton and protect it for life

... Interestingly, DAPT also blocks the action of secretases that snip into fragments the amyloid precursor protein (APP) in brain cells. Some of these cleaved APP fragments clump together to form "plaques" in the brains of patients with Alzheimer's disease that contribute to the death of brain cells. DAPT is...

Notch-ing glucose into place

...g a sugar to certain areas of these repeats. Bellen said, The sugars play a crucial role to ensure that Notch is folded properly and that it can be cleaved at the cell membrane. If cleavage does not occur, there is no Notch signaling. Rumi is the first protein identified that can transfer glucose to prote...

First look at an enzyme target for antibacterial and cancer drugs

...po IIs lower domain swings open, the second DNA segment is released and the cleaved DNA segment is reconnected. In many ways, the enzyme works like a set of...nting the enzymes from completing their tasks. In the case of topo IIs, the cleaved segments of DNA remain attached to the topo II so that they cannot be resea...
cleaved in Medical Technology

TRACON Pharmaceuticals' Small Molecule TRC102 and Antibody TRC105 to be Presented at ASCO 2009

...met needs in these areas with first-in-class product candidates that will complement existing therapies. TRC093 is a monoclonal antibody that binds to cleaved collagen to inhibit angiogenesis and tumor growth that began dosing in a Phase 1 clinical trial in cancer patients in July, 2007. TRC105 is a monoclon...

Micromet Announces the Publication of BiTE Antibody Review in Drugs of the Future

...MT293 (formerly D93), also known as TRC093, a first-in-class humanized monoclonal antibody that inhibits angiogenesis and tumor cell growth by binding cleaved collagen. MT293, which is currently being tested in a phase 1 clinical trial, is licensed to TRACON Pharmaceuticals, Inc. and is being developed for t...

Tacere Therapeutics Enters Collaboration and License Agreement With Pfizer To Develop and Commercialize RNAi Hepatitis C Drug

...ion) at high levels following a single intravenous administration. In preclinical animal studies, this "cocktail in one drug" monotherapy targeted and cleaved the Hepatitis C virus itself at three different sites simultaneously without toxicity. About Tacere Therapeutics, Inc. Tacere is an innovative bio...

Micromet Announces Changes in Management Team

...MT293 (formerly D93), also known as TRC093, a first-in-class humanized monoclonal antibody that inhibits angiogenesis and tumor cell growth by binding cleaved collagen. MT293, which is currently being tested in a phase 1 clinical trial, is licensed to TRACON Pharmaceuticals, Inc. and is being developed for t...

Positive Glufosfamide Results From a Phase 2 Clinical Trial Presented at European Cancer Conference (ECCO)

...osfamide may be preferentially transported into tumors compared to most normal tissues. Inside cells, the linkage between glucose and the alkylator is cleaved to release the active drug. About Pancreatic Cancer The American Cancer Society estimates that 37,170 patients will be diagnosed with pancreatic can...
cleaved in Medical Products

ndigo OPTIMA Laser System

Description:...energy from a 1 cm area at the distal tip of the fiberoptic to create an ellipsoidal lesion in the tissue being treated. The Bare-Tip Fiberoptic has a cleaved bare tip which provides for controlled incision, excision or coagulation of tissues. Each of these fiberoptic devices consists of a connector, a trans...
Company:Johnson and Johnson

ACE - REA Hypertension / Cardiac Evaluation, Cardiovascular 001-RK-ACD Angiotensin Converting Enzyme

Description:...l proximal tubular cells, but is mostly found in endothelial cells. It is attached to the endothelial surface membrane by an anchor peptide and can be cleaved to be released into the blood circulation as soluble enzyme. Angiotensin converting enzyme (ACE) catalyzes the conversion of angiotensin I to an...
Company:ALPCO Diagnostics

Angiotensin II RIA Hypertension / Cardiac Evaluation, Cardiovascular 001-RK-A22

Description:... cells of the kidneys, cleaves angiotensinogen to produce the decapeptide angiotensin I (Ang I) which is physiologically inactive. Ang I is rapidly cleaved by the angiotensin converting enzyme (ACE) in plasma, vascular endothelial cells, kidney, lung and other tissues, into Ang II, the major active compon...
Company:ALPCO Diagnostics

C-Peptide EIA Diabetes and Obesity Markers 008-10-1136-01

Description:...in1,3. Human C-peptide is a 31 amino acid chain with a molecular mass of approximately 3020 daltons. Within the pancreatic b-cell, proinsulin is cleaved into one molecule of C-peptide and one molecule of insulin. C-peptide is subsequently released into the circulation at concentrations equimolar to th...
Company:ALPCO Diagnostics

Ultrasensitive C-Peptide EIA Diabetes and Obesity Markers 008-10-1141-01

Description:...nsulin1,3. Human C-peptide is a 31 amino acid chain with a molecular mass of approximately 3020 daltons. Within the pancreatic -cell, proinsulin is cleaved into one molecule of C-peptide and one molecule of insulin. C-peptide is subsequently released into the circulation at concentrations equimolar to tho...
Company:ALPCO Diagnostics
cleaved in Medical Dictionary

Haptoglobin

.... The world's first wiki where authorship really matters. Due credit and reputation for authors. ... Haptoglobin (Hp) is unusual in that it is cleaved in the ... Haptoglobin ... When the haptoglobin and hemoglobin attach, the new molecule goes to the liver, ... The haptoglobin is destroye...

Fibrinogen

... and ... fibrin- fibrinogen split products. fibrin-stabilizing factor. fibrin-stabilizing factor ... Following vascular injury, fibrinogen is cleaved by ... Fibrinogen biosynthesis. ... Amino acid sequence studies on the alpha chain of human fibrinogen . ... These substances include fibr...
cleaved in Biological News

Tips from the American Journal of Pathology

...es at the University of Michigan have identified a cleaved form of galectin-3 as a marker for prostate cancer...rence, Wang et al hypothesized that galectin-3 was cleaved during prostate cancer progression. They identified cleaved galectin-3 in later stage prostate cancer, and det...

CSHL scientists find a new class of small RNAs and define its function

... Curiously, PASRs and non-PASRs may not be initially synthesized in their "short" form. The CSHL team proposes a model in which mature long RNAs are cleaved followed by a capping of the newly generated long RNA fragment. This is followed by the clipping of the end of the capped long RNA to produce a short ...

Stowers Institute's Baumann Lab identifies key step in maturation pathway of telomerase

...rally, this involves exonucleolytic degradation, the gradual removal of nucleotides one at a time until the mature end has been reached. Some RNAs are cleaved near the end before exonucleolytic degradation proceeds to generate the mature end. We now show that 3' end processing for telomerase RNA uses a funda...

Using novel tool, UD researchers dig through cell 'trash' and find treasure

...the UD technique. Rather than searching for the cleaved RNAs one by one in a tedious process that previous...on at which the molecule has been cut. Because the cleaved molecules are recognizable by the high level of th...libraries produced a distinct "signature" for each cleaved messenger RNA molecule, which can be assigned to i...

Cholesterol metabolism links early- and late-onset Alzheimer's disease

...ld age than those who don't have the mutation. Bu and colleagues demonstrated that APP and apolipoprotein E have a molecular connection. When APP is cleaved by a specific enzyme in the brain, it releases A-beta plus a small protein fragment. The fragment then can regulate apolipoprotein E, which moves chol...

Who gives stem cells their marching orders?

...eir neighbors. However, to carry out these tasks, the Nodal protein must be cleaved by specific enzymes. The enzymes act as a sort of regulatory switch, increa...tember issue of the journal Developmental Cell, the researchers explain how cleaved and uncleaved forms of the Nodal protein act together to let the stem cells...

New understanding of parasite cell structures may provide treatments for serious tropical diseases

... with cellular energy and also serve as markers for cellular recognition. The researchers discovered a new function for these glycolipids--they are cleaved in response to cell stress caused by changes in osmotic pressure and relative acidity or alkalinity. The research by the UGA team is especially imp...

Major WHO study concludes calcium supplements can reduce complications during pregnancy

...ottom. The similarity to a face ends at the top of the molecule, where two flaps open to reveal a cavity. That is where enzymes and other proteins are cleaved into the parts necessary to assemble infectious virus particles. Structural studies of this cavity helped scientists find the original protease inhibi...

Computer simulation hints at new HIV drug target

...ottom. The similarity to a face ends at the top of the molecule, where two flaps open to reveal a cavity. That is where enzymes and other proteins are cleaved into the parts necessary to assemble infectious virus particles. Structural studies of this cavity helped scientists find the original protease inhibi...

Advanced genomics and proteomics improve the diagnosis and treatment of a deadly lung disease

...ies of how Dicer functions, Doudna said. In particular, scientists would like to know how Dicer is involved in downstream events, how it hands off the cleaved RNA and directs it to the right gene targets. Resolving the structure of Dicer, Doudna noted, was a technical challenge as the crystals are small. ...
cleaved in Biological Technology

Incorrectly cleaved protein leads to schizophrenia

Leuven, Belgium Schizophrenia is a disease that strikes an average of 4000 Belgians every year. The causes of this psychiatric disorder are not yet clear. But now, VIB researchers connected to the Katholieke Universiteit Leuven have discovered that a disturbed cleavage of the Nrg-1 protein lies a...

Sigma-Aldrich and the University of Illinois Offer New Boronic Acid Surrogates to Researchers Worldwide Through Licensing Agreement

...o, unlike other boronic acid derivatives that may exhibit reduced reactivity relative to their boronic acid counterparts, the MIDA boronate esters are cleaved under exceptionally mild conditions to release the coupling-active boronic acid. The MIDA technology highlights Sigma-Aldrich's continuing efforts t...

Transgenomic Introduces SURVEYOR(R) Endonuclease Adaptor-Ligated Libraries (SEAL) for Determining Whole Genome Sequence Variation

... a linker that attaches an identification tag of known sequence to the ends cleaved by the SURVEYOR Nuclease, SEAL generates a library of genetic variations pr...ized to generate mismatches in heteroduplexed DNA which is then treated and cleaved by SURVEYOR Nuclease. SURVEYOR Nuclease can detect genetic variations in sa...

Oncolys BioPharma and Tacere Therapeutics Sign Strategic Alliance and License Agreement to Develop and Commercialize RNAi Hepatitis C Drug

...ion) at high levels following a single intravenous administration. In preclinical animal studies, this "cocktail in one drug" monotherapy targeted and cleaved the Hepatitis C virus itself at three different sites simultaneously without toxicity. About Oncolys BioPharma, Inc. Oncolys BioPharma is a privat...

A New, Unique and Unrivalled Rat/Mouse PINP Assay for Pharmaceutical, Clinical and Academic Research Organizations.

...generation of type I collagen is a crucial step in bone formation where type I collagen is the major organic component of bone matrix. Propeptides are cleaved from both the N- and C-terminal ends of the procollagen molecule in equimolar concentrations during collagen synthesis. Thus, the quantification of N-...

Micromet to Present at the 2007 RBC Capital Markets Healthcare Conference on December 12, 2007

...MT293 (formerly D93); also known as TRC093, a first-in-class humanized monoclonal antibody that inhibits angiogenesis and tumor cell growth by binding cleaved collagen. MT293 is licensed to TRACON Pharmaceuticals, Inc. and is being developed in a phase 1 clinical trial for the treatment of patients with canc...

Micromet, Inc. Elects Joseph P. Slattery to Board of Directors

...MT293 (formerly D93), also known as TRC093, a first-in-class humanized monoclonal antibody that inhibits angiogenesis and tumor cell growth by binding cleaved collagen. MT293, which is currently being tested in a phase 1 clinical trial, is licensed to TRACON Pharmaceuticals, Inc. and is being developed for t...

Micromet to Present at the Acumen BioFin Rodman & Renshaw 9th Annual Healthcare Conference on November 7, 2007

...MT293 (formerly D93); also known as TRC093, a first-in-class humanized monoclonal antibody that inhibits angiogenesis and tumor cell growth by binding cleaved collagen. MT293 is licensed to TRACON Pharmaceuticals, Inc. and is being developed in a phase 1 clinical trial for the treatment of patients with canc...

Micromet Data Presented at the International AACR-NCI-EORTC Conference Support the Development of Adecatumumab (MT201) in Earlier Stage Cancer Disease Settings

...MT293 (formerly D93), also known as TRC093, a first-in-class humanized monoclonal antibody that inhibits angiogenesis and tumor cell growth by binding cleaved collagen. MT293 is licensed to TRACON Pharmaceuticals, Inc. and is being developed in a phase 1 clinical trial for the treatment of patients with canc...

Isis Awarded $1.5 Million NIH Grant to Improve Chemical Properties of RNAi-Based Therapeutics

... associate with proteins to form an RNA-induced silencing complex (RISC). The antisense RNA within active RISC binds to its mRNA target, which is then cleaved and degraded by the RNase enzyme in the complex. Although most currently practiced methods of inducing the RNAi mechanism utilize double-stranded RNAs...
cleaved in Biological Products

Anti-Notch 1, cleaved (Val1744) Antibody, Unconjugated from Cell Signaling Technology

Description: ...
Company:Cell Signaling Technology

MTT Reagent A from CHEMICON

Description:... Reagent A: MTT, (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrasodium bromide), 50mg/vial. MTT is a pale yellow substrate that is cleaved by living cells to yield a dark blue formazan product. This process requires active mitochondria, and even freshly dead cells do not cleave significan...
Company:CHEMICON

AmpliTaq Gold DNA Polymerase from Applied Biosystems

Description:... is inactive. The result is that mis-primed primers are not extended. Once the reaction reaches optimal annealing temperatures, the chemical moiety is cleaved during a heat activation step, releasing active AmpliTaq® DNA enzyme. The yield of specific product increases because reactants are not wasted in...
Company:Applied Biosystems

TACE Fluorometric (MCA)) Assay Kit, InnoZyme™ from Calbiochem

Description:...the scissile amide bond, G-L, releases the fluorophore from the quenching molecule, Dpa, resulting in an increase in fluorescence. Fluorescence of the cleaved product, MCA-KPLG, is measured at an excitation wavelength of ~324 nm and emission wavelength of ~400 nm. The level of fluorescence is directly relate...
Company:Calbiochem

PARP Cleavage Detection Kit from Calbiochem

Description:...DP-ribose) polymerase (PARP) cleavage by Western blotting. PARP is an enzyme implicated in DNA damage and repair mechanisms. During apoptosis, PARP is cleaved by caspase-3. Cleavage of PARP from the native 116 kDa to 85 kDa is a hallmark of apoptosis. Each kit is provided with a highly specific rabbit polycl...
Company:Calbiochem
cleaved in Biological Definition

Antibody

...s. The monomer is composed of two heavy and two light chains. Together this gives six to eight constant domains and four variable domains. If it is cleaved with enzymes papain and pepsin , we get two Fab ( f ragment b inding a ntigen) fragments and an Fc ( f ragment c rystallizable) fragment. ...

Apoptosis

...(Ptc1) survive and proliferate; but, in the absence of Shh, one of the ends of this same Ptc1 receptor (the carboxyl-terminal, inside the membrane) is cleaved by caspase-3, an action that exposes an apoptosis-producing domain (see the Perspective by Isabel Guerrero and Ariel Ruiz i Altaba and the research re...

Hydrolysis

... Hydrolysis is a chemical process in which a molecule is cleaved into two parts by the addition of a molecule of water . This is distinct from a hydration reaction , in which water molecules are added to a substa...
cleaved in Biological Dictionary

Signal Sequence

...MAGE: ... ... on Signal Sequence ... The signal sequence is then cleaved from the polypeptide when it ... Gene design of signal sequence for t...e- sequence that targets the ... The signal sequence is immediately cleaved from the polypeptide once it has been ... This signal sequence proce...

S1 nuclease

....B.: 3.1.30.1. Nuclease S1 , isolated from ... Albumin, Nuclease -Free. Deoxyribonuclease I. Deoxyribonucleic Acid and Related Products ... ... cleaved by Single-Strand Specific S1 Nuclease , J Biomolec Struct Dynamics 6, ... Purification and Properties of S1 Nuclease from Aspergillus , Method...

Polyprotein

...nal to Gag polyprotein . ... The polyprotein is cleaved during and after budding; this process is termed m...ssRNA is translated into a polyprotein , which is cleaved into all structural ... POLG_CSFVB Genome polypro...polyprotein • Euglena ... GAG polyprotein is cleaved to into four proteins that are found in the matu...

Palindromic Sequence

...term. ... Palindromic sequence . Palindromicity. Palindromist. Palindromist. Palindromist ... Only one palindromic sequence was successfully cleaved by IN. ... The palindromic sequence in the 2-LTR circles generated in retroviral ... We find evidence that the palindromic motif has a clea...

Klenow Fragment

... The Klenow fragment is a large protein fragment produced when DNA polymerase I from E. coli is enzymatically cleaved by the protease subtilisin. First reported in 1970, it retains the 5’ → 3’ polymerase activity and the 3’ →... The large or Klenow fragment o...

Gene duplication

...n ... An ancient gene duplication allowed one copy of the gene to evolve ... A second gene duplication gave rise to a third enzyme that cleaved at another residue. ... ... rate of gene duplication in eukaryotic genomes and the subsequent half ... evolutionary processes of gene duplic...

Exonuclease

.... A highly processive enzyme that acts in the 5' to 3' direction, ... Exonuclease Reaction ... affinity chromatography, Lambda Exonuclease is cleaved from the ... Definition of exonuclease from the Merriam-Webster Online Dictionary with audio pronunciations, thesaurus, Word of the Day, and word...

Blastomeres

...lls, known as blastomeres . ... blastomeres and embryonic cells in planarian embryonic development ... ferent blastomeres which ... gote has cleaved into several blastomeres that do not ... Some blastomeres differentiate and form an embryonic epidermis and an ... b Three signal positive cl...

Blastocyst

...er ... A blastocyst is an embryo that has developed ... Details blastocyst embryo transfer, a technique with higher implantation rates than cleaved embryo transfer. ... A blastocyst has about 120 cells. ... As one of the most important and effective breakthroughs in assisted reproductive te...
Other Tags
(Date:7/23/2014)... California (PRWEB) July 23, 2014 World ... home-delivered fully prepared healthy gourmet cuisine, received rave reviews ... the LA’s Largest Mixer. Mixer attendees were amazed that ... July 17th 2014, World Gardens Café, the premier provider ... cuisine, had a booth at Dave Linden’s LA’s Largest ...
(Date:7/23/2014)... 23, 2014 Daily Face & Body is ... safer alternative to Botox called Stem Cell Technology Facial ... anti-aging product used to help people smooth, tone, and rejuvenate ... be used as a safe alternative to Botox, a popular ... toxins or health risks as opposed to Botox. In addition, ...
(Date:7/23/2014)... (PRWEB) July 23, 2014 On July 19 ... awareness at the NBC 4 New York and New York ... East Rutherford, NJ. , The team, which included ... main sponsor, offered free hearing health screenings and answered any ... advanced hearing technology. , Also sponsored by the ...
(Date:7/23/2014)... According to the latest market reports compiled ... region, the Northern Virginia real estate market ... quickly throughout the area, and median sale prices have ... Virginia market includes the city of Alexandria, and Arlington, ... Virginia region saw median sale prices increase in some ...
(Date:7/23/2014)... Once viewed with suspicion as a New Age ... $14 billion-a-year business and arguably the most successful segment ... Way We Die , award-winning journalists Fran Smith and ... population and their families. It’s the first book to ... the stories of patients, caregivers and cutting-edge researchers, as ...
Breaking Medicine News(10 mins):Health News:Healthy Food Gets Rave Reviews at LA’s Largest Mixer 2Health News:Local Denver Skin Care Company Releases Safer Alternative to Botox 2Health News:The HearStrong Foundation Provides Hearing Healthcare Awareness at the NBC 4 New York and New York Giants Health & Fitness Expo 2014 2Health News:Northern Virginia Real Estate Company Pasquali Realty Group Announces Median Sale Price Increased in the Region in June 2014 2Health News:Dealing with Loss: Library Journal Calls Changing the Way We Die an Essential Read 2
(Date:7/22/2014)... challenges faced by researchers in modifying properties of nanomaterials ... simple technique, thanks to recent innovative studies conducted by ... Through the use of a simple, efficient and low ... research teams, led by Professor Sow Chorng Haur from ... Science, demonstrated that the properties of two different types ...
(Date:7/22/2014)... of a multinational, collaborative effort, researchers from the Icahn ... over 100 locations in the human genome associated with ... study published on any psychiatric disorder to date, conducted ... Nature , point to biological mechanisms and pathways that ... to treating the disorder, which has seen little innovation ...
(Date:7/22/2014)... in schoolyards that feature natural habitats and trees and ... and inattention, according to a University of Colorado Boulder ... such settings also provide stress-reducing benefits for youth, according ... & Place. The study is one of the ... between student access to green settings and stress. , ...
Breaking Biology News(10 mins):NUS scientists use low cost technique to improve properties and functions of nanomaterials 2NUS scientists use low cost technique to improve properties and functions of nanomaterials 3Mount Sinai scientists and international team shed new light on schizophrenia 2Mount Sinai scientists and international team shed new light on schizophrenia 3Natural-terrain schoolyards reduce children's stress, says Colorado University-Boulder study 2Natural-terrain schoolyards reduce children's stress, says Colorado University-Boulder study 3
Other Contents