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Study helps clarify role of vitamin D in cancer therapy

A colon cancer cell isn't a lost cause. Vitamin D can tame the rogue cell by adjusting everything from its gene expression to its cytoskeleton. In the Nov. 17 issue of the Journal of Cell Biology , Ordez-Morn et al. show that one pathway governs the vitamin's diverse effects. The results help cla...

Changes to Family and Medical Leave Act Clarify Employer Responsibilities

SUNRISE, Fla., April 22 /PRNewswire/ -- Applying the Family and Medical Leave Act (FMLA) has confused employers and human resources departments across the country. A recent change and several proposed amendments to the Act have expanded the program to military families, and will clarify applic...

ReGen Biologics Clarifies Recent Press about the Menaflex Device

... HACKENSACK, N.J., Aug 5 /PRNewswire/ -- ReGen Biologics, a Hackensack, NJ based orthopedic products company seeks to clarify several statements regarding its Menaflex collagen meniscus implant that were made in a press release that was issued on Tuesday, August 4, by a party...

Savient Pharmaceuticals Receives Complete Response Letter from U.S. Food and Drug Administration for KRYSTEXXA(TM)

...Mitigation Strategy (REMS) (Medication Guide and Communication Plan). The Company intends to immediately request a meeting with the FDA to discuss and clarify the issues raised in the complete response letter. Under FDA regulations, the Company believes that this meeting is deemed a "Type A" meeting, meaning...

Less Common Procedures, Less Common Than Thought

...s consumer survey. While the media has coined these cosmetic procedures as 'fringe' and made it seem that they are in high demand, it is important to clarify the facts. The results reveal that less common cosmetic procedures are generally over-hyped and over-analyzed. According to survey results, ...

The International Association of Fire Fighters and Masimo Team Up on a New Global Campaign to Raise Awareness of Carbon Monoxide-Related Death and Injury Risks for Fire Fighters

... place undue reliance on these forward-looking statements, which speak only as of today's date. We do not undertake any obligation to update, amend or clarify these forward-looking statements or the "Risk Factors" contained in our Quarterly Report on Form 10-Q for the fiscal quarter ended April 4, 2009, whet...

Masimo Receives FDA Clearance for New Rainbow(R) Resposable(TM) Sensor System

... place undue reliance on these forward-looking statements, which speak only as of today's date. We do not undertake any obligation to update, amend or clarify these forward-looking statements or the "Risk Factors" contained in our Quarterly Report on Form 10-Q for the fiscal quarter year ended April 4, 2009,...

Masimo Announces Settlement of Lawsuit

... place undue reliance on these forward-looking statements, which speak only as of today's date. We do not undertake any obligation to update, amend or clarify these forward-looking statements or the "Risk Factors" contained in our Quarterly Report on Form 10-Q for the fiscal quarter ended April 4, 2009, whet...

Versus Technology, Inc. Partners With Microsoft(R) To Promote Health Care Automation in Windows 7 Computing Environments

...ir rate of commercialization, services, prices and adequacy of financing, and other factors. The Company undertakes no obligation to update, amend, or clarify forward-looking statements, whether because of new information, future events, or otherwise. ...

A Phase III Alzheimer's Drug Increases Levels of Beta Amyloid in the Brain - But Still Provides Benefits

... "This result is highly unexpected in what may prove to be a clinically beneficial Alzheimer's drug," Gandy said. "We need more research to further clarify how dimebolin affects beta amyloid levels in the brain." "A number of ideas need to be pursued. It may turn out that the drug works by gettin...

clarify in Medical Technology

New Studies Presented at European Society of Anaesthesia Further Validate Masimo PVI(TM) for Noninvasive and Continuous Fluid Monitoring

... place undue reliance on these forward-looking statements, which speak only as of today's date. We do not undertake any obligation to update, amend or clarify these forward-looking statements or the "Risk Factors" contained in our Quarterly Report on Form 10-Q for the fiscal quarter year ended April 4, 2009,...

Two New Clinical Studies Show That Limited Exposure to Blood Transfusion Significantly Increases Morbidity and Mortality After Surgery

... place undue reliance on these forward-looking statements, which speak only as of today's date. We do not undertake any obligation to update, amend or clarify these forward-looking statements or the "Risk Factors" contained in our Quarterly Report on Form 10-Q for the fiscal quarter ended April 4, 2009, whet...

Induction Chemotherapy Followed by ChemoRadiotherapy Increased Time-to-Treatment Failure Compared to ChemoRadiotherapy Alone in Patients With Unresectable Locally Advanced Head & Neck Cancer

...cal Oncology at Emory University , Atlanta, GA, USA. Dr. Khuri, a renowned head and neck cancer expert, also added: "These data may help define and clarify standard approaches to the treatment of patients with advanced unresectable disease." About the Spanish Head and Neck Cancer Cooperative Group,...

New NIH-Funded Study Shows Masimo Rainbow SET(R) May Help Clinicians Assess Oxygenation in Children With Sickle Cell Disease

... place undue reliance on these forward-looking statements, which speak only as of today's date. We do not undertake any obligation to update, amend or clarify these forward-looking statements or the "Risk Factors" contained in our Quarterly Report on Form 10-Q for the fiscal quarter ended April 4, 2009, whet...

Studies Presented at AACR Annual Meeting Highlight Multiple Immunomodulatory Mechanisms of Peregrine's PS-Targeting Antibodies

...also demonstrated the anti-tumor potential of PGN635 in vitro and in a number of animal cancer models. "Data from our experiments has helped to clarify details regarding the mechanisms responsible for the anti-tumor results observed with Peregrine's PS-targeting antibodies," said Dr. Monica Friedrich,...

Avon Protection Systems Issues Correction/Clarification on ST53 SCBA System

... BALTIMORE, April 17 /PRNewswire/ -- Avon Protection Systems wishes to correct and clarify its news release issued on March 10, 2009 regarding the ST53 SCBA (self-contained breathing apparatus) system and any implications about NIOSH approva...

Savient Provides Update on Pegloticase BLA

... Company Files Amendments to Strengthen and clarify BLA Data FDA Extends PDUFA Action Date to Ju...hat the Company filed amendments to strengthen and clarify the data included in the previously submitted pegl.... "We believe the steps we have taken further clarify the favorable risk to benefit profile of peglotica...

Synvista Therapeutics Announces Published Data Demonstrating Elevation of Carboxymethyl-Lysine (CML) Is Associated with Decline in Renal Function and Arterial Stiffness in Older Adults

...omarkers in that they can be lowered by modifying diet or through drug intervention (e.g., use of statins). Synvista's current research is designed to clarify the relationship between A.G.E.s and chronic cardiovascular and renal disease. About Synvista Therapeutics Synvista Therapeutics i...

Michael J. Fox Foundation Announces $11 Million in 2009 Funding for Translational, Pre-Clinical and Clinical Parkinson's Disease Research

...ls meet the review criteria will be invited to submit full proposals. For each program, a conference call with MJFF Research Programs staff to further clarify the aims and goals will be held in advance of the application deadline. Date and time details for each conference call are available at http://www.mi...

Prometheus Presents Findings From Development of PROMETHEUS(R) IBS Diagnostic, First Blood Test for IBS, at ACG Annual Scientific Meeting

...ROMETHEUS IBS Diagnostic is the first in a series of tests we are developing for this complex syndrome. It provides physicians a valuable tool to help clarify or validate other clinical findings. This test further strengthens our growing portfolio of proprietary, high-value diagnostics and complementary phar...

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Rheumatoid factor

... factor to be detected in healthy ... ... JRA with the presence of the rheumatoid factor (RF) antibody ... Rheumatoid factor (RF), to clarify whether a child with polyarticular JRA is RF ... This article describes the rheumatoid factor (RF) test, and it explains how RF contributes to...

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Ali Shilatifard and colleagues aim to clarify the definition of 'epigenetics'

Ali Shilatifard, Ph.D., Investigator, has joined with a team of colleagues to propose an operational definition of "Epigenetics" a rapidly growing research field that investigates heritable alterations in gene expression caused by mechanisms other than changes in DNA sequence. Dr. Shilatifa...

CSHL scientists clarify editing error underlying genetic neurodegenerative disease

Two molecular biologists at Cold Spring Harbor Laboratory have uncovered important new details about how a gene mutation causes a cellular editing error that results in a devastating disease called pontocerebellar hypoplasia (PCH). The new findings were published online, ahead of print, on Januar...

Study helps clarify role of soil microbes in global warming

Athens, Ga. Current models of global climate change predict warmer temperatures will increase the rate that bacteria and other microbes decompose soil organic matter, a scenario that pumps even more heat-trapping carbon into the atmosphere. But a new study led by a University of Georgia researche...

UCLA researchers clarify function of glucose transport molecule

Researchers at the David Geffen School of Medicine at UCLA have solved the structure of a class of proteins known as sodium glucose co-transporters (SGLTs), which pump glucose into cells. These transport proteins are used in the treatment of chronic diarrhea via oral rehydration therapy, saving th...

Scientists clarify a mechanism of epigenetic inheritance

Although letters representing the three billion pairs of molecules that form the rungs of the helical DNA ladder are routinely called the human genetic code, the DNA they comprise transmits traits across generations in a variety of ways, not all of which depend on the sequence of letters in the co...

Studies clarify risk factors for mother-to-child transmission of hepatitis C virus

Breastfeeding does not raise the risk of mother-to-child transmission of hepatitis C virus (HCV), according to two new studies published in the December 1 issue of The Journal of Infectious Diseases, now available online. One study found that infant girls are twice as likely to be infected as in...

Ancient DNA helps clarify the origins of two extinct New World horse species

The Patagonian Hippidion horse genus and North American stilt-legged horses have found a new place on the evolutionary tree, according to a new article in the open access journal PLoS Biology. In the paper, Jaco Weinstock, Alan Cooper, and colleagues use ancient DNA to argue that the Hippidion genu...

AGU journal highlights -- Aug. 6, 2009

...onal flows directly driven by zonal winds are balanced by deepwater return flows that are slightly lagged in time. They point out that the study helps clarify the dynamic mechanisms that relate wind stress to ocean mass flows in the Southern Ocean and demonstrates the usefulness of the GRACE satellites in mo...

The tiny difference in the genes of bacteria

...ome of bacteria. Every single bacterial strain has such characteristic repeats. "With this method we are able to identify bacterial strains as well as clarify their genetic relationships. Furthermore, we can show how new pathogenic variants develop," says Manfred Hfle, researcher at the HZI. The results have...

The tiny difference in the genes of bacteria

...ome of bacteria. Every single bacterial strain has such characteristic repeats. "With this method we are able to identify bacterial strains as well as clarify their genetic relationships. Furthermore, we can show how new pathogenic variants develop," says Manfred Hfle, researcher at the HZI. The results have...

clarify in Biological Technology

Paperwork: Buckypapers clarify electrical, optical behavior of nanotubes

Using highly uniform samples of carbon nanotubessorted by centrifuge for lengthmaterials scientists at the National Institute of Standards and Technology (NIST) have made some of the most precise measurements yet of the concentrations at which delicate mats of nanotubes become transparent, conduct...

Stem cells' 'suspended' state preserved by key step, scientists report

...r the reprogramming of specialized cells back to the pluripotent stem cell state. The team plans to study chromatin remodeling in still more detail to clarify what other molecules work in concert with the Chd1 gene to direct the process. This would aid efforts to increase the efficiency and safety of reprogr...

New Study Funded By the National Institutes of Health (NIH) Finds Masimo SpCO(R) May Provide a Noninvasive Measure of Acute Asthma Severity in Children

... place undue reliance on these forward-looking statements, which speak only as of today's date. We do not undertake any obligation to update, amend or clarify these forward-looking statements or the "Risk Factors" contained in our Quarterly Report on Form 10-Q for the fiscal quarter ended April 4, 2009, whet...

Savient Announces New Date for FDA Arthritis Advisory Panel Review of KRYSTEXXA(TM) for Treatment Failure Gout

... adequate therapy available. In January, the Company submitted to the FDA several key amendments for the KRYSTEXXA BLA to further strengthen and clarify the overall BLA application. The FDA reviewed and accepted the amendments and determined that the additional information contained in the submissions ...

Savient Pharmaceuticals Reports First Quarter 2009 Financial Results

...nal Highlights: Filed key amendments to our Biologics License Application (BLA) for KRYSTEXXA(TM) (pegloticase) to strengthen and clarify data included in our previously submitted BLA. The BLA priority review Prescription Drug User Fee Act (PDUFA) action date was extended by three month...

Immunotech Laboratories Announces South American Strategy

...ovel therapeutic platform of Irreversible Pepsin Fraction (IPF) for the treatment of HIV/AIDS. Furthermore, Immunotech Laboratories would like to clarify an editorial error in our press release dated April 1, 2009. Mr. David Miller was stated as "and founder of ACT UP HIV/AIDS activist group". The corre...

New Clinical Study Shows Masimo PVI(TM) Accurately Predicts Fluid Responsiveness in the ICU

... place undue reliance on these forward-looking statements, which speak only as of today's date. We do not undertake any obligation to update, amend or clarify these forward-looking statements or the "Risk Factors" contained in our Annual Report on Form 10-K for the fiscal year ended January 3, 2009, whether ...

Masimo Initiates Full Market Release of First-Ever Noninvasive Continuous Hemoglobin Monitor

... place undue reliance on these forward-looking statements, which speak only as of today's date. We do not undertake any obligation to update, amend or clarify these forward-looking statements or the "Risk Factors" contained in our Annual Report on Form 10-K for the fiscal year ended January 3, 2009, whether ...

Controversial Study to Test Link Between Insomnia and Sleep Apnea

...cs. This approach provides data much closer to what goes on in the general population compared to sleep center cohorts. "This opportunity will clarify whether Sleep Apnea is a common problem often overlooked in Chronic Insomnia patients," declared Dr. Barry Krakow, principal investigator and medical ...

New Multi-Center Study Finds Masimo SET Pulse Oximetry Screening Significantly Improves Detection of Congenital Heart Disease in Newborns

... place undue reliance on these forward-looking statements, which speak only as of today's date. We do not undertake any obligation to update, amend or clarify these forward-looking statements or the "Risk Factors" contained in our Quarterly Report on Form 10-Q for the fiscal quarter ended September 27, 2008,...

clarify in Biological Definition

Apoptosis

...esearch like the one carried out by Thibert and her colleagues has begun to clarify some of the fundamental aspects of morphogenesis , or the development of o...ic factor. Work carried out by Takaoka and colleagues has contributed to clarify the role played by interferon in the treatment of some forms of human cance...

Fermentation

...ns , concentrate and sterilize the wort. Hops add flavour, aroma and bitterness to the beer. At the end of the boil, the hopped wort settles to clarify it in a vessel called a "whirl-pool" and the clarified wort is then cooled. The wort is then moved into a "fermentation vessel" where yeast is ad...

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Isozymes

...alter ... In various model systems, PKC isozymes have variously been found to be either ... Expression of PKC isozymes in human basophils. To clarify which PKC isozymes were present in ... Downregulation of PKC isozymes with overnight PMA treatment. ... Twelve different isozymes have now be...