Sun Pharma to launch chiral version of omeprazole soon

Many drugs have two or more forms of the same chemical entity but the molecules arranged differently in space. Of the isomers, only one generally offers all the therapeutic benefits with the others having side-effects. Isolation of benefits results in smaller dosages with lesser side-effects. ...

Synthetech Announces Fiscal 2009 Results

... fine chemicals company specializing in organic synthesis, biocatalysis and chiral technologies. We develop and manufacture amino acid derivatives, specialty amino acids, peptide fragments and proprietary custom chiral intermediates and specialty resins, primarily for the pharmaceutical indust...

DSM Joins the American Chemical Society Green Chemistry Institute(R)'s Pharmaceutical Roundtable

...rmediates, registered materials and active pharmaceutical ingredients. Our technologies include biocatalysis, homogeneous catalysis, fermentation and chiral technologies. DSM delivers comprehensive custom manufacturing services to the spectrum of pharmaceutical companies including emerging pharmaceutical ...

Synthetech Earns National Recognition for Performance Improvement Program

... fine chemicals company specializing in organic synthesis, biocatalysis and chiral technologies. Synthetech develops and manufactures amino acid derivatives, specialty amino acids, peptide fragments, proprietary custom chiral intermediates and specialty resins, primarily for the pharmaceutical indust...

Synthetech Reports Second Quarter Fiscal 2009 Results

... fine chemicals company specializing in organic synthesis, biocatalysis and chiral technologies. We develop and manufacture amino acid derivatives, specialty amino acids, peptide fragments, proprietary custom chiral intermediates and specialty resins, primarily for the pharmaceutical indust...

Synthetech Announces Appointment of Dr. Gregory R. Hahn as President and Chief Executive Officer

... fine chemicals company specializing in organic synthesis, biocatalysis and chiral technologies. Synthetech develops and manufactures amino acid derivatives, specialty amino acids, peptide fragments, proprietary custom chiral intermediates and specialty resins, primarily for the pharmaceutical indust...

New method enables design, production of extremely novel drugs

...s chemical strategy is that the resulting compounds are produced selectively as single mirror images. Pharmaceutical companies prefer to develop new chiral drugs (chiral meaning handed) as a single isomer because opposite mirror images can have different biological effects and may be harmful. A small a...

Argonne's Blue Gene/P to host large cadre of INCITE researchers

...sufficiently fine-grained lattices that have sufficiently small up and down quark masses in order to enable the extrapolation of key quantities of the chiral and continuum limits. The gauge configurations will be used to determine a wide range of physical quantities that are important to high energy and nuc...

Results promising for computational quantum chemical methods for drug development

...e in The Journal of Physical Chemistry A. Many chiral molecules are important for medical treatment for ...esses ranging from acid-reflux to cancer. The term chiral means that two mirror images of a molecule cannot ...using. In other words, when you have a sample of a chiral molecule, how do you distinguish between the left ...

VioQuest Pharmaceuticals Announces Third Quarter and Nine Months 2007 Results

...D8 and type II dendritic cells. -- VioQuest completed the sale of its chiral Quest subsidiary in July. The Company raised a total of $5.4 million through the sale of chiral Quest and the issuance of senior convertible promissory notes. VioQues...

chiral in Medical Technology

DSM and LibraGen Sign Agreement to Co-Develop Transaminases for Production of Chiral Amines

PARSIPPANY, N.J., VIENNA, Austria and TOULOUSE, France, Sept. 16 /PRNewswire/ -- DSM and LibraGen, a bacterial diversity-based process and discovery specialist, announced today that they have signed an agreement to co-develop new omega-transaminases for production of chiral amines. Under the t...

New Report 'Looking at Chiral Technologies' Analyzes the Global Market Growth Forecasts Driven By Two Very Important Components as Single Isomer Drugs and Single Enantiomer Pharmaceuticals

DUBLIN, Ireland--(BUSINESS WIRE)--Jun 21, 2007 - Research and Markets (http://www.researchandmarkets.com/reports/c60415) has announced the addition of Looking at Chiral Technologies to their offering. The advancements in molecular research and continued untiring efforts of the research industry to...

VioQuest Pharmaceuticals Announces Data Presentation for Its Akt Inhibitor VQD-002, at American Association for Cancer Research Annual Meeting

...e treatment of leishmaniasis or any other indication, or that VioQuest will receive any proceeds in connection with a sale or other disposition of its chiral Quest division. Other risks and uncertainties include the possibility that the results of clinical trials will not support VioQuest's claims, the poss...

Arisaph Pharmaceuticals Announces Results of its Potent Smart DPP-4 Inhibitor, ARI-2243, at the ADA

...evelop ultra-smart drugs that are efficacious and act on select targets. Arisaph has successfully applied its specificity profiling and retro-inversal chiral chemistry technology platforms to synthesize promising candidate drugs for seven targets, including ARI-2243, a lead candidate for DPP-4 inhibition to...

chiral in Medical Dictionary

Lactic acid

...rs and running from Running Planet Lactic acid (IUPAC systematic name: 2-hydroxypropanoic acid ), also known as milk ... Lactic acid is chiral and has two optical isomers. ... Lactic acid is ONE of the 'waste byproducts' resulting from the chemical ... The lactic acid system is ...

chiral in Biological News

NTU professor discovers method to efficiently produce less toxic drugs using organic molecules

... takes place for example, during the production of chiral drugs. In his study, Professor Zhong, who is fr... which will be useful for the synthesis of certain chiral drug molecules which will be less toxic and produc...e, for example, in synthesising certain drugs with chiral centers. Professor Zhong is also filing for ano...

Scientists give a hand(edness) to the search for alien life

... when organisms reproduce, their offspring possess chiral molecules that have the same handedness as those i... If the surface had just a collection of random chiral molecules, half would go left, half right, Germer ...ich is an essential component of life. Because chiral molecules reflect light in a way that indicates th...

Separating the good from the bad

...respect to their ability to forage for food, since chiral effects make them drift off-course. But it is also... research. One of the best-known instances of a chiral molecule causing widespread harm occurred in the 1...her causes birth defects. In another commonly used chiral drug, naproxen, one isomer is analgesic; the other...

Nanotube's 'tapestry' controls its growth

...the new formula's predictions have been borne out by a number of laboratory reports. For example, the formula predicts that nanotubes with the largest chiral angle will grow fastest because they have the most exposed threads -- something that's been shown in several experiments. "Chirality is one of the ...

Argonne scientists discover possible mechanism for creating 'handedness' in biological molecules

...years." Rosenberg used X-rays from the Advanced Photon Source to bombard chiral molecules adsorbed on a magnetic substrate and x-ray photoelectron spectros... "Our study shows that spin-polarized secondary electrons interacting with chiral molecules could produce a significant excess of a given chirality in pre-bi...

Complex systems and Mars missions help understand how life began

...evelop in time and space. Breaking the symmetry One promising area is the discovery of reaction systems that lead to the spontaneues generation of chiral asymmetry. It is a universal property of life that compounds such as amino acids and sugars exist exclusively in a one-handed form although both forms...

Luminescence shines new light on proteins

...and/glove interaction) - the most abundant protein in blood." Based on a chiral lanthanide complex, the probe emits circularly polarised light that inverts...cence changed dramatically. Prof Parker says: "This is the first example of chiral inversion using an emissive probe in this way." The researchers have be...

American Chemical Society's Weekly PressPac -- July 30, 2008

...that the Food & Drug Administration approved in 2007 contained at least one chiral molecule as its central active component. But creating one specific conf...d industry, chemists are identifying new catalysts and reactions to produce chiral compounds faster, more efficiently, and with fewer environmental risks, suc...

National Institutes of Health award Williams professor $217,710 research grant

... origin. This study will build on Smith's earlier work on pyran-based products, which was funded by a 2003 National Science Foundation (NSF) grant. chiral pyran-based ring systems (six-membered rings composed of carbon and oxygen atoms) are found in numerous biologically relevant natural product classes....

Kilogram quantities at last!

...ese researchers" Isocitric acid is a compound with chiral centerscarbon atoms with four different groups bound to them. There are always two versions of a chiral center, one being the mirror image of the other. Smaller, easily accessible chiral compounds are useful building blocks for the synth...

chiral in Biological Technology

Sumitomo Corporation of America Named Exclusive Distribution and Sales Agent for Chiral Quest

- Faster delivery, efficient supply chain, and reduced cost for pharmaceutical manufacturers NEW YORK, April 14 /PRNewswire/ -- Sumitomo Corporation of America (SCOA) has reached an agreement with Chiral Quest, Inc., a manufacturer and developer of chiral products usin...

Synthetech Reports First Quarter Fiscal 2010 Results

... fine chemicals company specializing in organic synthesis, biocatalysis and chiral technologies. We develop and manufacture amino acid derivatives, specialty amino acids, peptide fragments and proprietary custom chiral intermediates and specialty resins, primarily for the pharmaceutical indust...

Video shows nanotube spins as it grows

...ictions of how nanotubes grow," Yakobson said. "The video shows rotational movement during growth, as carbon atoms are added in pairs to the twisting, chiral network of carbon atoms that comprise the nanotube." ...

PDS Biotechnology Corporation Finalizes Commercial Licensing Agreement with Merck Eprova AG to Utilize Merck Eprova's Enantiomers of DOTAP Chloride in Immunotherapies

...xclusive license from Merck Eprova AG to utilize Merck Eprova's proprietary chiral lipid DOTAP Chloride in Versamune(TM)-HPV and other products in development...ogy will own the intellectual property rights to products incorporating the chiral DOTAP lipids for immunotherapeutic applications. Versamune(TM)-HPV i...

Researchers control the assembly of nanobristles into helical clusters

... represents a critical step towards the development of an efficient adhesive or capture and release system for drug delivery and may be used to induce chiral flow patterns to enhance the mixing and transport of various particles at the micron- and submicron sale. "We have teased apart and replicated a ub...

Amicus Therapeutics Adds Sol J. Barer, Ph.D. to Board of Directors

...tive Committee of the Board of Directors. He previously served as Senior Vice President, Science and Technology, and Vice President/ General Manager, chiral Products, from 1991 to 1994, and the Vice President, Technology, from 1987 to 1991. Dr. Barer is on the Board of Trustees of Rutgers University , Bo...

Sigma-Aldrich (Nasdaq: SIAL) Reports 18.5% Gain in Q3 2008 Diluted EPS and Reaffirms Full Year 2008 Diluted EPS Forecast. Q3 2008 Sales Increase 7.4%. Buyback Authorization Increased by 10 Million Shares.

...3 2008. Growth also benefited from new service initiatives launched earlier in the year and recent new product introductions of ultrapure proteins and chiral products. Research Essentials (Reported growth- Q3: 8.6%, YTD: 10.9%; Organic growth- Q3: 5.3%, YTD: 4.6%): Q3 2008 organic sales growth continued t...

Synthetech Announces New Director of Manufacturing

...ural amino acids, peptide chemistry and multi-step chiral organic synthesis. I am eager to build on Synthete...pecializing in organic synthesis, biocatalysis and chiral technologies. Synthetech develops and manufactures...amino acids, peptide fragments, proprietary custom chiral intermediates and specialty resins, primarily for ...

CBDM.T, The Market and Business Intelligence Company Reviews The Enzyme Market

...billion in 2007. Biocatalysis is also more frequently applied by chemical companies, since it is the pertinent technology for the manufacturing of chiral drugs and sometimes for oil-based chemistry substitution. Enzymes are a key element in performing biocatalysis (biocatalysts are in fact enzymes). Thi...

Increased Capacity For Porcine Liver Esterase

...dicator of blood or urine infection. Porcine liver esterase is also used on a large commercial scale as a biocatalyst in the resolution of mixtures of chiral esters by hydrolysis to produce optically active carboxylic acids. Lee Biosolutions growth for porcine liver esterase is attributed to meeting strin...

chiral in Biological Products

P/ACE™ MDQ Molecular Characterization System from Beckman Coulter

Description:.... These systems are application based -- optimally configured with software, hardware and chemistry. Applications include the analysis of basic drugs, chiral pharmaceuticals, carbohydrates, proteins, glycoproteins and nucleic acids....
Company:Beckman Coulter

chiral in Biological Definition

Amine

...he nitrogen of an amine around the nitrogen's lone electron pair is usually possible, the nitrogen in the amine functional group will usually not be a chiral center. The volatile amines often have fishy smells. Synthesis primary amines are firstly produced due to the Gabriel Synthesis ....

Louis Pasteur

... and could exist in two different forms that resemble one another as a left- and right-hand glove resemble one another. As the first demonstration of chiral molecules, it was quite an achievement, but Pasteur then went on to his more famous work in the field of biology/medicine. His doctoral thesis on ...

chiral in Biological Dictionary

Chromatography

... Liquid Chromatography Applications. Normal and Reverse Phase Applications ... Ionic Interaction Chromatography . Diquat and Paraquat Herbicides. chiral Applications ... Pall chromatography products can be used for ... Bottled (bulk) chromatography resins. Mustang™ ion exchange membrane devices ...

Amino acids

...broad range of functions in the body. Those amino acids having green colored names are essential diet components, ... The configurations of the chiral amino acids are the same when written as a ... You Can't Gain Without Them ... Amino acids are essential to the human body. ... The body,...

Amino acid

...d whose side group is cyclic and ... Those amino acids having green colored names are essential diet components, ... The configurations of the chiral amino acids are the same when written as a ... Amino acids are very small biomolecules with an average molecular weight of about 135 dalton...