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chemotherapeutics in Medical News

Viral Genetics Has Option Under Issued Key Patent for Cancer Drug

...igh rate glucose metabolism, characteristic of cancer cells. The administration of 2-deoxy-D-glucose can be used in combination with current, standard chemotherapeutics and/or in combination with etomoxir, an inhibitor of fatty acid oxidation. Drug resistant tumor cells commonly use fatty acid metabolism to meet their...

Poniard Pharmaceuticals Presents Final Results of Phase 1 Study of Oral Picoplatin Demonstrating Bioavailability

...ief medical officer of Poniard. "We believe that oral picoplatin may offer opportunities for studies in new indications and in combinations with other chemotherapeutics or with radiation therapy. The administration options for oral picoplatin may provide more convenience to cancer patients and could enable the potenti...

How chemotherapy drugs block blood vessel growth, slow cancer spread

...demy of Sciences Early Edition, suggest that a subgroup of cancer patients might particularly benefit from these drugs. The anthracycline class of chemotherapeutics doxorubicin (Adriamycin), daunorubicin, epirubicin, idarubicin have been used for four decades to treat many types of cancer, including leukemia, ly...

Immunomedics to Present at 27th Annual J.P. Morgan Healthcare Conference

...gies that allow us to create humanized antibodies that can be used either alone in unlabeled or "naked" form, or conjugated with radioactive isotopes, chemotherapeutics or toxins, in each case to create highly targeted agents. Using these technologies, we have built a pipeline of therapeutic product candidates that u...

UIC researchers hunting drugs for devastating parasitic disease

...ng a new drug to treat the disease. Despite a worsening global impact of this disease, little progress has been made toward the development of new chemotherapeutics against it, says Alan Kozikowski, professor and director of UIC's Drug Discovery Program and coordinator of the project. Drugs compounded from the...

Integrating genetic information with breast cancer risk factors may help refine prognosis

...could be more immediately used in current clinical practice, once issues regarding cost and accessibility are addressed, in instances wherein multiple chemotherapeutics or chemotherapeutic combinations are Food and Drug Administration approved, as in early stage breast cancer, and are considered the standard of care, ...

IUPUI scientists report first 3-D view of anti-cancer agent

...o what type of cancers we could target with bleomycin if we can decrease the toxicity, said Dr. Georgiadis, a structural biologist. Many successful chemotherapeutics are DNA targeting agents. ...

Advances in drug screening: building a better haystack for the needles of tomorrow

...ight be susceptible to harm from the necessary blunt force use of therapeutics. Smith and her colleagues used a cell-based assay program that pits chemotherapeutics against neuroblastoma tumor-initiating cells (TICs) and skin-derived precursors (SKPs). As their full-name suggests, TICs are cancer stem cells develo...

Cancer Research: Yet Another Milestone

...cterized gene, called txr1, whose increased expression in prostate cancer cells confers resistance to taxane drugs. Taxanes are a class of widely-used chemotherapeutics (marketed as docetaxel and paclitaxel) that prevent cancer cell growth by inhibiting microtubule breakdown and subsequent cell division. The research...

New Compound Could Strengthen The Effect Of Chemotherapy

...n . Study results showed over 48 hours, small amounts of SP-4-84 made camptothecin 75-times more effective. The compound sensitizes cancer cells to chemotherapeutics by blocking the cancer cell's ability to survive the damage caused by chemotherapeutic drugs. However, this was only true for cancerous cells , when t...
chemotherapeutics in Medical Technology

Immunomedics Announces Preclinical Therapy Results of SN-38 Immunoconjugate for Colorectal Cancer

...gies that allow us to create humanized antibodies that can be used either alone in unlabeled or "naked" form, or conjugated with radioactive isotopes, chemotherapeutics or toxins, in each case to create highly targeted agents. Using these technologies, we have built a pipeline of therapeutic product candidates that u...

Poniard Pharmaceuticals Provides Year-End Clinical Update at 2007 Lazard Capital Markets Healthcare Conference

... product addressing multiple indications, combinations and formulations. Picoplatin has an improved safety profile compared to existing platinum-based chemotherapeutics and was designed to overcome platinum resistance. Picoplatin has been evaluated in more than 750 patients and has demonstrated activity in multiple in...

Poniard Pharmaceuticals Initiates Randomized Phase 2 Trial of Picoplatin for First-Line Treatment of Metastatic Colorectal Cancer

... the maximum tolerated dose for this dosing regimen. About Picoplatin Picoplatin has an improved safety profile compared to existing platinum- based chemotherapeutics and was designed to overcome platinum resistance. Poniard's strategy is to develop picoplatin as a platform product that can be used second-line in pa...

Nereus Pharmaceuticals to Present Data at the American Association for Cancer Research 2007 Annual Meeting

...lated" side effects of cardiotoxicity, hemodynamic changes and neuropathies. Like other VDAs, NPI-2358 also combines effectively with standard of care chemotherapeutics in human tumor xenograft models. Nereus has a family of over 400 synthetic small molecule diterpenes that modulate IKK and many downstream cytokines...

Spectrum Pharmaceuticals Announces Data From Three Oncology Programs Presented at the American Association of Cancer Research Annual Meeting

...elective ETB receptor agonist that has been demonstrated in preclinical studies to selectively enhance tumor blood flow and potentiate the efficacy of chemotherapeutics in various tumor models. Improved transient blood flow to the tumor is associated with a net increase in tumor oxygenation, which may be exploited to ...

Promising Results with Epratuzumab and Chemotherapy in Children with Acute Lymphoblastic Leukemia

...gies that allow us to create humanized antibodies that can be used either alone in unlabeled or "naked" form, or conjugated with radioactive isotopes, chemotherapeutics or toxins, in each case to create highly targeted agents. Using these technologies, we have built a pipeline of therapeutic product candidates that ut...

Repeated Radioimmunotherapy With 131I-Labetuzumab Appears Safe and Effective in Colorectal Cancer with Liver Metastases

...gies that allow us to create humanized antibodies that can be used either alone in unlabeled or "naked" form, or conjugated with radioactive isotopes, chemotherapeutics or toxins, in each case to create highly targeted agents. Using these technologies, we have built a pipeline of therapeutic product candidates that ut...

Immunomedics Reports Initial Clinical Results With Hpam4 For Pancreatic Cancer Therapy

...gies that allow us to create humanized antibodies that can be used either alone in unlabeled or "naked" form, or conjugated with radioactive isotopes, chemotherapeutics or toxins, in each case to create highly targeted agents. Using these technologies, we have built a pipeline of therapeutic product candidates that ut...

Fractionated Radioimmunotherapy With (90)Y-epratuzumab in Non-Hodgkin's Lymphoma Appears Safe and Active in a Phase I/II Study

...gies that allow us to create humanized antibodies that can be used either alone in unlabeled or "naked" form, or conjugated with radioactive isotopes, chemotherapeutics or toxins, in each case to create highly targeted agents. Using these technologies, we have built a pipeline of therapeutic product candidates that ut...
chemotherapeutics in Biological News

UC Davis discovery offers hope for treating kidney cancer

...aid Robert Weiss, a UC Davis professor of nephrology and chief of nephrology at the Sacramento VA Medical Center. "We wanted to find ways to help make chemotherapeutics as effective as possible at the lowest doses possible." Newer medications work by destabilizing cancer cells at the DNA level, which reduces their ...

Damon Runyon Cancer Research Foundation awards prestigious fellowships to 17 top young investigators

... School, Boston, Massachusetts, is focusing her research on understanding how enzymes synthesize medicinal compounds in nature. Because many powerful chemotherapeutics are small molecules produced by microorganisms, her efforts will hopefully contribute to the discovery of next generation anticancer agents. Alla...

Wiggle room: Cornell researcher borrows idea from sperm to provide energy for nanoscale robots

...it can potentially last longer and regulate its own task rate. Another potential use for this technology: creating nanoscale pumps that could release chemotherapeutics or antibiotics into specific places in the body. ...

JCI table of contents: Aug. 16, 2007

...O, but not either agent alone, leading the authors to suggest that combining IDO inhibitors with chemotherapeutic agents might improve the efficacy of chemotherapeutics in individuals with cancer. TITLE: Plasmacytoid dendritic cells from mouse tumor-draining lymph nodes directly activate mature Tregs via indoleamin...

Tumor cells evade death through autophagy

... study has clinical implications as it indicates that adjunct treatment with inhibitors of autophagy might increase the efficacy of apoptosis-inducing chemotherapeutics in human patients with cancer. ...

Report lists top 20 most-vulnerable African carnivores

... Telomerase inhibitors have been in clinical development for many years, but, Cech said, progress has been slow. "The development of anti-telomerase chemotherapeutics has been challenged by the fact that there was no structural basis for thinking about the problem," he said. "There was no picture in any detail of wh...

Groovy protein essential for promoting cancer development

... Telomerase inhibitors have been in clinical development for many years, but, Cech said, progress has been slow. "The development of anti-telomerase chemotherapeutics has been challenged by the fact that there was no structural basis for thinking about the problem," he said. "There was no picture in any detail of wh...
chemotherapeutics in Biological Technology

Telik Reports Preclinical Results at AACR Annual Meeting

...the growth of nine established cell lines of various tumor types and retained its effectiveness against cancer cell lines resistant to standard cancer chemotherapeutics including adriamycin, paclitaxel, and carboplatin. Treatment of human cancer cells with TLK58747 led to the activation of the DNA damage-respo...

VisEn Launches Next-Generation Fast ('Fluorescence Activatible Sensor Technology') Agent Platform for Expanded Performance in Imaging Disease Biomarkers In Vivo

...e 750 FAST as a mechanistic biomarker for therapeutic activity, which was closely associated with tumor progression", said Dr. Peterson. Both of the chemotherapeutics in the study inhibited the MMPSense 750 FAST signal in tumors by 88% and 70%, respectively (p=0.0042 and 0.026) only one day after beginning the t...

Nereus Pharmaceuticals Initiates ADVANCE, a Randomized Phase 2 Clinical Trial of NPI-2358 in Non-Small Cell Lung Cancer

...afety, pharmacokinetics and efficacy of the combination. Preclinical and clinical data suggest that VDAs may be complementary or synergistic with chemotherapeutics and anti-angiogenesis agents due to the different targets and mechanisms of action. In addition, the non-overlapping side effect profile of VDAs comp...

Oncolytics Biotech Inc. Announces 2008 Second Quarter Results

... and the reovirus and the use of the reovirus as a co-therapy with existing chemotherapeutics and radiation. In the second quarter of 2008, we continued to review our co... and the reovirus and the use of the reovirus as a co-therapy with existing chemotherapeutics and radiation. During the first half of 2008, we have been reviewing our co...

Oncolytics Biotech Inc. Announces 2008 First Quarter Results

...oration activity continues to focus on the interaction of the immune system and the reovirus and the use of the reovirus as a co-therapy with existing chemotherapeutics and radiation. We still expect that our pre-clinical trial expenses and research collaborations in 2008 will remain consistent with 2007. Other ...

Exelixis Submits XL139 Diligence Report to Bristol-Myers Squibb

...ue. In addition, recent data suggest that hedgehog signaling may play a key role in cancer stem cell (CSC) proliferation and the resistance of CSCs to chemotherapeutics and radiotherapy. "One of our key R&D goals is to simultaneously develop multiple compounds focused on key pathways and targets that play important ...

A 'Must Read' for Breast Cancer Patients

...e cancers, these protocols only increase median survival by several months. Patent 7,309,486 discloses novel protocols that allow the two classes of chemotherapeutics to function synergistically. The protocols are designed to provide a way of holding the cancer in check indefinitely. All proliferating cells progre...

JCI table of contents: Dec. 3, 2007

...the accompanying commentary by Zachary Schafer and Joan Brugge from Harvard Medical School, Boston, these data raise the possibility that IL-6targeted chemotherapeutics might be effective for the treatment of patients with certain forms of breast and lung cancer. Massimiliano Bonaf and colleagues from the Universit...

FDA: Tortoise, hare, or something else?

...rapy. For example, radical surgery such as organ transplants were not only imagined but became routine. Ever more powerful drugs, including cancer chemotherapeutics that previously were weapons for chemical warfare, became standard pharmacopeia. Emboldened by these successes, and to some extent encouraged by the s...
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