Also in the June 10 JNCI

... Novel Targeted Therapy Reduces chemoresistance in Mouse Model of Melanoma A novel small molecule inhibitor reduced both endogenous and drug-induced resistance to chemotherapy in a mouse model o...

Karmanos Researchers Report Enhanced Chemosensitivity of Pancreatic Cancer Cells by Black Seed Component

...e seeds, has been isolated for its promise as a chemopreventative agent. Pancreatic cancer cells currently have a high degree of inherent and acquired chemoresistance to standard chemotherapy agents Gemcitabine and/or Oxaliplatin, making these drugs only moderately effective. "Our goal with this study was to inc...

Researchers Hone in on Cancer Stem Cells for Melanoma

...e cancer's resistance to chemotherapeutic agents. "The findings establish a direct relationship between cancer stem cells, cancer progression, and chemoresistance in a human solid malignancy," Frank said. "This is a relationship that has been invoked often, but these findings provide first evidence of such a dir...

chemoresistance in Medical Technology

A Worldwide Phase III Clinical Trial Seeks U.S. Patients to Explore Investigational Drug Phenoxodiol

... about the efficacy of weekly carboplatin. In laboratory studies using animal models of cancer and human cell lines, phenoxodiol was shown to reverse chemoresistance to standard chemotherapies, including platinum drugs, taxanes, gemcitabine, topotecan and doxorubicin. The ability of phenoxodiol to reverse multi-dru...