Celebrex shows benefit in first-of-its-kind lung cancer chemoprevention trial

HOUSTON - Celecoxib, the anti-inflammatory medication also known by the trade name Celebrex, has proven to be safe and reduces a specific proliferation measurement of precancerous lesions in the lung, according to a study from The University of Texas M. D. Anderson Cancer Center. This finding demo...

Periodic Dieting May Cut Breast Cancer Risk

...ding how calorie restriction provides protection against the development of mammary tumors should help us identify pathways that could be targeted for chemoprevention studies," she said in a news release. "Further identification of serum factors that are involved in tumor development would possibly provide a way to ...

The Center for the Biology of Chronic Disease Highlights Anti-Cancer Activities of the Food Extracts Quercetin, EGCG, Glycyrrhizin, and Trans-Cinnamaldehyde

...lial adenomatous polyposis. Clin Gastroenterol Hepatol. 2006 Aug;4(8):1035-8. EGCG (a compound found in green tea) 1. Bettuzzi S, et al. chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: a preliminary...

M. D. Anderson study predicts dramatic growth in cancer rates among US elderly, minorities

...mes all the more vital and should be strongly encouraged, said Smith. In the study, Smith and his team site: vaccinations for hepatitis B and HPV; the chemoprevention agents tamoxifen and raloxifene; interventions for tobacco and alcohol; and removal of pre-malignant lesions, such as colon polyps. These findings ...

Data Show Dutasteride Reduces Prostate Cancer Diagnosis in Men With Increased Risk

...edicine in St. Louis, held a special session for interested media at 12:15 p.m. in the AUA Press Suite. The REDUCE trial is the first to examine chemoprevention for prostate cancer in men at increased risk for the disease. The trial involved 8,200 men ages 50 - 75 who were randomly assigned to receive a placeb...

Long-term L-carnitine supplementation prevents development of liver cancer

...ation alone or in combination with other natural chemopreventive compounds could be used to prevent, slow or reverse the occurrence of liver cancer. chemoprevention is defined as the use of naturally occurring and/or synthetic compounds in cancer therapy in which the occurrence of cancer can be entirely prevented,...

Licorice compound offers new cancer prevention strategy

...evention is the best approach for reducing colorectal cancer deaths, few medical strategies exist to prevent the disease. One promising target for chemoprevention is the enzyme cyclooxygenase 2 (COX-2), which promotes colorectal cancer progression via the action of the enzyme's inflammatory products, the prostag...

New ASCO/AUA guideline recommends men and their doctors discuss using 5-ARIs to reduce prostate cancer risk

...nes the use of 5-ARIs as a method of "chemoprevention" for prostate cancer. chemoprevention is the use of a natural, synthetic or biologic substance to reverse, suppre... for the prevention of prostate cancer The ASCO/AUA recommendations on chemoprevention for prostate cancer are based on evidence gathered from clinical trials, in...

Also in the Feb. 24 JNCI

...orial, Eric A. Klein, M.D., of the Glickman Urological and Kidney Institute in Ohio, reviewed the history of selenium and vitamin E in prostate cancer chemoprevention efforts and put the new data into context. "the study is noteworthy for demonstrating that even short-term exposure (i.e., 3 6 weeks) to these agents...

Also in the Jan. 27 JNCI

...reated with vehicle alone. "Taken together, these findings may provide the basis for further preclinical and clinical investigation of BITC for the chemoprevention and/or chemotherapy of pancreatic cancer," the authors conclude. Contact: Mark Hendricks, mark.hendricks@ttuhsc.edu , 806-356-4000, ext 245 Mo...

chemoprevention in Medical Technology

Theranostics Health Announces Involvement with Major Academic Medical Center in Study Funded by Susan G. Komen for the Cure(R)

...ation in hundreds of key signaling proteins directly from randomly obtained periareolar breast fine-needle aspiration to assess individual response to chemoprevention in high-risk patients. This information can be used to develop a rapid test that matches the right prevention agent to each patient based on the biolo...

PTC Therapeutics Presents Encouraging Phase 1 Results of its Novel VEGF Inhibitor, PTC299, at 30th Annual San Antonio Breast Cancer Symposium

...onsors innovative preclinical and clinical/translational research that may result in substantial improvements over current approaches to breast cancer chemoprevention and therapy. As part of the Congressionally Directed Medical Research Programs, it administers funds for peer-reviewed research toward specific diseas...

Immunosuppressant Drug Prevents Tobacco Induced Lung Cancer in Mice

...ributed to smoking. Quitting smoking reduces lung cancer risk by about 50 percent, said NCI Director John E. Niederhuber, M.D. By exploring methods of chemoprevention via agents such as rapamycin, we may be able to further reduce lung cancer risk. Previous studies in mice have shown that nicotine and its metabo...

chemoprevention in Biological News

Plant-derived molecules, genetic manipulation point to future chemoprevention methods

Scientists are using genetic studies and natural chemicals, such as plant-derived triterpenoids, to further our knowledge on how genetic and early molecular interactions can lead to cancer, and how those early interactions can be manipulated to stave off a variety of cancers. The latest studies wit...

The way you eat may affect your risk for breast cancer

...ding how calorie restriction provides protection against the development of mammary tumors should help us identify pathways that could be targeted for chemoprevention studies," said Margot P. Cleary, Ph.D., professor at the Hormel Institute, University of Minnesota. "Further identification of serum factors that are ...

Statin therapy ineffective in breast cancer prevention

...ncer. Scientists under the auspices of the NCI, including Ronald Lubet, Ph.D., an NCI program director, and Clinton Grubbs, Ph.D., director of the chemoprevention Center at the University of Alabama at Birmingham conducted laboratory work in animals to determine if statins actually prevent both ER-positive and E...

Meyskens honored with AACR-Prevent Cancer Foundation award

... work examined the translation of laboratory-based chemoprevention into clinical trials. Meyskens led the development... developed the topical all-trans-retinoic acid for chemoprevention of cervical intraepithelial neoplasia (CIN), the f...ns will give an award lecture entitled, Optimizing chemoprevention by Minimizing Risk-Benefit and Maximizing Risk-Red...

Synthetic cocoa chemical slows growth of tumors in human cell lines

...compound found in cocoa beans slowed growth and accelerated destruction of human tumors in laboratory studies, and should be tested further for cancer chemoprevention or even treatment, say researchers at Georgetown University Medical Center. "We have all heard that eating chocolate is good for you; this study sug...

Should children be permitted to get genetic testing for BRCA 1/2 mutations?

...t an increased risk of developing breast and/or ovarian cancer. Risk reduction options such as prophylactic surgeries, heightened surveillance and or chemoprevention are generally not recommended until the age of 25. We already know that many adults who choose to undergo genetic testing do it for their childrens...

Gene variation may elevate risk of liver tumor in patients with cirrhosis

...ular pathway controlled by EGF and its receptor EGFR which is known to be important in several types of cancer appears to be an excellent target for chemoprevention studies. This is a deadly cancer and so progress in prevention and early detection is critically important. HCC is the sixth most common solid tu...

Avocados may help prevent oral cancer, OSU study shows

... are published online in the journal Seminars in Cancer Biology . Lead author Steven M. D'Ambrosio, a member of the molecular carcinogenesis and chemoprevention program at Ohio State's Comprehensive Cancer Center, also wrote an accompanying editorial for the journal, discussing the cancer-fighting potential of...

Chemicals in brown algae may protect against skin cancer

...ctive at fairly low doses both orally and topically," says principal investigator Gary D. Stoner, professor emeritus of internal medicine and a cancer chemoprevention researcher. "These findings suggest that, even when eaten, these compounds get to skin cells and neutralize the cancer-causing oxygen radicals t...

Inflammation and drugs to control this activity studied in a variety of tumors sites

...studies have shown a profound effect by COX-2 blockers against a variety of cancers," he said. Harris said that these results have implications for chemoprevention of breast cancer and other cancers. This particular study is a sub-study of four types of cancer, including prostate, lung and colon cancer. The resea...

chemoprevention in Biological Technology

Moffitt Cancer Center Receives Prestigious SPORE Grant Worth More Than $10 Million

...ong Chen, Ph.D., Bepler 2. -- Antitumor mechanism of src inhibitors -- Eric Haura, M.D., Jin Cheng, M.D., Ph.D., and Jack Pledger, Ph.D. 3. chemoprevention with enzasataurin -- Bepler and Mark Alexandrow, Ph.D. 4. P53-based vaccine for small cell lung cancer -- Dmitry Gabrilovich, M.D., Ph.D....

chemoprevention in Biological Definition

Cancer

...er . Finasteride , a 5-alpha reductase inhibitor , has been shown to lower the risk of prostate cancer. Other examples of drugs that show promise for chemoprevention include COX-2 inhibitors (which inhibit a cyclooxygenase enzyme involved in the synthesis of proinflammatory prostaglandins ). Considerable res...