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checkpoint in Medical News

TGen-led team is 1 of 7 selected for $1 million skin-cancer grants

...ty Michael Krauthammer, M.D., Ph.D., Yale University David Stern, Ph.D., Yale University Combinatorial Immunotherapy for Melanoma with B7-H1/PD-1 checkpoint Blockade Principal Investigators: Team Lead: Drew Pardoll, M.D., Ph.D., Johns Hopkins University Lieping Chen, M.D., Ph.D., Johns Hopkins Univers...

A breakthrough in gastric carcinogenesis

... checkpoint with forkhead and ring finger (CHFR) is a mitotic stress checkpoint gene whose promoter is frequently methylated in various kinds of cancer. In...

AFGE: TSA Must Do More to Protect Its Workforce and the Public

...ot be given masks for fear that it would cause public panic. However, at Dallas/Fort Worth Airport, baggage screeners were given protective gear while checkpoint screeners - who come in direct contact with travelers - are being denied the gear. "TSA has an unfortunate pattern of inconsistent responses when...

Mayo researchers discover mechanism of cell type-specific signaling in tumor development

... growth factor stimulation. In the absence of Erbin (or Merlin), however, TGF-β stimulates PAK2 activity in some epithelia, overcoming a critical checkpoint in tumor progression. The findings are important, says Dr. Leof, because they delineate a process by which tumors might be formed and allow future ...

Protein's essential role in repairing damaged cells revealed

...hat information to an enzyme called the ATM (ataxia-telangiectasia mutated) checkpoint kinase. The ATM kinase controls the cell's response to double-strand br... "The fact that we have now separated the functions of DNA repair from the checkpoint functions means we may have identified a target that can sensitize tumors t...

Burnham researchers illuminate mechanisms that regulate DNA damage control and replication

...esearchers show that Ddk actively controls S-phase checkpoint signaling and plays a crucial role in triggering t...ation of DNA replication, but it also monitors the checkpoint during DNA damage control and eventually overrides the checkpoint to re-initiates DNA replication." These finding...

Does HBV infection induce acute cellular DNA damage?

... Eukaryotic cells employ multiple strategies of checkpoint signaling and DNA repair mechanisms to monitor and... repair damaged DNA. There are two branches of the checkpoint response pathway, ataxia telangiectasia-mutated (A...s the consequences of activation of the DNA damage checkpoint by degradation of...

U of T professor first Canadian woman to win prestigious international science prize

...be used to encrypt identification documents such as passports, foiling fraud and offering a potentially speedy alternative to waiting in long security checkpoint or government lines. Her group has also created inexpensive water-based semiconductor nanoparticles capable of boosting light in the infrared spe...

Stem-cell sentry sounds the alarm to maintain balance between cancer and aging, U-M researchers find

... the cell is going to divide in the wrong way, the checkpoint senses there's a problem and sends the signal: 'Do...U-M Medical School. If everything looks OK, the checkpoint allows adult stem-cell division to proceed, provid...ave not yet identified the molecules that form the checkpoint mechanism. But they've seen it at work in adult st...

A potential approach to treatment of hepatitis B virus infection

... Eukaryotic cells employ multiple strategies of checkpoint signaling and DNA repair mechanisms to monitor and... repair damaged DNA. There are two branches in the checkpoint response pathwayataxia telangiectasia-mutated (ATM... ATR and Chk1 phosphorylation levels, however, ATR checkpoint signaling was blocked downstream of the p53-depend...
checkpoint in Medical Technology

Nemours Center for Childhood Cancer Research Team at the Alfred I. duPont Hospital for Children Identifies the Function of a Biomarker Present in Prostate Cancer Cells: New Insight into Therapeutic Benefit for Patients with Advanced Prostate Cancer

...Cells have several checkpoints to ensure that the chromosomes are equally separated during cell division. Anaphase-promoting complex (APC) is one such checkpoint regulatory protein involved in the proper segregation of chromosomes during cell division. This complex monitors the timing of cell division and provi...

Medarex Highlights Strength in Antibody Development and Underlying Pipeline Strategy at R&D Day Event in New York City

...of product candidates that address important disease pathways in oncology and inflammatory diseases, including immune modulation by co-stimulatory and checkpoint molecules, inhibition of pro-inflammatory cytokines, and B-cell targeted approaches. In addition to providing an update on the broad program for ipili...

ArQule Announces Acceptance of Clinical Data on ARQ 197, c-Met Inhibitor, for Oral Presentation at ASCO

...d is the lead product from the Company's Activated checkpoint Therapy (ACT) platform. The American Associat...f the Metabolites of ARQ 501 ((beta)-lapachone), a checkpoint pathway activator in clinical development -- Pharmacodynamic biomarkers for checkpoint pathway activator ARQ501 in a human colon xenograf...
checkpoint in Medical Products

Aegis Checkpoint Temperature Reporting and Alarm System

Description: Aegis CheckPoint is an automated, wireless, computerized remote temperature monitoring, recording, logging and alert system for refrigerator, freezer, incubator and water bath to replace chart recorders, data loggers and manual temperature log reports. The system installs on an existing PC and c...
Company:Aegis Scientific, Inc.
checkpoint in Biological News

Death, division or cancer? Newly discovered checkpoint process holds the line in cell division

Each day, a staggering number of cells perform a feat that still amazes researchers with its complexity: they divide to produce perfect replicas of each other. The process is called mitosis, and an inability to control it is one of the hallmarks of cancer. Little is known about the biochemica...

New research finds possible genetic link to cause of pregnancy loss and disorders

...ul of genes as the culprits, including Bub1. The gene plays a role in a checkpoint that ensures that chromosomes are properly divided during meiosis, the cell division process that enables a stem cell to become an egg. This checkpoint hiccups when Bub1 is mutated, sometimes producing an egg with an extra chro...

Cellular discovery may lead to targeted treatment for rare form of anemia

...Thomas believes DBA slowly evolves into cancer when this specific molecular checkpoint is lost. This results in the body being genetically reprogrammed over time,...ts leading to this abnormal cell death and targeting the specific molecular checkpoint that controls cell death, we may be able to develop new drugs that would in...

LocatePLUS Announces Election of Independent Board

...zens safe. We are honored to stand shoulder-to-shoulder with law enforcement. We are privileged to be relied upon to confirm a suspicion at a border checkpoint or to whisper a warning at a roadside stop." About LocatePLUS LocatePLUS and its subsidiaries serve 13,500 security-sensitive clients ac...

SectorWatch.biz Issues Commentary for Investors of Homeland Defense Companies FOUR, MAGS, NSSC, PNTR, BCO, and CKP

...ystems Ltd. (Nasdaq: MAGS ), Napco Security Systems Inc. (Nasdaq: NSSC ), Pointer Telocation (Nasdaq: PNTR ), Brinks Company (NYSE: BCO ), and checkpoint Systems Inc. (NYSE: CKP ). To view the FiSpace.net exclusive article " Marks of Progress " visit: http://fispace.net/security-protection-ser...

The Burnham Buzz, February 2009

...fied the molecular machinery that regulates DNA replication and the S-phase checkpoint of the cell cycle. Wei Jiang, Ph.D., showed that the protein kinase complex... Ddk acts as a quality control protein and stops replication at the S-phase checkpoint of the cell cycle. Halting the cell cycle at the S-phase allows for DNA rep...

Biologists discover link between CGG repeats in DNA and neurological disorders

...ts causing the checkpoints to fail?" With replication stalled, Mirkin and his research team found that the CGG repeats did not respond to the key checkpoint protein called Mrc1 in yeast or claspin in humans. Both proteins work to repair replication malfunctions during the S phase of the cell cycle. Apparen...

Clear(R) Secures $44.4 Million in Venture Funding

...h a high-tech card which allows them to access designated security lanes nationwide for an annual fee of $128. Clear members pass through the security checkpoint faster, with more predictability and less hassle. Applicants start their enrollment at flyclear.com and complete the process at an enrollment location...

Monash researchers uncover cancer survival secrets

... chromosomes, and gain a growth and survival advantage. "Our studies have shown that PTK pathways are intimately associated with the regulation of checkpoint responses during DNA replication," Assoc Prof Tiganis said. "We have identified one mechanism by which PTKs may remain activated and allow cancer c...

A new cellular pathway linked to cancer is identified by NYU researchers

... Pagano. Tumor cells already have a less efficient checkpoint because of defects in other regulatory pathways. U...e mutations in p53, a tumor suppressor gene and G2 checkpoint regulator that operates in a separate pathway. ...eckpoint, normal cells have a fully functioning G2 checkpoint and divide less frequently, sparing them from drug...
checkpoint in Biological Technology

RNAi Helps Illuminate the Inner Workings of the Cell Cycle: Synthetic RNAissance™ Genes Created by DNA2.0 Enable Key Research

...ubiquitination of Cdc20 is required to prevent a cell from dividing before all of its chromosomes are lined up on the mitotic spindle. This cell cycle checkpoint is essential to prevent serious genetic damage in animals from yeast to humans. "We were delighted to help Dr. Pines by designing and making ...

FDA Grants Orphan Drug Designation to TREANDA, an Investigational Treatment for Chronic Lymphocytic Leukemia

...rapid, sustained single- and double-strand DNA damage, which results in apoptosis, or programmed cell death in the tumor. TREANDA also induces mitotic checkpoint inhibition, which results in non-apoptotic cell death. These novel dual-action, anti-tumor effects of TREANDA may be attributed to its unique chemical...

DNA Damage and Repair - Quantification of Sub-Cellular Events Using Automated Confocal Imaging

...from organisms as diverse as bacteria, yeast, drosophila, rodents and man (Friedberg et al. 2005). The presence of DNA damage may lead to cell cycle checkpoint arrest to allow time for DNA repair processes to occur. If however, the system becomes overwhelmed or the DNA repair mechanisms are impaired, the cell...
checkpoint in Biological Definition

Mitosis

... a microtubule before separation begins. It is thought that unattached kinetochores control this process by generating a signal - the mitotic spindle checkpoint - that tells the cell to wait before proceeding to anaphase. There are many theories as to how this is accomplished, some of them involving the gene...

Mitosis

... a microtubule before separation begins. It is thought that unattached kinetochores control this process by generating a signal - the mitotic spindle checkpoint - that tells the cell to wait before proceeding to anaphase. There are many theories as to how this is accomplished, some of them involving the gene...
checkpoint in Biological Dictionary

Stem cell

..... Perfect candor should rule in stem cell research. ... STEM CELLS Promotes Miodrag Stojkovi to Editor. ... MicroRNA 92b Controls the G1/S checkpoint Gene p57 in Human Embryonic Stem Cells ... ... dark side of stem cells . ... leukemia initiation in stem cells does not necessarily ... ...

Pachytene

...usually becomes disassembled and can no ... In addition, the pachytene checkpoint requires the chromatin silencing factor ... Pachytene arrest also requi... B, when SCs are uniformly distributed ... We find that the pachytene checkpoint requires Sum1, a transcriptional repressor ... NDT80 is required for exit...

Mitotic spindle

... ... Mitotic Spindle Enrichment ... The mitotic spindle assembly checkpoint prevents the onset of anaphase as long ... Mitotic Cell Death Is Associated with the Activation of the Spindle checkpoint ... radial array into a bipolar mitotic spindle that carries out ......

G2 phase

...and then assaying for ... suggest that plants may regulate the G2 - phase checkpoint in ... The G1 phase can be slowed by reducing the nutrients available ...leading cancer journals. ... UV radiation causes both G1 and G2 phase checkpoint arrest in vitro cultured cells. ... " G2 phase is the third, final,...

Cell cycle

...events involving the growth, replication, and division of a eukaryotic ... or permanently withdrawing from the cell cycle . ... Cell cycle checkpoint Cell cycle checkpoints are control mechanisms that ensure the fidelity of cell division in eukaryotic cells An interactive animation illust...
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