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Elusive HIV shape change revealed; Key clue to how virus infects cells

Structural biologists at Children's Hospital Boston and Harvard Medical School have shown how a key part of the human immunodeficiency virus (HIV) changes shape, triggering other changes that allow the AIDS virus to enter and infect cells. Their findings, published in the Feb. 24 issue of the journal Nature, offer clues that will help guide vaccine and treatment approaches. Researchers led...

Iron Deficiency Sparks Dramatic Changes In Gene Expression

Researchers at Duke University Medical Centerhave demonstrated for the first time what happens inside a cell when itis deprived of the essential nutrient iron. Iron is found abundantly inred meats, shellfish dried fruits, whole grains, spinach, seeds andother foods.Their study in yeast cells demonstrated that iron-starved cellspreserve the little iron they possess by shutting down the major...

Researchers trace evolution to relatively simple genetic changes

In a stunning example of evolution at work, scientists have now found that changes in a single gene can produce major changes in the skeletal armor of fish living in the wild. "Our motivation is to try to understa...

Plants defy Mendel's inheritance laws, may prompt textbook changes

Contrary to inheritance laws the scientific world has accepted for more than 100 years, some plants revert to normal traits carried by their grandparents, bypassing genetic abnormalities carried by both parents. These mutant parent plants apparently have hidden templates containing genetic information from the preceding generation that can be transferred to their offspring, even though the...

Scientists Propose Sweeping Changes to Naming of Bird Neurosystems to Acknowledge Their True Brainpower

The Food and Drug Administration (FDA) has granted approval to Mylan Technologies, Inc., for the first generic version of Alza Corporation's Duragesic Patch (Fentanyl Transdermal System) used to treat patients suffering from severe chronic pain that cannot be managed with alternative analgesics. When applied to the skin, this patch technology delivers fentanyl, an opioid pain medication that is s...

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Change at Biology Products

Anion Exchange ProteinChip Arrays from Ciphergen

Description:Ciphergen's ProteinChip arrays have been developed for affinity capture of proteins from biological samples. A variety of ProteinChip chemical surfaces allow differential capture of proteins according to their unique biochemical properties. Each chip has eight different spots, allowing side-by-side sample comparison, and the chips are color-coded with a unique hydrophobic coating. Ciphergen's pro...
Company:Ciphergen

Cation Exchange ProteinChip Arrays from Ciphergen

Description:Ciphergen's ProteinChip arrays have been developed for affinity capture of proteins from biological samples. A variety of ProteinChip chemical surfaces allow differential capture of proteins according to their unique biochemical properties. Each chip has eight different spots, allowing side-by-side sample comparison, and the chips are color-coded with a unique hydrophobic coating. Ciphergen's pro...
Company:Ciphergen

Anti-Na+ / H+ Exchanger-1, isoform NHE1 Monoclonal Antibody, Unconjugated from CHEMICON

Description:Na+/H+ exchanger, isoform NHE1....
Company:CHEMICON

T4 Polynucleotide Kinase Exchange Reaction Buffer from Invitrogen

Description:For use with T4 Polynucleotide Kinase for labeling of 5' ends (5' phosphate ends) of nucleic acids. In the exchange reaction T4 Polynucleotide Kinase transfers the 5' phosphate group from DNA to ADP and subsequently transfers the Gamma-phosphate of ATP to the free 5' hydroxyl group to rephosphorylate the DNA....
Company:Invitrogen

Change at Biology Technology

Detect Single Nucleotide Sequence Changes with Mx4000 Molecular Beacon Allelic Discrimination Kits

Allelic discrimination kits with excellent specificity, sensitivity, andassay throughput Stratagene Because of their unique hairpin conformation, molecular beacon probes canrecognize single base differences, making them ideal for mutation detection andallelic discrimination. Base...

New Temperature Cycler Features Interchangeable Blocks

Michelle Cayouette Jane Moores Jason Capodanno Michael Steege Michael Rahilly Stratagene Infinitytemperature cycler, a new temperature cycler withinterchangeable blocks for...

Mammalian Expression Vectors with Interchangeable Selectable Markers

Site-specific recombinase-based vector system Stratagene system of eukaryotic expression vectors offers unparalleled convenience. The drug-resistance genes of these vectors can be exchanged without subcloning. Through site-specific recombination, hygromycin, puromycin,...

Monitoring Receptor-Mediated Changes in [Ca2+]i Using Single-Wavelength and Dual-Wavelength Indicators on the FlexStation Workstation

Simon Lydford & Petra Averbeck, Molecular Devices Limited, U.K. The FlexStation scanning fluorometer integrates sensitive optics, fluid transfer and temperature control, making it ideal for kinetic, cell-based fluorometric assays, such as the measurement of intracellular calcium, membrane potential and intracellular pH. <...

It's not Y2K, but changes to Daylight Saving Time could cause tech problems

will have significant implications for organizations worldwide, but few business organizations are prepared to address their potential information technology impacts, according to a new <a href="http://www.gartner.com/DisplayDocument?ref=g_search&id=500284&subref=simplesea...

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Change at Medicine News

GlaxoSmithKline - Changes Lamictal(R) Label Appearance and Packaging

Lamictal, an antiepileptic drug, is one of the several prescription drugs that has encountered the problem of dispensing errors. Dispensing errors are often a result of miscommunication, which can include poor hand writing of the prescription and confusion between drugs with similar names.// It is important for patients with epilepsy not to have an interruption in treatment be...

Drug abuse leads to long standing changes in the brain

Methamphetamine, a highly addictive stimulant drug, whose abuse has reached epidemic proportions in many parts of the world, causes long-term changes in the human brain that are associated with impaired memory and motor coordination, according to a study published in theAmerican Journal of Psychiatry. Researchers found that these effects are seen even in methamphetamine addicts who have been off...

Inspiring positive life changes

Exhibiting people evidence of the harm unhealthy habits do can motivate them to change.Researchers in Texas have reviewed a number of studies on biomarkers indicators of health or disease status to see// if a knowledge of these can affect people's behaviour. They learned that if you reveal factors like carbon monoxide levels in blood - increased by smoking it does encourage people t...

FDA changes rules on testing drugs for children

The FDA is suspending a rule that lets the government require safety testing of adult medicines commonly given to children, a move that has drawn the ire of some Democratic lawmakers. FDA says Congress recently reauthorized financial incentives for manufacturers to do those studies. The FDA said it wants to see if the new law makes the old mandate, which drug makers hated, unnecessary.//...

Dietary Changes Could Reduce The Risk for Stroke

Dietary modification could be a simple way to reduce the risk of stroke say researchers. The research shows a diet that consists of meats,// refined grains and desserts is associated with a greater risk for stroke than a diet of fruits, vegetables, fish, legumes and whole grains. The study included dietary information on 71,768 female nurses between 38 and 63 years old. The women had no...

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Change at Medicine Products

Burton 1200 Chair-exchanger

Description:If you presently have an exam chair that is separate from the instrument stand, we can solve your access problem with a Burton 1200 Chair-exchanger...
Company:Burton Ophthalmic

BchiVac V-1000 vacuum pump, w/Pump Controller V-719, and automatic change over valve

Description:Model V-1000 is a new addition to the powerful PTFE membrane vacuum pump line from Bchi. This high performance pump can achieve an ultimate vacuum of 1 mbar or a flow rate of 64 L/min. Distillation applications from lab size up to industrial size rotary evaporators BchiVac V-1000 product fe...
Company:Brinkmann

TC-312 Techne Thermal Cycler (interchangeable block)

Description:The Techne TC-312 Thermal Cycler is one of the smallest footprints on the market. Features & Benefits include: Fast ramping, low cost, PC Control and networking, Alpha-numeric screen, keypad and program naming, Ready-to-go templates, interchangeable blocks. The TC-312 has numerous applications in Molecular Biology and Diagnostic laboratories and is suitable for use with diagnostic kits. Include...
Company:MIDSCI

PERRY Exchange Dilator

Description:A particular challenge in transseptal left heart catheterization occurs when the initial guiding sheath must be exchanged for a sheath with an alternate curve while maintaining the septal wall position. Traditionally, such an exchange has required a repeat septal puncture--complex in a heparinized patient. Biosense Webster has overcome this problem with the unique PERRY exchange dilator used with...
Company:Biosense Webster, a Johnson & Johnson Company

Chromosome Analysis, Sister Chromatid Exchange

Description:ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories' clients include more than half of the nation's university teaching hospitals and children's hospitals, maj...
Company:ARUP Laboratories

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Change at Medicine Technology

Clinical Trial Results Change Standard of Care for Pancreatic Cancer Patients, Future Therapies Discussed

CHICAGO, June 05, 2007 /PRNewswire-USNewswire/ -- The BarbaraAnn Karmanos Cancer Institute's Philip A. Philip, M.D., Ph.D.F.R.C.P., professor of medicine and oncology, presented the outcomeof one of the largest randomized phase III pancreas cancer clinicaltrials in North America and chaired an education session about thefuture of pancreatic cancer therapies at the American Society ofClin...

FDA Announces Change of Location Notice for Upcoming Advisory Committee Meeting

ROCKVILLE, Md., April 18, 2007--Due to water damage caused byflooding over the weekend, FDA has been forced to change thelocation for the upcoming Antiviral Drugs Advisory Committeemeeting on April 24, 2007 to discuss new drug application formaraviroc 300 milligram tablets. Originally scheduled to be held atthe FDA, Center for Drug Evaluation and Research Advisory CommitteeConference Roo...

KineMed Presents Data Measuring Changes in Reverse Cholesterol Transport for the First Time

Research Breakthrough Will Aid in Developing Therapies to Preventand Reverse Atherosclerotic Heart Disease EMERYVILLE, Calif., May 10, 2007 /PRNewswire/ -- KineMed, Inc.,a pathway-based drug discovery and development company, announcedtoday the first method for measuring the efflux of cholesterol fromtissues in animals through the pathway known as reverse cholesteroltransport (RCT). RCT i...

Study Shows Children With ADHD Who Start on Strattera are More Likely to Change Therapies

Prime Therapeutics recommends clinical utilization managementprograms ST. PAUL, Minn., April 10, 2007 /PRNewswire/ -- Pharmacy benefitmanager Prime Therapeutics (Prime) today announced the results of astudy on the utilization of Strattera(R) (atomoxetine) for treatingattention deficit hyperactivity disorder (ADHD) in children. Thestudy found that children who start on Strattera were 4.2 t...

Change at Medicine Dictionary

Myopathic changes

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