Study in this Week's Issue of Cell Finds Injected Growth Factor Spurs Heart Regeneration

...also stimulated production of a cellular receptor for NRG1, known as ErbB4, cardiomyocyte proliferation was further enhanced, demonstrating that NRG1 works by stimul...en the patch was placed over the site of cardiac injury in rats, it induced cardiomyocyte proliferation and improved heart function (Nature Medicine 2007; 13:962-9)...

Master Stem Cell for Human Heart Identified

...They then purified the cells, cloned them and tracked their journey from single stem cell to the three major lineages of heart cells -- smooth muscle, cardiomyocyte muscle and endothelial cells. Chien said that he thought it would be "entirely unlikely" that scientists would be able to use these cells to "grow...

Human Heart Can Make New Cells

...rate, but there has been substantial controversy as to the rate of cellular turnover," he said. This new study, using carbon dating, suggests that cardiomyocyte regeneration can occur, but to a very limited degree, Fonarow said. "Whether there will be medical or gene therapies that can safely and effecti...

American Society for Investigative Pathology Award presented to David M. Engman

...mmune response is made up of two factions: the antigenic molecular mimicry between parasite and heart proteins and cardiac autoimmunity resulting from cardiomyocyte damage by the parasite. By using advanced equipment, the lab is attempting to re-establish immune tolerance to heart antigens while enhancing a robus...

JCI table of contents: Sept. 4, 2007

...du . View the PDF of this article at: https://www.the-jci.org/article.php?id=31901 ACCOMPANYING COMMENTARY TITLE: Alternative signaling: cardiomyocyte beta1-adrenergic receptors signal through EGFRs AUTHOR CONTACT: Stefan Engelhardt University of Würzburg, Würzburg, Germany.. Phone: 49-931-2...

Scientists Demonstrate Heart Cell Replication in Mice

... The researchers believe that a sustained-delivery periostin patch may one day be helpful in treating adults with heart attack, and in encouraging cardiomyocyte proliferation in children with congenital heart disease. "Many patients with severe congenital heart disease eventually hit a place where the ...

Cell Wall of Pneumonia Bacteria Can Cause Brain and Heart Damage

... fact, mice pretreated for 16 hours with CV-6209 survived, while mice treated after inoculation of cell wall did not. “Our success in preserving cardiomyocyte function even in the presence of cell wall suggests that it might be possible to safely pre-treat people infected with S. pneumoniae with a drug that ...

Rescuing Injured Hearts by Enhancing Regeneration

... by inhibiting an enzyme known as p38 MAP kinase, which normally suppresses cardiomyocyte replication. [See: http://www.childrenshospital.org/newsroom /Site1339/ma...me. Engel and colleagues recently reported another compound that stimulates cardiomyocyte proliferation (Chemistry and Biology, Sept. 2006), and others are under inv...

"Miracle" Cancer Drug Gleevec Can be Toxic to the Heart

...gainst such tumors but not cause heart problems. “We’ve learned something about the biology of the heart,” Dr. Force says. “ABL is important for cardiomyocyte health. We also can learn something about how to stay away from these targets that are important and optimize the drugs.” In other studies, the ...

cardiomyocyte in Medical Technology

Injection Reverses Heart-Attack Damage

...also stimulated production of a cellular receptor for NRG1, known as ErbB4, cardiomyocyte proliferation was further enhanced, demonstrating that NRG1 works by stimul...en the patch was placed over the site of cardiac injury in rats, it induced cardiomyocyte proliferation and improved heart function ( Nature Medicine 2007; 13:962-...

Cardium Reports on Applicability of Corgentin to Stem Cell Therapies: Independent Studies Indicate that Ad5IGF-1 Potentiates Stem Cells to Improve Cardiac Function After Heart Attack

...Executive Officer. "The well-documented biological properties of IGF-1 protein include the inhibition of programmed cell death or apoptosis, adaptive cardiomyocyte hypertrophy, proliferation of cardiac progenitor cells and angiogenesis. These observations provide a strong scientific rationale for the clinical dev...

Bioheart Reports Promising Results From Preclinical Study of Adipose-Derived Acute Cell Therapy

...evaluated at 60 days. The treatment arms, however, showed a tendency toward cardiomyocyte regeneration, prominent angiogenesis (growth of new blood vessels) when eva...se of human cells in preclinical studies. These results are indicative of cardiomyocyte regeneration and suggest that the injection of ADSCs after AMI may have the...

cardiomyocyte in Medical Dictionary

Contraction

...usands of Brands. Hundreds of Stores. Calcium cycling/excitation- contraction coupling. Heart failure - basic studies ... FABP4 Acutely Inhibits cardiomyocyte Contraction ... A contraction stress test checks to see if your baby (fetus) will be okay with the reduced oxygen levels that normally occ...

cardiomyocyte in Biological News

First direct mechanical communication of mitochondria, cardiomyocyte nucleus shown

In a paper being presented in two American Physiological Society sessions at Experimental Biology 2006, a joint Estonian-French team demonstrated "for the first time that mitochondria are able to induce nuclear deformation, suggesting that mitochondria may mechanically regulate nuclear function." ...

MDC researchers prevent virus induced myocarditis

...e (MDC) Berlin-Buch, Germany, have now abolished the infection by blocking the receptor which is required for virus entry. "We did not detect a single cardiomyocyte that was infected by the virus. Inflammation of the heart muscle associated with this virus infection did not develop," Dr. Shi said. ( Journal of Ame...

Cardiac cell transplant studies show promise in cardiac tissue repair

...technique shows promise as a feasible new strategy for myocardial repair." cardiomyocyte survival was counted at one, three and seven days after culture to see if p...nction was measured before and 28 days after treatment. Results showed that cardiomyocyte survival increased significantly in the co-cultured group. Although cardiom...

New source of heart stem cells discovered

...expressing cell, the researchers could identify these descendants by looking for RFP. "If the marker shows up in a cardiomyocyte, then I know that cardiomyocyte came from the Cre-expressing progenitor," said Pu. At the moment, scientists are still trying to figure out whether and how the Wt1-expressing prog...

Geron Demonstrates hESC-derived cardiomyocytes improve heart function after myocardial infarction

... failure patients die within two years of diagnosis. Were developing our cardiomyocyte product, GRNCM1, to address the large unmet need in heart failure, Dr. Okar...ter infarction but two days prior to cell injection) and at four weeks post cardiomyocyte implantation. All animals exhibited significant cardiac dysfunction two day...

JCI table of contents: Aug. 9, 2007

...that cell death by necrosis also has a role in the cardiomyocyte loss that accompanies heart failure in mice. In...on that Ca2+- and mitochondrial-dependent necrotic cardiomyocyte death is a cellular event that contributes to hear... disease that involves both apoptotic and necrotic cardiomyocyte death. TITLE: Ca2+- and mitochondrial-dependent...

Rescuing injured hearts by enhancing regeneration

... by inhibiting an enzyme known as p38 MAP kinase, which normally suppresses cardiomyocyte replication. [See: www.childrenshospital.org/newsroom/Site1339/mainpageS13...me. Engel and colleagues recently reported another compound that stimulates cardiomyocyte proliferation (Chemistry and Biology, Sept. 2006), and others are under inv...

Cell wall of pneumonia bacteria can cause brain and heart damage

...n fact, mice pretreated for 16 hours with CV-6209 survived, while mice treated after inoculation of cell wall did not. "Our success in preserving cardiomyocyte function even in the presence of cell wall suggests that it might be possible to safely pre-treat people infected with S. pneumoniae with a drug that ...

cardiomyocyte in Biological Technology

Cellular Dynamics International and Roche Expand Existing Cardiotoxicity Screening Agreement

...xperiments. The agreement also includes an ongoing cardiomyocyte supply contract post collaboration. Embarked ...'s next phase is to detect drug-induced changes in cardiomyocyte activity across a spectrum of compounds. While it ...are thrilled with the expansion of our Roche human cardiomyocyte program," said Robert Palay, CDI Chief Executive O...

Cardium's Corgentin Preclinical Program Shows High Levels of Targeting to Acutely Ischemic Heart Muscle Following Intracoronary Infusion

... damage to heart muscle and improve cardiac healing following a heart attack. The inherent biological properties of IGF-I, which include inhibition of cardiomyocyte apoptosis, adaptive cardiomyocyte hypertrophy, recruitment of cardiac progenitor cells, as well as the induction of angiogenesis and enhancement of ca...

cardiomyocyte in Biological Dictionary

Sarcolemma

...eceptors close Ca release channels ... ... represent KATP channels in sarcolemma of human cardiomyocytes and are ... in inside-out patches from cardiomyocyte sarcolemma ,1 2 directly link changes in ... ... (excitation) of the muscle cell membrane (the sarcolemma ) to muscular contraction. ... Regu...